Pathobiochemical Changes in Diabetic Skeletal Muscle as Revealed by Mass-Spectrometry-Based Proteomics

Insulin resistance in skeletal muscle tissues and diabetes-related muscle weakness are serious pathophysiological problems of increasing medical importance. In order to determine global changes in the protein complement of contractile tissues due to diabetes mellitus, mass-spectrometry-based proteomics has been applied to the investigation of diabetic muscle. This review summarizes the findings from recent proteomic surveys of muscle preparations from patients and established animal models of type 2 diabetes. The potential impact of novel biomarkers of diabetes, such as metabolic enzymes and molecular chaperones, is critically examined. Disease-specific signature molecules may be useful for increasing our understanding of the molecular and cellular mechanisms of insulin resistance and possibly identify new therapeutic options that counteract diabetic abnormalities in peripheral organ systems. Importantly, the biomedical establishment of biomarkers promises to accelerate the development of improved diagnostic procedures for characterizing individual stages of diabetic disease progression, including the early detection of prediabetic complications.

• Publication year

  2012

• Venue

  Journal of Nutrition and Metabolism

• Publication date

  2012-02-29

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1155/2012/893876PMID 22523676PMCID 3317182
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The proteomic signature of insulin-resistant human skeletal muscle reveals increased glycolytic and decreased mitochondrial enzymes

  2012cited by this paper
• Study of diabetic nephropathy in the proteomic era.

  2011cited by this paper
• Personalized medicine in diabetes.

  2011cited by this paper
• Skeletal muscle proteomics: current approaches, technical challenges and emerging techniques

  2011cited by this paper
• Changes in expression of skeletal muscle proteins between obesity-prone and obesity-resistant rats induced by a high-fat diet.

  2011cited by this paper
• Characterization of Human Myotubes From Type 2 Diabetic and Nondiabetic Subjects Using Complementary Quantitative Mass Spectrometric Methods*

  2011cited by this paper
• Diabetic nephropathy in humans: pathologic diversity

  2011cited by this paper
• Welcome to Skeletal Muscle

  2011cited by this paper
• Genetics of type 2 diabetes.

  2011cited by this paper
• Proteomic analysis of the mitochondria-enriched fraction from diabetic rat skeletal muscle

  2011cited by this paper
• Unraveling pancreatic islet biology by quantitative proteomics

  2011cited by this paper
• Metabolic benefits of resistance training and fast glycolytic skeletal muscle.

  2011cited by this paper
• Mouse models of diabetic nephropathy

  2011cited by this paper
• Skeletal muscle tissue from the Goto-Kakizaki rat model of type-2 diabetes exhibits increased levels of the small heat shock protein Hsp27.

  2011cited by this paper
• Therapeutic approaches to target inflammation in type 2 diabetes.

  2011cited by this paper
• New insights in diabetic foot infection.

  2011cited by this paper
• Biomarkers for the Prediction of Type 2 Diabetes and Cardiovascular Disease

  2011cited by this paper
• Some views on proteomics in diabetes

  2011cited by this paper
• Diversity of human skeletal muscle in health and disease: contribution of proteomics.

  2011cited by this paper
• Regular physical exercise training assists in preventing type 2 diabetes development: focus on its antioxidant and anti-inflammatory properties

  2011cited by this paper
• Is diabetes mellitus a continuous spectrum?

  2011cited by this paper
• Serum biomarker of diabetic peripheral neuropathy indentified by differential proteomics.

  2011cited by this paper
• Human ATP synthase beta is phosphorylated at multiple sites and shows abnormal phosphorylation at specific sites in insulin-resistant muscle

  2010influential reference
• Proteomic discovery of diabetic nephropathy biomarkers.

  2010cited by this paper
• Proteomic profiling of non-obese type 2 diabetic skeletal muscle.

  2010cited by this paper
• Pathogenesis of Insulin Resistance in Skeletal Muscle

  2010cited by this paper
• Fibre types in skeletal muscle: a personal account

  2010cited by this paper
• Diabetic cardiomyopathy, causes and effects

  2010cited by this paper
• The effect of exercise and nutrition on intramuscular fat metabolism and insulin sensitivity.

  2010cited by this paper
• Proteomics of skeletal muscle differentiation, neuromuscular disorders and fiber aging

  2010cited by this paper
• Differential expression of skeletal muscle proteins in high‐fat diet‐fed rats in response to capsaicin feeding

  2010cited by this paper
• Phosphoproteome Analysis of Functional Mitochondria Isolated from Resting Human Muscle Reveals Extensive Phosphorylation of Inner Membrane Protein Complexes and Enzymes*

  2010cited by this paper
• Mass spectrometric identification of dystrophin isoform Dp427 by on-membrane digestion of sarcolemma from skeletal muscle.

  2010cited by this paper
• DIGE analysis of rat skeletal muscle proteins using nonionic detergent phase extraction of young adult versus aged gastrocnemius tissue.

