SDF-1/CXCR4-Mediated Migration of Transplanted Bone Marrow Stromal Cells Toward Areas of Heart Myocardial Infarction Through Activation of PI3K/Akt

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of Cardiovascular Pharmacology

• Publication date

  2010-05-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1097/FJC.0b013e3181d7a384PMID 20179608
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• SDF-1alpha/CXCR4-mediated migration of systemically transplanted bone marrow stromal cells towards ischemic brain lesion in a rat model.

  2008cited by this paper
• Intravenous infusion of mesenchymal stem cells enhances regional perfusion and improves ventricular function in a porcine model of myocardial infarction

  2008cited by this paper
• Therapeutic Benefit of Bone Marrow Stromal Cells Administered 1 Month after Stroke

  2007cited by this paper
• Migration of Endothelial Progenitor Cells Mediated by Stromal Cell-Derived Factor-1α/CXCR4 via PI3K/Akt/eNOS Signal Transduction Pathway

  2007cited by this paper
• [Filtrating smooth muscle progenitor cells from mouse bone marrow mesenchymal stem cells by recombinant Psm22alpha-EGFP-1].

  2007cited by this paper
• Migration of Bone Marrow and Cord Blood Mesenchymal Stem Cells In Vitro Is Regulated by Stromal‐Derived Factor‐1‐CXCR4 and Hepatocyte Growth Factor‐c‐met Axes and Involves Matrix Metalloproteinases

  2006cited by this paper
• Nitric oxide cytoskeletal-induced alterations reverse the endothelial progenitor cell migratory defect associated with diabetes.

  2006cited by this paper
• A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development

  2006cited by this paper
• Estrogen reduces endothelial progenitor cell senescence through augmentation of telomerase activity

  2005cited by this paper
• Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis.

  2005cited by this paper
• Akt1/protein kinase Bα is critical for ischemic and VEGF-mediated angiogenesis

  2005cited by this paper
• VEGF-A and PlGF-1 stimulate chemotactic migration of human mesenchymal progenitor cells.

  2005cited by this paper
• Renal SDF-1 signals mobilization and homing of CXCR4-positive cells to the kidney after ischemic injury.

  2005cited by this paper
• Activation of Phosphatidylinositol 3-Kinase and Extracellular Signal-Regulated Kinase Is Required for Glial Cell Line-Derived Neurotrophic Factor-Induced Migration and Invasion of Pancreatic Carcinoma Cells

  2004cited by this paper
• Engineering Ex Vivo–Expanded Marrow Stromal Cells to Secrete Calcitonin Gene–Related Peptide Using Adenoviral Vector

  2004cited by this paper
• Adult stem cell therapy in perspective.

  2003cited by this paper
• Stromal Cell-derived Factor 1α Stimulates Human Glioblastoma Cell Growth through the Activation of Both Extracellular Signal-regulated Kinases 1/2 and Akt

  2003cited by this paper
• Systemic Delivery of Bone Marrow–Derived Mesenchymal Stem Cells to the Infarcted Myocardium: Feasibility, Cell Migration, and Body Distribution

  2003cited by this paper
• Effect of stromal-cell-derived factor 1 on stem-cell homing and tissue regeneration in ischaemic cardiomyopathy.

  2003cited by this paper
• Stromal Cell–Derived Factor-1 Effects on Ex Vivo Expanded Endothelial Progenitor Cell Recruitment for Ischemic Neovascularization

  2003cited by this paper
• Endothelial progenitor cell proliferation and differentiation is regulated by erythropoietin Rapid Communication

  2003cited by this paper
• Role of the alpha-chemokine stromal cell-derived factor (SDF-1) in the developing and mature central nervous system.

  2003cited by this paper
• Stem cell therapy in a caprine model of osteoarthritis.

  2003cited by this paper
• Role of the α‐chemokine stromal cell‐derived factor (SDF‐1) in the developing and mature central nervous system

  2003cited by this paper
• Signalling pathways involved in the chemotactic activity of CXCL12 in cultured rat cerebellar neurons and CHP100 neuroepithelioma cells.

  2003cited by this paper
• Endothelial progenitor cell proliferation and differentiation is regulated by erythropoietin.

  2003cited by this paper
• Mesenchymal stem cell implantation in a swine myocardial infarct model: engraftment and functional effects.

