Dysregulation of cytochrome P450 17alpha-hydroxylase messenger ribonucleic acid stability in theca cells isolated from women with polycystic ovary syndrome.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of Clinical Endocrinology and Metabolism

• Publication date

  2005-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1210/JC.2004-1860PMID 15598676
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Clinical Investigations Two Single Nucleotide Polymorphisms in the CYP17 and COMT Genes—Relation to Bone Mass and Longitudinal Bone Changes in Postmenopausal Women with or without Hormone Replacement Therapy The Danish Osteoporosis Prevention Study

  2004cited by this paper
• Increased cytochrome P450 17alpha-hydroxylase promoter function in theca cells isolated from patients with polycystic ovary syndrome involves nuclear factor-1.

  2004cited by this paper
• Estrogen‐metabolizing gene polymorphisms in the assessment of breast carcinoma risk and fibroadenoma risk in Caucasian women

  2004cited by this paper
• The molecular signature of polycystic ovary syndrome (PCOS) theca cells defined by gene expression profiling.

  2004cited by this paper
• Valproate potentiates androgen biosynthesis in human ovarian theca cells.

  2004cited by this paper
• cAMP controls human renin mRNA stability via specific RNA-binding proteins.

  2004cited by this paper
• Down-regulation of soluble guanylyl cyclase expression by cyclic AMP is mediated by mRNA-stabilizing protein HuR.

  2004cited by this paper
• Two Single Nucleotide Polymorphisms in the CYP17 and COMT Genes—Relation to Bone Mass and Longitudinal Bone Changes in Postmenopausal Women with or without Hormone Replacement Therapy

  2004cited by this paper
• A multi-protein complex containing cold shock domain (Y-box) and polypyrimidine tract binding proteins forms on the vascular endothelial growth factor mRNA. Potential role in mRNA stabilization.

  2004cited by this paper
• Some New Thoughts on the Pathophysiology and Genetics of Polycystic Ovary Syndrome

  2003cited by this paper
• Variation in resistin gene promoter not associated with polycystic ovary syndrome.

  2003cited by this paper
• Regulation of α-Globin mRNA Stability

  2003cited by this paper
• Regulation of alpha-globin mRNA stability.

  2003cited by this paper
• The Molecular Phenotype of Polycystic Ovary Syndrome (PCOS) Theca Cells and New Candidate PCOS Genes Defined by Microarray Analysis*

  2003cited by this paper
• Fructose modulates GLUT5 mRNA stability in differentiated Caco-2 cells: role of cAMP-signalling pathway and PABP (polyadenylated-binding protein)-interacting protein (Paip) 2.

  2003cited by this paper
• HADHB, HuR, and CP1 Bind to the Distal 3′-Untranslated Region of Human Renin mRNA and Differentially Modulate Renin Expression*

  2003cited by this paper
• Overexpression of theca-cell messenger RNA in polycystic ovary syndrome does not correlate with polymorphisms in the cholesterol side-chain cleavage and 17alpha-hydroxylase/C(17-20) lyase promoters.

  2002cited by this paper
• An Iron-responsive Element Type II in the 5′-Untranslated Region of the Alzheimer's Amyloid Precursor Protein Transcript*

  2002cited by this paper
• mRNA Stability and the Control of Gene Expression: Implications for Human Disease

  2002cited by this paper
• Elevated dehydroepiandrosterone sulfate levels as the reproductive phenotype in the brothers of women with polycystic ovary syndrome.

  2002cited by this paper
• The genetic basis of polycystic ovary syndrome.

  2002cited by this paper
• Hypoxia May Increase Rat Insulin mRNA Levels by Promoting Binding of the Polypyrimidine Tract-binding Protein (PTB) to the Pyrimidine-rich Insulin mRNA 3′-Untranslated Region

  2002cited by this paper
• NF-1C, Sp1, and Sp3 are essential for transcription of the human gene for P450c17 (steroid 17alpha-hydroxylase/17,20 lyase) in human adrenal NCI-H295A cells.

  2001cited by this paper
• Regulation of mRNA stability in mammalian cells.

  2001influential reference
• Evidence for association of polycystic ovary syndrome in caucasian women with a marker at the insulin receptor gene locus.

  2001cited by this paper
• The biochemical basis for increased testosterone production in theca cells propagated from patients with polycystic ovary syndrome.

  2001cited by this paper
• When the message goes awry: disease-producing mutations that influence mRNA content and performance.

