The R-SNARE endobrevin/VAMP-8 mediates homotypic fusion of early endosomes and late endosomes.

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Molecular Biology of the Cell

• Publication date

  2000-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/MBC.11.10.3289PMID 11029036PMCID PMC14992
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1999influential reference
• Fusion of endosomes involved in synaptic vesicle recycling.

  1999influential reference
• Vesicle-associated membrane protein 4 is implicated in trans-Golgi network vesicle trafficking.

  1999cited by this paper
• Membrane fusion and exocytosis.

  1999cited by this paper
• GS32, a novel Golgi SNARE of 32 kDa, interacts preferentially with syntaxin 6.

  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
• Identification of a minimal core of the synaptic SNARE complex sufficient for reversible assembly and disassembly.

  1998cited by this paper
• EEA1 links PI(3)K function to Rab5 regulation of endosome fusion

  1998cited by this paper
• Syntaxin 12, a Member of the Syntaxin Family Localized to the Endosome*

  1998cited by this paper
• A new beat for the SNARE drum.

  1998cited by this paper
• Reconstitution of Retrograde Transport from the Golgi to the ER In Vitro

  1998cited by this paper
• Syntaxin 5 is a common component of the NSF- and p97-mediated reassembly pathways of Golgi cisternae from mitotic Golgi fragments in vitro.

  1998cited by this paper
• Endobrevin, a novel synaptobrevin/VAMP-like protein preferentially associated with the early endosome.

  1998influential reference
• Syntaxin 7, a Novel Syntaxin Member Associated with the Early Endosomal Compartment*

  1998cited by this paper
• Three Novel Proteins of the Syntaxin/SNAP-25 Family*

  1998cited by this paper
• Seven Novel Mammalian SNARE Proteins Localize to Distinct Membrane Compartments*

  1998cited by this paper
• A model for structural similarity between different SNARE complexes based on sequence relationships.

  1998cited by this paper
• A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function.

  1997cited by this paper
• The diversity of Rab proteins in vesicle transport.

  1997cited by this paper
• Protein transport. A fusion of new ideas.

  1997cited by this paper
• NSF is required for transport from early to late endosomes.

  1997cited by this paper
• Export of Cellubrevin from the Endoplasmic Reticulum Is Controlled by BAP31

  1997influential reference
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  1997cited by this paper
• Neurotransmitter release - four years of SNARE complexes.

  1997cited by this paper
• Homotypic vacuolar fusion mediated by t- and v-SNAREs

  1997cited by this paper
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  1996cited by this paper
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  1996cited by this paper
• Mammalian Sly1 Regulates Syntaxin 5 Function in Endoplasmic Reticulum to Golgi Transport*

  1996cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
• Tetanus toxin-mediated cleavage of cellubrevin impairs exocytosis of transferrin receptor-containing vesicles in CHO cells

  1994cited by this paper
• Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly.

  1994cited by this paper
• Localization of Rab5 to synaptic vesicles identifies endosomal intermediate in synaptic vesicle recycling pathway.

  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1993cited by this paper
• Cytoplasmic dynein-dependent vesicular transport from early to late endosomes [published erratum appears in J Cell Biol 1994 Feb;124(3):397]

  1993cited by this paper
• Synaptic transmission: a bidirectional and self-modifiable form of cell-cell communication.

  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
• Protein translocation into proteoliposomes reconstituted from purified components of the endoplasmic reticulum membrane.

  1993cited by this paper
• A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation.

  1992cited by this paper
• rab5 controls early endosome fusion in vitro.

  1991cited by this paper
• Characterization of the early endosome and putative endocytic carrier vesicles in vivo and with an assay of vesicle fusion in vitro

  1989cited by this paper
• Synaptic vesicles immunoisolated from rat cerebral cortex contain high levels of glutamate.

  1989influential reference
• Biosynthesis, glycosylation, movement through the Golgi system, and transport to lysosomes by an N-linked carbohydrate-independent mechanism of three lysosomal integral membrane proteins.

  1986cited by this paper
• Protein p38: an integral membrane protein specific for small vesicles of neurons and neuroendocrine cells

  1986cited by this paper
• A 38,000-dalton membrane protein (p38) present in synaptic vesicles.

  1985cited by this paper
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  1985cited by this paper
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  1985cited by this paper
• Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles.

  1985cited by this paper
• A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids.

  1984cited by this paper
• Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

  1976cited by this paper
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  1973cited by this paper

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  2025cites this paper
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  2025cites this paper
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  2023cites this paper
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  2023cites this paper
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  2023cites this paper
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  2022cites this paper
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  2020cites this paper
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  2018cites this paper
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