A mutant form of the Ran/TC4 protein disrupts nuclear function in Xenopus laevis egg extracts by inhibiting the RCC1 protein, a regulator of chromosome condensation.

No abstract is available for this paper.

• Publication year

  1994

• Venue

  EMBO Journal

• Publication date

  1994-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/j.1460-2075.1994.tb06911.xPMID 7988569PMCID PMC395539
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A fission yeast RCC1‐related protein is required for the mitosis to interphase transition.

  1994cited by this paper
• Effects of mutant Ran/TC4 proteins on cell cycle progression

  1994cited by this paper
• Evidence for a dual role for TC4 protein in regulating nuclear structure and cell cycle progression

  1994cited by this paper
• A family of proteins that stabilize the Ran/TC4 GTPase in its GTP-bound conformation.

  1994cited by this paper
• A G protein involved in nucleocytoplasmic transport: the role of Ran.

  1994cited by this paper
• Chromatin transitions during early Xenopus embryogenesis: changes in histone H4 acetylation and in linker histone type.

  1993cited by this paper
• Absence of somatic histone H1 in oocytes and preblastula embryos of Xenopus laevis.

  1993cited by this paper
• Prp20, the Saccharomyces cerevisiae homolog of the regulator of chromosome condensation, RCC1, interacts with double-stranded DNA through a multi-component complex containing GTP-binding proteins.

  1993cited by this paper
• The Saccharomyces cerevisiae SDC25 C-domain gene product overcomes the dominant inhibitory activity of Ha-Ras Asn-17.

  1993cited by this paper
• The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

  1993cited by this paper
• Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor [published erratum appears in J Cell Biol 1994 Jan;124(1-2):217]

  1993cited by this paper
• Regulation of RNA processing and transport by a nuclear guanine nucleotide release protein and members of the Ras superfamily.

  1993cited by this paper
• Ran/TC4: a small nuclear GTP-binding protein that regulates DNA synthesis

  1993cited by this paper
• GSP1 and GSP2, genetic suppressors of the prp20-1 mutant in Saccharomyces cerevisiae: GTP-binding proteins involved in the maintenance of nuclear organization

  1993cited by this paper
• RCC1 in the cell cycle: the regulator of chromosome condensation takes on new roles.

  1993cited by this paper
• Defects in mRNA 3'-end formation, transcription initiation, and mRNA transport associated with the yeast mutation prp20: possible coupling of mRNA processing and chromatin structure.

  1992cited by this paper
• RCC1, a regulator of mitosis, is essential for DNA replication

  1992cited by this paper
• Amino acid residues in the Ras-like GTPase Rab3A that specify sensitivity to factors that regulate the GTP/GDP cycling of Rab3A.

  1992cited by this paper
• Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1

  1991cited by this paper
• Systems for the study of nuclear assembly, DNA replication, and nuclear breakdown in Xenopus laevis egg extracts.

  1991cited by this paper
• Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide.

  1991cited by this paper
• Loss of RCC1, a nuclear DNA‐binding protein, uncouples the completion of DNA replication from the activation of cdc2 protein kinase and mitosis.

  1991cited by this paper
• Eukaryotic proteins expressed in Escherichia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase.

  1991cited by this paper
• Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase.

  1991cited by this paper
• The GTPase superfamily: a conserved switch for diverse cell functions

  1990cited by this paper
• Cloning of Xenopus RCC1 cDNA, a homolog of the human RCC1 gene: complementation of tsBN2 mutation and identification of the product.

  1990cited by this paper
• Premature chromosome condensation is induced by a point mutation in the hamster RCC1 gene

  1990cited by this paper
• A yeast mutant, PRP20, altered in mRNA metabolism and maintenance of the nuclear structure, is defective in a gene homologous to the human gene RCC1 which is involved in the control of chromosome condensation

  1990cited by this paper
• Completion of DNA replication is monitored by a feedback system that controls the initiation of mitosis in vitro: studies in Xenopus.

