Regulation of TNFRSF and innate immune signalling complexes by TRAFs and cIAPs

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Cell Death and Differentiation

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/cdd.2009.114PMID 19680262
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Two distinct signalling cascades target the NF-κB regulatory factor c-IAP1 for degradation

  2009cited by this paper
• Involvement of linear polyubiquitylation of NEMO in NF-κB activation

  2009cited by this paper
• CARP2 deficiency does not alter induction of NF-kappaB by TNFalpha.

  2009cited by this paper
• Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1).

  2009cited by this paper
• The ubiquitin‐editing enzyme A20 requires RNF11 to downregulate NF‐κB signalling

  2009cited by this paper
• Structural basis for recognition of diubiquitins by NEMO.

  2009cited by this paper
• Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2.

  2009cited by this paper
• Both cIAP1 and cIAP2 regulate TNFα-mediated NF-κB activation

  2008cited by this paper
• Receptor-Interacting Protein Homotypic Interaction Motif-Dependent Control of NF-κB Activation via the DNA-Dependent Activator of IFN Regulatory Factors1

  2008cited by this paper
• c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α (TNFα)-induced NF-κB Activation*

  2008cited by this paper
• CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation.

  2008cited by this paper
• Receptor-Interacting Protein Homotypic Interaction Motif-Dependent Control of NF- B Activation via the DNA-Dependent Activator of IFN Regulatory Factors

  2008cited by this paper
• Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies.

  2008cited by this paper
• cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination.

  2008cited by this paper
• TRADD protein is an essential component of the RIG-like helicase antiviral pathway.

  2008cited by this paper
• The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors

  2008cited by this paper
• Activation of noncanonical NF-κB requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2, TRAF3 and the kinase NIK

  2008cited by this paper
• Essential Cytoplasmic Translocation of a Cytokine Receptor–Assembled Signaling Complex

  2008cited by this paper
• Cutting Edge: The Dependence of Plasma Cells and Independence of Memory B Cells on BAFF and APRIL1

  2008cited by this paper
• Crosstalk via the NF-kappaB signaling system.

  2008influential reference
• Control of canonical NF-κB activation through the NIK–IKK complex pathway

  2008cited by this paper
• The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals.

  2008cited by this paper
• TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFα

  2008cited by this paper
• Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses

  2008cited by this paper
• Roles of TRAF molecules in B lymphocyte function.

  2008cited by this paper
• TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor.

  2008influential reference
• Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling

  2008cited by this paper
• The host defense of Drosophila melanogaster.

  2007cited by this paper
• E2–BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages

  2007cited by this paper
• Tumor Necrosis Factor Receptor 2 Signaling Induces Selective c-IAP1-dependent ASK1 Ubiquitination and Terminates Mitogen-activated Protein Kinase Signaling*

  2007cited by this paper
• Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.

  2007influential reference
• Faculty Opinions recommendation of IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis.

  2007influential reference
• IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis.

  2007influential reference
• A Fourth IkB Protein within the NF-kB Signaling Module

  2007cited by this paper
• Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma.

  2007influential reference
• IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis.

  2007cited by this paper
• Tumor necrosis factor receptor-associated factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organs.

  2007cited by this paper
• A fourth IkappaB protein within the NF-kappaB signaling module.

  2007cited by this paper
• The Inhibitor of Apoptosis Protein Fusion c-IAP2·MALT1 Stimulates NF-κB Activation Independently of TRAF1 AND TRAF2*

  2006cited by this paper
• TWEAK shall inherit the earth

  2006cited by this paper
• Inhibitor of Apoptosis Protein cIAP2 Is Essential for Lipopolysaccharide-Induced Macrophage Survival

  2006cited by this paper
• Rescue of TRAF3-null mice by p100 NF-κB deficiency

  2006cited by this paper
• The Drosophila Inhibitor of Apoptosis Protein DIAP2 Functions in Innate Immunity and Is Essential To Resist Gram-Negative Bacterial Infection

  2006cited by this paper
• Circuitry of nuclear factor kappaB signaling.

  2006cited by this paper
• Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected].

  2006influential reference
• A ubiquitin ligase complex assembles linear polyubiquitin chains

  2006cited by this paper
• Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

  2006influential reference
• Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO.

  2006influential reference
• Ubiquitin and endocytic protein sorting.

  2005cited by this paper
• Rip1 Mediates the Trif-dependent Toll-like Receptor 3- and 4-induced NF-κB Activation but Does Not Contribute to Interferon Regulatory Factor 3 Activation*

  2005cited by this paper
• Essential function for the kinase TAK1 in innate and adaptive immune responses

  2005cited by this paper
• IAPs, RINGs and ubiquitylation

  2005influential reference
• Posttranscriptional Downregulation of c-IAP2 by the Ubiquitin Protein Ligase c-IAP1 In Vivo

  2005cited by this paper
• TNF受容体(TNFR)関連因子(TRAF)3はTRAF結合性TNFRによる非定型的NFκB経路のTRAF2/5介在性活性化の阻害物質として働く

  2005cited by this paper
• TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRs.