  2001cited by this paper
• An in Vitro Assay to Study Regulated mRNA Stability

  2000cited by this paper
• Expression of Phosphodiesterase 4D (PDE4D) Is Regulated by Both the Cyclic AMP-dependent Protein Kinase and Mitogen-activated Protein Kinase Signaling Pathways

  2000cited by this paper
• Thirty-seven candidate genes for polycystic ovary syndrome: strongest evidence for linkage is with follistatin.

  1999cited by this paper
• Polymorphism T-->C (-34 bp) of gene CYP17 promoter in Greek patients with polycystic ovary syndrome.

  1999cited by this paper
• Augmented androgen production is a stable steroidogenic phenotype of propagated theca cells from polycystic ovaries.

  1999cited by this paper
• Protein Kinase A Stimulates Binding of Multiple Proteins to a U-Rich Domain in the 3′-Untranslated Region of Lactate Dehydrogenase A mRNA That Is Required for the Regulation of mRNA Stability*

  1998cited by this paper
• Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome.

  1998cited by this paper
• Insulin stimulates testosterone biosynthesis by human thecal cells from women with polycystic ovary syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction system.

  1998cited by this paper
• Phenotype and genotype in polycystic ovary syndrome.

  1998cited by this paper
• 17α-Hydroxyprogesterone Responses to Leuprolide and Serum Androgens in Obese Women with and without Polycystic Ovary Syndrome after Dietary Weight Loss1

  1997cited by this paper
• 17 alpha-Hydroxyprogesterone responses to leuprolide and serum androgens in obese women with and without polycystic ovary syndrome offer dietary weight loss.

  1997cited by this paper
• Frequency of a polymorphism in the regulatory region of the 17α‐hydroxylase‐17,20‐lyase (CYP17) gene in hyperandrogenic states

  1997cited by this paper
• The genetic basis of polycystic ovary syndrome.

  1997cited by this paper
• Evidence for a primary abnormality of thecal cell steroidogenesis in the polycystic ovary syndrome

  1997cited by this paper
• Transcription of the human genes for cytochrome P450scc and P450c17 is regulated differently in human adrenal NCI-H295 cells than in mouse adrenal Y1 cells.

  1997cited by this paper
• Expression of steroidogenic acute regulatory protein (StAR) in the human ovary.

  1996cited by this paper
• 5' polymorphism of the CYP17 gene is not associated with serum testosterone levels in women with polycystic ovaries.

  1996cited by this paper
• Steroidogenic factor 1-dependent promoter activity of the human steroidogenic acute regulatory protein (StAR) gene.

  1996cited by this paper
• cAMP enhances inducible nitric oxide synthase mRNA stability in cardiac myocytes.

  1995cited by this paper
• Polycystic ovaries and premature male pattern baldness are associated with one allele of the steroid metabolism gene CYP17.

  1994cited by this paper
• Regulation of human cytochrome P450scc and adrenodoxin messenger ribonucleic acids in JEG-3 cytotrophoblast cells.

  1992cited by this paper
• Regulation of 3 beta-hydroxysteroid dehydrogenase in adrenocortical cells: effects of angiotensin-II and transforming growth factor beta.

  1991cited by this paper
• Pituitary-ovarian responses to nafarelin testing in the polycystic ovary syndrome.

  1989cited by this paper
• [Diagnostic criteria for polycystic ovary syndrome].

  1989cited by this paper
• Cytochrome P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues.

  1987cited by this paper
• Cloning and Sequence of the Human Gene for P450cl7 (Steroid 17α-Hydroxylase/17,20 Lyase): Similarity with the Gene for P450c21

  1987cited by this paper
• Properties of the exonuclease activity that degrades H4 histone mRNA.

  1987cited by this paper
• Cloning and sequence of the human gene for P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): similarity with the gene for P450c21.

  1987cited by this paper
• Hormonal regulation of P450scc (20,22-desmolase) and P450c17 (17 alpha-hydroxylase/17,20-lyase) in cultured human granulosa cells.

  1986cited by this paper
• A new technique for the assay of infectivity of human adenovirus 5 DNA.

  1973cited by this paper
• Journal of Clinical Endocrinology and Metabolism Printed in U.S.A. Copyright © 1998 by The Endocrine Society Prevalence of the Polycystic Ovary Syndrome in Unselected Black and White Women of the Southeastern United States: A Prospective Study*

  year unknowncited by this paper
• The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright © 2000 by The Endocrine Society Differential Activity of the Cytochrome P450 17�- Hydroxylase and Steroidogenic Acute Regulatory Protein Gene Promoters in Normal and Polycystic

  year unknowncited by this paper

• Kaempferol ameliorates PCOS by alleviating metabolic and endocrine abnormalities as well as oxidative stress.

