Heme oxygenase‐1–mediated autophagy protects against hepatocyte cell death and hepatic injury from infection/sepsis in mice

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Hepatology

• Publication date

  2011-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/hep.24324PMID 21437926PMCID PMC9976293
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2010cited by this paper
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  2010cited by this paper
• Mitochondria and reactive oxygen species.

  2009cited by this paper
• Autophagy activation by NFkappaB is essential for cell survival after heat shock.

  2009cited by this paper
• Role of haem oxygenase‐1 in microbial host defence

  2009cited by this paper
• Autophagy activation by NFκB is essential for cell survival after heat shock

  2009cited by this paper
• Mitochondria and reactive oxygen species.

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• Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice.

  2008cited by this paper
• Carbon monoxide activates NF-kappaB via ROS generation and Akt pathways to protect against cell death of hepatocytes.

  2008cited by this paper
• Mitochondria and cellular oxygen sensing in the HIF pathway.

  2008cited by this paper
• Self-eating and self-killing: crosstalk between autophagy and apoptosis.

  2007cited by this paper
• Self-eating and self-killing: crosstalk between autophagy and apoptosis

  2007cited by this paper
• Carbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species

  2007cited by this paper
• Apoptosis and autophagy: regulatory connections between two supposedly different processes

  2007cited by this paper
• Macroautophagy versus mitochondrial autophagy: a question of fate?

  2005cited by this paper
• Reactive Oxygen Species : An Evolution in Function

  2005cited by this paper
• Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure.

  2004cited by this paper
• Mitochondrial dysfunction in sepsis

  2003cited by this paper
• Carbon Monoxide Inhibition of Apoptosis during Ischemia-Reperfusion Lung Injury Is Dependent on the p38 Mitogen-activated Protein Kinase Pathway and Involves Caspase 3*

  2003cited by this paper
• Carbon Monoxide Protects against Liver Failure through Nitric Oxide–induced Heme Oxygenase 1

  2003cited by this paper
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  2000influential reference
• Cationic colloidal silica membrane perturbation as a means of examining changes at the sinusoidal surface during liver regeneration.

  1999cited by this paper
• Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction.

  1999cited by this paper
• Differential expression pattern of heme oxygenase-1/heat shock protein 32 and nitric oxide synthase-II and their impact on liver injury in a rat model of hemorrhage and resuscitation.

  1999cited by this paper
• Nitric oxide inhibition of cytochrome oxidase and mitochondrial respiration: Implications for inflammatory, neurodegenerative and ischaemic pathologies

  1997cited by this paper
• Inhibition of cytochrome-c oxidase activity during prolonged hypoxia.

  1995cited by this paper

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  2025cites this paper
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• Ethyl pyruvate ameliorates heat stroke-induced multiple organ dysfunction and inflammatory responses by induction of stress proteins and activation of autophagy in rats

  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
• Autophagy plays a double-edged sword role in liver diseases

  2021cites this paper
• Astaxanthin protects against early acute kidney injury in severely burned rats by inactivating the TLR4/MyD88/NF-κB axis and upregulating heme oxygenase-1

  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020influential citation
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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