The X11 proteins, Abeta production and Alzheimer's disease.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Trends in Neurosciences

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 16545469
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Notch signalling in vertebrate neural development

  2006cited by this paper
• Expression of human FE65 in amyloid precursor protein transgenic mice is associated with a reduction in β‐amyloid load

  2005cited by this paper
• Assigning functions to distinct regions of the N-terminus of the prion protein that are involved in its copper-stimulated, clathrin-dependent endocytosis

  2005cited by this paper
• Transcription regulation by the adaptor protein Fe65 and the nucleosome assembly factor SET

  2005cited by this paper
• Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP.

  2005cited by this paper
• Solution Structure of the Second PDZ Domain of the Neuronal Adaptor X11α and its Interaction with the C-terminal Peptide of the Human Copper Chaperone for Superoxide Dismutase

  2005cited by this paper
• Fasciclin II Signals New Synapse Formation through Amyloid Precursor Protein and the Scaffolding Protein dX11/Mint

  2005cited by this paper
• BACE1 Cytoplasmic Domain Interacts with the Copper Chaperone for Superoxide Dismutase-1 and Binds Copper*

  2005cited by this paper
• A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein.

  2005cited by this paper
• beta-Secretase, APP and Abeta in Alzheimer's disease.

  2005cited by this paper
• RNA interference-mediated silencing of X11alpha and X11beta attenuates amyloid beta-protein levels via differential effects on beta-amyloid precursor protein processing.

  2005cited by this paper
• Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimer's Disease

  2005cited by this paper
• The neuronal adaptor protein X11beta reduces amyloid beta-protein levels and amyloid plaque formation in the brains of transgenic mice.

  2004cited by this paper
• Proteolytic Processing of Amyloid-β Precursor Protein by Secretases Does Not Require Cell Surface Transport*

  2004cited by this paper
• Amyloid-beta precursor protein processing in neurodegeneration.

  2004cited by this paper
• Neuronal membrane cholesterol loss enhances amyloid peptide generation

  2004cited by this paper
• The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor

  2004cited by this paper
• Mutation of the feh‐1 gene, the Caenorhabditis elegans orthologue of mammalian Fe65, decreases the expression of two acetylcholinesterase genes

  2004cited by this paper
• Adaptor protein interactions: modulators of amyloid precursor protein metabolism and Alzheimer's disease risk?

  2004cited by this paper
• Clioquinol Mediates Copper Uptake and Counteracts Copper Efflux Activities of the Amyloid Precursor Protein of Alzheimer's Disease*

  2004cited by this paper
• X11alpha impairs gamma- but not beta-cleavage of amyloid precursor protein.

  2004cited by this paper
• Dissection of Amyloid-β Precursor Protein-dependent Transcriptional Transactivation*

  2004cited by this paper
• The metallobiology of Alzheimer's disease.

  2003cited by this paper
• Novel Cadherin-related Membrane Proteins, Alcadeins, Enhance the X11-like Protein-mediated Stabilization of Amyloid β-Protein Precursor Metabolism*

  2003cited by this paper
• In vivo reduction of amyloid-beta by a mutant copper transporter.

  2003cited by this paper
• The neuronal adaptor protein X11alpha reduces Abeta levels in the brains of Alzheimer's APPswe Tg2576 transgenic mice.

  2003cited by this paper
• Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

  2003cited by this paper
• C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression.

  2003cited by this paper
• Trace amounts of copper in water induce β-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease

  2003cited by this paper
• Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Aβ production in APP23 transgenic mice

  2003cited by this paper
• Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1.

  2003cited by this paper
• A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission

  2003cited by this paper
• Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts

  2003cited by this paper
• Evidence That Synaptically Released β-Amyloid Accumulates as Extracellular Deposits in the Hippocampus of Transgenic Mice

  2002cited by this paper
• Characterization of an amyloid precursor protein-binding protein Fe65L2 and its novel isoforms lacking phosphotyrosine-interaction domains.

  2002cited by this paper
• Regulation of APP-Dependent Transcription Complexes by Mint/X11s: Differential Functions of Mint Isoforms

  2002cited by this paper
• Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein.

