Simvastatin: two decades in a circle.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Cardiovascular Therapeutics

• Publication date

  2008-06-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1111/j.1527-3466.2008.00047.xPMID 18485137
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effects of simvastatin on NF-κB-DNA binding activity and monocyte chemoattractant protein-1 expression in a rabbit model of atherosclerosis

  2008cited by this paper
• Randomized Clinical Stroke Trials in 2007

  2008cited by this paper
• Nicotinic acid induces secretion of prostaglandin D2 in human macrophages: an in vitro model of the niacin flush.

  2007cited by this paper
• Simvastatin: present and future perspectives

  2007cited by this paper
• An assessment of statin safety by hepatologists.

  2006cited by this paper
• Evaluation of the pharmacokinetic interaction between fluvastatin XL and cyclosporine in renal transplant recipients.

  2006cited by this paper
• Stroke Prevention and Statin Treatment

  2006cited by this paper
• Statin/fibrate combination in patients with metabolic syndrome or diabetes: evaluating the risks of pharmacokinetic drug interactions

  2006cited by this paper
• Effects of simvastatin on NF-kappaB-DNA binding activity and monocyte chemoattractant protein-1 expression in a rabbit model of atherosclerosis.

  2006cited by this paper
• Striated muscle safety of ezetimibe/simvastatin (Vytorin).

  2006cited by this paper
• Short- and long-term influence of diet and simvastatin on brachial artery endothelial function.

  2006cited by this paper
• Acute Antiinflammatory Properties of Statins Involve Peroxisome Proliferator–Activated Receptor-α via Inhibition of the Protein Kinase C Signaling Pathway

  2006cited by this paper
• Simvastatin enhances bone morphogenetic protein receptor type II expression.

  2006cited by this paper
• An assessment of statin safety by muscle experts.

  2006cited by this paper
• The effect of simvastatin on triglyceride-rich lipoproteins in patients with type 2 diabetic dyslipidemia: a SILHOUETTE Trial Sub-study *

  2006cited by this paper
• Nitric Oxide Mechanisms in the Pathogenesis of Global Risk

  2006cited by this paper
• Effectiveness and efficiency of different guidelines on statin treatment for preventing deaths from coronary heart disease: modelling study

  2006cited by this paper
• Simvastatin Reduces Serum Level of Vascular Endothelial Growth Factor in Hypercholesterolemic Patients

  2006cited by this paper
• Computational diagnosis of protein conformational diseases: Short molecular dynamics simulations reveal a fast unfolding of r‐LDL mutants that cause familial hypercholesterolemia

  2006cited by this paper
• Simvastatin treatment improves endothelial function and increases fibrinolysis in patients with hypercholestrolemia.

  2006cited by this paper
• The effect of high-dose simvastatin on free fatty acid metabolism in patients with type 2 diabetes mellitus.

  2006cited by this paper
• Depletion of substrates for protein prenylation increases apoptosis in human periovulatory granulosa cells

  2006cited by this paper
• Re‐assessing the relationship between cholesterol, statins and Alzheimer's disease

  2006cited by this paper
• Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines

  2006cited by this paper
• Thematic review series: The Pathogenesis of Atherosclerosis. An interpretive history of the cholesterol controversy, part V: The discovery of the statins and the end of the controversy 1 Published, JLR Papers in Press, April 3, 2006.

  2006cited by this paper
• Statin safety: an overview and assessment of the data--2005.

  2006cited by this paper
• HMG-CoA reductase inhibitors induce apoptosis in pericytes.

  2006cited by this paper
• Diabetes prevention: is there more to it than lifestyle changes?

  2006cited by this paper
• Simvastatin induces heat shock factor 1 in vascular endothelial cells.

  2006cited by this paper
• Clinical perspectives of statin-induced rhabdomyolysis.

  2006cited by this paper
• Building on the specialist's antihypertensive treatment recommendation: it's just the beginning.

