Cell Autonomous and Nonautonomous Mechanisms Drive Hematopoietic Stem/progenitor Cell Loss in the Absence of DNA Repair

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Stem Cells

• Publication date

  2013-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/stem.1261PMID 23097336PMCID PMC3582850
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model

  2012cited by this paper
• A mouse model of accelerated liver aging caused by a defect in DNA repair

  2012cited by this paper
• Ewing sarcoma gene Ews regulates hematopoietic stem cell senescence.

  2011cited by this paper
• Genome-wide Analysis of Simultaneous GATA1/2, RUNX1, FLI1, and SCL Binding in Megakaryocytes Identifies Hematopoietic Regulators

  2011cited by this paper
• Maintenance of genomic integrity in hematopoietic stem cells

  2011cited by this paper
• Physiological consequences of defects in ERCC1-XPF DNA repair endonuclease.

  2011cited by this paper
• SerpinB1 protects the mature neutrophil reserve in the bone marrow

  2011cited by this paper
• Accelerated hematopoietic stem cell aging in a mouse model of dyskeratosis congenita responds to antioxidant treatment

  2011cited by this paper
• Linking functional decline of telomeres, mitochondria and stem cells during ageing

  2010cited by this paper
• Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity.

  2010cited by this paper
• Stem cells and the aging hematopoietic system.

  2010cited by this paper
• Hematopoietic Stem Cell Defects in Mice with Deficiency of Fancd2 or Usp1

  2010cited by this paper
• Accelerated aging of intervertebral discs in a mouse model of progeria

  2010cited by this paper
• Altered Hematopoiesis in Mice Lacking DNA Polymerase μ Is Due to Inefficient Double-Strand Break Repair

  2009cited by this paper
• XPF-ERCC1 Participates in the Fanconi Anemia Pathway of Cross-Link Repair

  2009cited by this paper
• DNA repair is crucial for maintaining hematopoietic stem cell function.

  2008cited by this paper
• Aging and stem cell renewal

  2008cited by this paper
• ERCC1-XPF Endonuclease Facilitates DNA Double-Strand Break Repair

  2008cited by this paper
• Stems cells and the pathways to aging and cancer.

  2008cited by this paper
• Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment

  2007cited by this paper
• Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment.

  2007cited by this paper
• DNA repair is limiting for haematopoietic stem cells during ageing

  2007cited by this paper
• Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

  2007cited by this paper
• FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress.

  2007cited by this paper
• Hematopoietic stem cell aging: mechanism and consequence.

  2007cited by this paper
• FoxO transcription factors and stem cell homeostasis: insights from the hematopoietic system.

  2007cited by this paper
• How stem cells age and why this makes us grow old

  2007cited by this paper
• Osteoclasts eat stem cells out of house and home

  2006cited by this paper
• Effects of Aging on the Common Lymphoid Progenitor to Pro-B Cell Transition1

  2006cited by this paper
• Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

  2006cited by this paper
• Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells

  2006cited by this paper
• Cell intrinsic alterations underlie hematopoietic stem cell aging.

  2005cited by this paper
• Reduced hematopoietic reserves in DNA interstrand crosslink repair‐deficient Ercc1−/− mice

  2005cited by this paper
• Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

  2004cited by this paper
• Repair and genetic consequences of endogenous DNA base damage in mammalian cells.

  2004cited by this paper
• The Structure-Specific Endonuclease Ercc1-Xpf Is Required To Resolve DNA Interstrand Cross-Link-Induced Double-Strand Breaks

  2004cited by this paper
• Deletion of the Nucleotide Excision Repair Gene Ercc1 Reduces Immunoglobulin Class Switching and Alters Mutations Near Switch Recombination Junctions

  2004cited by this paper
• p16 and ARF: activation of teenage proteins in old age.

