The B Cell Antigen Receptor and Overexpression of MYC Can Cooperate in the Genesis of B Cell Lymphomas

A variety of circumstantial evidence from humans has implicated the B cell antigen receptor (BCR) in the genesis of B cell lymphomas. We generated mouse models designed to test this possibility directly, and we found that both the constitutive and antigen-stimulated state of a clonal BCR affected the rate and outcome of lymphomagenesis initiated by the proto-oncogene MYC. The tumors that arose in the presence of constitutive BCR differed from those initiated by MYC alone and resembled chronic B cell lymphocytic leukemia/lymphoma (B-CLL), whereas those that arose in response to antigen stimulation resembled large B-cell lymphomas, particularly Burkitt lymphoma (BL). We linked the genesis of the BL-like tumors to antigen stimulus in three ways. First, in reconstruction experiments, stimulation of B cells by an autoantigen in the presence of overexpressed MYC gave rise to BL-like tumors that were, in turn, dependent on both MYC and the antigen for survival and proliferation. Second, genetic disruption of the pathway that mediates signaling from the BCR promptly killed cells of the BL-like tumors as well as the tumors resembling B-CLL. And third, growth of the murine BL could be inhibited by any of three distinctive immunosuppressants, in accord with the dependence of the tumors on antigen-induced signaling. Together, our results provide direct evidence that antigenic stimulation can participate in lymphomagenesis, point to a potential role for the constitutive BCR as well, and sustain the view that the constitutive BCR gives rise to signals different from those elicited by antigen. The mouse models described here should be useful in exploring further the pathogenesis of lymphomas, and in preclinical testing of new therapeutics.

• Publication year

  2008

• Venue

  PLoS Biology

• Publication date

  2008-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1371/journal.pbio.0060152PMID 18578569PMCID 2435152
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• AID is required for germinal center–derived lymphomagenesis

  2008cited by this paper
• MHC class II structural requirements for the association with Igalpha/beta, and signaling of calcium mobilization and cell death.

  2008cited by this paper
• Aberrant immunoglobulin class switch recombination and switch translocations in activated B cell–like diffuse large B cell lymphoma

  2007cited by this paper
• TUMORS OF HEMATOPOIETIC AND LYMPHOID TISSUES

  2007cited by this paper
• Conditional transgenic models define how MYC initiates and maintains tumorigenesis.

  2006cited by this paper
• Dissecting the mechanism of T-cell anergy with immunophilin ligands.

  2006cited by this paper
• B cell receptors in TCL1 transgenic mice resemble those of aggressive, treatment-resistant human chronic lymphocytic leukemia.

  2006influential reference
• BCL-6 Negatively Regulates Expression of the NF-κB1 p105/p50 Subunit1

  2005cited by this paper
• Aggressive B‐cell lymphomas: a review based on the workshop of the XI Meeting of the European Association for Haematopathology

  2005cited by this paper
• Mechanisms of B-cell lymphoma pathogenesis

  2005cited by this paper
• The protooncogene MYC can break B cell tolerance.

  2005cited by this paper
• BCL-6 negatively regulates expression of the NF-kappaB1 p105/p50 subunit.

  2005cited by this paper
• Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice.

  2005cited by this paper
• Survival of Resting Mature B Lymphocytes Depends on BCR Signaling via the Igα/β Heterodimer

  2004cited by this paper
• Surface μ Heavy Chain Signals Down-Regulation of the V(D)J-Recombinase Machinery in the Absence of Surrogate Light Chain Components

  2004cited by this paper
• Cre-lox-regulated conditional RNA interference from transgenes.

  2004cited by this paper
• mTOR signaling to translation.

  2004cited by this paper
• Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha/beta heterodimer.

  2004cited by this paper
• Rational siRNA design for RNA interference

  2004cited by this paper
• Will mTOR inhibitors make it as cancer drugs?

  2003cited by this paper
• Proliferation and Survival of Activated B Cells Requires Sustained Antigen Receptor Engagement and Phosphoinositide 3-Kinase Activation1

  2003cited by this paper
• Activation-induced cytidine deaminase in chronic lymphocytic leukemia B cells: expression as multiple forms in a dynamic, variably sized fraction of the clone.

