Ginsenoside Rg3 inhibits phenylephrine‐induced vascular contraction through induction of nitric oxide synthase

No abstract is available for this paper.

• Publication year

  2003

• Venue

  British Journal of Pharmacology

• Publication date

  2003-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.bjp.0705490PMID 14534150PMCID PMC1574077
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inhibition of lipopolysaccharide‐inducible nitric oxide synthase, TNF‐α and COX‐2 expression by sauchinone effects on I‐κBα phosphorylation, C/EBP and AP‐1 activation

  2003cited by this paper
• Potentiation of lipopolysaccharide-inducible cyclooxygenase 2 expression by C2-ceramide via c-Jun N-terminal kinase-mediated activation of CCAAT/enhancer binding protein beta in macrophages.

  2003cited by this paper
• Thrombin induces nitric-oxide synthase via Galpha12/13-coupled protein kinase C-dependent I-kappaBalpha phosphorylation and JNK-mediated I-kappaBalpha degradation.

  2003cited by this paper
• Thrombin Induces Nitric-oxide Synthase via Gα12/13-coupled Protein Kinase C-dependent I-κBα Phosphorylation and JNK-mediated I-κBα Degradation*

  2003cited by this paper
• Aminoguanidine renders inducible nitric oxide synthase knockout mice more susceptible to Salmonella typhimurium infection.

  2002cited by this paper
• Galpha(q) and Gbetagamma regulate PAR-1 signaling of thrombin-induced NF-kappaB activation and ICAM-1 transcription in endothelial cells.

  2002cited by this paper
• JunB/AP-1 and NF-kappa B-mediated induction of nitric oxide synthase by bovine type I collagen in serum-stimulated murine macrophages.

  2002cited by this paper
• G a q and G bg Regulate PAR-1 Signaling of Thrombin-Induced NF- k B Activation and ICAM-1 Transcription in Endothelial Cells

  2002cited by this paper
• Ginsenoside potentiates NO-mediated neurogenic vasodilatation of monkey cerebral arteries.

  2001cited by this paper
• Liquid chromatographic determination of less polar ginsenosides in processed ginseng.

  2001influential reference
• Stimulation of nitric oxide synthesis by the aqueous extract of Panax ginseng root in RAW 264.7 cells

  2001cited by this paper
• [Pharmacokinetic studies of 20(R)-ginsenoside RG3 in human volunteers].

  2001cited by this paper
• Distinct involvement of NF‐κB and p38 mitogen‐activated protein kinase pathways in serum deprivation‐mediated stimulation of inducible nitric oxide synthase and its inhibition by 4‐hydroxynonenal

  2001cited by this paper
• What is the role of nitric oxide in murine and human host defense against tuberculosis?Current knowledge.

  2001cited by this paper
• Effect of Korea red ginseng on the blood pressure in conscious hypertensive rats.

  2000cited by this paper
• Effects of red ginseng upon vascular endothelial function in patients with essential hypertension.

  2000cited by this paper
• Inducible nitric oxide synthase: a little bit of good in all of us

  2000cited by this paper
• Induction of inducible nitric oxide synthase by ginsenosides in cultured porcine endothelial cells.

  2000cited by this paper
• Steaming of ginseng at high temperature enhances biological activity.

  2000cited by this paper
• Phorbol ester synergistically increases interferon regulatory factor-1 and inducible nitric oxide synthase induction in interferon-gamma-treated RAW 264.7 cells.

  2000cited by this paper
• Phorbol ester synergistically increases interferon regulatory factor-1 and inducible nitric oxide synthase induction in interferon-γ-treated RAW264.7 cells

  2000cited by this paper
• Src-family Tyrosine Kinases in Activation of ERK-1 and p85/p110-phosphatidylinositol 3-Kinase by G/CCKBReceptors*

  1999cited by this paper
• Specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and interferon-gamma.

  1999cited by this paper
• Up-regulation of interleukin-1beta-stimulated interleukin-8 in human keratinocytes by nitric oxide.

  1999cited by this paper
• The ginsenoside Rg3 evokes endothelium-independent relaxation in rat aortic rings: role of K+ channels.

  1999influential reference
• Ginsenoside Rg3 mediates endothelium-dependent relaxation in response to ginsenosides in rat aorta: role of K+ channels.

  1999influential reference
• Activation of phosphatidylinositol 3-kinase, protein kinase B, and p70 S6 kinases in lipopolysaccharide-stimulated Raw 264.7 cells: differential effects of rapamycin, Ly294002, and wortmannin on nitric oxide production.

