Regulation of integrin activation through the B-cell receptor

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Journal of Cell Science

• Publication date

  2008-07-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/jcs.017905PMID 18596256
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• CD19 is essential for B cell activation by promoting B cell receptor–antigen microcluster formation in response to membrane-bound ligand

  2008cited by this paper
• Phospholipase C-γ2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen

  2008cited by this paper
• The rap GTPases regulate B cell morphology, immune-synapse formation, and signaling by particulate B cell receptor ligands.

  2008cited by this paper
• Follicular shuttling of marginal zone B cells facilitates antigen transport

  2008cited by this paper
• Phospholipase C-γ2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen

  2008influential reference
• Activation of the small GTPase Rac2 via the B cell receptor regulates B cell adhesion and immunological-synapse formation.

  2008cited by this paper
• Integrin modulation and signaling in leukocyte adhesion and migration

  2007cited by this paper
• Structural basis of integrin regulation and signaling.

  2007cited by this paper
• Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells

  2007cited by this paper
• Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells

  2007cited by this paper
• Functional insights on the polarized redistribution of leukocyte integrins and their ligands during leukocyte migration and immune interactions

  2007cited by this paper
• Immature hematopoietic cells display selective requirements for adhesion‐ and degranulation‐promoting adaptor protein in development and homeostatsis

  2007cited by this paper
• Mechanisms for segregating T cell receptor and adhesion molecules during immunological synapse formation in Jurkat T cells

  2007cited by this paper
• Bruton's tyrosine kinase and phospholipase Cgamma2 mediate chemokine-controlled B cell migration and homing.

  2007cited by this paper
• Force as a facilitator of integrin conformational changes during leukocyte arrest on blood vessels and antigen-presenting cells.

  2007cited by this paper
• Compartmentalization of ITAM and integrin signaling by adapter molecules

  2007cited by this paper
• B cells acquire particulate antigen in a macrophage-rich area at the boundary between the follicle and the subcapsular sinus of the lymph node.

  2007cited by this paper
• The ADAP/SKAP55 Signaling Module Regulates T-Cell Receptor-Mediated Integrin Activation through Plasma Membrane Targeting of Rap1

  2006cited by this paper
• B‐cell activation by membrane‐bound antigens is facilitated by the interaction of VLA‐4 with VCAM‐1

  2006influential reference
• B cell recognition of membrane-bound antigen: an exquisite way of sensing ligands.

  2006influential reference
• T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster.

  2006cited by this paper
• Reconstructing and Deconstructing Agonist-Induced Activation of Integrin αIIbβ3

  2006cited by this paper
• Rac1 and Rac2 regulate macrophage morphology but are not essential for migration

  2006cited by this paper
• B Cell Ligand Discrimination Through a Spreading and Contraction Response

  2006influential reference
• Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3.

  2006cited by this paper
• Actin and agonist MHC–peptide complex–dependent T cell receptor microclusters as scaffolds for signaling

  2005cited by this paper
• Integrin regulation.

  2005cited by this paper
• Rho GTPases: biochemistry and biology.

  2005cited by this paper
• Linking Rap to cell adhesion.

  2005cited by this paper
• Intracellular signalling controlling integrin activation in lymphocytes

  2005cited by this paper
• Regulation of In Vitro and In Vivo Immune Functions by the Cytosolic Adaptor Protein SKAP-HOM

  2005cited by this paper
• Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76

  2005cited by this paper
• Binding of Cytoplasmic Proteins to the CD19 Intracellular Domain Is High Affinity, Competitive, and Multimeric1

  2004influential reference
• Rap1 promotes cell spreading by localizing Rac guanine nucleotide exchange factors

  2004cited by this paper
• VLA-4 integrin concentrates at the peripheral supramolecular activation complex of the immune synapse and drives T helper 1 responses.

  2004cited by this paper
• Rap1-mediated Lymphocyte Function-associated Antigen-1 Activation by the T Cell Antigen Receptor Is Dependent on Phospholipase C-γ1*

  2004cited by this paper
• RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion.

  2004cited by this paper
• LFA-1/ICAM-1 interaction lowers the threshold of B cell activation by facilitating B cell adhesion and synapse formation.

  2004influential reference
• Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils

  2004cited by this paper
• The Rap GTPases Regulate Integrin-mediated Adhesion, Cell Spreading, Actin Polymerization, and Pyk2 Tyrosine Phosphorylation in B Lymphocytes*

  2004influential reference
• The B cell antigen receptor controls integrin activity through Btk and PLC gamma 2

  2003cited by this paper
• Integrin avidity regulation: are changes in affinity and conformation underemphasized?

  2003cited by this paper
• Bidirectional Transmembrane Signaling by Cytoplasmic Domain Separation in Integrins

  2003influential reference
• LAB: A new membrane-associated adaptor molecule in B cell activation

  2003cited by this paper
• The B Cell Antigen Receptor Controls Integrin Activity through Btk and PLCγ2

  2003influential reference
• RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1

  2003cited by this paper
• Integrin-dependence of Lymphocyte Entry into the Splenic White Pulp

  2003influential reference
• Rac2 Specificity in Macrophage Integrin Signaling

  2003cited by this paper
• Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling.

  2002cited by this paper
• Integrin-Mediated Long-Term B Cell Retention in the Splenic Marginal Zone

  2002cited by this paper
• BLNK: molecular scaffolding through ‘cis’‐mediated organization of signaling proteins

  2002cited by this paper
• Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses.

  2002cited by this paper
• Non–T Cell Activation Linker (NTAL)

  2002cited by this paper
• T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

  2002cited by this paper
• Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells.