  1990cited by this paper
• Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line

  1990cited by this paper
• Yeast pheromone response pathway: characterization of a suppressor that restores mating to receptorless mutants

  1989cited by this paper
• A trypsin-sensitive receptor on membrane vesicles is required for nuclear envelope formation in vitro

  1988cited by this paper
• Assembly of spaced chromatin promoted by DNA synthesis in extracts from Xenopus eggs.

  1988cited by this paper
• Steps in the assembly of replication-competent nuclei in a cell-free system from Xenopus eggs

  1988cited by this paper
• Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP

  1988cited by this paper
• Nuclear import can be separated into distinct steps in vitro: nuclear pore binding and translocation.

  1988cited by this paper
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  1987cited by this paper
• Exposure to caffeine and suppression of DNA replication combine to stabilize the proteins and RNA required for premature mitotic events

  1987cited by this paper
• Initiation of DNA replication in nuclei and purified DNA by a cell-free extract of Xenopus eggs.

  1986cited by this paper
• Expression of p21 proteins in Escherichia coli and stereochemistry of the nucleotide‐binding site.

  1986cited by this paper
• Changes in the nuclear lamina composition during early development of Xenopus laevis.

  1985cited by this paper
• Roles of cytosol and cytoplasmic particles in nuclear envelope assembly and sperm pronuclear formation in cell-free preparations from amphibian eggs

  1984cited by this paper
• The synthesis of protein(S) for chromosome condensation may be regulated by a post‐transcriptional mechanism

  1981cited by this paper

• Reconstitution of lamin assembly on nuclear pore complex-containing membranes

  2025cites this paper
• RCC1 depletion drives protein transport defects and rupture in micronuclei

  2024cites this paper
• Ran-GTP assembles a specialized spindle structure for accurate chromosome segregation in medaka early embryos

  2024cites this paper
• RhoA- and Cdc42-induced antagonistic forces underlie symmetry breaking and spindle rotation in mouse oocytes

  2021cites this paper
• RhoA- and Ran-induced antagonistic forces underlie symmetry breaking and spindle rotation in mouse oocytes

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  2019cites this paper
• RanGTP and importin β regulate meiosis I spindle assembly and function in mouse oocytes

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• Acentriolar microtubule organization centers and Ran‐mediated microtubule formation pathways are both required in porcine oocytes

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• RCC1 regulates inner centromeric composition in a Ran-independent fashion

  2018cites this paper
• Exportin Crm 1 is repurposed as a docking protein to generate 1 microtubule organizing centers at the nuclear pore 2 3 4

  2018cites this paper
• F-Actin nucleated on chromosomes coordinates their capture by microtubules in oocyte meiosis

  2018cites this paper
• F-actin patches nucleated on chromosomes coordinate capture by microtubules in oocyte meiosis

  2018cites this paper
• Exportin Crm1 is repurposed as a docking protein to generate microtubule organizing centers at the nuclear pore

  2017cites this paper
• Developmentally Regulated GTP binding protein 1 (DRG1) controls microtubule dynamics

  2017cites this paper
• Post-translational lysine-acetylation of Ran and its regulation by Sirtuin deacetylases

  2016cites this paper
• Assays to Study Mitotic Centrosome and Spindle Pole Assembly and Regulation.

  2016cites this paper
• Spatial gradients controlling spindle assembly.

  2015cites this paper
• The Ran-GTP gradient spatially regulates XCTK2 in the spindle.

  2015cites this paper
• Small GTP-binding protein Ran is regulated by posttranslational lysine acetylation

  2015cites this paper
• Inter-Cellular Transport of Ran GTPase

  2015cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2011cites this paper
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  2010cites this paper
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  2010cites this paper
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  2009cites this paper
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  2009cites this paper
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  2006cites this paper
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  2004cites this paper
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  2004cites this paper
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  2000cites this paper
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  1999cites this paper
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  1999cites this paper
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