  1998cited by this paper
• Effect of red ginseng on blood pressure in patients with essential hypertension and white coat hypertension.

  1998cited by this paper
• DNA damage induced by peroxynitrite: subsequent biological effects.

  1997influential reference
• Inhibition of inducible nitric oxide synthase gene expression and enzyme activity by epigallocatechin gallate, a natural product from green tea.

  1997cited by this paper
• Enhancement of radiation-inducible hepatic glutathione-S-transferases Ya, Yb1, Yb2, Yc1, and Yc2 gene expression by oltipraz: possible role in radioprotection.

  1997cited by this paper
• THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

  1996cited by this paper
• Regulation of transcription by MAP kinase cascades.

  1996cited by this paper
• Immunostimulating Polysaccharides from Panax notoginseng

  1996influential reference
• The NF-kappa B and I kappa B proteins: new discoveries and insights.

  1996cited by this paper
• Signalling pathways: jack of all cascades.

  1996cited by this paper
• Regulation and function of inducible nitric oxide synthase during sepsis and acute inflammation.

  1995cited by this paper
• Different induction mechanisms of mRNA for inducible nitric oxide synthase in rat smooth muscle cells in culture and in aortic strips

  1994cited by this paper
• Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase.

  1994cited by this paper
• Ginsenosides evoke endothelium-dependent vascular relaxation in rat aorta.

  1994cited by this paper
• Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide

  1993cited by this paper
• Tyrosine kinase inhibitors suppress endotoxin- and IL-1 beta-induced NO synthesis in aortic smooth muscle cells.

  1993cited by this paper
• Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon-gamma and bacterial lipopolysaccharide.

  1993cited by this paper
• CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein.

  1990cited by this paper
• Astrocytes and glioblastoma cells express novel octamer-DNA binding proteins distinct from the ubiquitous Oct-1 and B cell type Oct-2 proteins.

  1990cited by this paper
• In vitro activation and nuclear translocation of NF-kappa B catalyzed by cyclic AMP-dependent protein kinase and protein kinase C

  1989influential reference
• The molecular heterogeneity of protein kinase C and its implications for cellular regulation

  1988cited by this paper
• Vascular endothelial cells synthesize nitric oxide from L-arginine

  1988cited by this paper
• Chemical studies on oriental plant drugs. XIV. Protopanaxadiol, a genuine sapogenin of ginseng saponins.

  1966cited by this paper
• What is the role

  1964cited by this paper

• Mikania micrantha invasion restructures rhizosphere nitrogen cycling through enzyme activation, microbial recruitment, and allelopathic regulation.

  2026cites this paper
• The effect of ginseng supplementation on CVD risk factors: a comprehensive systematic review and dose–response meta-analysis

  2025cites this paper
• Ginseng supplementation and vascular function: a systematic review and meta-analysis of clinical trials

  2025cites this paper
• Genome-wide identification and integrated analysis of the WNK kinase gene family and expression analysis of PgWNK genes under methyl jasmonate treatment in Panax ginseng

  2025cites this paper
• Ginseng extract (Ginsenoside RG3) combined with STING agonist reverses TAM/M2 polarization to inhibit TNBC evolution

  2024cites this paper
• Anti-inflammatory Mechanism of Morin Hydrate by Suppressing the NF-κB/MAPKs Mediated Cell Migration and Modulating Src/FAK and β-Catenin

  2023cites this paper
• Pharmacological properties, molecular mechanisms and therapeutic potential of ginsenoside Rg3 as an antioxidant and anti-inflammatory agent

  2022cites this paper
• Ginseng in vascular dysfunction: A review of therapeutic potentials and molecular mechanisms

  2022cites this paper
• Mechanisms and Efficacy of Traditional Chinese Medicine in Heart Failure

  2022cites this paper
• Impact of health and lifestyle food supplements on periodontal tissues and health

  2022cites this paper
• Ginsenoside Rg3 ameliorates acetaminophen-induced hepatotoxicity by suppressing inflammation and oxidative stress.

  2021cites this paper
• Comparative Study Before and After Washing Face with Ginseng CP Soap

  2021cites this paper
• Ginsenosides in vascular remodeling: cellular and molecular mechanisms of their therapeutic action.