  2006cited by this paper
• Role of RhoA inactivation in reduced cell proliferation of human airway smooth muscle by simvastatin.

  2006influential reference
• Statins and bone metabolism.

  2006cited by this paper
• Effect of statins on platelet PAR-1 thrombin receptor in patients with the metabolic syndrome (from the PAR-1 inhibition by statins [PARIS] study).

  2006cited by this paper
• Low density lipoprotein cholesterol, statins and cardiovascular events: a meta–analysis

  2006cited by this paper
• Statin safety and drug interactions: clinical implications.

  2006cited by this paper
• Statin safety: a systematic review.

  2006cited by this paper
• Efficacy and tolerability of combined treatment with L-carnitine and simvastatin in lowering lipoprotein(a) serum levels in patients with type 2 diabetes mellitus.

  2006cited by this paper
• Acute Antiinflammatory Properties of Statins Involve Peroxisome Proliferator–Activated Receptor-α via Inhibition of the Protein Kinase C Signaling Pathway

  2006cited by this paper
• Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans.

  2006cited by this paper
• Building on the Specialist's Antihypertensive Treatment Recommendation: It's Just the Beginning

  2006cited by this paper
• Treatment with statins in the acute phase of ischemic stroke

  2005cited by this paper
• The ability of statins to protect low density lipoprotein from oxidation in hypercholesterolemic patients.

  2005cited by this paper
• The pleiotropic effects of statins

  2005cited by this paper
• HMG-CoA Reductase Inhibitors Reduce IκB Kinase Activity Induced by Oxidative Stress in Monocytes and Vascular Smooth Muscle Cells

  2005cited by this paper
• Statins and thrombin.

  2005cited by this paper
• Atheroma stabilizing effects of simvastatin due to depression of macrophages or lipid accumulation in the atheromatous plaques of coronary plaque-prone WHHL rabbits.

  2005cited by this paper
• Impact of simvastatin on hemostatic and fibrinolytic regulators in Type 2 diabetes mellitus.

  2005cited by this paper
• Cholesterol, lipids, and statins.

  2005cited by this paper
• Evaluation of Cases of Severe Statin-Related Transaminitis Within a Large Health Maintenance Organization

  2005influential reference
• Evaluation of cases of severe statin-related transaminitis within a large health maintenance organization.

  2005cited by this paper
• Reporting rate of rhabdomyolysis with fenofibrate + statin versus gemfibrozil + any statin.

  2005influential reference
• Resolution of apoptosis in atherosclerotic plaque by dietary modification and statin therapy.

  2005cited by this paper
• Safety of statins: effects on muscle and the liver.

  2005cited by this paper
• Long term efficacy of simvastatin in renal transplant recipients treated with cyclosporine or tacrolimus

  2005cited by this paper
• Early intensive versus a delayed conservative simvastatin strategy in patients with acute coronary syndromes.

  2005cited by this paper
• Regulation of Vascular Tone from Spontaneously Hypertensive Rats by the HMG-CoA Reductase Inhibitor, Simvastatin

  2005cited by this paper
• Mortality and incidence of cancer during 10-year follow-up of the Scandinavian Simvastatin Survival Study (4S).

  2004influential reference
• Simvastatin Induces Heme Oxygenase-1: A Novel Mechanism of Vessel Protection

  2004cited by this paper
• Reduction of cardiovascular events by simvastatin in nondiabetic coronary heart disease patients with and without the metabolic syndrome: subgroup analyses of the Scandinavian Simvastatin Survival Study (4S).

  2004cited by this paper
• Matrix Metalloproteinase-2 and −9 Differentially Regulate Smooth Muscle Cell Migration and Cell-Mediated Collagen Organization

  2004cited by this paper
• Effect of simvastatin on endothelium-dependent vaso-relaxation and endogenous nitric oxide synthase inhibitor.

  2004cited by this paper
• Role of simvastatin as an immunomodulator in type 2 diabetes.

