The Fanconi anaemia pathway orchestrates incisions at sites of crosslinked DNA

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of Pathology

• Publication date

  2012-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/path.3002PMID 21956823
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype

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• Structure of the FANCI-FANCD2 Complex: Insights into the Fanconi Anemia DNA Repair Pathway

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• Mammalian BTBD12 (SLX4) Protects against Genomic Instability during Mammalian Spermatogenesis

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• Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice

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• Mechanism of RAD51-Dependent DNA Interstrand Cross-Link Repair

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• Myelodysplasia and leukemia of Fanconi anemia are associated with a specific pattern of genomic abnormalities that includes cryptic RUNX1/AML1 lesions.

  2011cited by this paper
• Mutations of the SLX4 gene in Fanconi anemia

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• Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway

  2011cited by this paper
• [13C2]-Acetaldehyde promotes unequivocal formation of 1,N2-propano-2'-deoxyguanosine in human cells.

  2011cited by this paper
• KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents

  2010cited by this paper
• Ku70 Corrupts DNA Repair in the Absence of the Fanconi Anemia Pathway

  2010cited by this paper
• A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.

  2010cited by this paper
• Determination of cisplatin 1,2-intrastrand guanine-guanine DNA adducts in human leukocytes by high-performance liquid chromatography coupled to inductively coupled plasma mass spectrometry.

  2010cited by this paper
• Mutation of the RAD51C gene in a Fanconi anemia–like disorder

  2010cited by this paper
• Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2.

  2010cited by this paper
• Knockdown of Fanconi anemia genes in human embryonic stem cells reveals early developmental defects in the hematopoietic lineage.

  2010cited by this paper
• Fertility recovery and pregnancy after allogeneic hematopoietic stem cell transplantation in Fanconi anemia patients

  2010cited by this paper
• Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents.

  2010cited by this paper
• FAN1 Acts with FANCI-FANCD2 to Promote DNA Interstrand Cross-Link Repair

  2010cited by this paper
• Checkpoint signaling from a single DNA interstrand crosslink.

  2009cited by this paper
• The Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair

  2009cited by this paper
• Xpf and Not the Fanconi Anaemia Proteins or Rev3 Accounts for the Extreme Resistance to Cisplatin in Dictyostelium discoideum

  2009cited by this paper
• Drosophila MUS312 and the vertebrate ortholog BTBD12 interact with DNA structure-specific endonucleases in DNA repair and recombination.

  2009cited by this paper
• Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair.

  2009cited by this paper
• Mouse models of Fanconi anemia.

  2009cited by this paper
• The Walker B motif in avian FANCM is required to limit sister chromatid exchanges but is dispensable for DNA crosslink repair

  2009cited by this paper
• Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insights.

  2009cited by this paper
• Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases.

  2009cited by this paper
• XPF-ERCC1 Participates in the Fanconi Anemia Pathway of Cross-Link Repair

  2009cited by this paper
• The genetic and molecular basis of Fanconi anemia.

  2009cited by this paper
• Fanconi anemia and its diagnosis.

  2009cited by this paper
• Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype.

  2009cited by this paper
• Monoubiquitylation in the Fanconi anemia DNA damage response pathway.

  2009cited by this paper
• Fancm-deficient mice reveal unique features of Fanconi anemia complementation group M.

  2009cited by this paper
• Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.

  2009cited by this paper
• The XPA-binding domain of ERCC1 Is Required for Nucleotide Excision Repair but Not Other DNA Repair Pathways*

  2009cited by this paper
• Structural and functional relationships of the XPF/MUS81 family of proteins.

  2008cited by this paper
• Mechanism of replication-coupled DNA interstrand crosslink repair.

  2008cited by this paper
• FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway

  2008cited by this paper
• Cancer risks in Fanconi anemia: findings from the German Fanconi Anemia Registry

  2008cited by this paper
• Processing of a Psoralen DNA Interstrand Cross-link by XPF-ERCC1 Complex in Vitro*

  2008influential reference
• Clinical and molecular characteristics of squamous cell carcinomas from Fanconi anemia patients.

  2008cited by this paper
• FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3

  2008cited by this paper
• Structural basis for the recruitment of ERCC1‐XPF to nucleotide excision repair complexes by XPA

  2007cited by this paper
• Human Mus81 and FANCB independently contribute to repair of DNA damage during replication

  2007cited by this paper
• Identification of the Fanconi Anemia Complementation Group I Gene, FANCI

  2007cited by this paper
• The ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells

  2007cited by this paper
• Fanconi’s anemia in monozygotic twins

  2007cited by this paper
• Fanconi anemia and DNA replication repair.

