Reduced hematopoietic reserves in DNA interstrand crosslink repair‐deficient Ercc1−/− mice

No abstract is available for this paper.

• Publication year

  2005

• Venue

  EMBO Journal

• Publication date

  2005-02-23

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.emboj.7600542PMID 15692571PMCID PMC549615
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1979cited by this paper
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  1962influential reference
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