  2003cited by this paper
• Visualization of the Genesis and Fate of Isotype-switched B Cells during a Primary Immune Response

  2003influential reference
• Bethesda proposals for classification of lymphoid neoplasms in mice.

  2002cited by this paper
• Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma

  2002cited by this paper
• A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy.

  2002cited by this paper
• The proto-oncogene c-myc in hematopoietic development and leukemogenesis

  2002cited by this paper
• Interferon γ Is Required for Activation-induced Death of T Lymphocytes

  2002cited by this paper
• Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

  2002cited by this paper
• Ligand-independent Signaling Functions for the B Lymphocyte Antigen Receptor and Their Role in Positive Selection during B Lymphopoiesis

  2001cited by this paper
• The B-cell receptor of a hepatitis C virus (HCV)-associated non-Hodgkin lymphoma binds the viral E2 envelope protein, implicating HCV in lymphomagenesis.

  2001cited by this paper
• Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes.

  2001cited by this paper
• The Initiation of B Cell Clonal Expansion Occurs Independently of Pre-B Cell Receptor Formation1

  2001cited by this paper
• FROM BURKITT'S LYMPHOMA TO CHRONIC ACTIVE EPSTEIN-BARR VIRUS (EBV) INFECTION: An Expanding Spectrum of EBV-Associated Diseases

  2001cited by this paper
• The combination of chemotherapy and systemic immunotherapy with soluble B7-immunoglobulin G leads to cure of murine leukemia and lymphoma and demonstration of tumor-specific memory responses.

  2001cited by this paper
• Translocations involving c-myc and c-myc function

  2001cited by this paper
• The circulating auto-antibodies to p53 protein in the follow-up of lymphoma patients.

  2001cited by this paper
• Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

  2001cited by this paper
• Treatment of high-grade lymphoid malignancies in adults.

  2001cited by this paper
• Epstein-Barr Virus Small RNAs Potentiate Tumorigenicity of Burkitt Lymphoma Cells Independently of an Effect on Apoptosis

  2000cited by this paper
• Molecular analysis of immunoglobulin genes in diffuse large B-cell lymphomas.

  2000cited by this paper
• correction: Signalling through CD30 protects against autoimmune diabetes mediated by CD8 T cells

  2000cited by this paper
• Sequence analysis of the immunoglobulin antigen receptor of hepatitis C virus-associated non-Hodgkin lymphomas suggests that the malignant cells are derived from the rheumatoid factor-producing cells that occur mainly in type II cryoglobulinemia.

  2000cited by this paper
• How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis

  2000cited by this paper
• Autoimmune hemolytic anemia in patients with non-Hodgkin's lymphoma: characteristics and significance.

  2000cited by this paper
• The IL-2 Receptor Promotes Lymphocyte Proliferation and Induction of the c-myc, bcl-2, and bcl-x Genes Through the trans-Activation Domain of Stat51

  2000cited by this paper
• Reversibility of acute B-cell leukaemia induced by BCR–ABL1

  2000cited by this paper
• The Significance of Autoantibodies in Non-Hodgkin's Lymphoma

  2000cited by this paper
• Ongoing immunoglobulin somatic mutation in germinal center B cell-like but not in activated B cell-like diffuse large cell lymphomas.

  2000cited by this paper
• Burkitt Lymphoma in the Mouse

  2000cited by this paper
• Molecular biology of Burkitt's lymphoma.

  2000cited by this paper
• World Health Organization classification of tumors

  2000cited by this paper
• Specific Expression of Activation-induced Cytidine Deaminase (AID), a Novel Member of the RNA-editing Deaminase Family in Germinal Center B Cells*

  1999cited by this paper
• Essential role for oncogenic Ras in tumour maintenance

  1999cited by this paper
• Transient excess of MYC activity can elicit genomic instability and tumorigenesis.

  1999cited by this paper
• Transgenic models of lymphoid neoplasia and development of a pan-hematopoietic vector

  1999cited by this paper
• Reversible tumorigenesis by MYC in hematopoietic lineages.