  2007cited by this paper
• FANCI is a second monoubiquitinated member of the Fanconi anemia pathway

  2007cited by this paper
• FAAP100 is essential for activation of the Fanconi anemia‐associated DNA damage response pathway

  2007cited by this paper
• Genomic Screening in Vivo Reveals the Role Played by Vacuolar H+ ATPase and Cytosolic Acidification in Sensitivity to DNA-Damaging Agents Such as Cisplatin

  2007cited by this paper
• Fanconi anemia is associated with a defect in the BRCA2 partner PALB2

  2007cited by this paper
• Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair.

  2007cited by this paper
• Cells deficient in the FANC/BRCA pathway are hypersensitive to plasma levels of formaldehyde.

  2007cited by this paper
• Natural gene therapy in monozygotic twins with Fanconi anemia.

  2006cited by this paper
• Fanconi anaemia complementation group B presenting as X linked VACTERL with hydrocephalus syndrome

  2006cited by this paper
• A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis

  2006cited by this paper
• Guido Fanconi (1892–1979): a jack of all trades

  2006cited by this paper
• A Role for PCNA Ubiquitination in Immunoglobulin Hypermutation

  2006cited by this paper
• The WD40 Repeats of FANCL Are Required for Fanconi Anemia Core Complex Assembly*

  2006cited by this paper
• The structure‐specific endonuclease Mus81–Eme1 promotes conversion of interstrand DNA crosslinks into double‐strands breaks

  2006cited by this paper
• Genotoxicity of acetaldehyde- and crotonaldehyde-induced 1,N2-propanodeoxyguanosine DNA adducts in human cells.

  2006cited by this paper
• Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.

  2006cited by this paper
• Disruption of Murine Mus81 Increases Genomic Instability and DNA Damage Sensitivity but Does Not Promote Tumorigenesis

  2005cited by this paper
• Aldehyde Sources, Metabolism, Molecular Toxicity Mechanisms, and Possible Effects on Human Health

  2005cited by this paper
• Fanconi anemia: adult head and neck cancer and hematopoietic mosaicism.

  2005cited by this paper
• The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair

  2005cited by this paper
• Detection of somatic mosaicism and classification of Fanconi anemia patients by analysis of the FA/BRCA pathway.

  2005cited by this paper
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  2005cited by this paper
• In utero origins of childhood leukaemia.

  2005cited by this paper
• Myelodysplastic syndrome.

  2005cited by this paper
• Fanconi Anemia Protein FANCD2 Promotes Immunoglobulin Gene Conversion and DNA Repair through a Mechanism Related to Homologous Recombination

  2005cited by this paper
• Reduced hematopoietic reserves in DNA interstrand crosslink repair‐deficient Ercc1−/− mice

  2005cited by this paper
• Functional relationships of FANCC to homologous recombination, translesion synthesis, and BLM

  2005cited by this paper
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  2005cited by this paper
• The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway

  2005cited by this paper
• Individualized risks of first adverse events in patients with Fanconi anemia.

  2004cited by this paper
• The Fanconi anaemia gene FANCC promotes homologous recombination and error-prone DNA repair.

  2004cited by this paper
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  2004cited by this paper
• Complex chromosomal abnormalities in utero, 5 years before leukaemia *

  2004cited by this paper
• Involvement of Mammalian Mus81 in Genome Integrity and Tumor Suppression

  2004cited by this paper
• Growth Retardation, Early Death, and DNA Repair Defects in Mice Deficient for the Nucleotide Excision Repair Enzyme XPF

  2004cited by this paper
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  2004cited by this paper
• Functional Interaction of Monoubiquitinated FANCD2 and BRCA2/FANCD1 in Chromatin

  2004cited by this paper
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  2003cited by this paper
• A novel ubiquitin ligase is deficient in Fanconi anemia

  2003cited by this paper
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  2003cited by this paper
• Knockdown of Zebrafish Fancd 2 Causes Developmental Abnormalities via p 53-Dependent Apoptosis

  2003cited by this paper
• Fanconi’s Anemia and Clinical Radiosensitivity

  2003cited by this paper
• Oncogenes and Tumor Suppressors (795 articles) Review Articles (434 articles)

  2003cited by this paper
• Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice.