  2002cited by this paper
• The failing heart

  2002cited by this paper
• MCP-1, MIP-1, IL-8 and Ischemic Cerebral Tissue Enhance Human Bone Marrow Stromal Cell Migration in Interface Culture

  2002cited by this paper
• Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases

  2002cited by this paper
• Neovascularization of ischemic myocardium by human bone-marrow–derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function

  2001cited by this paper
• Transendocardial delivery of autologous bone marrow enhances collateral perfusion and regional function in pigs with chronic experimental myocardial ischemia.

  2001cited by this paper
• Mobilized bone marrow cells repair the infarcted heart, improving function and survival

  2001cited by this paper
• HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway.

  2001cited by this paper
• Bone marrow cells regenerate infarcted myocardium

  2001cited by this paper
• Mammalian MAP kinase signalling cascades

  2001cited by this paper
• Stromal cell-derived factor-1 a stimulates tyrosine phosphorylation of multiple focal adhesion proteins and induces migration of hematopoietic progenitor cells : roles of phosphoinositide-3 kinase and protein kinase C

  2000cited by this paper
• Stromal cell-derived factor-1alpha stimulates tyrosine phosphorylation of multiple focal adhesion proteins and induces migration of hematopoietic progenitor cells: roles of phosphoinositide-3 kinase and protein kinase C.

  2000cited by this paper
• Chemokine receptors and their role in inflammation and infectious diseases.

  2000cited by this paper
• The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes.

  1999cited by this paper
• Regulation of Cell Contraction and Membrane Ruffling by Distinct Signals in Migratory Cells

  1999cited by this paper
• B Cell Antigen Receptor Engagement Inhibits Stromal Cell–derived Factor (SDF)-1α Chemotaxis and Promotes Protein Kinase C (PKC)-induced Internalization of CXCR4

  1999cited by this paper
• Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice.

  1998cited by this paper
• The α-Chemokine, Stromal Cell-derived Factor-1α, Binds to the Transmembrane G-protein-coupled CXCR-4 Receptor and Activates Multiple Signal Transduction Pathways*

  1998cited by this paper
• Chemokines and leukocyte traffic

  1998cited by this paper
• The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry

  1996cited by this paper
• Molecular cloning and structure of a pre-B-cell growth-stimulating factor.

  1994cited by this paper

• Transcription Factor SOX10 Improves Migration and Homing of MSCs After Myocardial Infarction by Upregulating CXCR4

  2025cites this paper
• Serum stromal cell-derived factor 1α as a prognostic indicator in elderly patients with acute myeloid leukemia receiving CAG-based chemotherapy

  2025cites this paper
• CXCR4/CXCL12 axis: “old” pathway as “novel” target for anti‐inflammatory drug discovery

  2024cites this paper
• Therapeutic Role of Bone Marrow Mesenchymal Stem Cells (BMSCs) in Nonalcoholic Steatohepatitis (NASH) Cirrhosis.

  2024cites this paper
• AdipoRon accelerates bone repair of calvarial defect in diet-induced obesity mice

  2023cites this paper
• The beneficial effects of mesenchymal stem cells and their exosomes on myocardial infarction and critical considerations for enhancing their efficacy.

  2023cites this paper
• Chemokine C-X-C receptor 4 mediates recruitment of bone marrow-derived nonhematopoietic and immune cells to the pregnant uterus

  2022cites this paper
• Evidence of Stem Cells Mobilization in the Blood of Patients with Pancreatitis: A Potential Link with Disease Severity

  2022cites this paper
• An ApoA-I Mimic Peptide of 4F Promotes SDF-1α Expression in Endothelial Cells Through PI3K/Akt/ERK/HIF-1α Signaling Pathway

  2022cites this paper
• The SDF-1/CXCR4 signaling pathway directs the migration of systemically transplanted bone marrow mesenchymal stem cells towards the lesion site in a rat model of spinal cord injury.