  2005cited by this paper
• TNF‐α induced c‐IAP1/TRAF2 complex translocation to a Ubc6‐containing compartment and TRAF2 ubiquitination

  2005cited by this paper
• Receptor-Specific Signaling for Both the Alternative and the Canonical NF-κB Activation Pathways by NF-κB-Inducing Kinase

  2004cited by this paper
• RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation.

  2004cited by this paper
• Faculty Opinions recommendation of De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling.

  2004cited by this paper
• Receptor-specific signaling for both the alternative and the canonical NF-kappaB activation pathways by NF-kappaB-inducing kinase.

  2004cited by this paper
• TRAF2 differentially regulates the canonical and noncanonical pathways of NF-kappaB activation in mature B cells.

  2004influential reference
• De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling

  2004cited by this paper
• Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF‐κB

  2004influential reference
• Expanded Nuclear Roles for IκBs

  2004cited by this paper
• The kinase activity of Rip1 is not required for tumor necrosis factor-alpha-induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2.

  2004cited by this paper
• TNF Family Member B Cell-Activating Factor (BAFF) Receptor-Dependent and -Independent Roles for BAFF in B Cell Physiology1

  2004cited by this paper
• Shaping the nuclear action of NF-kappaB.

  2004cited by this paper
• Receptor interacting protein is ubiquitinated by cellular inhibitor of apoptosis proteins (c‐IAP1 and c‐IAP2) in vitro

  2004cited by this paper
• The multifaceted roles of TRAFs in the regulation of B-cell function

  2004cited by this paper
• Regulation of the NF-κB-inducing Kinase by Tumor Necrosis Factor Receptor-associated Factor 3-induced Degradation*

  2004influential reference
• Key Molecular Contacts Promote Recognition of the BAFF Receptor by TNF Receptor-Associated Factor 3: Implications for Intracellular Signaling Regulation1

  2004cited by this paper
• Shaping the nuclear action of NF-κB

  2004cited by this paper
• Two Adjacent Trimeric Fas Ligands Are Required for Fas Signaling and Formation of a Death-Inducing Signaling Complex

  2003influential reference
• Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes.

  2003cited by this paper
• A Role for NF-κB Essential Modifier/IκB Kinase-γ (NEMO/IKKγ) Ubiquitination in the Activation of the IκB Kinase Complex by Tumor Necrosis Factor-α*

  2003cited by this paper
• A role for NEMO/IKKγ Ubiquitination in the activation of the IκB kinase complex by TNF-α

  2003cited by this paper
• Lymphotoxin and lipopolysaccharide induce NF‐κB‐p52 generation by a co‐translational mechanism

  2003cited by this paper
• TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology

  2003cited by this paper
• Tumor Necrosis Factor Receptor-associated Factor 2 (TRAF2)-deficient B Lymphocytes Reveal Novel Roles for TRAF2 in CD40 Signaling*

  2003cited by this paper
• A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha.

  2003cited by this paper
• TRAF6-deficient mice display hypohidrotic ectodermal dysplasia

  2002cited by this paper
• The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways.

  2002cited by this paper
• Analysis of an Ethylnitrosourea-generated Mouse Mutation Defines a Cell Intrinsic Role of Nuclear Factor κB2 in Regulating Circulating B Cell Numbers

  2002cited by this paper
• TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2

  2002cited by this paper
• Apoptotic crosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8.

  2002cited by this paper
• TNFR-Associated Factor-3 Is Associated With BAFF-R and Negatively Regulates BAFF-R-Mediated NF-κB Activation and IL-10 Production

  2002cited by this paper
• BAFF-induced NEMO-independent processing of NF-kappa B2 in maturing B cells.

  2002cited by this paper
• CD40 regulates the processing of NF-kappaB2 p100 to p52.

  2002cited by this paper
• CD40 regulates the processing of NF‐κB2 p100 to p52

  2002cited by this paper
• The Lymphotoxin-β Receptor Induces Different Patterns of Gene Expression via Two NF-κB Pathways

  2002cited by this paper
• Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila

  2002cited by this paper
• TRAF1 is a negative regulator of TNF signaling. enhanced TNF signaling in TRAF1-deficient mice.

  2001cited by this paper
• Differential Signaling and Tumor Necrosis Factor Receptor–Associated Factor (Traf) Degradation Mediated by Cd40 and the Epstein-Barr Virus Oncoprotein Latent Membrane Protein 1 (Lmp1)

  2001influential reference
• A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis.

  2001cited by this paper
• Abnormal immune function of hemopoietic cells from alymphoplasia (aly) mice, a natural strain with mutant NF-κB-inducing kinase

  2001cited by this paper
• An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent Pathway

  2001cited by this paper
• A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction.

  2000cited by this paper
• Abnormal Immune Function of Hemopoietic Cells from Alymphoplasia (aly) Mice, a Natural Strain with Mutant NF-κB-Inducing Kinase1

  2000cited by this paper
• Mechanism of I kappa B alpha binding to NF-kappa B dimers.

  2000cited by this paper
• Mechanism of IκBα Binding to NF-κB Dimers*

  2000cited by this paper

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• Epstein-Barr Virus Latent Membrane Protein 1 targets cIAP1, cIAP2 and TRAF2 for Proteasomal Degradation to Activate the Non-canonical NF-κB Pathway

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• Roles of c-IAP proteins in TNF receptor family activation of NF-κB signaling.

  2015cites this paper
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