  2003cited by this paper
• Cryptic rearrangement involving MLL and AF10 occurring in utero

  2003cited by this paper
• Cancer in Fanconi anemia.

  2003cited by this paper
• Leukemia in twins: lessons in natural history.

  2003cited by this paper
• A Multiprotein Nuclear Complex Connects Fanconi Anemia and Bloom Syndrome

  2003cited by this paper
• Prenatal origin of hyperdiploid acute lymphoblastic leukemia in identical twins

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• Origins of chromosome translocations in childhood leukaemia

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• trans-Fatty acids promote p53-dependent apoptosis triggered by cisplatin-induced DNA interstrand crosslinks via the Nox-RIP1-ASK1-MAPK pathway

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• Fanconi Anemia Complementation Group E, a DNA Repair-Related Gene, Is a Potential Marker of Poor Prognosis in Hepatocellular Carcinoma

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• MutSβ Stimulates Holliday Junction Resolution by the SMX Complex.

  2020cites this paper
• FANCD2–FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair

  2020cites this paper
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  2019cites this paper
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  2019cites this paper
• Functional Comparison of XPF Missense Mutations Associated to Multiple DNA Repair Disorders

  2019cites this paper
• Expression and prognostic significance of Fanconi anemia group D2 protein and breast cancer type 1 susceptibility protein in familial and sporadic breast cancer

  2019cites this paper
• Mechanistic link between DNA damage sensing, repairing and signaling factors and immune signaling.

  2019cites this paper
• FANCD2-FANCI is a clamp stabilized on DNA by monoubiquitination during DNA repair

  2019cites this paper
• Biochemical Characterization of FAN1 Nuclease

  2018cites this paper
• Genotoxicity of tetrahydrofolic acid to hematopoietic stem and progenitor cells

  2018cites this paper
• The role of SLX4 and its associated nucleases in DNA interstrand crosslink repair

  2018cites this paper
• Mutagenesis, Genetic Disorders and Diseases

  2018cites this paper
• Cellular Repair of DNA–DNA Cross-Links Induced by 1,2,3,4-Diepoxybutane

  2017cites this paper
• Regulation of various DNA repair pathways by E3 ubiquitin ligases

  2017cites this paper
• Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia

  2017cites this paper
• Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function

  2017cites this paper
• Systematic analysis of DNA crosslink repair pathways during development and aging in Caenorhabditis elegans

  2017cites this paper
• Strategic role of the ubiquitin-dependent segregase p97 (VCP or Cdc48) in DNA replication

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• FANCJ suppresses microsatellite instability and lymphomagenesis independent of the Fanconi anemia pathway

  2015cites this paper
• Skin and Mucosal Human Papillomavirus Seroprevalence in Persons with Fanconi Anemia

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• MicroRNAs in Normal and Malignant Myelopoiesis

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• FANCD2 influences replication fork processes and genome stability in response to clustered DSBs

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• The Fanconi Anemia C Protein Binds to and Regulates Stathmin-1 Phosphorylation

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• Ubiquitin-SUMO Circuitry Controls Activated Fanconi Anemia ID Complex Dosage in Response to DNA Damage

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• AluY-mediated germline deletion, duplication and somatic stem cell reversion in UBE2T defines a new subtype of Fanconi anemia

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• The Fanconi Anemia DNA Repair Pathway Is Regulated by an Interaction between Ubiquitin and the E2-like Fold Domain of FANCL*

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• Regulation and Targeting of the FANCD2 Activation in DNA Repair

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• FANCD2 re-expression is associated with glioma grade and chemical inhibition of the Fanconi Anaemia pathway sensitises gliomas to chemotherapeutic agents

  2014cites this paper
• The Genetic and Biochemical Basis of FANCD2 Monoubiquitination

  2014cites this paper
• DNA interstrand cross-link repair requires replication fork convergence

  2014cites this paper
• Defective FANCI Binding by a Fanconi Anemia-Related FANCD2 Mutant

  2014cites this paper
• Inherited bone marrow failure syndromes in adolescents and young adults

  2014cites this paper
• A concomitant loss of dormant origins and FANCC exacerbates genome instability by impairing DNA replication fork progression

  2014cites this paper
• A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses.

  2014cites this paper
• Quantification and repair of psoralen-induced interstrand crosslinks in human cells.

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• Expression and purification of human FANCI and FANCD2 using Escherichia coli cells.

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