  2021cites this paper
• Chemical components of ginseng, their biotransformation products and their potential as treatment of hypertension

  2020cites this paper
• Chemical components of ginseng, their biotransformation products and their potential as treatment of hypertension

  2020cites this paper
• Endothelium-Independent Vasodilatory Effect of Sailuotong (SLT) on Rat Isolated Tail Artery

  2020cites this paper
• Biotransformation of ginsenoside Rb1 to Gyp‐XVII and minor ginsenoside Rg3 by endophytic bacterium Flavobacterium sp. GE 32 isolated from Panax ginseng

  2019cites this paper
• Effect of Korean Red Ginseng (Panax Ginseng C.A. Meyer) and American Ginseng (Panax Quinquefolius L.) on Blood Pressure Control and Cardiometabolic Risk Factors

  2019influential citation
• Herbal Medicine of the 21st Century: A Focus on the Chemistry, Pharmacokinetics and Toxicity of Five Widely Advocated Phytotherapies.

  2019cites this paper
• Ginsenoside Rg3 Prolongs Survival of the Orthotopic Hepatocellular Carcinoma Model by Inducing Apoptosis and Inhibiting Angiogenesis

  2019cites this paper
• Simultaneous quantification of six nonpolar ginsenosides in white ginseng by reverse-phase high-performance liquid chromatography coupled with integrated pulsed amperometric detection

  2019cites this paper
• Stimulating effect of fermented ginseng leaf saponin on the differentiation and mineralization of murine osteoblastic MC3T3-E1 cells

  2019cites this paper
• Ginsenoside Rg3 protects against iE-DAP–induced endothelial-to-mesenchymal transition by regulating the miR-139-5p–NF-κB axis

  2019cites this paper
• Cardioprotection and natural polyphenols: an update of clinical and experimental studies.

  2018cites this paper
• Anti-inflammatory activity of Caralluma Fimbrata- raw 264 macrophage cell lines

  2018cites this paper
• Ginsenoside Rg3 disrupts actin-cytoskeletal integrity leading to contractile dysfunction and apoptotic cell death in vascular smooth muscle.

  2018cites this paper
• Bioactivity-guided isolation of ginsenosides from Korean Red Ginseng with cytotoxic activity against human lung adenocarcinoma cells

  2018cites this paper
• Method development for the certification of a ginsenoside calibration solution via liquid chromatography with absorbance and mass spectrometric detection.

  2018cites this paper
• Vascular activity of protopanaxadiol and protopanaxatriol, the major saponin fractions isolated from roots of Panax notoginseng

  2018cites this paper
• Anti-inflammatory and anti-genotoxic activity of branched chain amino acids (BCAA) in lipopolysaccharide (LPS) stimulated RAW 264.7 macrophages

  2017cites this paper
• Ginseng Berry and its Biological Effects as a Natural Phytochemical

  2016cites this paper
• Oryza sativa (Rice) Hull Extract Inhibits Lipopolysaccharide-Induced Inflammatory Response in RAW264.7 Macrophages by Suppressing Extracellular Signal-regulated Kinase, c-Jun N-terminal Kinase, and Nuclear Factor-κB Activation

  2016cites this paper
• Gintonin facilitates catecholamine secretion from the perfused adrenal medulla

  2016cites this paper
• Anti-atherogenic effect of Humulus japonicus in apolipoprotein E-deficient mice

  2016cites this paper
• Enzymatic transformation of ginseng leaf saponin by recombinant β‐glucosidase (bgp1) and its efficacy in an adipocyte cell line

  2016cites this paper
• Biotransformation of major ginsenoside Rb1 to pharmacologically active ginsenoside Rg3 through fermentation by Weissella hellenica DC06 in newly developed medium

  2016cites this paper
• Anti‐Inflammatory Effects of the Flowers of Prunus persica var. davidiana

  2016cites this paper
• Enzymatic transformation of ginsenoside Rb1 to ginsenoside 20(S)-Rg3 by GH3 β-glucosidase from Thermotoga thermarum DSM 5069T

  2015cites this paper
• Therapeutic Potential of Ginsenosides in Management of Atherosclerosis

  2015cites this paper
• Anti-inflammatory effect of Morinda citrifolia leaf extract on macrophage RAW 264.7 cells

  2015cites this paper
• Ginsenosides and amino acids in flavored ginseng chips as affected by food formulation and processing technology

  2015cites this paper
• Protective Effect of Panax ginseng Ethanol Extracts Against Bisphenol A (BPA) in Mouse Male Germ Cells

  2015cites this paper
• An enzymatically fortified ginseng extract inhibits proliferation and induces apoptosis of KATO3 human gastric cancer cells via modulation of Bax, mTOR, PKB and IκBα.