  2004cited by this paper
• Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

  2003cited by this paper
• Identification of the haematopoietic stem cell niche and control of the niche size

  2003cited by this paper
• Osteoblastic cells regulate the haematopoietic stem cell niche

  2003cited by this paper
• ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes.

  2003cited by this paper
• Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

  2003cited by this paper
• Age-related changes of human bone marrow: a histometric estimation of proliferative cells, apoptotic cells, T cells, B cells and macrophages.

  2000cited by this paper
• A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

  2000cited by this paper
• Dynamic changes in mouse hematopoietic stem cell numbers during aging.

  1999cited by this paper
• Dynamic Changes in Mouse Hematopoietic Stem Cell Numbers During Aging

  1999cited by this paper
• Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4.

  1999cited by this paper
• Identification of clonogenic common lymphoid progenitors in mouse bone marrow.

  1997cited by this paper
• Long-Term Lymphohematopoietic Reconstitution by a Single CD34-Low/Negative Hematopoietic Stem Cell

  1996cited by this paper
• The aging of hematopoietic stem cells

  1996cited by this paper
• Comparison of haemopoiesis in young and old mice.

  1986cited by this paper

• Loss of SYNCRIP unleashes APOBEC-driven mutagenesis, tumor heterogeneity, and AR-targeted therapy resistance in prostate cancer

  2023cites this paper
• Reduction of senescent fibro‐adipogenic progenitors in progeria‐aged muscle by senolytics rescues the function of muscle stem cells

  2022cites this paper
• ATR activity controls stem cell quiescence via the cyclin F–SCF complex

  2022cites this paper
• Different responses to DNA damage determine ageing differences between organs

  2022cites this paper
• An aged immune system drives senescence and ageing of solid organs

  2021cites this paper
• Nervous System-Systemic Crosstalk in SARS-CoV-2/COVID-19: A Unique Dyshomeostasis Syndrome

  2021influential citation
• SOX2 and p53 Expression Control Converges in PI3K/AKT Signaling with Versatile Implications for Stemness and Cancer

  2020cites this paper
• XPF-ERCC1 protects liver, kidney and blood homeostasis outside the canonical excision repair pathways

  2020cites this paper
• Murine models of accelerated aging and musculoskeletal disease.

  2019cites this paper
• Rapamycin Rescues Age-Related Changes in Muscle-Derived Stem/Progenitor Cells from Progeroid Mice

  2019cites this paper
• DNA damage in aging, the stem cell perspective

  2019cites this paper
• Nuclear Genomic Instability and Aging.

  2018cites this paper
• MicroRNAs Reprogram Tumor Immune Response.

  2018cites this paper
• Mouse Models to Disentangle the Hallmarks of Human Aging

  2018cites this paper
• DNA-damage response in hematopoietic stem cells: an evolutionary trade-off between blood regeneration and leukemia suppression.

  2017cites this paper
• Supplementation with Lactobacillus plantarum WCFS1 Prevents Decline of Mucus Barrier in Colon of Accelerated Aging Ercc1−/Δ7 Mice

  2016cites this paper
• mTOR signaling plays a critical role in the defects observed in muscle‐derived stem/progenitor cells isolated from a murine model of accelerated aging

  2016cites this paper
• Genome Integrity in Aging: Human Syndromes, Mouse Models, and Therapeutic Options.

  2016cites this paper
• Concise Review: Hematopoietic Stem Cell Aging and the Prospects for Rejuvenation

  2015cites this paper
• Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis

  2015cites this paper
• Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle.

  2014influential citation
• Purinergic P2Y₁₄ receptor modulates stress-induced hematopoietic stem/progenitor cell senescence.

  2014cites this paper
• SCTM20140132 1..9

  2014cites this paper
• Stem Cells: The Pursuit of Genomic Stability

  2014influential citation
• Differences between human and rodent DNA-damage response in hematopoietic stem cells: at the crossroads of self-renewal, aging and leukemogenesis

  2013cites this paper
• The aging immune system and nutritional interventions

  2011cites this paper