  2026cites this paper
• Impact of dietary fiber on PCOS: a systematic review

  2025influential citation
• Erchen Decoction ameliorates the rat model of polycystic ovary syndrome by regulating the steroid biosynthesis pathway.

  2025cites this paper
• Understanding hirsutism in PCOS

  2024cites this paper
• Tri-Chromium picolinate significantly improved the hormonal levels and CYP17A1 expression in female rats induced with polycystic ovary syndrome

  2024cites this paper
• The evolution of ovarian somatic cells characterized by transcriptome and chromatin accessibility across rodents, monkeys, and humans

  2024cites this paper
• An Update on the Genetics of Polycystic Ovary Syndrome

  2024cites this paper
• Obesity and Polycystic Ovary Syndrome

  2024cites this paper
• Effects of Berberine on glucolipid metabolism among dehydroepiandrosterone-induced rats of polycystic ovary syndrome with insulin-resistance

  2024cites this paper
• Biochemical Classification Diagnosis of Polycystic Ovary Syndrome Based on Serum Steroid Hormones.

  2024cites this paper
• Endocrine activities modulated by adipose-mesenchymal stem cell in an animal model induced to polycystic ovary syndrome

  2024cites this paper
• Therapeutic effects and molecular mechanisms of quercetin in gynecological disorders.

  2024cites this paper
• Therapeutic Potential of Mesenchymal Stem Cells in PCOS.

  2023cites this paper
• Alleviative Effects of Adipose Tissue-derived Stem Cells and α-NETA on Metabolic, Biochemical, and Endocrine Parameters in a Letrozole-induced Rat Model of PCOS.

  2023cites this paper
• Single-Cell RNA-Seq Identifies Pathways and Genes Contributing to the Hyperandrogenemia Associated with Polycystic Ovary Syndrome

  2023influential citation
• Associations of LH and FSH with reproductive hormones depending on each stage of the menopausal transition

  2023influential citation
• Histological and molecular evaluation of Mentha arvensis extract on a polycystic ovary syndrome rat model

  2023cites this paper
• Low temperature plasma protects against inflammatory agents-mediated dysfunction of theca cells via enhancing MANF expression

  2023cites this paper
• Differentiating Polycystic Ovary Syndrome from Adrenal Disorders

  2022cites this paper
• Apigenin exerts protective effect and restores ovarian function in dehydroepiandrosterone induced polycystic ovary syndrome rats: a biochemical and histological analysis

  2022cites this paper
• Loci on chromosome 12q13.2 encompassing ERBB3, PA2G4 and RAB5B are associated with polycystic ovary syndrome.

  2022cites this paper
• De Novo and Depot-Specific Androgen Production in Human Adipose Tissue: A Source of Hyperandrogenism in Women with Obesity

  2022cites this paper
• Syndrome des ovaires polykystiques

  2022cites this paper
• Follicular Fluid: A Powerful Tool for the Understanding and Diagnosis of Polycystic Ovary Syndrome

  2022cites this paper
• Systemic and ovarian inflammation in women with polycystic ovary syndrome.

  2022cites this paper
• The role of polymorphism in various potential genes on polycystic ovary syndrome susceptibility and pathogenesis

  2021cites this paper
• Effects of IL‐18 on the proliferation and steroidogenesis of bovine theca cells: Possible roles in the pathogenesis of polycystic ovary syndrome

  2020cites this paper
• Steroid metabolome profiling of follicular fluid in normo- and hyperandrogenic women with polycystic ovary syndrome.

  2020cites this paper
• The interference effects of bisphenol A on the synthesis of steroid hormones in human ovarian granulosa cells

  2020cites this paper
• СИНДРОМ ПОЛІКІСТОЗНИХ ЯЄЧНИКІВ ЯК ЧИННИК ЕНДОКРИННОГО БЕЗПЛІДДЯ

  2020cites this paper
• Nicotinamide and its metabolite N1-Methylnicotinamide alleviate endocrine and metabolic abnormalities in adipose and ovarian tissues in rat model of Polycystic Ovary Syndrome.

  2020cites this paper
• Syndrome des ovaires polymicrokystiques

  2020cites this paper
• Síndrome de ovarios poliquísticos

  2020cites this paper
• Selenium and Polycystic Ovary Syndrome; Current Knowledge and Future Directions: A Systematic Review

  2019cites this paper
• Le syndrome des ovaires polykystiques

  2019cites this paper
• Hyperandrogenism in polycystic ovarian syndrome and role of CYP gene variants: a review

  2019cites this paper
• Adipose Tissue is a Potential Source of Hyperandrogenism in Obese Female Rats

  2018cites this paper
• Ovarian Follicular Theca Cell Recruitment, Differentiation, and Impact on Fertility: 2017 Update.