  2022cites this paper
• N2‐Polarized Neutrophils Guide Bone Mesenchymal Stem Cell Recruitment and Initiate Bone Regeneration: A Missing Piece of the Bone Regeneration Puzzle

  2021cites this paper
• Neovascularization: The Main Mechanism of MSCs in Ischemic Heart Disease Therapy

  2021cites this paper
• Distinct Expression Patterns of Cxcl12 in Mesenchymal Stem Cell Niches of Intact and Injured Rodent Teeth

  2021cites this paper
• Role of miRNA-324-5p-Modified Adipose-Derived Stem Cells in Post-Myocardial Infarction Repair

  2021cites this paper
• Dual mechanism design to enhance bone formation by overexpressed SDF-1 ADSCs in magnesium doped calcium phosphate scaffolds

  2021cites this paper
• SDF-1/CXCR4 Augments the Therapeutic Effect of Bone Marrow Mesenchymal Stem Cells in the Treatment of Lipopolysaccharide-Induced Liver Injury by Promoting Their Migration Through PI3K/Akt Signaling Pathway

  2020cites this paper
• Mesenchymal Stem Cells for Cutaneous Wound Healing

  2020cites this paper
• Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy

  2020cites this paper
• Stromal cell-derived factor-1 (SDF-1) expression in very preterm human lungs: potential relevance for stem cell therapy for bronchopulmonary dysplasia

  2020cites this paper
• Cellular and molecular reactions to dental implants

  2020cites this paper
• SDF-1 secreted by mesenchymal stem cells promotes the migration of endothelial progenitor cells via PI3K/Akt pathway

  2020cites this paper
• IL-11 and soluble VCAM-1 are important components of Hypoxia Conditioned Media and crucial for Mesenchymal Stromal Cells attraction.

  2020cites this paper
• Musashi 1-positive cells derived from mouse embryonic stem cells treated with LY294002 are prone to differentiate into intestinal epithelial-like tissues.

  2019cites this paper
• Transforming Growth Factor-&bgr; Promotes Homing and Therapeutic Efficacy of Human Mesenchymal Stem Cells to Glioblastoma

  2019cites this paper
• Exosomes influence the behavior of human mesenchymal stem cells on titanium surfaces.

  2019cites this paper
• Pretreatment with G-CSF Could Enhance the Antifibrotic Effect of BM-MSCs on Pulmonary Fibrosis

  2019cites this paper
• Exosomes derived from SDF1‐overexpressing mesenchymal stem cells inhibit ischemic myocardial cell apoptosis and promote cardiac endothelial microvascular regeneration in mice with myocardial infarction

  2019cites this paper
• Synergistic effects of stromal cell-derived factor-1α and bone morphogenetic protein-2 treatment on odontogenic differentiation of human stem cells from apical papilla cultured in the VitroGel 3D system

  2019cites this paper
• In vivo somatic cell reprogramming for tissue regeneration: the emerging role of the local microenvironment.

  2018cites this paper
• Deferoxamine promotes mesenchymal stem cell homing in noise‐induced injured cochlea through PI3K/AKT pathway

  2018cites this paper
• Glioma Stem Cell Niches in Human Glioblastoma Are Periarteriolar

  2018cites this paper
• The hypoxic peri-arteriolar glioma stem cell niche, an integrated concept of five types of niches in human glioblastoma.

  2018cites this paper
• Cardiac support device (ASD) delivers bone marrow stem cells repetitively to epicardium has promising curative effects in advanced heart failure

  2018cites this paper
• Surface glycan pattern of canine, equine, and ovine bone marrow‐derived mesenchymal stem cells

  2018cites this paper
• Periarteriolar Glioblastoma Stem Cell Niches Express Bone Marrow Hematopoietic Stem Cell Niche Proteins

  2018cites this paper
• Transplantation of Cardiac Mesenchymal Progenitor Cell Sheets for Myocardial Vascularization after an Infarction ( Experimental Study )

  2018influential citation
• Intraperitoneal infusion of mesenchymal stem cell attenuates severity of collagen antibody induced arthritis

  2018cites this paper
• Induced Expression of Endogenous CXCR4 in iPSCs by Targeted CpG Demethylation Enhances Cell Migration Toward the Ligand CXCL12

  2018cites this paper
• Stromal cell-derived factor-1α and transforming growth factor-β1 synergistically facilitate migration and chondrogenesis of synovium-derived stem cells through MAPK pathways.

  2017cites this paper
• CXCL12 overexpression promotes the angiogenesis potential of periodontal ligament stem cells

  2017cites this paper
• BMSC-derived microvesicles assist the migration and homing of multiple myeloma XG-7

  2017cites this paper
• Metabolically conditioned media derived from bone marrow stromal cells or human skin fibroblasts act as effective chemoattractants for mesenchymal stem cells

  2017cites this paper
• Novel therapeutic strategies to target leukemic cells that hijack compartmentalized continuous hematopoietic stem cell niches.

