Expression of evolutionarily novel genes in tumors

The evolutionarily novel genes originated through different molecular mechanisms are expressed in tumors. Sometimes the expression of evolutionarily novel genes in tumors is highly specific. Moreover positive selection of many human tumor-related genes in primate lineage suggests their involvement in the origin of new functions beneficial to organisms.It is suggested to consider the expression of evolutionarily young or novel genes in tumors as a new biological phenomenon, a phenomenon of TSEEN (tumor specifically expressed, evolutionarily novel) genes.

• Publication year

  2016

• Venue

  Infectious Agents and Cancer

• Publication date

  2016-07-19

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1186/s13027-016-0077-6PMID 27437030PMCID 4949931
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Database resources of the National Center for Biotechnology Information

  2017cited by this paper
• Cell signaling: Principles and mechanisms

  2017cited by this paper
• Study of tumor-specific expression of some evolutionary new genes.

  2016cited by this paper
• LINE-1 Retrotransposons and Their Role in Cancer

  2015cited by this paper
• Differential expression analysis of human endogenous retroviruses based on ENCODE RNA-seq data

  2015cited by this paper
• The decline of human endogenous retroviruses: extinction and survival

  2015cited by this paper
• Activation and regulation of endogenous retroviral genes in the human pituitary gland and related endocrine tumours

  2015cited by this paper
• P126: The human oncogenome evolution advances ahead of the evolution of human protein-coding genome and other specific gene classes

  2015cited by this paper
• Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells

  2015cited by this paper
• Splice factor mutations and alternative splicing as drivers of hematopoietic malignancy

  2015cited by this paper
• HMGA1-pseudogene expression is induced in human pituitary tumors

  2015cited by this paper
• The role of tissue factor isoforms in cancer biology

  2015cited by this paper
• Evolutionary origin and human-specific expansion of a cancer/testis antigen gene family.

  2014cited by this paper
• New genes contribute to genetic and phenotypic novelties in human evolution.

  2014cited by this paper
• HMGA1-pseudogene overexpression contributes to cancer progression

  2014cited by this paper
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  2014cited by this paper
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  2014cited by this paper
• ELFN1-AS1: A Novel Primate Gene with Possible MicroRNA Function Expressed Predominantly in Human Tumors

  2014cited by this paper
• Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes

  2014cited by this paper
• Hallmarks of alternative splicing in cancer

  2014cited by this paper
• Unfixed Endogenous Retroviral Insertions in the Human Population

  2014cited by this paper
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  2014cited by this paper
• Alternative splicing in cancer: implications for biology and therapy

  2014cited by this paper
• Endogenous Retroviruses and the Development of Cancer

  2014cited by this paper
• Splice variants of MDM2 in oncogenesis.

  2014cited by this paper
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• Pan-vertebrate comparative genomics unmasks retrovirus macroevolution

  2014cited by this paper
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  2013cited by this paper
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  2013cited by this paper
• The role of human endogenous retroviral long terminal repeat sequences in human cancer (Review).

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• The Novelty of Human Cancer/Testis Antigen Encoding Genes in Evolution

  2013cited by this paper
• Endogenous Retroviruses as Targets for Antitumor Immunity in Renal Cell Cancer and Other Tumors

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• HERV-K(HML-2), the Best Preserved Family of HERVs: Endogenization, Expression, and Implications in Health and Disease

  2013cited by this paper
• Differential expression of nanog1 and nanogp8 in colon cancer cells.

  2012cited by this paper
• ProteinHistorian: Tools for the Comparative Analysis of Eukaryote Protein Origin

  2012cited by this paper
• Human endogenous retroviruses and cancer: causality and therapeutic possibilities.

  2012cited by this paper
• GENCODE: The reference human genome annotation for The ENCODE Project

  2012cited by this paper
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  2012cited by this paper
• Alternative Splicing and Its Impact as a Cancer Diagnostic Marker

  2012cited by this paper
• Pseudogenes: Newly Discovered Players in Human Cancer

  2012cited by this paper
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  2012cited by this paper
• CLLU1 expression distinguishes chronic lymphocytic leukemia from other mature B-cell neoplasms.

  2012cited by this paper
• Expressed pseudogenes in the transcriptional landscape of human cancers.

  2012cited by this paper
• A model of developmental evolution: selection, pleiotropy and compensation.

  2012cited by this paper
• The GENCODE pseudogene resource

  2012cited by this paper
• Database resources of the National Center for Biotechnology Information

  2011cited by this paper
• The Expansion of the PRAME Gene Family in Eutheria

  2011cited by this paper
• Cancer/testis (CT) antigens, carcinogenesis and spermatogenesis

  2011cited by this paper
• Abstract 3858: Transcribed locus Hs.633957: A new tumor-associated primate-specific gene with possible microRNA function

  2011cited by this paper
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• A transcribed pseudogene of MYLK promotes cell proliferation

  2011cited by this paper
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  2011cited by this paper
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  2011cited by this paper
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  2011cited by this paper
• [Locus HS.633957 expression in human gastrointestinal tract and tumors].

  2011cited by this paper
• Potential mechanisms of endogenous retroviral-mediated genomic instability in human cancer.

  2010cited by this paper
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  2010cited by this paper
• Mobilizing diversity: transposable element insertions in genetic variation and disease

  2010cited by this paper
• Regulation of cancer germline antigen gene expression: implications for cancer immunotherapy.

  2010influential reference
• The evolution of gene duplications: classifying and distinguishing between models

  2010cited by this paper
• Aberrant epigenetic landscape in cancer: how cellular identity goes awry.

  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010cited by this paper
• Origins, evolution, and phenotypic impact of new genes.

  2010cited by this paper
• Endogenous Retroviruses and Cancer

  2010cited by this paper
• [Tumor-specific expression of PBOV1, a new gene in evolution].

  2010cited by this paper
• Distinguishing among evolutionary models for the maintenance of gene duplicates.

  2009cited by this paper
• POU5F1P1, a putative cancer susceptibility gene, is overexpressed in prostatic carcinoma

  2009cited by this paper
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  2009cited by this paper
• The origins and impact of primate segmental duplications.

  2009cited by this paper
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  2009cited by this paper
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• Cancer-associated regulation of alternative splicing

  2009cited by this paper
• Connexin43 pseudogene in breast cancer cells offers a novel therapeutic target

  2009cited by this paper
• [Expression of transcripts related to the cluster HS.633957 in human normal and tumor tissues].

  2009cited by this paper
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• Cancer/testis (CT) antigens: Potential targets for immunotherapy

  2009cited by this paper
• The life and death of gene families

  2009cited by this paper
• Recent de novo origin of human protein-coding genes.

  2009cited by this paper
• Recent duplication and positive selection of the GAGE gene family

  2008cited by this paper
• Activation and transposition of endogenous retroviral elements in hypomethylation induced tumors in mice

  2008cited by this paper
• [Tumors and evolution].

  2008cited by this paper

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