  2004cited by this paper
• Statin-Induced Improvement of Endothelial Progenitor Cell Mobilization, Myocardial Neovascularization, Left Ventricular Function, and Survival After Experimental Myocardial Infarction Requires Endothelial Nitric Oxide Synthase

  2004cited by this paper
• Randomized clinical stroke trials in 2003

  2004cited by this paper
• Rhabdomyolysis associated with hydroxymethylglutaryl-coenzyme A reductase inhibitors.

  2004cited by this paper
• Comparative pharmacokinetic interaction profiles of pravastatin, simvastatin, and atorvastatin when coadministered with cytochrome P450 inhibitors.

  2004cited by this paper
• Statin-Induced Cholesterol Lowering and Plaque Regression After 6 Months of Magnetic Resonance Imaging–Monitored Therapy

  2004cited by this paper
• Simvastatin treatment restores vasoconstriction and the inhibitory effect of LPC on endothelial relaxation via affecting oxidizing metabolism in diabetic rats.

  2004cited by this paper
• Effects of grapefruit juice on pharmacokinetics of atorvastatin and pravastatin in Japanese.

  2004cited by this paper
• A Novel Anti-Inflammatory Role of Simvastatin in a Murine Model of Allergic Asthma1

  2004cited by this paper
• Rhabdomyolysis with HMG‐CoA reductase inhibitors and gemfibrozil combination therapy

  2004cited by this paper
• Design and baseline characteristics of the Incremental Decrease in End Points through Aggressive Lipid Lowering study.

  2004cited by this paper
• Simvastatin: a review

  2004cited by this paper
• Early intensive vs a delayed conservative simvastatin strategy in patients with acute coronary syndromes: phase Z of the A to Z trial.

  2004cited by this paper
• Rhabdomyolysis associated with hydroxymethylglutaryl-coenzyme A reductase inhibitors☆

  2004cited by this paper
• Effects of Atorvastatin and Simvastatin on Low-Density Lipoprotein Subtraction Profile, Low-Density Lipoprotein Oxidizability, and Antibodies to Oxidized Low-Density Lipoprotein in Relation to Carotid Intima Media Thickness in Familial Hypercholesterolemia

  2004cited by this paper
• Endothelium‐dependent and ‐independent vasodilator effects of eugenol in the rat mesenteric vascular bed

  2003cited by this paper
• MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trial.

  2003influential reference
• Long term statin treatment reduces lipoprotein(a) concentrations in heterozygous familial hypercholesterolaemia

  2003cited by this paper
• Regression of carotid and femoral artery intima-media thickness in familial hypercholesterolemia: treatment with simvastatin.

  2003cited by this paper
• Statins Inhibit Secretion of Metalloproteinases-1, -2, -3, and -9 From Vascular Smooth Muscle Cells and Macrophages

  2003cited by this paper
• HMG-CoA Reductase Inhibitors Regulate Inflammatory Transcription Factors in Human Endothelial and Vascular Smooth Muscle Cells

  2003cited by this paper
• Lipid-lowering-independent effects of simvastatin on the kidney in experimental hypercholesterolaemia.

  2003cited by this paper
• HMG CoA reductase inhibitor suppresses the expression of tissue factor and plasminogen activator inhibitor-1 induced by angiotensin II in cultured rat aortic endothelial cells.

  2003cited by this paper
• Hepatotoxicity of hypolipidemic drugs.

  2003cited by this paper
• Heart Protection Study

  2003influential reference
• Correlates of endothelial function and their relationship with inflammation in patients with familial hypercholesterolaemia.

  2003cited by this paper
• Effectiveness of statin-gemfibrozil combination therapy in patients with mixed hyperlipidemia: experience of a community lipid clinic and safety review from the literature.

  2003cited by this paper
• Simvastatin Rescues Rats From Fatal Pulmonary Hypertension by Inducing Apoptosis of Neointimal Smooth Muscle Cells

  2003cited by this paper
• Early statin therapy restores endothelial function in children with familial hypercholesterolemia.

