Prevalence of autoantibodies to the 65- and 67-kD isoforms of glutamate decarboxylase in insulin-dependent diabetes mellitus.

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Journal of Clinical Investigation

• Publication date

  1993-09-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1172/JCI116714PMID 8376591PMCID PMC288282
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme

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• Pancreatic beta cells express two autoantigenic forms of glutamic acid decarboxylase, a 65-kDa hydrophilic form and a 64-kDa amphiphilic form which can be both membrane-bound and soluble.

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• 64,000 Mr autoantibodies as predictors of insulin-dependent diabetes.

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• Islet cell antibodies in diabetes mellitus associated with a mitochondrial tRNA(Leu(UUR)) gene mutation.

  2009cites this paper
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