  2002cited by this paper
• Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

  2001cited by this paper
• A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60.

  2001cited by this paper
• Copper Specifically Regulates Intracellular Phosphorylation of the Wilson's Disease Protein, a Human Copper-transporting ATPase*

  2001cited by this paper
• Phosphorylation regulates intracellular trafficking of beta-secretase.

  2001cited by this paper
• Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production.

  2001cited by this paper
• Phosphorylation and Cu+Coordination-dependent DNA Binding of the Transcription Factor Mac1p in the Regulation of Copper Transport*

  2001cited by this paper
• The Neuronal Adaptor Protein X11α Interacts with the Copper Chaperone for SOD1 and Regulates SOD1 Activity*

  2001cited by this paper
• Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid.

  2001cited by this paper
• Fe65 and X11beta co-localize with and compete for binding to the amyloid precursor protein.

  2000cited by this paper
• Regulation of X11L-dependent Amyloid Precursor Protein Metabolism by XB51, a Novel X11L-binding Protein*

  2000cited by this paper
• X11 alpha and x11 beta interact with presenilin-1 via their PDZ domains.

  2000cited by this paper
• Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport.

  2000cited by this paper
• Copper chaperone for superoxide dismutase is essential to activate mammalian Cu/Zn superoxide dismutase.

  2000cited by this paper
• Ultrastructural localization of mint1 at synapses in mouse hippocampus

  2000cited by this paper
• PDZ domain-dependent suppression of NF-kappaB/p65-induced Abeta42 production by a neuron-specific X11-like protein.

  2000cited by this paper
• Modulation of amyloid precursor protein metabolism by X11alpha /Mint-1. A deletion analysis of protein-protein interaction domains.

  2000cited by this paper
• SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein

  1999cited by this paper
• Mint2/X11‐like colocalizes with the Alzheimer's disease amyloid precursor protein and is associated with neuritic plaques in Alzheimer's disease

  1999cited by this paper
• Regulation of β-Amyloid Secretion by FE65, an Amyloid Protein Precursor-binding Protein*

  1999cited by this paper
• Interaction of a Neuron-specific Protein Containing PDZ Domains with Alzheimer’s Amyloid Precursor Protein*

  1999cited by this paper
• X11 Interaction with β-Amyloid Precursor Protein Modulates Its Cellular Stabilization and Reduces Amyloid β-Protein Secretion*

  1998cited by this paper
• Alzheimer Amyloid Protein Precursor in the Rat Hippocampus: Transport and Processing through the Perforant Path

  1998cited by this paper
• The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion.

  1998cited by this paper
• A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain.

  1998cited by this paper
• Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein.

  1996cited by this paper
• cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein.

  1996cited by this paper
• The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system.

  1996cited by this paper
• The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein

  1996cited by this paper
• The Amyloid Precursor Protein of Alzheimer's Disease in the Reduction of Copper(II) to Copper(I)

  1996cited by this paper
• Generation of Amyloidogenic C-terminal Fragments during Rapid Axonal Transport in Vivo of -Amyloid Precursor Protein in the Optic Nerve (*)

  1995cited by this paper
• The Regions of the Fe65 Protein Homologous to the Phosphotyrosine Interaction/Phosphotyrosine Binding Domain of Shc Bind the Intracellular Domain of the Alzheimer's Amyloid Precursor Protein (*)

  1995cited by this paper
• Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.

  1990cited by this paper

• Therapeutic Options for Alzheimer’s Disease and Aging-Associated Cognitive Decline: State of the Art in the ACH2.0 Paradigm

  2026cites this paper
• Alzheimer’s Is a Multiform Disease of Sustained Neuronal Integrated Stress Response Driven by the C99 Fragment Generated Independently of AβPP; Proteolytic Production of Aβ Is Suppressed in AD-Affected Neurons: Evolution of a Theory

  2025cites this paper
• Production of Amyloid-β in the Aβ-Protein-Precursor Proteolytic Pathway Is Discontinued or Severely Suppressed in Alzheimer’s Disease-Affected Neurons: Contesting the ‘Obvious’