  2015influential citation
• Research Article Effect of Rg3-enriched Korean red ginseng (Panax ginseng) on arterial stiffness and blood pressure in healthy individuals: a randomized controlled trial

  2014cites this paper
• Effects and mechanisms of ginseng and ginsenosides on cognition.

  2014cites this paper
• Morphological Characterization, Chemical Components, and Biofunctional Activities of Panax ginseng, Panax quinquefolium, and Panax notoginseng Roots: A Comparative Study

  2014cites this paper
• Evaluation of anti-inflammatory activity of Dracaena cinnabari Balf. f. resin

  2014cites this paper
• Effects of taraxasterol on iNOS and COX-2 expression in LPS-induced RAW 264.7 macrophages.

  2014cites this paper
• Efficacy and safety of Korean red ginseng for cold hypersensitivity in the hands and feet: a randomized, double-blind, placebo-controlled trial.

  2014cites this paper
• Inhibitory Effects of Ginsenoside-Rb2 on Nicotinic Stimulation-Evoked Catecholamine Secretion

  2014cites this paper
• Compounds from Chinese herbal medicines as reversal agents for P-glycoprotein-mediated multidrug resistance in tumours

  2014cites this paper
• Urupocidin A: a new, inducing iNOS expression bicyclic guanidine alkaloid from the marine sponge Monanchora pulchra.

  2014cites this paper
• Aphrodisiac effects of Panax ginseng extract standardized with ginsenoside Rg 3 in male rats

  2014cites this paper
• Effect of Rg3-enriched Korean red ginseng (Panax ginseng) on arterial stiffness and blood pressure in healthy individuals: a randomized controlled trial.

  2014cites this paper
• The Effect of Ginseng (The Genus Panax) on Glycemic and Vascular Health

  2014cites this paper
• Anti-Inflammatory Activity of the Methanol Extract of Moutan Cortex in LPS-Activated Raw 264 . 7 Cells

  2014cites this paper
• Protective effect of taraxasterol against LPS-induced endotoxic shock by modulating inflammatory responses in mice

  2014cites this paper
• Enzymatic transformation of ginsenosides in Korean Red Ginseng (Panax ginseng Meyer) extract prepared by Spezyme and Optidex

  2014cites this paper
• Blood pressure lowering effect of Korea ginseng derived ginseol K-g1.

  2014cites this paper
• Bioconversion of Ginsenosides in the American Ginseng (西洋參 Xī Yáng Shēn) Extraction Residue by Fermentation with Lingzhi (靈芝 Líng Zhī, Ganoderma Lucidum)

  2013cites this paper
• Longterm effect of American ginseng extract (Panax quinquefolius l.) on glycemic control in type 2 diabetic patients.

  2013cites this paper
• Effects of Korean Red Ginseng extract on tissue plasminogen activator and plasminogen activator inhibitor-1 expression in cultured rat primary astrocytes

  2013cites this paper
• Optimization of the selective preparation of 20(R)-ginsenoside Rg3 catalyzed by d, l-tartaric acid using response surface methodology.

  2013cites this paper
• [Nondestructive recognization of mountain cultivated ginseng and garden cultivated ginseng by FTIR microspectroscopy].

  2013cites this paper
• Effect of Korean red ginseng on cold hypersensitivity in the hands and feet: study protocol for a randomized controlled trial

  2013cites this paper
• The Amelioration of N-Acetyl-p-Benzoquinone Imine Toxicity by Ginsenoside Rg3: The Role of Nrf2-Mediated Detoxification and Mrp1/Mrp3 Transports

  2013cites this paper
• Bioconversion of Ginsenosides in the American Ginseng (西洋參 Xī Yáng Shēn) Extraction Residue by Fermentation with Lingzhi (靈芝 Líng Zhī, Ganoderma Lucidum)

  2013cites this paper
• Nrf2 in Host Defense: Over the Rainbow

  2013cites this paper
• Anti-inflammatory activity of ethyl acetate fraction of the seeds of Brucea Javanica.