  1999cited by this paper
• Suboptimal Cross-linking of Antigen Receptor Induces Syk-dependent Activation of p70S6 Kinase through Protein Kinase C and Phosphoinositol 3-Kinase*

  1999cited by this paper
• A Third-Generation Lentivirus Vector with a Conditional Packaging System

  1998cited by this paper
• Analysis of VH genes in follicular and diffuse lymphoma shows ongoing somatic mutation and multiple isotype transcripts in early disease with changes during disease progression.

  1998cited by this paper
• Antigen receptor signaling: integration of protein tyrosine kinase functions

  1998cited by this paper
• Insight into Burkitt's lymphoma from immunoglobulin variable region gene analysis.

  1998cited by this paper
• The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation

  1997cited by this paper
• Antigen receptor signaling gives lymphocytes a long life.

  1997influential reference
• Detection of EBV RNA (EBER‐1 and EBER‐2) in Malaria Lymph Nodes by In Situ Hybridization

  1997cited by this paper
• Dissociation of cytokine signals for proliferation and apoptosis.

  1997cited by this paper
• Principles of the revised European-American Lymphoma Classification (from the International Lymphoma Study Group).

  1997cited by this paper
• In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death.

  1997influential reference
• Heterogeneity of B-lymphoid tumors in E mu-myc transgenic mice.

  1996cited by this paper
• The mechanism of action of cyclosporin A and FK506.

  1996cited by this paper
• Conditional gene expression in secretory tissues and skin of transgenic mice using the MMTV‐LTR and the tetracycline responsive system

  1995cited by this paper
• Burkitt's lymphomas express VH genes with a moderate number of antigen-selected somatic mutations.

  1995cited by this paper
• Critical role of the interleukin 2 (IL-2) receptor gamma-chain-associated Jak3 in the IL-2-induced c-fos and c-myc, but not bcl-2, gene induction.

  1995cited by this paper
• Prevention of Tumor Formation in a Mouse Model of Burkitt’s Lymphoma by 6 Weeks of Treatment with Anti-c-myc DNA Phosphorothioate

  1995cited by this paper
• Analysis of VH genes used by neoplastic B cells in endemic Burkitt's lymphoma shows somatic hypermutation and intraclonal heterogeneity.

  1995cited by this paper
• Burkitt’s Lymphoma Is a Malignancy of Mature B Cells Expressing Somatically Mutated V Region Genes

  1995cited by this paper
• Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter.

  1994cited by this paper
• Tolerance and Ways to Break It a

  1993cited by this paper
• Suppression of apoptosis in a cytotoxic T-cell line by interleukin 2-mediated gene transcription and deregulated expression of the protooncogene bcl-2.

  1993cited by this paper
• Neoplastic lymphoproliferation in autoimmune disease: an updated review.

  1992cited by this paper
• Autoantibodies to c-myc protein: elevated levels in patients with African Burkitt's lymphoma and normal Ghanians.

  1992cited by this paper
• Strain Dependency of Cell‐type Specificity and Onset of Lymphoma Development in Eμ‐myc Transgenic Mice

  1992cited by this paper
• Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

  1992cited by this paper
• Breakdown of self-tolerance in anergic B lymphocytes

  1991cited by this paper
• Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens

  1991cited by this paper
• Biology and treatment of small non-cleaved cell lymphoma.

  1989cited by this paper
• Transgenic mice bearing the human c-myc gene activated by an immunoglobulin enhancer: a pre-B-cell lymphoma model.

  1988cited by this paper
• A human immunoglobulin gene reduces the incidence of lymphomas in c-Myc-bearing transgenic mice

  1988cited by this paper
• Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice

  1988cited by this paper
• The c-myc oncogene perturbs B lymphocyte development in E-mu-myc transgenic mice.

  1986cited by this paper
• Distinctions between endemic and sporadic forms of epstein‐barr virus‐positive burkitt's lymphoma

  1985cited by this paper
• Biclonal B-cell lymphoma.

  1984cited by this paper
• Autoantibodies in three populations of Burkitt's lymphoma patients.

  1983cited by this paper
• Sequence of the murine and human cellular myc oncogenes and two modes of myc transcription resulting from chromosome translocation in B lymphoid tumours.

  1983cited by this paper
• Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells.