  2002cited by this paper
• Impaired B and T Cell Antigen Receptor Signaling in p110δ PI 3-Kinase Mutant Mice

  2002cited by this paper
• The Direct Recruitment of BLNK to Immunoglobulin α Couples the B-Cell Antigen Receptor to Distal Signaling Pathways

  2002cited by this paper
• B cells acquire antigen from target cells after synapse formation

  2001influential reference
• Positive Regulation of T Cell Activation and Integrin Adhesion by the Adapter Fyb/Slap

  2001cited by this paper
• Coupling of the TCR to Integrin Activation by SLAP-130/Fyb

  2001cited by this paper
• Faculty Opinions recommendation of Crystal structure of the extracellular segment of integrin alpha Vbeta3.

  2001cited by this paper
• Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation

  2001cited by this paper
• Vav and the B cell signalosome

  2001cited by this paper
• Crystal Structure of the Extracellular Segment of Integrin αVβ3

  2001cited by this paper
• Association of SLP‐65 / BLNK with the B cell antigen receptor through a non‐ITAM tyrosine of Ig‐α 

  2001cited by this paper
• B cells extract and present immobilized antigen: implications for affinity discrimination

  2000cited by this paper
• Genetic defect in human X-linked agammaglobulinemia impedes a maturational evolution of pro-B cells into a later stage of pre-B cells in the B-cell differentiation pathway.

  2000cited by this paper
• Genetic defect.

  2000cited by this paper
• Xid-like phenotypes: a B cell signalosome takes shape.

  2000cited by this paper
• B cell development and activation defects resulting in xid-like immunodeficiency in BLNK/SLP-65-deficient mice.

  2000cited by this paper
• BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells.

  1999cited by this paper
• Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK--functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling.

  1999cited by this paper
• Lymphocyte Migration in Lymphocyte Function-associated Antigen (LFA)-1–deficient Mice

  1999cited by this paper
• BLNK Required for Coupling Syk to PLCγ2 and Rac1-JNK in B Cells

  1999cited by this paper
• Three-dimensional segregation of supramolecular activation clusters in T cells

  1998cited by this paper
• Dendritic cells interact directly with naive B lymphocytes to transfer antigen and initiate class switching in a primary T-dependent response.

  1998cited by this paper
• Dendritic cells

  1998cited by this paper
• Are changes in integrin affinity and conformation overemphasized?

  1998cited by this paper
• LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.

  1998cited by this paper
• FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells.

  1998influential reference
• Affinity dependence of the B cell response to antigen: a threshold, a ceiling, and the importance of off-rate.

  1998cited by this paper
• BLNK: a central linker protein in B cell activation.

  1998cited by this paper
• Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production.

  1997cited by this paper
• Identification of Two Tyrosine Phosphoproteins, pp70 and pp68, Which Interact with Phospholipase Cγ, Grb2, and Vav after B Cell Antigen Receptor Activation*

  1997cited by this paper
• Molecular Cloning of SLAP-130, an SLP-76-associated Substrate of the T Cell Antigen Receptor-stimulated Protein Tyrosine Kinases*

  1997cited by this paper
• Molecular Cloning of SKAP55, a Novel Protein That Associates with the Protein Tyrosine Kinase p59 fyn in Human T-lymphocytes*

  1997cited by this paper
• Follicular dendritic cell-derived antigen and accessory activity in initiation of memory IgG responses in vitro.

  1996cited by this paper
• Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav

  1995cited by this paper
• Germinal centers.

  1994cited by this paper
• Adhesion through the LFA-1 (CD11a/CD18)-ICAM-1 (CD54) and the VLA-4 (CD49d)-VCAM-1 (CD106) pathways prevents apoptosis of germinal center B cells.

  1994cited by this paper
• 濾胞樹状細胞(Follicular dendritic cell)の細胞起源

  1994cited by this paper
• Integrins: versatility, modulation, and signaling in cell adhesion.

  1992cited by this paper
• The B-cell antigen receptor of the five immunoglobulin classes

  1991cited by this paper
• Adhesion of human B cells to follicular dendritic cells involves both the lymphocyte function-associated antigen 1/intercellular adhesion molecule 1 and very late antigen 4/vascular cell adhesion molecule 1 pathways

  1991cited by this paper
• Molecular components of the B-cell antigen receptor complex of the IgM class

  1990cited by this paper
• Adhesion receptors of the immune system

  1990cited by this paper
• Antigen receptor tail clue

  1989cited by this paper
• T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

  1989influential reference
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  1988cited by this paper
• Antigen-specific interaction between T and B cells

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• Evaluation of Constitutive or Induced Activation State of the VLA-4 Integrin in Human and Murine Samples.

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• Pan-cancer single-cell dissection reveals phenotypically distinct B cell subtypes.

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• Molecular Profiling Identifies CD49d and CD79b as Predictive Markers for Acquired Acalabrutinib Resistance in Patients With Chronic Lymphocytic Leukemia

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• The VLA-4 integrin is constitutively active in circulating chronic lymphocytic leukemia cells via BCR autonomous signaling: a novel anchor-independent mechanism exploiting soluble blood-borne ligands

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• Role of the tumor microenvironment in CLL pathogenesis.

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• BCR/integrin interaction in CLL: a physiological remnant with clinical relevance.

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• Combinatorial treatment rescues tumour-microenvironment-mediated attenuation of MALT1 inhibitors in B-cell lymphomas

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• Zanubrutinib (BGB-3111), a Second-Generation Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase and Its Utility in Treating Chronic Lymphocytic Leukemia

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