  2018cites this paper
• Tetragonia tetragonioides (Pall.) Kuntze Regulates Androgen Production in a Letrozole-Induced Polycystic Ovary Syndrome Model

  2018cites this paper
• Antiandrogen Treatment Ameliorates Reproductive and Metabolic Phenotypes in the Letrozole-Induced Mouse Model of PCOS

  2018cites this paper
• The Genetics of Polycystic Ovary Syndrome: From Genome-Wide Association to Molecular Mechanisms

  2018cites this paper
• Treatment strategies for women with polycystic ovary syndrome

  2018cites this paper
• Therapeutic potentials of Quercetin in management of polycystic ovarian syndrome using Letrozole induced rat model: a histological and a biochemical study

  2018cites this paper
• Pathologic significance of SET/I2PP2A-mediated PP2A and non-PP2A pathways in polycystic ovary syndrome (PCOS).

  2017cites this paper
• Genetic and epigenetic factors of polycystic ovary syndrome

  2016cites this paper
• Link Between Genetics and PCOS: A Brief Review

  2016cites this paper
• [Genetic and epigenetic factors of polycystic ovary syndrome].

  2016cites this paper
• Phosphatidylinositide 3-kinase inhibition: A new potential target for the treatment of polycystic ovarian syndrome

  2016cites this paper
• Relationship between Advanced Glycation End Products and Steroidogenesis in PCOS

  2016cites this paper
• eation du CHU de Nice

  2016cites this paper
• A Dietary Medium-Chain Fatty Acid, Decanoic Acid, Inhibits Recruitment of Nur77 to the HSD3B2 Promoter In Vitro and Reverses Endocrine and Metabolic Abnormalities in a Rat Model of Polycystic Ovary Syndrome.

  2016cites this paper
• Atorvastatina y concentraciones de proteína C reactiva en mujeres con síndrome de ovarios poliquísticos y sobrepeso

  2016cites this paper
• L'hormone anti-müllerienne dans le syndrome des ovaires polykystiques. Quelle valeur diagnostique ? Évaluation du dosage de l'hormone anti-müllerienne à l'aide du kit Ultra-sensitive Ansh Labs assays dans le centre d'Aide Médicale à la Procréation du CHU de Nice

  2015cites this paper
• Androgens as double-edged swords: Induction and suppression of follicular development

  2015cites this paper
• L'hormone anti-müllerienne dans le syndrome des ovaires polykystiques. Quelle valeur diagnostique ? Évaluation du dosage de l'hormone anti-müllerienne à l'aide du kit Ultra-sensitive Ansh Labs assays dans le centre d'Aide Médicale à la Procréation du CHU de Nice

  2015cites this paper
• Targets to treat androgen excess in polycystic ovary syndrome

  2015cites this paper
• Functional genomics of PCOS: from GWAS to molecular mechanisms.

  2015cites this paper
• Insulin Resistance and Lipotoxicity in PCOS: Causes and Consequences

  2014cites this paper
• Decreased myo-inositol to chiro-inositol (M/C) ratios and increased M/C epimerase activity in PCOS theca cells demonstrate increased insulin sensitivity compared to controls.

  2014cites this paper
• Association between polycystic ovary syndrome and metabolic syndrome.

  2014cites this paper
• The striking similarities in the metabolic associations of female androgen excess and male androgen deficiency.

  2014cites this paper
• Developmental programming: prenatal steroid excess disrupts key members of intraovarian steroidogenic pathway in sheep.

  2014cites this paper
• Polycystic Ovary Syndrome: Features, Diagnostic Criteria and Treatments

  2014cites this paper
• Ovarian Dysfunction in Polycystic Ovary Syndrome

  2014cites this paper
• Defects in Ovarian Steroid Hormone Biosynthesis

  2014cites this paper
• Efectos del resveratrol en la fisiología ovárica y su potencial aplicación en el síndrome de ovario poliquístico

  2014cites this paper
• Metformin induces a prompt decrease in LH-stimulated testosterone response in women with PCOS independent of its insulin-sensitizing effects

  2014cites this paper
• γ-chain, apolipoprotein A-IV (apoA-IV) precursor and α-1-B- glycoprotein (A1BG)] in follicular fluids from PCOS patients were identified with matrix-assisted laser desorption/ioniza- tion-time-of-flight mass spectrometry (MALDI-TOF-MS) and nano LC-MS/MS. Western blot analysis confirmed that the prot

  2013cites this paper
• SET/PP2A system regulates androgen production in ovarian follicles in vitro.