  2002cited by this paper
• Low-Density Lipoprotein Level Reduction by the 3-Hydroxy-3-Methylglutaryl Coenzyme-A Inhibitor Simvastatin Is Accompanied by a Related Reduction of F2-Isoprostane Formation in Hypercholesterolemic Subjects: No Further Effect of Vitamin E

  2002cited by this paper
• Antiinflammatory effect of simvastatin in patients with rheumatoid arthritis.

  2002cited by this paper
• Simvastatin Lowers C-Reactive Protein Within 14 Days: An Effect Independent of Low-Density Lipoprotein Cholesterol Reduction

  2002cited by this paper
• Statin therapy: beyond cholesterol lowering and antiinflammatory effects.

  2002cited by this paper
• Atorvastatin lowers lipoprotein(a) but not apolipoprotein(a) fragment levels in hypercholesterolemic subjects at high cardiovascular risk.

  2002cited by this paper
• A look to the future: new treatment guidelines and a perspective on statins.

  2002cited by this paper
• Comparative Effects of Diet and Statin on NO Bioactivity and Matrix Metalloproteinases in Hypercholesterolemic Patients With Coronary Artery Disease

  2002cited by this paper
• Lipid Lowering by Simvastatin Induces Regression of Human Atherosclerotic Lesions: Two Years’ Follow-Up by High-Resolution Noninvasive Magnetic Resonance Imaging

  2002cited by this paper
• Issues concerning the monitoring of statin therapy in hypercholesterolemic subjects with high plasma lipoprotein (a) levels

  2002cited by this paper

• Statin-treated RBC dynamics in a microfluidic porous-like network.

  2024cites this paper
• Simvastatin and Captopril Combined Transdermal Delivery System for Controlling Blood Pressure and Fat: Design, Characterization, and In Vivo Pharmacokinetic Evaluation

  2024cites this paper
• Statins and oral biofilm: simvastatin as a promising drug to control periodontal dysbiosis.

  2022cites this paper
• Rethinking transdermal drug delivery using PVA-NLC based films

  2021cites this paper
• Interaction of the cholesterol reducing agent simvastatin with zwitterionic DPPC and charged DPPG phospholipid membranes.

  2019cites this paper
• Differential Effects of Simvastatin on Membrane Organization and Dynamics in Varying Phases.

  2019cites this paper
• Simvastatin protects photoreceptors from oxidative stress induced by all‐trans‐retinal, through the up‐regulation of interphotoreceptor retinoid binding protein

  2019cites this paper
• Prosarcopenic Effects of Statins May Limit Their Effectiveness in Patients with Heart Failure.

  2018cites this paper
• Effects of simvastatin on serum adiponectin: a meta-analysis of randomized controlled trials

  2017cites this paper
• Recent advances in lipidomics: Analytical and clinical perspectives.

  2017cites this paper
• Does poly(vinyl alcohol) act as an amphiphilic polymer? An interaction study with simvastatin

  2016cites this paper
• Effect of Simvastatin on Proliferation of Vascular Smooth Muscle Cells During Delayed Cerebral Vasospasm After Subarachnoid Hemorrhage.

  2016cites this paper
• Can lipid nanoparticles improve intestinal absorption?

  2016cites this paper
• Pharmacogenetics and Statin Treatment: Reality or Theory?

  2015cites this paper
• CYP3A5 genotyping for assessing the efficacy of treatment with simvastatin and atorvastatin

  2015cites this paper
• Recent Advances in Dendrimer Research for Cardiovascular Diseases.

  2015cites this paper
• The Effect of Simvastatin on Infection‐Induced Inflammatory Response of Human Fetal Membranes

  2015cites this paper
• Comparative efficacy of pitavastatin and simvastatin in patients with hypercholesterolemia: a meta-analysis of randomized controlled clinical trials

  2015cites this paper
• Protective effects of pulp and kernel oils from Canarium odontophyllum fruit in normal and hypercholesterolemic rabbits

  2015cites this paper
• Statins Treatment under the Umbrella of Pharmacogenetics

  2015cites this paper
• Passive and active strategies for transdermal delivery using co-encapsulating nanostructured lipid carriers: in vitro vs. in vivo studies.

