A Phase II Randomized Clinical Trial of a Nutritional Formulation for Cognition and Mood in Alzheimer's Disease

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Journal of Alzheimer's Disease

• Publication date

  2015-03-18

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.3233/JAD-142499PMID 25589719
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Preventing Alzheimer's Disease: Some Light in the Darkness.

  2019influential reference
• The Relationship Between Associative Learning, Transfer Generalization, and Homocysteine Levels in Mild Cognitive Impairment

  2015cited by this paper
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• Towards an Aging-Specific Cognitive Phenotype: The Freedom House Study

  2014cited by this paper
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  2014influential reference
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  2014cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2012influential reference
• [The new 2011 recommendations of the National Institute on Aging and the Alzheimer's Association on diagnostic guidelines for Alzheimer's disease: Preclinal stages, mild cognitive impairment, and dementia].

  2012cited by this paper
• Preventing Alzheimer’s Disease

  2012cited by this paper
• The Relationship between Associative Learning, Transfer Generalization, and Homocysteine Levels in Mild Cognitive Impairment

  2012cited by this paper
• Plasma oxidative stress parameters in men and women with early stage Alzheimer type dementia.

  2012cited by this paper
• Advancing Alzheimer's disease diagnosis, treatment, and care: Recommendations from the Ware Invitational Summit

  2012influential reference
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  2012cited by this paper
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  2012cited by this paper
• A potential design flaw of randomized trials of vitamin supplements.

  2011influential reference
• Alzheimer's disease.

  2011cited by this paper
• The growing burden of Alzheimer's disease.

  2011cited by this paper
• One-carbon metabolism and Alzheimer's disease: is it all a methylation matter?

  2011cited by this paper
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  2010cited by this paper
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  2008cited by this paper
• Dementia

  2008cited by this paper
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  2008cited by this paper
• [Alzheimer type dementia].

  2008cited by this paper
• S-Adenosyl Methionine: A Natural Therapeutic Agent Effective Against Multiple Hallmarks and Risk Factors Associated with Alzheimer's Disease

  2008cited by this paper
• Effects of Dietary Supplementation with N-Acetyl Cysteine, Acetyl-l-Carnitine and S-Adenosyl Methionine on Cognitive Performance and Aggression in Normal Mice and Mice Expressing Human ApoE4

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  1998cited by this paper
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  1997cited by this paper
• The Neuropsychiatric Inventory

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• Clinical validity of the Mattis Dementia Rating Scale in detecting Dementia of the Alzheimer type. A double cross-validation and application to a community-dwelling sample.

  1995cited by this paper

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  2024cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
• Nutritional interventions in patients with Alzheimer’s disease and other late-life cognitive disorders

  2018cites this paper
• Application of N-Acetylcysteine in Neurological Disorders

  2018cites this paper
• Overview on the Effects of N-Acetylcysteine in Neurodegenerative Diseases

  2018cites this paper
• Pharmacoepigenomic Interventions as Novel Potential Treatments for Alzheimer’s and Parkinson’s Diseases

  2018influential citation
• S-Adenosyl Methionine and Transmethylation Pathways in Neuropsychiatric Diseases Throughout Life

  2018cites this paper
• Apparent Cognitive Decline as Revealed by an Executive Function Test within a Cohort of Elderly Individuals Self-Reporting Normal Cognitive Performance

  2018cites this paper
• Epigenetics and cognitive disorders-translational aspects

  2017cites this paper
• While I Still Remember: 30 Years of Alzheimer’s Disease Research

  2017cites this paper
• S-Adenosylmethionine (SAMe) for Neuropsychiatric Disorders: A Clinician-Oriented Review of Research.

  2017cites this paper
• New Therapeutics to Modulate Mitochondrial Function in Neurodegenerative Disorders.

  2017cites this paper
• Vitamin E for Alzheimer's dementia and mild cognitive impairment.

  2017cites this paper
• Evaluation of the Neuroprotective Potential of N-Acetylcysteine for Prevention and Treatment of Cognitive Aging and Dementia.

  2017cites this paper
• Reply - Letter to the Editor - Nutritional supplements and dementia.

  2017cites this paper
• The effect of N‐acetylcysteine (NAC) on human cognition – A systematic review

  2017influential citation
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper