Genotoxicity of tetrahydrofolic acid to hematopoietic stem and progenitor cells

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Cell Death and Differentiation

• Publication date

  2018-03-06

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1038/s41418-018-0089-4PMID 29511342PMCID PMC6219486
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism

  2017cited by this paper
• One‐carbon metabolism and epigenetics: understanding the specificity

  2016cited by this paper
• The Fanconi anaemia pathway: new players and new functions

  2016cited by this paper
• TGF-β Inhibition Rescues Hematopoietic Stem Cell Defects and Bone Marrow Failure in Fanconi Anemia.

  2016cited by this paper
• Functions, Regulation, and Therapeutic Implications of the ATR Checkpoint Pathway.

  2016cited by this paper
• Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen

  2015cited by this paper
• Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells

  2015cited by this paper
• Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice

  2015cited by this paper
• Highly proliferative primitive fetal liver hematopoietic stem cells are fueled by oxidative metabolic pathways.

  2015cited by this paper
• Regulation of the Rev1–pol ζ complex during bypass of a DNA interstrand cross‐link

  2015cited by this paper
• What is the DNA repair defect underlying Fanconi anemia?

  2015cited by this paper
• DNA interstrand cross-link repair requires replication fork convergence

  2014cited by this paper
• Mechanism and regulation of incisions during DNA interstrand cross-link repair.

  2014cited by this paper
• XPF-ERCC1 acts in Unhooking DNA interstrand crosslinks in cooperation with FANCD2 and FANCP/SLX4.

  2014cited by this paper
• Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle.

  2014cited by this paper
• Folate intake and the risk of prostate cancer: a systematic review and meta-analysis

  2014cited by this paper
• A high-throughput in vivo micronucleus assay for genome instability screening in mice

  2014cited by this paper
• Fanconi anemia and the development of leukemia.

  2014influential reference
• Why does the bone marrow fail in Fanconi anemia?

  2014cited by this paper
• Repair of a DNA-protein crosslink by replication-coupled proteolysis.

  2014cited by this paper
• Causes of genome instability.

  2013cited by this paper
• Alcohol, DNA Methylation, and Cancer

  2013cited by this paper
• Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function

  2012cited by this paper
• Current clinical management of Fanconi anemia

  2012cited by this paper
• The Fanconi anaemia pathway orchestrates incisions at sites of crosslinked DNA

  2012cited by this paper
• A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2.

  2012cited by this paper
• Maintenance of genomic integrity in hematopoietic stem cells

  2011influential reference
• Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11.

  2011cited by this paper
• Hallmarks of cancer: the next generation.

  2011cited by this paper
• Disease-specific hematopoietic cell transplantation: nonmyeloablative conditioning regimen for dyskeratosis congenita

  2011cited by this paper
• Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway

  2011cited by this paper
• Folic acid and prevention of colorectal adenomas: A combined analysis of randomized clinical trials

  2011cited by this paper
• Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice

  2011cited by this paper
• Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia.

  2010cited by this paper
• Lymphocyte Development Requires S-nitrosoglutathione Reductase

  2010cited by this paper
• Ku70 Corrupts DNA Repair in the Absence of the Fanconi Anemia Pathway

  2010cited by this paper
• Mouse models of Fanconi anemia.

  2009influential reference
• The Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair

  2009cited by this paper
• Fanconi anemia and its diagnosis.

  2009cited by this paper
• Mouse models for ATR deficiency.

  2009influential reference
• Folate-mediated one-carbon metabolism.

  2008cited by this paper
• Folic acid for the prevention of colorectal adenomas: a randomized clinical trial.

  2007cited by this paper
• Folic acid and prevention of colorectal adenomas.

  2007cited by this paper
• Folate-mediated one-carbon metabolism and neural tube defects: balancing genome synthesis and gene expression.

  2007cited by this paper
• Human Mus81 and FANCB independently contribute to repair of DNA damage during replication

  2007cited by this paper
• Fanconi's Anemia, transplantation, and cancer

  2005cited by this paper
• Diagnosis of Fanconi Anemia by Diepoxybutane Analysis

  2003cited by this paper
• A splicing mutation affecting expression of ataxia–telangiectasia and Rad3–related protein (ATR) results in Seckel syndrome

  2003influential reference
• Impact of folate deficiency on DNA stability.

  2002cited by this paper
• Defective hematopoiesis and hepatic steatosis in mice with combined deficiencies of the genes encoding Fancc and Cu/Zn superoxide dismutase.

  2001cited by this paper
• Folic acid deficiency and cancer: mechanisms of DNA instability.

  1999cited by this paper
• [Folate deficiency, cancer and congenital abnormalities. Is there a connection?].

  1996cited by this paper
• The mechanism of the condensation of formaldehyde with tetrahydrofolic acid.

  1966cited by this paper

• Mechanisms of genome instability from cellular folate stress.

  2025cites this paper
• Multi-modal investigation of doxorubicin-induced osteoporosis: Network toxicology, machine learning, and imaging techniques

  2025cites this paper
• Analysis of blood biochemistry and non-targeted metabolomics of endometritis in dairy cows.

  2024cites this paper
• Relationship of dietary natural folate and synthetic folic acid co-exposure patterns with biological aging: findings from NHANES 2003-2018.

  2024cites this paper
• Dual effects of endogenous formaldehyde on the organism and drugs for its removal

  2023cites this paper
• Comparative study on the gastrointestinal- and immune- regulation functions of Hedysari Radix Paeparata Cum Melle and Astragali Radix Praeparata cum Melle in rats with spleen-qi deficiency, based on fuzzy matter-element analysis

  2022cites this paper
• FANCD2 maintains replication fork stability during misincorporation of the DNA demethylation products 5-hydroxymethyl-2’-deoxycytidine and 5-hydroxymethyl-2’-deoxyuridine

  2022cites this paper
• Fanconi anemia proteins participate in a break-induced-replication-like pathway to counter replication stress

  2021cites this paper
• Animal models of Fanconi anemia: A developmental and therapeutic perspective on a multifaceted disease.

  2021cites this paper
• The toxic side of one-carbon metabolism and epigenetics

  2020influential citation
• Formate metabolism in health and disease

  2019cites this paper