  2014cites this paper
• Impact of CYP3A5 Gene Polymorphism on Efficacy of Simvastatin

  2014cites this paper
• Monacolin K affects lipid metabolism through SIRT1/AMPK pathway in HepG2 cells

  2013cites this paper
• A rapid reversed-phase HPLC method for the simultaneous analysis of olanzapine and simvastatin in dual nanostructured lipid carriers

  2013cites this paper
• High fat diets and pathology in the guinea pig. Atherosclerosis or liver damage?

  2013cites this paper
• Simvastatin reduces wasting and improves cardiac function as well as outcome in experimental cancer cachexia.

  2013cites this paper
• Monacolin K affects lipid metabolism through SIRT1/AMPK pathway in HepG2 cells

  2013cites this paper
• The effects of membrane cholesterol and simvastatin on red blood cell deformability and ATP release.

  2012cites this paper
• A clinically significant interaction between warfarin and simvastatin is unique to carriers of the

  2012cites this paper
• A clinically significant interaction between warfarin and simvastatin is unique to carriers of the CYP2C9*3 allele.

  2012cites this paper
• Lipid-lowering effects of ezetimibe and simvastatin in combination

  2011cites this paper
• Effekt av statiner på de lysosomale cysteinproteasene legumain, cathepsin B og L i monocytter/makrofager

  2011cites this paper
• Options for the treatment of hyperlipidemia in Type 2 diabetes mellitus and hypothyroidism: lowering the cardiovascular risk.

  2011cites this paper
• The effects of simvastatin on angiogenesis: studied by an original model of atherosclerosis and acute myocardial infarction in rabbit

  2011cites this paper
• Formulation and evaluation of colon targeted tablets containing simvastatin solid dispersion

  2011cites this paper
• Lipid-lowering effects of ezetimibe & simvastatin in combination Drug Profile Pharmacokinetics

  2011cites this paper
• Assessment and clinical relevance of non-fasting and postprandial triglycerides: an expert panel statement.

  2011cites this paper
• Drug utilization patterns and cardiovascular outcomes in elderly patients newly initiated on atorvastatin or simvastatin.

  2011cites this paper
• Simvastatin improves clinical scores in a rabbit multiple infarct ischemic stroke model: synergism with a ROCK inhibitor but not the thrombolytic tissue plasminogen activator.

  2010cites this paper
• Comparison of Effects of Simvastatin Versus Atorvastatin on Oxidative Stress in Patients With Coronary Heart Disease

  2010cites this paper
• Niacin in the prevention of atherosclerosis: Significance of vasodilatation.

  2010cites this paper
• Comparison of the Effects of Simvastatin versus Atorvastatin on Oxidative Stress in Patients With Type 2 Diabetes Mellitus

  2010cites this paper
• Efficacy of simvastatin or ezetimibe on tissue factor, von Willebrand's factor and C-reactive protein in patients with hypercholesterolaemia.

  2010cites this paper
• Update on statin-mediated anti-inflammatory activities in atherosclerosis

  2009cites this paper
• Zocor Forte (simvastatin) has a neuroprotective effect against LPS striatal dopaminergic terminals injury, whereas against MPP+ does not.

  2009cites this paper
• The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor simvastatin reduces thrombolytic-induced intracerebral hemorrhage in embolized rabbits.

  2009cites this paper
• Effect of atorvastatin on expression of IL-10 and TNF-alpha mRNA in myocardial ischemia-reperfusion injury in rats.

  2009cites this paper
• Comparison of pitavastatin with simvastatin in primary hypercholesterolaemia or combined dyslipidaemia

  2009cites this paper
• Vascular Health and Risk Management Dovepress Lipidomics in Vascular Health: Current Perspectives

  year unknowncites this paper