Coronavirus virulence genes with main focus on SARS-CoV envelope gene

Highlights • Coronaviruses have evolved proteins to counteract innate immune responses.• Several diseases induced by coronaviruses have an immunopathological origin.• SARS-CoV E protein is essential to induce an inflammatory response leading to death.• E protein amino-terminal, transmembrane and carboxy-terminal domains foster virulence.• E protein ion channel activity and PDZ domain binding motif promote edema, ARDS and disease.

• Publication year

  2014

• Venue

  Virus Research

• Publication date

  2014-08-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.virusres.2014.07.024PMID 25093995PMCID 4261026
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• The amino-terminal, transmembrane, and carboxy-terminal domains of SARS-CoV E protein foster virulence, and its ion channel activity plus PDZ domain binding motif promote edema, ARDS, and disease.

  Confidence 0.96

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewKiller Whale (322360f1c1) review
• SARS-CoV E protein is essential for inducing the inflammatory response associated with death.

  Confidence 0.97

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewKiller Whale (322360f1c1) review
• Several coronavirus-induced diseases have an immunopathological origin.

  Confidence 0.88

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewKiller Whale (322360f1c1) review
• Coronaviruses have evolved proteins that counter innate immune responses.

  Confidence 0.95

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewKiller Whale (322360f1c1) review

• amino-terminal domain

  protein domain

  The N-terminal region of the E protein discussed as one of its functional structural domains.

  Aliases: N-terminal domain

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewKiller Whale (322360f1c1) review
• ards

  syndrome

  Acute respiratory distress syndrome, a severe lung injury syndrome mentioned as a disease outcome.

  Aliases: acute respiratory distress syndrome

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewKiller Whale (322360f1c1) review
• carboxy-terminal domain

  protein domain

  The C-terminal region of the E protein discussed as one of its functional structural domains.

  Aliases: C-terminal domain

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewKiller Whale (322360f1c1) review
• coronaviruses

  virus family

  A family of enveloped RNA viruses discussed here as pathogens that encode proteins affecting host immunity and disease severity.

  Aliases: coronavirus

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewKiller Whale (322360f1c1) review
• death

  outcome

  The lethal outcome associated here with severe coronavirus-induced inflammatory disease.

  Aliases: mortality

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewKiller Whale (322360f1c1) review
• disease

  outcome

  The overall pathological condition resulting from coronavirus infection discussed in the abstract.

  Aliases: illness

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewKiller Whale (322360f1c1) review
• edema

  clinical sign

  Pathological fluid accumulation discussed as a disease manifestation linked to E protein functions.

  Aliases: oedema

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewKiller Whale (322360f1c1) review
• immunopathological origin

  pathogenesis concept

  A disease mechanism in which tissue damage and symptoms arise primarily from the host immune response.

  Aliases: immunopathology

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewKiller Whale (322360f1c1) review
• inflammatory response

  immune response

  The host inflammatory reaction induced in the context of SARS-CoV E protein virulence.

  Aliases: inflammation

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewKiller Whale (322360f1c1) review
• innate immune responses

  immune process

  The host's early, non-specific immune defenses that are targeted by viral proteins in this review.

  Aliases: innate immunity

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewKiller Whale (322360f1c1) review
• ion channel activity

  molecular activity

  The ability of the E protein to form or support ion-conducting activity across membranes.

  Aliases: viroporin activity

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewKiller Whale (322360f1c1) review
• pdz domain binding motif

  motif

  A short sequence motif in the E protein that interacts with host PDZ-domain-containing proteins.

  Aliases: PBM

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewKiller Whale (322360f1c1) review
• sars-cov e protein

  viral protein

  The envelope protein encoded by SARS coronavirus and examined here as a virulence factor.

  Aliases: SARS coronavirus envelope protein, E protein

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewKiller Whale (322360f1c1) review
• transmembrane domain

  protein domain

  The membrane-spanning region of the E protein discussed as part of its structure-function relationship.

  Aliases: TM domain

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewB (s683577b42) reviewKiller Whale (322360f1c1) review

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• Meteorological factors correlate with transmission of 2019-nCoV: Proof of incidence of novel coronavirus pneumonia in Hubei Province, China

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• A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug-Repurposing

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• Spiking Pandemic Potential: Structural and Immunological Aspects of SARS-CoV-2

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• Potential effects of curcumin in the treatment of COVID‐19 infection

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• Temporal evolution and adaptation of SARS-COV-2 codon usage

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• Corona virus versus existence of human on the earth: A computational and biophysical approach

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• COVID-19 Perfect Storm (Part I): Cytokine Release Syndrome in Aged People

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• A compendium answering 150 questions on COVID‐19 and SARS‐CoV‐2

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• Targeting the NLRP3 Inflammasome in Severe COVID-19

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• Immunology of COVID‐19: Mechanisms, clinical outcome, diagnostics, and perspectives—A report of the European Academy of Allergy and Clinical Immunology (EAACI)

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• SARS-CoV2 envelope protein: non-synonymous mutations and its consequences

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• Vaccine development against coronavirus (2003 to present): An overview, recent advances, current scenario, opportunities and challenges

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• Expansion of Single Cell Transcriptomics Data of SARS-CoV Infection in Human Bronchial Epithelial Cells to COVID-19

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• Role of the early secretory pathway in SARS-CoV-2 infection

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• Application of Bayesian phylogenetic inference modelling for evolutionary genetic analysis and dynamic changes in 2019-nCoV

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• Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection

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• Host-membrane interacting interface of the SARS coronavirus envelope protein: Immense functional potential of C-terminal domain

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• Pathogenetic profiling of COVID-19 and SARS-like viruses

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• Product of natural evolution (SARS, MERS, and SARS-CoV-2); deadly diseases, from SARS to SARS-CoV-2

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