Regulation by complementary idiotypes. Ig protects the clone producing it

A/He mice actively producing complementary or anti-idiotypic antibody directed against a combining site structure for phosphorylcholine (PC) have profound and long-lasting suppression of their response to PC. B cells from unresponsive mice are unresponsive in vitro, and attempts to demonstrate suppressor cells in unresponsive mice were unsuccessful. Although the process ultimately responsible for suppression has not been defined, suppression can be initiated by anti-idiotypic antibody alone and prevented by complementary Ig; i.e., by anti-PC antibody. Furthermore, a suppressed anti-PC response can be rescued by sublethal irradiation and anti-PC antibody given passively. The recovery of the suppressed response is slow and presumably results from maturation from "stem" cells, which are protected from tolerization by the passively given antibody. Thus, by extrapolation, one of the functions of secreted Ig may be to protect the clone that produces it.

• Publication year

  1981

• Venue

  Journal of Experimental Medicine

• Publication date

  1981-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/JEM.153.6.1377PMID 6454747PMCID 2186185
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1980cited by this paper
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  1980cited by this paper
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  1980influential reference
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  1980cited by this paper
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  1980cited by this paper
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  1980cited by this paper
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  1978influential reference
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  1978cited by this paper
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  1978cited by this paper
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  1978cited by this paper
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  1978cited by this paper
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  1977cited by this paper
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  1977cited by this paper
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  1977cited by this paper
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  1977cited by this paper
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  1976influential reference
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  1975cited by this paper
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  1984cites this paper
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