  2025cites this paper
• ACH2.0/E, the Consolidated Theory of Conventional and Unconventional Alzheimer’s Disease: Origins, Progression, and Therapeutic Strategies

  2024cites this paper
• A PDZ tandem repeat folds and unfolds via different pathways

  2024cites this paper
• Advances in the cell biology of the trafficking and processing of amyloid precursor protein: impact of familial Alzheimer's disease mutations

  2024cites this paper
• Quintessential Synergy: Concurrent Transient Administration of Integrated Stress Response Inhibitors and BACE1 and/or BACE2 Activators as the Optimal Therapeutic Strategy for Alzheimer’s Disease

  2024cites this paper
• On the Inadequacy of the Current Transgenic Animal Models of Alzheimer’s Disease: The Path Forward

  2024cites this paper
• Fine-Tuned Expression of Evolutionarily Conserved Signaling Molecules in the Ciona Notochord

  2024cites this paper
• The AICD interactome: implications in neurodevelopment and neurodegeneration

  2024cites this paper
• The Amyloid Cascade Hypothesis 2.0 for Alzheimer’s Disease and Aging-Associated Cognitive Decline: From Molecular Basis to Effective Therapy

  2023cites this paper
• Next Generation Therapeutic Strategy for Treatment and Prevention of Alzheimer’s Disease and Aging-Associated Cognitive Decline: Transient, Once-in-a-Lifetime-Only Depletion of Intraneuronal Aβ (iAβ) by Its Targeted Degradation via Augmentation of Intra-iAβ-Cleaving Activities of BACE1 and/or BACE2

  2023cites this paper
• The US9-Derived Protein gPTB9TM Modulates APP Processing Without Targeting Secretase Activities

  2022cites this paper
• A synaptomic analysis reveals dopamine hub synapses in the mouse striatum

  2022cites this paper
• Targeting the APP-Mint2 Protein-Protein Interaction with a Peptide-Based Inhibitor Reduces Amyloid-β Formation.

  2021cites this paper
• Investigating Pathogenetic Mechanisms of Alzheimer’s Disease by Systems Biology Approaches for Drug Discovery

  2021cites this paper
• Structural and thermodynamical insights into the binding and inhibition of FIH-1 by the N-terminal disordered region of Mint3

  2021cites this paper
• Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer

  2021cites this paper
• Binding mechanism underlying FIH-1 suppression caused by the N-terminal disordered region of Mint3

  2021influential citation
• Mint3 is dispensable for pancreatic and kidney functions in mice

  2020cites this paper
• Synaptomic analysis of dopaminergic inputs reveal hub synapses in the mouse striatum

  2020influential citation
• Autism genes and the leukocyte transcriptome in autistic toddlers relate to pathogen interactomes, infection and the immune system. A role for excess neurotrophic sAPP&agr; and reduced antimicrobial A&bgr;

  2019cites this paper
• Effects of the Pentapeptide P33 on Memory and Synaptic Plasticity in APP/PS1 Transgenic Mice: A Novel Mechanism Presenting the Protein Fe65 as a Target

  2019cites this paper
• Arc Regulates Transcription of Genes for Plasticity, Excitability and Alzheimer’s Disease

  2019cites this paper
• Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer’s disease

  2019cites this paper
• Systems-wide analysis unravels the new roles of CCM signal complex (CSC)

  2019cites this paper
• Structure and Synaptic Function of Metal Binding to the Amyloid Precursor Protein and its Proteolytic Fragments

  2017cites this paper
• Amyloid precursor protein traffics from the Golgi directly to early endosomes in an Arl5b‐ and AP4‐dependent pathway

  2017influential citation
• M344 promotes nonamyloidogenic amyloid precursor protein processing while normalizing Alzheimer’s disease genes and improving memory

  2017cites this paper
• Integrated functions of membrane‐type 1 matrix metalloproteinase in regulating cancer malignancy: Beyond a proteinase

  2017cites this paper
• Dysregulation of intracellular trafficking and endosomal sorting in Alzheimer's disease: controversies and unanswered questions.

