Enzymatic formation of acetylgalactosamine.

Several papers have been published on the biosynthesis of glucosamine in different organisms (l-3), but the reactions which lead to the synthesis of galactosamine have hardly been explored. The first indication of its mode of synthesis came from the isolation of uridine diphosphate’ acetylgalactosamine from liver by Pontis (4). This finding showed that the transformation of acetylhexosamines is similar to that of the pair glucosegalactose which has been studied in detail (5, 6). Pontis mentioned that, upon incubation of UDP-acetylglucosamine with a crude liver extract, some acetylgalactosamine was formed, but he did not investigate whether the substance appeared in the free or combined form. Further work on the point is reported in this paper. The products arising by the action of rat liver homogenate on UDP-acetylglucosamine were found to be free acetylgalactosamine and uridine monophosphate.

• Publication year

  1957

• Venue

  Journal of Biological Chemistry

• Publication date

  1957-03-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/s0021-9258(18)64933-6PMID 13416241
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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