  2010cited by this paper
• The role of mitochondria in the pathophysiology of skeletal muscle insulin resistance.

  2010cited by this paper
• Comparative analysis of fat and muscle proteins in fenofibrate-fed type II diabetic OLETF rats: the fenofibrate-dependent expression of PEBP or C11orf59 protein.

  2010cited by this paper
• Increased Reactive Oxygen Species Production and Lower Abundance of Complex I Subunits and Carnitine Palmitoyltransferase 1B Protein Despite Normal Mitochondrial Respiration in Insulin-Resistant Human Skeletal Muscle

  2010cited by this paper
• Visual Dysfunction Associated with Diabetic Retinopathy

  2010cited by this paper
• Long term bed rest with and without vibration exercise countermeasures: Effects on human muscle protein dysregulation

  2010cited by this paper
• Vitreous Proteomics and Diabetic Retinopathy

  2010cited by this paper
• Proteomics in diabetes research.

  2009cited by this paper
• The role of mitochondria in health and disease.

  2009cited by this paper
• Excessive Loss of Skeletal Muscle Mass in Older Adults With Type 2 Diabetes

  2009cited by this paper
• Management of the metabolic syndrome and type 2 diabetes through lifestyle modification.

  2009cited by this paper
• Proteomics by mass spectrometry: approaches, advances, and applications.

  2009cited by this paper
• Universal sample preparation method for proteome analysis

  2009cited by this paper
• Proteomic changes associated with diabetes in the BB-DP rat.

  2009cited by this paper
• Experimental rat models to study the metabolic syndrome.

  2009cited by this paper
• Is skeletal muscle mitochondrial dysfunction a cause or an indirect consequence of insulin resistance in humans?

  2009cited by this paper
• Comparative proteomic profile of rat sciatic nerve and gastrocnemius muscle tissues in ageing by 2‐D DIGE

  2009cited by this paper
• Four grams of glucose.

  2009cited by this paper
• Attenuation of inflammation and cellular stress‐related pathways maintains insulin sensitivity in obese type I interleukin‐1 receptor knockout mice on a high‐fat diet

  2009cited by this paper
• Biochemical and proteomic approaches for the study of membrane microdomains.

  2009cited by this paper
• Glucotoxicity and pancreatic proteomics.

  2009cited by this paper
• Universal sample preparation method for proteome analysis

  2009cited by this paper
• Proteomic investigation of changes in human vastus lateralis muscle in response to interval‐exercise training

  2009cited by this paper
• Proteolysis activation and proteome alterations in murine skeletal muscle submitted to 1 week of hindlimb suspension

  2009cited by this paper
• Proteomics and diabetic retinopathy.

  2009cited by this paper
• Proteomics Analysis of Human Skeletal Muscle Reveals Novel Abnormalities in Obesity and Type 2 Diabetes

  2009influential reference
• Diabetic cardiomyopathy

  2009cited by this paper
• Changes in the rat skeletal muscle proteome induced by moderate-intensity endurance exercise.

  2008cited by this paper
• Genes and type 2 diabetes mellitus

  2008cited by this paper
• Amino acid supplements improve native antioxidant enzyme expression in the skeletal muscle of diabetic mice.

  2008cited by this paper
• Proteomics of mitochondrial inner and outer membranes

  2008cited by this paper
• Type 2 diabetes: Gaining insight into the disease process using proteomics

  2008cited by this paper
• The pathobiochemical role of the dystrophin-dystroglycan complex and the Ca2+-handling apparatus in diabetes-related muscle weakness (Review).

  2008cited by this paper
• Proteomics in diabetic nephropathy

  2008cited by this paper
• Proteomic studies in animal models of diabetes

  2008cited by this paper
• Proteomic profiling of beta-cells using a classical approach - two-dimensional gel electrophoresis.

  2008cited by this paper
• Characterization of the Human Skeletal Muscle Proteome by One-dimensional Gel Electrophoresis and HPLC-ESI-MS/MS*S

  2008cited by this paper
• A DIGE approach for the assessment of rat soleus muscle changes during unloading: effect of acetyl‐L‐carnitine supplementation

  2008cited by this paper
• Transcriptome and Proteome Expressions Involved in Insulin Resistance in Muscle and Activated T-Lymphocytes of Patients with Type 2 Diabetes

  2008cited by this paper
• Non-covalent and covalent protein labeling in two-dimensional gel electrophoresis.

  2008cited by this paper
• Type 2 diabetes mellitus and skeletal muscle metabolic function.

  2008cited by this paper
• Diabetic cardiomyopathy: insights into pathogenesis, diagnostic challenges, and therapeutic options.

  2008cited by this paper
• A Combination of Nutriments Improves Mitochondrial Biogenesis and Function in Skeletal Muscle of Type 2 Diabetic Goto–Kakizaki Rats

  2008cited by this paper
• Type 2 diabetes: new genes, new understanding.