  1982cited by this paper
• Autoimmune haemolysis: an 18-year study of 865 cases referred to a regional transfusion centre.

  1981cited by this paper
• Diffuse polyclonal B-cell lymphoma during primary infection with Epstein-Barr virus.

  1980cited by this paper
• AKR leukemogenesis: identification and biological significance of thymic lymphoma receptors for AKR retroviruses.

  1979cited by this paper
• Increased risk of lymphoma in sicca syndrome.

  1978cited by this paper
• Epidemiology of Burkitt Lymphoma

  1976cited by this paper

• Burkitt Lymphoma-A Guide to Biological Features, Diagnosis and Differential Diagnosis.

  2026cites this paper
• Paradoxical role and therapeutic potential of autophagy in lymphomas

  2025cites this paper
• Berberine as a natural immunomodulator of B lymphocytes

  2025cites this paper
• The multi-faceted roles of MYC in the prognosis of chronic lymphocytic leukemia

  2025cites this paper
• Ibrutinib Plus RCHOP versus RCHOP Only in Young Patients with Activated B-Cell-like Diffuse Large B-Cell Lymphoma (ABC-DLBCL): A Cost-Effectiveness Analysis

  2023cites this paper
• Repository of the Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Association

  2023cites this paper
• Human CD19-specific switchable CAR T-cells are efficacious as constitutively active CAR T-cells but cause less morbidity in a mouse model of human CD19+ malignancy

  2022cites this paper
• MYD88L265P and CD79B double mutations type (MCD type) of diffuse large B-cell lymphoma: mechanism, clinical characteristics, and targeted therapy

  2022cites this paper
• LncRNA FIRRE stimulates PTBP1‐induced Smurf2 decay, stabilizes B‐cell receptor, and promotes the development of diffuse large B‐cell lymphoma

  2022cites this paper
• Reframing Burkitt lymphoma: virology not epidemiology defines clinical variants

  2021cites this paper
• Forward and Reverse Genetics of B Cell Malignancies: From Insertional Mutagenesis to CRISPR-Cas

  2021cites this paper
• The Eµ-hnRNP K Murine Model of Lymphoma: Novel Insights into the Role of hnRNP K in B-Cell Malignancies

  2021cites this paper
• JNK/AP1 Pathway Regulates MYC Expression and BCR Signaling through Ig Enhancers in Burkitt Lymphoma Cells

  2020cites this paper
• SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma.

  2020cites this paper
• Repurposing a novel anti-cancer RXR agonist to attenuate acute GVHD and maintain graft-versus-leukemia responses.

  2020cites this paper
• Lymphome de Burkitt

  2020cites this paper
• Pathways of Organic Carbon Downward Transport by the Oceanic Biological Carbon Pump

  2019cites this paper
• The B‐cell receptor in control of tumor B‐cell fitness: Biology and clinical relevance

  2019cites this paper
• Pathways of organic carbon downward transport by the oceanic biological carbon pump

  2019cites this paper
• Pathogenic B‐cell receptor signaling in lymphoid malignancies: New insights to improve treatment

  2019cites this paper
• Human CD19-Targeted Mouse T Cells Induce B Cell Aplasia and Toxicity in Human CD19 Transgenic Mice.

  2018cites this paper
• ERYTHROCYTES FROM CONDITIONALLY MMORTALIZED HEMATOPOETC STEM CELLS

  2017cites this paper
• Identification of 11(13)-dehydroivaxillin as a potent therapeutic agent against non-Hodgkin's lymphoma

  2017cites this paper
• Tonic B-cell receptor signaling in diffuse large B-cell lymphoma.

  2017cites this paper
• EBV latent membrane protein 2A orchestrates p27kip1 degradation via Cks1 to accelerate MYC-driven lymphoma in mice.

  2017cites this paper
• Genes and pathways associated with the occurrence of malignancy in benign lymphoepithelial lesions

  2017cites this paper
• The B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3β inhibition

  2017cites this paper
• Quantitative phosphoproteomics for studying B-cell receptor signaling in Burkitt's lymphoma.

