A Neurobiological Model of Insomnia.

Insomnia is a common clinical condition resulting in significant costs and morbidity. Previous models of insomnia focusing on psychological and behavioral processes are useful clinically, but lack neurobiological specificity. We propose an insomnia model based on basic and clinical neuroscience findings, and hypothesize that insomnia results from persistent activity in wake-promoting neural structures during NREM sleep. The simultaneous occurrence of sleeping and waking neural activity helps to explain clinical phenomenology and treatment effects in insomnia.

• Publication year

  2011

• Venue

  Drug Discovery Today : Disease Models

• Publication date

  2011-12-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/J.DDMOD.2011.07.002PMID 22081772PMCID PMC3212043
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• Simultaneous sleeping and waking neural activity is presented as an explanation for insomnia's clinical phenomenology and treatment effects.

  Confidence 0.94

  박진우 (dztg5apj7m) extractionAK (4715169a40) reviewKiller Whale (322360f1c1) reviewmexicorea (qjvnbu8xg3) review
• Insomnia is hypothesized to arise from persistent activity in wake-promoting neural structures during NREM sleep.

  Confidence 0.97

  박진우 (dztg5apj7m) extractionAK (4715169a40) reviewKiller Whale (322360f1c1) reviewmexicorea (qjvnbu8xg3) review
• A neurobiological model of insomnia is proposed that is grounded in basic and clinical neuroscience findings.

  Confidence 0.96

  박진우 (dztg5apj7m) extractionAK (4715169a40) reviewKiller Whale (322360f1c1) reviewmexicorea (qjvnbu8xg3) review

• basic and clinical neuroscience findings

  evidence base

  Findings from basic neuroscience and clinical neuroscience that are used as the evidentiary basis for the proposed model.

  박진우 (dztg5apj7m) extractionAK (4715169a40) reviewKiller Whale (322360f1c1) reviewmexicorea (qjvnbu8xg3) review
• clinical phenomenology

  clinical feature

  The observable symptom pattern and clinical presentation of insomnia addressed by the model.

  박진우 (dztg5apj7m) extractionAK (4715169a40) reviewKiller Whale (322360f1c1) reviewmexicorea (qjvnbu8xg3) review
• insomnia

  condition

  A common clinical sleep condition discussed as the target disorder of the model.

  박진우 (dztg5apj7m) extractionAK (4715169a40) reviewKiller Whale (322360f1c1) reviewmexicorea (qjvnbu8xg3) review
• neurobiological model of insomnia

  model

  A proposed framework that explains insomnia using neural and sleep physiology mechanisms.

  Aliases: model of insomnia

  박진우 (dztg5apj7m) extractionAK (4715169a40) reviewKiller Whale (322360f1c1) reviewmexicorea (qjvnbu8xg3) review
• nrem sleep

  sleep stage

  A non-REM sleep state used here as the sleep period during which wake-related activity is hypothesized to persist.

  Aliases: NREM

  박진우 (dztg5apj7m) extractionAK (4715169a40) reviewKiller Whale (322360f1c1) reviewmexicorea (qjvnbu8xg3) review
• persistent activity

  neural activity

  Continued neural activation that remains present when it would ordinarily be reduced during sleep.

  박진우 (dztg5apj7m) extractionAK (4715169a40) reviewKiller Whale (322360f1c1) reviewmexicorea (qjvnbu8xg3) review
• simultaneous sleeping and waking neural activity

  activity pattern

  The coexistence of sleep-related and wake-related neural activity within the same sleep state.

  박진우 (dztg5apj7m) extractionAK (4715169a40) reviewKiller Whale (322360f1c1) reviewmexicorea (qjvnbu8xg3) review
• treatment effects

  treatment outcome

  The changes in insomnia symptoms produced by treatments that the model aims to account for.

  박진우 (dztg5apj7m) extractionAK (4715169a40) reviewKiller Whale (322360f1c1) reviewmexicorea (qjvnbu8xg3) review
• wake-promoting neural structures

  neural structure

  Brain structures involved in maintaining wakefulness that are implicated in the model.

  Aliases: wake-promoting structures

  박진우 (dztg5apj7m) extractionAK (4715169a40) reviewKiller Whale (322360f1c1) reviewmexicorea (qjvnbu8xg3) review

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