Lipid peroxidation in hepatic steatosis in humans is associated with hepatic fibrosis and occurs predominately in acinar zone 3

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Journal of Gastroenterology and Hepatology

• Publication date

  2001-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1046/j.1440-1746.2001.02445.xPMID 11422610
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Hepatic lipid peroxidation in hereditary hemochromatosis and alcoholic liver injury.

  1999cited by this paper
• Fibrosis in chronic hepatitis C correlates significantly with body mass index and steatosis

  1999cited by this paper
• Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes.

  1998cited by this paper
• Contribution of hepatic parenchymal and nonparenchymal cells to hepatic fibrogenesis in biliary atresia.

  1998cited by this paper
• Heterozygosity for hereditary hemochromatosis is associated with more fibrosis in chronic hepatitis C

  1998cited by this paper
• Gadolinium chloride suppresses hepatic oval cell proliferation in rats with biliary obstruction.

  1998cited by this paper
• Steatohepatitis: a tale of two "hits"?

  1998cited by this paper
• Non-alcoholic steatohepatitis (NASH): a disease of emerging identity and importance.

  1998cited by this paper
• Hepatic stellate cells

  1998cited by this paper
• Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis.

  1998cited by this paper
• Hepatic stellate cell activation in genetic haemochromatosis. Lobular distribution, effect of increasing hepatic iron and response to phlebotomy.

  1997cited by this paper
• In situ detection of lipid peroxidation in chronic hepatitis C: correlation with pathological features.

  1997cited by this paper
• Excess iron induces hepatic oxidative stress and transforming growth factor β1 in genetic hemochromatosis

  1997cited by this paper
• Neutrophil‐derived superoxide anion induces lipid peroxidation and stimulates collagen synthesis in human hepatic stellate cells: Role of nitric oxide

  1997cited by this paper
• Hepatic stellate cell activation occurs in the absence of hepatitis in alcoholic liver disease and correlates with the severity of steatosis.

  1996cited by this paper
• Acute and chronic hepatic steatosis lead to in vivo lipid peroxidation in mice.

  1996cited by this paper
• Threshold effect of liver iron content on hepatic inflammation and fibrosis in hepatitis B and C.

  1996cited by this paper
• Hepatic stellate cells.

  1996cited by this paper
• Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression.

  1995cited by this paper
• Idiopathic steatohepatitis in childhood: a multicenter retrospective study.

  1995cited by this paper
• Experimental liver cirrhosis induced by alcohol and iron.

  1995cited by this paper
• Iron storage, lipid peroxidation and glutathione turnover in chronic anti-HCV positive hepatitis.

  1995cited by this paper
• TGF-beta and collagen-alpha 1 (I) gene expression are increased in hepatic acinar zone 1 of rats with iron overload.

  1994cited by this paper
• Covalent protein adducts in the liver as a result of ethanol metabolism and lipid peroxidation.

  1994cited by this paper
• Stimulation of collagen α1(I) gene expression is associated with lipid peroxidation in hepatocellular injury: A link to tissue fibrosis?

  1994cited by this paper
• Stimulation of lipid peroxidation or 4-hydroxynonenal treatment increases procollagen alpha 1 (I) gene expression in human liver fat-storing cells.

  1993cited by this paper
• Increased 4‐hydroxynonenal levels in experimental alcoholic liver disease: Association of lipid peroxidation with liver fibrogenesis

  1992cited by this paper
• Classification of chronic viral hepatitis: a need for reassessment.

  1991cited by this paper
• Malondialdehyde and 4-hydroxynonenal protein adducts in plasma and liver of rats with iron overload.

  1990cited by this paper
• Antisera and monoclonal antibodies specific for epitopes generated during oxidative modification of low density lipoprotein.

  1990cited by this paper
• Stimulation of collagen gene expression by ascorbic acid in cultured human fibroblasts. A role for lipid peroxidation?

  1989cited by this paper
• Chemotactic activity of hydroxyalkenals on rat neutrophils.

  1985cited by this paper

• Plasma levels of soluble PD-1, TIM-3, LAG-3 and galectin-3 and the degree of liver fibrosis in CHC and the impact of successful antiviral treatment on their levels

  2025cites this paper
• Regulated necrosis at the crossroads of liver inflammation and cancer development.