  2017cites this paper
• Mesenchymal Stromal Cell Mechanisms of Immunomodulation and Homing

  2017cites this paper
• Baicalin attenuates chronic hypoxia-induced pulmonary hypertension via adenosine A2A receptor-induced SDF-1/CXCR4/PI3K/AKT signaling

  2017cites this paper
• In vitro cell behaviors of bone mesenchymal stem cells derived from normal and postmenopausal osteoporotic rats

  2017cites this paper
• Vascular stem cell migration in response to Dkk3 in vascular diseases : the emergence of a novel chemokine-like protein

  2017cites this paper
• SDF-1/CXCR4 axis induces human dental pulp stem cell migration through FAK/PI3K/Akt and GSK3β/β-catenin pathways

  2017cites this paper
• Mesenchymal Stem Cells in the Treatment of Amyotrophic Lateral Sclerosis.

  2016cites this paper
• Phosphatidylinositol 3-Kinase and Protein Kinase C Signaling Pathways Are Involved in Stromal Cell-derived Factor-1α-mediated Transmigration of Stem Cells from Apical Papilla.

  2016cites this paper
• Combination of low-energy shock-wave therapy and bone marrow mesenchymal stem cell transplantation to improve the erectile function of diabetic rats

  2016cites this paper
• Stichopus japonicus Polysaccharide, Fucoidan, or Heparin Enhanced the SDF-1α/CXCR4 Axis and Promoted NSC Migration via Activation of the PI3K/Akt/FOXO3a Signaling Pathway

  2016cites this paper
• Effect of bone marrow derived mesenchymal stem cells on lung pathology and inflammation in ovalbumin-induced asthma in mouse

  2016cites this paper
• Genetic Engineering of Mesenchymal Stem Cells to Induce Their Migration and Survival

  2016cites this paper
• Endogenous Mobilization of Bone-Marrow Cells Into the Murine Retina Induces Fusion-Mediated Reprogramming of Müller Glia Cells

  2016cites this paper
• Overexpression of protein kinase C ɛ improves retention and survival of transplanted mesenchymal stem cells in rat acute myocardial infarction

  2016cites this paper
• Cilostazol suppresses angiotensin II-induced apoptosis in endothelial cells

  2016cites this paper
• Cilostazol Improves Proangiogenesis Functions in Human Early Endothelial Progenitor Cells through the Stromal Cell-Derived Factor System and Hybrid Therapy Provides a Synergistic Effect In Vivo

  2016cites this paper
• Research progress of SDF-1/CXCR-4 pathway in mesenchymal stem cell homing after myocardial infarction

  2016cites this paper
• Effect of SDF-1/CXCR4 axis on the migration of transplanted bone mesenchymal stem cells mobilized by erythropoietin toward lesion sites following spinal cord injury

  2015cites this paper
• Activation of Notch1 signalling promotes multi-lineage differentiation of c-KitPOS/NKX2.5POS bone marrow stem cells: implication in stem cell translational medicine

  2015cites this paper
• Isoflurane Preconditioning Promotes the Survival and Migration of Bone Marrow Stromal Cells

  2015cites this paper
• Transplanted hUCB-MSCs migrated to the damaged area by SDF-1/CXCR4 signaling to promote functional recovery after traumatic brain injury in rats

  2015cites this paper
• SDF-1/CXCR4 Axis Promotes MSCs to Repair Liver Injury Partially through Trans-Differentiation and Fusion with Hepatocytes

  2015cites this paper
• Ex vivo exposure of bone marrow from chronic kidney disease donor rats to pravastatin limits renal damage in recipient rats with chronic kidney disease

  2015cites this paper
• Bone Marrow Therapies for Chronic Heart Disease

  2015cites this paper
• Activation of protein kinase C ε enhanced movement ability and paracrine function of rat bone marrow mesenchymal stem cells partly at least independent of SDF-1/CXCR4 axis and PI3K/AKT pathway.

  2015cites this paper
• Recent advances in bone regeneration using adult stem cells.

  2015cites this paper
• CXC Chemokine Receptor 4 Is Expressed Paravascularly in Apical Papilla and Coordinates with Stromal Cell-derived Factor-1α during Transmigration of Stem Cells from Apical Papilla.