  2013cites this paper
• Isolation and characterization of novel ginsenoside-hydrolyzing glycosidase from Microbacterium esteraromaticum that transforms ginsenoside Rb2 to rare ginsenoside 20(S)-Rg3

  2013cites this paper
• Optimization for Preparation of Lemon-catalyzed Ginsenoside Rg3 by Response Surface Method

  2013cites this paper
• Ginseng and Micronutrients for Vitality and Cognition

  2013cites this paper
• Transformation Techniques for the Large Scale Production of Ginsenoside Rg3

  2013cites this paper
• Bioactive Food as Dietary Interventions for the Aging Population

  2013cites this paper
• Effects of Korean ginseng berry extract on sexual function in men with erectile dysfunction: a multicenter, placebo-controlled, double-blind clinical study

  2013cites this paper
• Conversion of Ginsenoside Rb1 and Taxonomical Characterization of Stenotrophomonas sp. 4KR4 from Ginseng Rhizosphere Soil

  2013cites this paper
• Narirutin fraction from citrus peels attenuates LPS-stimulated inflammatory response through inhibition of NF-κB and MAPKs activation.

  2012cites this paper
• Effects of taraxasterol on inflammatory responses in lipopolysaccharide-induced RAW 264.7 macrophages.

  2012cites this paper
• American ginseng inhibits vascular smooth muscle cell proliferation via suppressing Jak/Stat pathway.

  2012cites this paper
• Simultaneous analysis method for polar and non-polar ginsenosides in red ginseng by reversed-phase HPLC-PAD.

  2012cites this paper
• Regulation of cellar cytokine production and NF-κB pathway by ginseng and ginsenosides

  2012cites this paper
• Panax notoginseng and its components decreased hypertension via stimulation of endothelial-dependent vessel dilatation.

  2012cites this paper
• Enzymatic biotransformation of ginsenoside Rb1 to 20(S)-Rg3 by recombinant β-glucosidase from Microbacterium esteraromaticum

  2012cites this paper
• Anti-Inflammatory Activity Is a Possible Mechanism by Which the Polyherbal Formulation Comprised of Nigella sativa (Seeds), Hemidesmus indicus (Root), and Smilax glabra (Rhizome) Mediates Its Antihepatocarcinogenic Effects

  2012cites this paper
• Stereospecific antioxidant effects of ginsenoside Rg3 on oxidative stress induced by cyclophosphamide in mice.

  2012cites this paper
• The therapeutic effects of the combined use of American ginseng (Panax quinquefolius L.) extract and Korean red ginseng (Panax Ginseng C.A. Meyer) extract in the management of type 2 diabetes mellitus and cardiovascular risk factors

  2012cites this paper
• Ginsenoside Rg3 inhibits colorectal tumor growth through the down-regulation of Wnt/ß-catenin signaling.

  2011cites this paper
• Therapeutic Potential of Ginseng in the Management of Cardiovascular Disorders

  2011cites this paper
• Inhibitory Effects of Total Ginseng Saponin on Catecholamine Secretion from the Perfused Adrenal Medulla of SHRs

  2011cites this paper
• Effects of florfenicol on LPS‐induced nitric oxide and prostaglandin E2 production in RAW 264.7 macrophages

  2011cites this paper
• Current Clinical Evidence for Korean Red Ginseng in Management of Diabetes and Vascular Disease: A Toronto's Ginseng Clinical Testing Program

  2010cites this paper
• 신규 혈관누출 차단제

  2010cites this paper
• Effects of Ginseng Radix on the Rat Hypothyroidism Induced by PTU (6-n-propyl-2-thiouracil)

  2010cites this paper
• Vascular smooth muscle dysfunction and remodeling induced by ginsenoside Rg3, a bioactive component of ginseng.

  2010cites this paper
• Ginsenoside Rg3 inhibits tumor necrosis factor-alpha-induced expression of cell adhesion molecules in human endothelial cells.

  2010cites this paper
• Identification of Anticoagulant Components in Korean Red Ginseng

  2010cites this paper
• Suppression of the inflammatory response by triterpenes isolated from the mushroom Ganoderma lucidum.

  2009cites this paper
• Effect of ginsam, a vinegar extract from Panax ginseng, on body weight and glucose homeostasis in an obese insulin-resistant rat model.

  2009cites this paper
• 20(S)‐ginsenoside Rg3, a neuroprotective agent, inhibits mitochondrial permeability transition pores in rat brain

  2009cites this paper
• Inhibitory effects of ivermectin on nitric oxide and prostaglandin E2 production in LPS-stimulated RAW 264.7 macrophages.

  2009cites this paper