  2025cites this paper
• Metabolic Dysfunction-Associated Steatotic Liver Disease: An Overview of Pharmacotherapy

  2025cites this paper
• Polydopamine nanoparticles as a non-pharmaceutical tool in the treatment of fatty liver disease

  2024cites this paper
• Mapping the evolution of liver aging research: A bibliometric analysis

  2024cites this paper
• AGK2, a SIRT2 inhibitor, ameliorates D‐galactose‐induced liver fibrosis by inhibiting fibrogenic factors

  2024cites this paper
• Emerging role of ferroptosis in metabolic dysfunction-associated steatotic liver disease: revisiting hepatic lipid peroxidation

  2024cites this paper
• Iron scavenging and suppression of collagen cross-linking underlie antifibrotic effects of carnosine in the heart with obesity

  2024cites this paper
• New Approaches in Heart Research: Prevention Instead of Cardiomyoplasty?

  2023cites this paper
• Understanding NAFLD: From Case Identification to Interventions, Outcomes, and Future Perspectives

  2023cites this paper
• Role of ferroptosis in fibrosis: From mechanism to potential therapy

  2023cites this paper
• Excess iron intake induced liver injury: The role of gut-liver axis and therapeutic potential.

  2023cites this paper
• Manjari Medika Grape Seed Extract Protects Methotrexate-Induced Hepatic Inflammation: Involvement of NF-κB/NLRP3 and Nrf2/HO-1 Signaling System

  2023cites this paper
• Oxidative Stress and Redox Signaling in the Pathophysiology of Liver Diseases.

  2022cites this paper
• The impact of health status, diet and lifestyle on non‐alcoholic fatty liver disease: Narrative review

  2022cites this paper
• Silymarin for Treating Toxic Liver Disease: International Consensus Recommendations

  2022cites this paper
• Investigation of the Effect of Exendin-4 on Oleic Acid-Induced Steatosis in HepG2 Cells Using Fourier Transform Infrared Spectroscopy

  2022cites this paper
• Constructing biomimetic liver models through biomaterials and vasculature engineering

  2022cites this paper
• The antifibrotic effect of policosanol in CCl4-induced liver fibrosis in rats

  2022cites this paper
• Steatosis, Steatohepatitis and Related Conditions

  2021cites this paper
• Long-Term Aspartame Administration Leads to Fibrosis, Inflammasome Activation, and Gluconeogenesis Impairment in the Liver of Mice

  2021cites this paper
• Iron loading induces cholesterol synthesis and sensitizes endothelial cells to TNFα-mediated apoptosis

  2021cites this paper
• The Neglected Role of Bile Duct Epithelial Cells in NASH

  2021cites this paper
• Mast Cells Promote Nonalcoholic Fatty Liver Disease Phenotypes and Microvesicular Steatosis in Mice Fed a Western Diet

  2021cites this paper
• Mitochondrial disease disrupts hepatic allostasis and lowers the threshold for immune-mediated liver toxicity

  2020cites this paper
• Geometry of Nutrition: Nutrients and NAFLD Progression

  2020cites this paper
• Interaction between iron and omega-3 fatty acids metabolisms: where is the cross-link?

  2020cites this paper
• Pathophysiological, Molecular and Therapeutic Issues of Nonalcoholic Fatty Liver Disease: An Overview

  2019cites this paper
• In vitro protective effect of ascorbic acid against antibiotic-induced hepatotoxicity.

  2019cites this paper
• Production of extracellular lysophosphatidic acid in the regulation of adipocyte functions and liver fibrosis

  2018cites this paper
• A novel role for ceramide synthase 6 in mouse and human alcoholic steatosis

  2018cites this paper
• Recent Insights into the Pathogenesis of Nonalcoholic Fatty Liver Disease.