  2017cites this paper
• Myc enhances B cell receptor signaling in precancerous B cells and confers resistance to Btk inhibition

  2017cites this paper
• Functional imaging in combination with mutation status aids prediction of response to inhibiting B-cell receptor signaling in lymphoma

  2017influential citation
• MYD88 L265P Mutations, But No Other Variants, Identify a Subpopulation of DLBCL Patients of Activated B-cell Origin, Extranodal Involvement, and Poor Outcome

  2016cites this paper
• Pathogenic role of B-cell receptor signaling and canonical NF-κB activation in mantle cell lymphoma.

  2016cites this paper
• Elucidation of tonic and activated B-cell receptor signaling in Burkitt’s lymphoma provides insights into regulation of cell survival

  2016cites this paper
• B-cell receptor signaling in chronic lymphocytic leukemia and other B-cell malignancies.

  2016cites this paper
• KSHV Latency Locus Cooperates with Myc to Drive Lymphoma in Mice

  2015cites this paper
• Avian pathogenic Escherichia coli (APEC) infection alters bone marrow transcriptome in chickens

  2015cites this paper
• Multilevel BCR signals toward CLL.

  2015cites this paper
• Clustering of Expression Data in Chronic Lymphocytic Leukemia Reveals New Molecular Subdivisions

  2015cites this paper
• A Time-Point Study Of Maslinic Acid-Induced Global Mrna Expression In Raji Cells

  2015cites this paper
• Clonality Analysis of Immunoglobulin Gene Rearrangement by Next-Generation Sequencing in Endemic Burkitt Lymphoma Suggests Antigen Drive Activation of BCR as Opposed to Sporadic Burkitt Lymphoma

  2015cites this paper
• Expansion of Human and Murine Hematopoietic Stem and Progenitor Cells Ex Vivo without Genetic Modification Using MYC and Bcl-2 Fusion Proteins

  2014cites this paper
• Transcriptome characterization by RNA sequencing identifies a major molecular and clinical subdivision in chronic lymphocytic leukemia

  2014cites this paper
• Targeting the B-cell receptor signaling pathway in B lymphoid malignancies

  2014cites this paper
• leukemia major molecular and clinical subdivision in chronic lymphocytic Transcriptome characterization by RNA sequencing identifies a Material

  2014cites this paper
• Regulation of MYC Expression and Differential JQ1 Sensitivity in Cancer Cells

  2014cites this paper
• Bruton's tyrosine kinase inhibitors: lessons learned from bench-to-bedside (first) studies

  2014cites this paper
• Oncogenic mechanisms in Burkitt lymphoma.

  2014cites this paper
• Epstein-Barr virus latent membrane protein 2A enhances MYC-driven cell cycle progression in a mouse model of B lymphoma.

  2014cites this paper
• Not like a wrecking ball: EBV fine-tunes MYC lymphomagenesis.

  2014cites this paper
• therapeutic target Mouse models of non-Hodgkins lymphoma reveal Syk as an important

  2013cites this paper
• Animal Models of Burkitt’s Lymphoma

  2013cites this paper
• B cell receptor signaling in chronic lymphocytic leukemia.

  2013cites this paper
• LYMPHOID NEOPLASIA The Myc-miR-17-92 axis ampli fi es B-cell receptor signaling via inhibition of ITIM proteins: a novel lymphomagenic feed-forward loop

  2013cites this paper
• New insights into pre-BCR and BCR signalling with relevance to B cell malignancies

  2013cites this paper
• The Myc-miR-17-92 axis amplifies B-cell receptor signaling via inhibition of ITIM proteins: a novel lymphomagenic feed-forward loop.

  2013cites this paper
• Gain-of-Function of Stat5 Leads to Excessive Granulopoiesis and Lethal Extravasation of Granulocytes to the Lung

  2013cites this paper
• Ibrutinib: a strong candidate for the future of mantle cell lymphoma treatment

  2013cites this paper
• ITIM proteins : a novel lymphomagenic feed-forward loop The Myc-miR-1792 axis amplifies B-cell receptor signaling via inhibition of

  2013cites this paper
• Anti‐tumor activity of a B‐cell receptor‐targeted peptide in a novel disseminated lymphoma xenograft model

  2012cites this paper
• CD19 is a major B cell receptor-independent activator of MYC-driven B-lymphomagenesis.