  2015cites this paper
• Regenerative Therapy and Immune Modulation Using Umbilical Cord Blood-Derived Cells.

  2015cites this paper
• CXC chemokine ligand 12a enhances chondrocyte proliferation and maturation during endochondral bone formation.

  2015cites this paper
• Bone Marrow-Derived Mesenchymal Stem Cells Repair Necrotic Pancreatic Tissue and Promote Angiogenesis by Secreting Cellular Growth Factors Involved in the SDF-1α/CXCR4 Axis in Rats

  2015cites this paper
• Statins, HMG-CoA Reductase Inhibitors, Improve Neovascularization by Increasing the Expression Density of CXCR4 in Endothelial Progenitor Cells

  2015cites this paper
• SDF1-A Facilitates Lin−/Sca1+ Cell Homing following Murine Experimental Cerebral Ischemia

  2014cites this paper
• Paracrine Mechanisms of Mesenchymal Stem Cell-Based Therapy: Current Status and Perspectives

  2014cites this paper
• Over-expression of CXCR4 on mesenchymal stem cells protect against experimental colitis via immunomodulatory functions in impaired tissue

  2014cites this paper
• Heart regeneration, stem cells, and cytokines

  2014cites this paper
• The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease

  2014cites this paper
• The SDF-1/CXCR4 axis regulates migration of transplanted bone marrow mesenchymal stem cells towards the pancreas in rats with acute pancreatitis

  2014influential citation
• Dopamine Mobilizes Mesenchymal Progenitor Cells Through D2‐Class Receptors and Their PI3K/AKT Pathway

  2014cites this paper
• Matrix metalloproteinase-9 is up-regulated by CCL19/CCR7 interaction via PI3K/Akt pathway and is involved in CCL19-driven BMSCs migration.

  2014cites this paper
• Glycan-based biomarkers for the quality assurance in stem cell therapy

  2014cites this paper
• The birth of ‘regenerative pharmacology’: a clinical perspective

  2013cites this paper
• Signaling molecules and pathways involved in MSC tumor tropism.

  2013cites this paper
• Emerging targets in cancer management: role of the CXCL12/CXCR4 axis

  2013cites this paper
• Enhancing the Migration Ability of Mesenchymal Stromal Cells by Targeting the SDF-1/CXCR4 Axis

  2013cites this paper
• Human mesenchymal stem cells in the treatment of neurological diseases.

  2013cites this paper
• Interactions between undifferentiated and osteogenically differentiated mesenchymal stromal cells during osteogenesis

  2013cites this paper
• N-Glycosylation Profile of Undifferentiated and Adipogenically Differentiated Human Bone Marrow Mesenchymal Stem Cells: Towards a Next Generation of Stem Cell Markers

  2013cites this paper
• Migration of CXCR4 gene‐modified bone marrow‐derived mesenchymal stem cells to the acute injured kidney

  2013cites this paper
• Mesenchymal Stem Cells and Tissue Repair

  2012cites this paper
• TGF-β1-induced LPP expression dependant on Rho kinase during differentiation and migration of bone marrow-derived smooth muscle progenitor cells

  2012cites this paper
• Overexpression of SDF-1α Enhanced Migration and Engraftment of Cardiac Stem Cells and Reduced Infarcted Size via CXCR4/PI3K Pathway

  2012influential citation
• Cardiac Stem Cells and their Roles in Myocardial Infarction

  2012cites this paper
• Stromal-cell-derived factor (SDF) 1-alpha in combination with BMP-2 and TGF-β1 induces site-directed cell homing and osteogenic and chondrogenic differentiation for tissue engineering without the requirement for cell seeding

  2012cites this paper
• Kinetics and function of mesenchymal stem cells in corneal injury.

  2012cites this paper
• CXCR4 gene transfer prevents pressure overload induced heart failure.

  2012cites this paper
• Mouse mesenchymal stem cells from bone marrow differentiate into smooth muscle cells by induction of plaque-derived smooth muscle cells.

  2011cites this paper
• Effect of chemokine receptor CXCR4 on hypoxia-induced pulmonary hypertension and vascular remodeling in rats

  2011cites this paper
• Transplantation of stem cells from human umbilical cord blood to improve regeneration after spinal cord injury

  2011cites this paper