  2018cites this paper
• Elevated Nrf-2 responses are insufficient to mitigate protein carbonylation in hepatospecific PTEN deletion mice

  2018cites this paper
• miR-26a Potentially Contributes to the Regulation of Fatty Acid and Sterol Metabolism In Vitro Human HepG2 Cell Model of Nonalcoholic Fatty Liver Disease

  2018cites this paper
• Inhibitory effect of blue honeysuckle extract on high-fat-diet-induced fatty liver in mice

  2018cites this paper
• Micronutrients in Nonalcoholic Fatty Liver Disease Pathogenesis

  2018cites this paper
• Differential carbonylation of proteins in end‐stage human fatty and nonfatty NASH

  2017cites this paper
• Liver Disease in Patients on Total Parenteral Nutrition.

  2017cites this paper
• Metabolic adaptations in models of fatty liver disease: Of mice and math

  2017cites this paper
• Interacción colesterol-gangliósido GD3 en la fibrosis hepática

  2017cites this paper
• A computational model of hepatic energy metabolism: Understanding the role of zonation in the development and treatment of non-alcoholic fatty liver disease (NAFLD).

  2017cites this paper
• Mitochondrial Damage and Mitophagy in Ischemia/Reperfusion-Induced Liver Injury

  2017cites this paper
• Metabolic adaptations in models of fatty liver disease Hijmans

  2017cites this paper
• Epigenome-Wide Association Studies Provide Insight into the Pathogenesis of Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis.

  2017cites this paper
• STK25 is a critical determinant in nonalcoholic steatohepatitis.

  2016cites this paper
• STK25 is a critical determinant in nonalcoholic steatohepatitis

  2016cites this paper
• A retinoic acid receptor β2 agonist reduces hepatic stellate cell activation in nonalcoholic fatty liver disease

  2016cites this paper
• Iron and non-alcoholic fatty liver disease

  2016cites this paper
• Nutritional therapy for nonalcoholic fatty liver disease.

  2016cites this paper
• Lifestyle and biological risk factors for liver fibrosis in the Miami Adult Studies on HIV (MASH) cohort: An HIV infected and HIV/HCV co-infected population

  2016cites this paper
• Role of NADPH oxidases in the redox biology of liver fibrosis

  2015cites this paper
• Abalone Protein Hydrolysates: Preparation, Angiotensin I Converting Enzyme Inhibition and Cellular Antioxidant Activity.

  2015cites this paper
• The link between Hepatic Vitamin A Metabolism and Nonalcoholic Fatty Liver Disease.

  2015cites this paper
• The indole derivative NecroX‐7 improves nonalcoholic steatohepatitis in ob/ob mice through suppression of mitochondrial ROS/RNS and inflammation

  2015cites this paper
• Is nonalcoholic fatty liver disease an endogenous alcoholic fatty liver disease? - A mechanistic hypothesis.

  2015cites this paper
• Oxidative Stress in Chronic Viral Hepatitis

  2015cites this paper
• Exacerbation of Insulin Resistance and Hepatic Steatosis Deriving from Zinc Deficiency in Patients with HCV-Related Chronic Liver Disease

  2015cites this paper
• Association Studies of HFE C282Y and H63D Variants with Oral Cancer Risk and Iron Homeostasis Among Whites and Blacks

  2015cites this paper
• Type 2 diabetes mellitus: limitations of conventional therapies and intervention with nucleic acid-based therapeutics.

  2015cites this paper
• Experimental models of liver fibrosis

  2015cites this paper
• Is nonalcoholic fatty liver disease an endogenous alcoholic fatty liver disease? - A mechanistic hypothesis.

  2015cites this paper
• Zonation of glucose and fatty acid metabolism in the liver: mechanism and metabolic consequences.

  2014cites this paper
• A lipoperoxidação plasmática como preditor de esteatohepatite não alcoólica em obesos mórbidos com doença hepática gordurosa não alcoólica

  2014cites this paper
• Paraoxonase 1 and oxidative stress in paediatric non‐alcoholic steatohepatitis

  2014cites this paper
• Application of Screening Experimental Designs to Assess Chromatographic Isotope Effect upon Isotope-Coded Derivatization for Quantitative Liquid Chromatography–Mass Spectrometry

  2014cites this paper
• Chronic hepatitis C and liver fibrosis.

  2014cites this paper
• Oxidative stress and hepatic Nox proteins in chronic hepatitis C and hepatocellular carcinoma.