  2008cited by this paper
• Membrane proteins and membrane proteomics

  2008cited by this paper
• Complementary methods to assist subcellular fractionation in organellar proteomics

  2008cited by this paper
• Sub‐cellular localization of membrane proteins

  2008cited by this paper
• Effects of regular exercise on cardiovascular risk factors profile and oxidative stress in obese type 2 diabetic patients in regard to SCORE risk

  2008cited by this paper
• Rodent models of streptozotocin‐induced diabetic nephropathy (Methods in Renal Research)

  2007cited by this paper
• Muscular mitochondrial dysfunction and type 2 diabetes mellitus

  2007cited by this paper
• Proteomic profiling of pathological and aged skeletal muscle fibres by peptide mass fingerprinting (Review).

  2007cited by this paper
• Proteomic profiling of animal models mimicking skeletal muscle disorders

  2007cited by this paper
• Proteomics and Systems Biology in Exercise and Sport Sciences Research

  2007cited by this paper
• Proteomic profiling of chronic low‐frequency stimulated fast muscle

  2007cited by this paper
• Altered fiber distribution and fiber-specific glycolytic and oxidative enzyme activity in skeletal muscle of patients with type 2 diabetes.

  2006cited by this paper
• Recent Insights into Experimental Mouse Models of Diabetic Nephropathy

  2006cited by this paper
• Decreased Muscle Strength and Quality in Older Adults With Type 2 Diabetes

  2006cited by this paper
• Two-dimensional difference gel electrophoresis

  2006cited by this paper
• Mitochondria: More Than Just a Powerhouse

  2006cited by this paper
• Diabetic uropathy.

  2006cited by this paper
• Mouse models of diabetic nephropathy.

  2005cited by this paper
• Development and application of rodent models for type 2 diabetes

  2005cited by this paper
• The development of the DIGE system: 2D fluorescence difference gel analysis technology

  2005cited by this paper
• Protein Detection Methods in Proteomics Research

  2005cited by this paper
• Proteome analysis of skeletal muscle from obese and morbidly obese women.

  2005influential reference
• Expression of the skeletal muscle dystrophin-dystroglycan complex and syntrophin-nitric oxide synthase complex is severely affected in the type 2 diabetic Goto-Kakizaki rat.

  2005cited by this paper
• Differential expression of the fast skeletal muscle proteome following chronic low-frequency stimulation.

  2005cited by this paper

• Evaluation of the toxicity potential of exercise and atorvastatin/metformin combination therapy on STZ-diabetic rats

  2024cites this paper
• Exploration of macromolecular phenotype of human skeletal muscle in diabetes using infrared spectroscopy

  2023cites this paper
• A two-layer continuously distributed capillary O2 transport model applied to blood flow regulation in resting skeletal muscle.

  2022cites this paper
• Glucose Levels as a Mediator of the Detrimental Effect of Abdominal Obesity on Relative Handgrip Strength in Older Adults

  2020cites this paper
• Ketogenic diets and protective mechanisms in epilepsy, metabolic disorders, cancer, neuronal loss, and muscle and nerve degeneration.

  2020cites this paper
• FIU Digital Commons All Faculty 1-1-2014 Introduction to Personalized Medicine in Diabetes Mellitus

  2019cites this paper
• Gender-effect on the contractile properties of skeletal muscle in streptozotocin-induced diabetic rats

  2018cites this paper
• Proteomic analysis of corneal endothelial cell-descemet membrane tissues reveals influence of insulin dependence and disease severity in type 2 diabetes mellitus

  2018cites this paper
• Effect of L-carnitine on diabetes-induced changes of skeletal muscles in rats

  2018cites this paper
• Infections: A Possible Risk Factor for Type 2 Diabetes.

  2017cites this paper
• Can a simple test of functional capacity add to the clinical assessment of diabetes?

  2016cites this paper
• Proteomic profiling of muscle fibre type shifting in neuromuscular diseases

  2016cites this paper
• SKELETAL MUSCLE: ONE OF THE SILENT TARGETS OF DIABETIC COMPLICATIONS

  2016cites this paper
• Association Between Increased Insulin Resistance Index HOMA-IR and COPD in a Nationally Representative Population Sample

  2015cites this paper
• Mitochondria in metabolic disease: Getting clues from proteomic studies

  2014cites this paper
• Frailty, sarcopenia and diabetes.

  2014cites this paper
• Introduction to Personalized Medicine in Diabetes Mellitus

  2014cites this paper
• Proteomics of exercise-induced skeletal muscle adaptations

  2013cites this paper
• Proteomic identification of biomarkers of skeletal muscle disorders.

  2013cites this paper
• Proteomic profiling of the contractile apparatus from skeletal muscle

  2013cites this paper
• Gender-Dimorphic Regulation of Skeletal Muscle Proteins in Streptozotocin-Induced Diabetic Rats

  2013cites this paper
• Proteome‐base biomarkers in diabetes mellitus: Progress on biofluids' protein profiling using mass spectrometry

  2012cites this paper