Functional nanoscale coupling of Lyn kinase with IgE-FcεRI is restricted by the actin cytoskeleton in early antigen-stimulated signaling

Spatial targeting of signaling components to activated receptors on the plasma membrane is key for initiating signal transduction. The actin cytoskeleton restricts antigen-stimulated colocalization of IgE-FcεRI with membrane-anchored signaling partner Lyn kinase, and this regulation is mediated by organization of plasma membrane lipids.

• Publication year

  2016

• Venue

  Molecular Biology of the Cell

• Publication date

  2016-11-07

• Fields of study

  Biology, Medicine, Materials Science, Chemistry

• Identifiers
  DOI 10.1091/mbc.E16-06-0425PMID 27682583PMCID 5221596
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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