  2014cites this paper
• Protective Effect of Nigella Sativa Against Diabetic Complications on The Liver in White Male Rats

  2013cites this paper
• Pediatric nonalcoholic fatty liver disease.

  2013cites this paper
• Relaxin Treatment Reverses Insulin Resistance in Mice Fed a High-Fat Diet

  2013cites this paper
• Cellular basis of hepatic fibrosis and its role in inflammation and cancer.

  2013cites this paper
• Amelioration of hepatic inflammation in a mouse model of NASH using a dithiocarbamate derivative

  2013cites this paper
• Increased Serum Levels of Oxidative Stress Markers in Patients with Liver

  2013cites this paper
• Non-alcoholic steatohepatitis in morbidly obese patients.

  2013cites this paper
• The Transforming Growth Factor-Beta (TGF-β) in Liver Fibrosis

  2013cites this paper
• Combined effects of an antioxidant and caspase inhibitor on the reversal of hepatic fibrosis in rats

  2013cites this paper
• TGF-β in Human Disease

  2013cites this paper
• Relaxin Treatment Reverses Insulin Resistance in High Fat-Fed Mice Running title: Relaxin Reverses Insulin Resistance

  2013cites this paper
• Increased Serum Levels of Oxidative Stress Markers in Patients with Liver Steatosis

  2013cites this paper
• NASH is an Inflammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications

  2012cites this paper
• Heat Shock Protein 70 Expression is Increased in the Liver of Neonatal Intrauterine Growth Retardation Piglets

  2012cites this paper
• Water extract of Vitis coignetiae Pulliat leaves attenuates oxidative stress and inflammation in progressive NASH rats.

  2012cites this paper
• Iron Metabolism in Nonalcoholic Fatty Liver Disease

  2012cites this paper
• Pro‐oxidants or anti‐oxidant defenses? Which one to blame in non‐alcoholic steatohepatitis pathogenesis?

  2012cites this paper
• Cellular glutathione in fatty liver in vitro models.

  2011cites this paper
• Mechanisms of hepatic fibrogenesis.

  2011cites this paper
• Non-alcoholic fatty liver induces insulin resistance and metabolic disorders with development of brain damage and dysfunction

  2011cites this paper
• Hepatic Lipid Peroxidation and Cytochrome P-450 2E1 in Pediatric Nonalcoholic Fatty Liver Disease and Its Subtypes

  2011influential citation
• Non-alcoholic fatty liver disease: is iron relevant?

  2011cites this paper
• Oxidative stress and glutathione in TGF-beta-mediated fibrogenesis.

  2010cites this paper
• Bariatric Surgery-Induced Weight Loss Reduces Hepatic Lipid Peroxidation Levels and Affects Hepatic Cytochrome P-450 Protein Content

  2010cites this paper
• Programação metabólica: estudo de parâmetros indicadores de resistência à insulina e espécies reativas de oxigê nio em ratos.

  2010cites this paper
• Antifibrotic effects of CGX, a traditional herbal formula, and its mechanisms in rats.

  2010cites this paper
• Altered circadian rhythm of the clock genes in fibrotic livers induced by carbon tetrachloride

  2010cites this paper
• Physiological adaptability of Tibet chicken embryo liver to hypoxia and its protein profile analysis.

  2010cites this paper
• Iron homeostasis, hepatocellular injury, and fibrogenesis in hemochromatosis: the role of inflammation in a noninflammatory liver disease.

  2010cites this paper
• The role of iron in nonalcoholic fatty liver disease: the story continues.

  2010cites this paper
• Iron Homeostasis, Hepatocellular Injury, and Fibrogenesis in Hemochromatosis: The Role of Inflammation in a Noninflammatory Liver Disease

  2010cites this paper
• Intragastrically Applicated CCl4-Thiopental Sodium Enhanced Lipid Peroxidation and Liver Fibrosis (Cirrhosis) in Rat: Malonedialdehyde as a Parameter of Lipid Peroxidation Correlated with Hydroxyproline as a Parameter of Collagen Synthesis (Deposition)

  2009cites this paper
• The liver and the waistline: Fifty years of growth

  2009cites this paper