  2012influential citation
• A defect of the INK4-Cdk4 checkpoint and Myc collaborate in blastoid mantle cell lymphoma-like lymphoma formation in mice.

  2012cites this paper
• Targeting Spleen Tyrosine Kinase (Syk) for Treatment of Human Disease

  2012cites this paper
• Pathogenesis of human B cell lymphomas.

  2012cites this paper
• The molecular regulation of apoptosis in b-cell neoplasms

  2012cites this paper
• Homeostatic chemokines guide lymphoma cells to tumor growth-promoting niches within secondary lymphoid organs

  2012cites this paper
• iNKT Cells Suppress the CD8+ T Cell Response to a Murine Burkitt’s-Like B Cell Lymphoma

  2012cites this paper
• Germinal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activation

  2012cites this paper
• Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis.

  2012cites this paper
• Journal of Pharmaceutics & Drug Delivery Research

  2012cites this paper
• The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia.

  2011cites this paper
• Genome‐wide DNA profiling better defines the prognosis of chronic lymphocytic leukaemia

  2011cites this paper
• Chemotactic signals released during Burkitt’s lymphoma cell death

  2011cites this paper
• IRF4 Is a Suppressor of c-Myc Induced B Cell Leukemia

  2011cites this paper
• LDOC1, A NOVEL BIOMARKER OF PROGNOSIS IN CHRONIC LYMPHOCYTIC LEUKEMIA

  2011cites this paper
• B‐cell receptor epitope recognition correlates with the clinical course of chronic lymphocytic leukemia

  2011cites this paper
• Molecular Pathology of Chronic Lymphocytic Leukemia

  2011cites this paper
• Cooperative function of CCR7 and lymphotoxin in the formation of a lymphoma-permissive niche within murine secondary lymphoid organs.

  2011cites this paper
• B-cell receptors and heavy chain diseases: guilty by association?

  2011cites this paper
• Myc roles in hematopoiesis and leukemia.

  2010cites this paper
• Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

  2010cites this paper
• c-Myc overexpression promotes a germinal center-like program in Burkitt's lymphoma

  2010cites this paper
• Novel insights into the molecular pathogenesis of gastric MALT lymphoma

  2010cites this paper
• Regulation of B Cell Gene Expression and Function by Ikaros, Helios and Bcl6

  2010cites this paper
• Stereotypical Chronic Lymphocytic Leukemia B-Cell Receptors Recognize Survival Promoting Antigens on Stromal Cells

  2010cites this paper
• Epstein-Barr virus in Burkitt’s lymphoma: A role for latent membrane protein 2A

  2010cites this paper
• The acquired deficiency of C1-inhibitor: lymphoproliferation and angioedema.

  2010cites this paper
• The Biology of MYC in Health and Disease: A High Altitude View

  2010cites this paper
• Advances in the understanding of MYC‐induced lymphomagenesis

  2010cites this paper
• Novel agents for the treatment of chronic lymphocytic leukemia.

  2010cites this paper
• Immunoglobulin Gene Rearrangements, Oncogenic Translocations, B-Cell Receptor Signaling, and B Lymphomagenesis

  2010cites this paper
• The tyrosine kinase Syk regulates the survival of chronic lymphocytic leukemia B cells through PKCδ and proteasome-dependent regulation of Mcl-1 expression

  2009cites this paper
• Delayed rejection of MHC class II-disparate skin allografts in mice treated with farnesyltransferase inhibitors.

  2009cites this paper
• Biological Pathways in B-cell Non-Hodgkin's Lymphoma

  2009cites this paper
• TC-PTP is required for the maintenance of MYC-driven B-cell lymphomas.

  2009cites this paper
• A novel method for long term bone marrow culture and genetic modification of murine neutrophils via retroviral transduction.

  2009cites this paper
• Mouse models of non-Hodgkin lymphoma reveal Syk as an important therapeutic target.

  2009cites this paper
• Epstein-Barr virus and its role in the pathogenesis of Burkitt's lymphoma: an unresolved issue.

  2009cites this paper
• B-cell receptor signaling in the genesis and maintenance of B-cell lymphoma.

  2008cites this paper
• Micromanagement of Lymphomas

  2008cites this paper