  2016cites this paper
• Fe65 negatively regulates Jagged1 signaling by decreasing Jagged1 protein stability through the E3 ligase Neuralized-like 1.

  2015cites this paper
• O-GlcNAcylation Promotes Non-Amyloidogenic Processing of Amyloid-β Protein Precursor via Inhibition of Endocytosis from the Plasma Membrane

  2015cites this paper
• The effects of the cellular and infectious prion protein on the neuronal adaptor protein X11α.

  2015cites this paper
• Serotonin 6 receptor controls alzheimer’s disease and depression

  2015cites this paper
• Rab Proteins and Alzheimer's: A Current Review of Their Involvement in Amyloid Beta Generation with Focus on Rab10 Expression in N2A-695 Cells

  2015cites this paper
• ATBF1 is a Novel Amyloid-β Protein Precursor (AβPP) Binding Protein that Affects AβPP Expression

  2014cites this paper
• Flavonoids as regulators of amyloid precursor protein processing

  2014cites this paper
• Circulating Methylated MINT2 Promoter DNA Is a Potential Poor Prognostic Factor in Gastric Cancer

  2014cites this paper
• Trafficking regulation of proteins in Alzheimer’s disease

  2014cites this paper
• Placental DNA methylation alterations associated with maternal tobacco smoking at the RUNX3 gene are also associated with gestational age.

  2013cites this paper
• Open-closed motion of Mint2 regulates APP metabolism.

  2013cites this paper
• Aberrant Methylation of Gene Associated CpG Sites Occurs in Borderline Personality Disorder

  2013cites this paper
• Trafficking in neurons: searching for new targets for Alzheimer's disease future therapies.

  2013cites this paper
• Regulation of Mint 1-dependent APP trafficking by N 1-Src

  2013cites this paper
• Engulfment adapter PTB domain containing 1 interacts with and affects processing of the amyloid-β precursor protein.

  2012cites this paper
• Alzheimer culprits: cellular crossroads and interplay.

  2012cites this paper
• IDENTIFICATION AND INVESTIGATION OF γ-SECRETASE ASSOCIATED PROTEINS FROM BRAIN

  2012cites this paper
• Trafficking and proteolytic processing of APP.

  2012cites this paper
• The physiology of the β‐amyloid precursor protein intracellular domain AICD

  2012cites this paper
• Amyloid and Alzheimer's Disease: Inside and Out

  2012cites this paper
• Genomic Organization and Promoter Cloning of the Human X11α Gene APBA1

  2012cites this paper
• Calsyntenin-1 shelters APP from proteolytic processing during anterograde axonal transport

  2012cites this paper
• Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production

  2012cites this paper
• Synaptic Autoregulation by Metalloproteases and γ-Secretase

  2011cites this paper
• APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms

  2011cites this paper
• Intracellular trafficking of the β‐secretase and processing of amyloid precursor protein

  2011cites this paper
• Growth arrest-specific 1 binds to and controls the maturation and processing of the amyloid- b precursor protein

  2011cites this paper
• Wild Type and Tangier Disease ABCA1 Mutants Modulate Cellular Amyloid-β Production Independent of Cholesterol Efflux Activity

  2011cites this paper
• The memory enhancing effect of the APP‐derived tripeptide Ac‐rER is mediated through CRMP2

  2011cites this paper
• Deletion of the Mint3/Apba3 Gene in Mice Abrogates Macrophage Functions and Increases Resistance to Lipopolysaccharide-induced Septic Shock*

  2011cites this paper
• The molecular basis of the interactions of copper metallochaperones

  2011cites this paper
• Tandem SAM domain structure of human Caskin1: a presynaptic, self-assembling scaffold for CASK.

  2011cites this paper
• Title Tandem SAM domain structure of human Caskin 1 : A presynaptic , self-assembling scaffold for CASK Permalink

  2011cites this paper
• GULP1 is a novel APP-interacting protein that alters APP processing.

  2011cites this paper
• Identification of Novel Candidate Genes for Alzheimer's Disease by Autozygosity Mapping using Genome Wide SNP Data

  2011cites this paper
• Growth arrest-specific 1 binds to and controls the maturation and processing of the amyloid-beta precursor protein.

  2011cites this paper
• Deficiency of the Copper Chaperone for Superoxide Dismutase Increases Amyloid-β Production

  2010cites this paper
• Increased amyloidogenic processing of transgenic human APP in X11-like deficient mouse brain

  2010cites this paper
• Regulation of cleavage of amyloid precursor protein

  2010cites this paper
• Caveolin-1 Regulates γ-Secretase-Mediated AβPP Processing by Modulating Spatial Distribution of γ-Secretase in Membrane

  2010cites this paper
• Genetic pathway‐based hierarchical clustering analysis of older adults with cognitive complaints and amnestic mild cognitive impairment using clinical and neuroimaging phenotypes

  2010cites this paper
• Regulation of β cleavage of amyloid precursor protein

  2010cites this paper
• Membrane rafts in Alzheimer's disease beta-amyloid production.

  2010cites this paper
• An X11α/FSBP complex represses transcription of the GSK3β gene promoter

  2010cites this paper
• Dab1 binds to Fe65 and diminishes the effect of Fe65 or LRP1 on APP processing

  2010cites this paper
• An X 11 / FSBP complex represses transcription of the GSK 3 gene promoter

  2010cites this paper
• Expression of the Neuronal Adaptor Protein X11α Protects Against Memory Dysfunction in a Transgenic Mouse Model of Alzheimer's Disease

  2010cites this paper
• Explore the function of KEL-8 in oxidative stress response and search for KEL-8 interacting proteins

  2009cites this paper
• X11beta rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice.

  2009cites this paper
• X11-Like Protein Deficiency Is Associated with Impaired Conflict Resolution in Mice

  2009cites this paper
• Phosphorylation of the amino‐terminal region of X11L regulates its interaction with APP

  2009cites this paper
• Neuronal protein trafficking associated with Alzheimer disease

  2009cites this paper
• Regulation of the Physiological Function and Metabolism of AβPP by AβPP Binding Proteins

  2009cites this paper
• X11alpha haploinsufficiency enhances Abeta amyloid deposition in Alzheimer's disease transgenic mice.

  2009cites this paper
• Mint3 Enhances the Activity of Hypoxia-inducible Factor-1 (HIF-1) in Macrophages by Suppressing the Activity of Factor Inhibiting HIF-1*

  2009cites this paper
• Substrate specificity of γ-secretase and other intramembrane proteases

  2008cites this paper
• Overexpression of APP stimulates basal and constitutive exocytosis in PC12 cells.

  2008cites this paper
• Functional interactions of APP with the apoE receptor family

  2008cites this paper
• Cell autonomous function of nogo and reticulons: The emerging story at the endoplasmic reticulum

  2008cites this paper
• X11 Proteins Regulate the Translocation of Amyloid β-Protein Precursor (APP) into Detergent-resistant Membrane and Suppress the Amyloidogenic Cleavage of APP by β-Site-cleaving Enzyme in Brain*

  2008cites this paper
• Genetic loci modulating amyloid-beta levels in a mouse model of Alzheimer's disease.

  2008cites this paper
• The FE65 proteins and Alzheimer's disease

  2008cites this paper
• Role of axonal transport in neurodegenerative diseases.

  2008cites this paper
• Adaptor Protein Sorting Nexin 17 Regulates Amyloid Precursor Protein Trafficking and Processing in the Early Endosomes*

  2008cites this paper
• Regulation of Amyloid β-Protein Precursor by Phosphorylation and Protein Interactions*

  2008cites this paper
• Amyloid Precursor Protein Trafficking, Processing, and Function*

  2008cites this paper
• Dendritic spine dynamics--a key role for kalirin-7.

  2008cites this paper
• Traumatic brain injury and Alzheimer's disease: a review.

  2007cites this paper
• Reduction of mint-1, mint-2, and APP overexpression in okadaic acid-treated neurons

  2007cites this paper