SCIENCE@home

Copy Number Analysis Indicates Monoclonal Origin of Lethal Metastatic Prostate Cancer

Wennuan Liu,Sari Laitinen,Sofia Khan,M. Vihinen,J. Kowalski,Guoqiang Yu,Li Chen,C. Ewing,M. Eisenberger,M. Carducci,W. Nelson,S. Yegnasubramanian,Jun Luo,Yue Wang,Jianfeng Xu,W. Isaacs,T. Visakorpi,Steven G Bova

Published 2009 in Nature Medicine

ABSTRACT

Many studies have shown that primary prostate cancers are multifocal and are composed of multiple genetically distinct cancer cell clones. Whether or not multiclonal primary prostate cancers typically give rise to multiclonal or monoclonal prostate cancer metastases is largely unknown, although studies at single chromosomal loci are consistent with the latter case. Here we show through a high-resolution genome-wide single nucleotide polymorphism and copy number survey that most, if not all, metastatic prostate cancers have monoclonal origins and maintain a unique signature copy number pattern of the parent cancer cell while also accumulating a variable number of separate subclonally sustained changes. We find no relationship between anatomic site of metastasis and genomic copy number change pattern. Taken together with past animal and cytogenetic studies of metastasis and recent single-locus genetic data in prostate and other metastatic cancers, these data indicate that despite common genomic heterogeneity in primary cancers, most metastatic cancers arise from a single precursor cancer cell. This study establishes that genomic archeology of multiple anatomically separate metastatic cancers in individuals can be used to define the salient genomic features of a parent cancer clone of proven lethal metastatic phenotype.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-43 of 43 references · Page 1 of 1

CITED BY

Showing 1-100 of 716 citing papers · Page 1 of 8

12348
Next