  2013influential citation
• Estudio de las características metabólicas, hormonales e inmunoinflamatorias de mujeres con síndrome de ovarios poliquísticos con o sin obesidad. Análisis del impacto del tratamiento con atorvastatina

  2013cites this paper
• Increased protein expression of LHCG receptor and 17α-hydroxylase/17-20-lyase in human polycystic ovaries.

  2013cites this paper
• Apolipoprotein A-IV as a novel gene associated with polycystic ovary syndrome.

  2013cites this paper
• SET protein up-regulated testosterone production in the cultured preantral follicles

  2013influential citation
• Expression of SET Protein in the Ovaries of Patients with Polycystic Ovary Syndrome

  2013cites this paper
• Infertilités féminines d'origine endocrinienne

  2012cites this paper
• ESTUDIO DE LAS CARACTERÍSTICAS METABÓLICAS, HORMONALES E INMUNOINFLAMATORIAS DE MUJERES CON SÍNDROME DE OVARIOS POLIQUÍSTICOS CON O SIN OBESIDAD. ANÁLISIS DEL IMPACTO DEL TRATAMIENTO CON ATORVASTATINA

  2012cites this paper
• Saturated fatty acid exposure induces androgen overproduction in bovine adrenal cells.

  2012cites this paper
• Validation of the obese Ossabaw miniature pig as a model of the obese polycystic ovary syndrome phenotype with concomitant metabolic syndrome: Exploration of polycystic ovary syndrome pathophysiology using in vivo and in vitro models

  2012cites this paper
• Cholesterol Side-Chain Cleavage Gene Expression in Theca Cells: Augmented Transcriptional Regulation and mRNA Stability in Polycystic Ovary Syndrome

  2012cites this paper
• Infertilidad femenina de origen endocrino

  2012cites this paper
• Subclinical inflammation in obese women with polycystic ovary syndrome

  2012cites this paper
• Resveratrol reduces steroidogenesis in rat ovarian theca-interstitial cells: the role of inhibition of Akt/PKB signaling pathway.

  2012cites this paper
• Simvastatin Reduces Steroidogenesis by Inhibiting Cyp17a1 Gene Expression in Rat Ovarian Theca-Interstitial Cells1

  2012cites this paper
• Hormonal and metabolic effects of polyunsaturated fatty acids in young women with polycystic ovary syndrome: results from a cross-sectional analysis and a randomized, placebo-controlled, crossover trial.

  2011cites this paper
• Hormonal and metabolic effects of polyunsaturated fatty acids in young women with polycystic ovary syndrome : results from a cross-sectional analysis and a randomized , placebo-controlled , crossover trial 1 – 4

  2011cites this paper
• Understanding polycystic ovarian syndrome pathogenesis: An updated of its genetic aspects

  2011cites this paper
• The correlation between Anthropometry and infertility in women

  2011cites this paper
• Resveratrol potentiates effects of simvastatin on inhibition of rat ovarian theca-interstitial cells steroidogenesis

  2011cites this paper
• Human cytochrome p450c17: single step purification and phosphorylation of serine 258 by protein kinase a.

  2010cites this paper
• Le syndrome des ovaires polymicrokystiques ― ou les follicules dans tous leurs excès

  2010cites this paper
• Metabolic and hormonal aspects of polycystic ovary syndrome: the impact of diet

  2010cites this paper
• [Polycystic ovary syndrome: A model of follicular excess].

  2010cites this paper
• Steroid profiles in ovarian follicular fluid in women with and without polycystic ovary syndrome, analyzed by liquid chromatography-tandem mass spectrometry.

  2010cites this paper
• NFX 1123 Increases hTERT Expression and Telomerase Activity Posttranscriptionally in Human Papillomavirus Type 16 E 6 Keratinocytes

  2009cites this paper
• NFX1-123 Increases hTERT Expression and Telomerase Activity Posttranscriptionally in Human Papillomavirus Type 16 E6 Keratinocytes

  2009cites this paper
• W poszukiwaniu etiopatogenezy zespo ∏ u policystycznych jajników ( PCOS ) Search for the ethiopathogenesis of polycystic ovary syndrome ( PCOS )

  2009cites this paper
• Critérios diagnósticos da síndrome dos ovários policísticos: uma permanente controvérsia

  2009cites this paper
• TGF-β Inhibits CYP17 Transcription in H295R Cells Acting via Activin Receptor-Like Kinase 5

  2009cites this paper
• Genetics of polycystic ovary syndrome.

  2009cites this paper
• The complex relationship between hypothalamic amenorrhea and polycystic ovary syndrome.

  2008cites this paper