The smad5 mutation somitabun blocks Bmp2b signaling during early dorsoventral patterning of the zebrafish embryo.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Development

• Publication date

  1999-05-15

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 10207140
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Strategies to perturb zebrafish development.

  1999cited by this paper
• Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo.

  1998cited by this paper
• SMADs: mediators and regulators of TGF-β signaling

  1998cited by this paper
• Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor.

  1998cited by this paper
• The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF‐β receptors

  1998cited by this paper
• The Drosophila Medea gene is required downstream of dpp and encodes a functional homolog of human Smad4.

  1998cited by this paper
• Smad 6 inhibits BMP / Smad 1 signaling by specifically competing with the Smad 4 tumor suppressor

  1998cited by this paper
• Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses.

  1998cited by this paper
• Follistatin and noggin are excluded from the zebrafish organizer.

  1998cited by this paper
• Smad2 role in mesoderm formation, left–right patterning and craniofacial development

  1998cited by this paper
• Mads and Smads in TGFβ signalling

  1998cited by this paper
• The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo.

  1998cited by this paper
• Mads and Smads in TGF beta signalling.

  1998cited by this paper
• SMADs: mediators and regulators of TGF-beta signaling.

  1998cited by this paper
• Ventral and lateral regions of the zebrafish gastrula, including the neural crest progenitors, are established by a bmp2b/swirl pathway of genes.

  1998cited by this paper
• The Drosophila gene Medea demonstrates the requirement for different classes of Smads in dpp signaling.

  1998cited by this paper
• A microsatellite genetic linkage map for zebrafish (Danio rerio)

  1998cited by this paper
• Patterning the Xenopus blastula.

  1997cited by this paper
• Mothers against dpp participates in a DDP/TGF-beta responsive serine-threonine kinase signal transduction cascade.

  1997cited by this paper
• Smad5 induces ventral fates in Xenopus embryo.

  1997cited by this paper
• Cloning and expression of three members of the zebrafish Bmp family: Bmp2a, Bmp2b and Bmp4.

  1997cited by this paper
• Daughters against dpp modulates dpp organizing activity in Drosophila wing development

  1997cited by this paper
• Signal transduction: Feedback from inhibitory SMADs

  1997cited by this paper
• Bmp-4 acts as a morphogen in dorsoventral mesoderm patterning in Xenopus.

  1997cited by this paper
• A polymorphic zebrafish line for genetic mapping using SSLPs on high-percentage agarose gels

  1997cited by this paper
• The zebrafish organizer requires chordino

  1997cited by this paper
• The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function.

  1997cited by this paper
• Antagonism within and around the organizer: BMP inhibitors in vertebrate body patterning.

  1997cited by this paper
• The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning.

  1997cited by this paper
• A structural basis for mutational inactivation of the tumour suppressor Smad4

  1997cited by this paper
• Xenopus Mad proteins transduce distinct subsets of signals for the TGF beta superfamily.

  1996cited by this paper
• Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye.

  1996cited by this paper
• MADR1, a MAD-related protein that functions in BMP2 signaling pathways.

  1996cited by this paper
• Receptor-associated Mad homologues synergize as effectors of the TGF-β response

  1996cited by this paper
• Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

  1996cited by this paper
• Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer

  1996cited by this paper
• A human Mad protein acting as a BMP-regulated transcriptional activator

  1996cited by this paper
• The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio.

  1996cited by this paper
• Bone morphogenetic protein-4 (BMP-4) acts during gastrula stages to cause ventralization of Xenopus embryos.

  1996cited by this paper
• Xenopus mad proteins transduce distinct subsets of signals for the TGFβ superfamily

  1996cited by this paper
• Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4.

  1996cited by this paper
• The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4.

  1996cited by this paper
• Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes.

  1996cited by this paper
• Xenopus mothers against decapentaplegic is an embryonic ventralizing agent that acts downstream of the BMP-2/4 receptor.

  1996cited by this paper
• dino and mercedes, two genes regulating dorsal development in the zebrafish embryo.

  1996cited by this paper
• DPC4, A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

  1996cited by this paper
• Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

  1996cited by this paper
• Genetic analysis of dorsoventral pattern formation in the zebrafish: requirement of a BMP-like ventralizing activity and its dorsal repressor.

  1996cited by this paper
• Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.

  1996cited by this paper
• Mutations affecting cell fates and cellular rearrangements during gastrulation in zebrafish.

  1996cited by this paper
• Centromere-linkage analysis and consolidation of the zebrafish genetic map.

  1996cited by this paper
• Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster.

  1995cited by this paper
• Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila.

  1995cited by this paper
• The zebrafish book : a guide for the laboratory use of zebrafish (Danio rerio)

  1995cited by this paper
• pXeX, a vector for efficient expression of cloned sequences in Xenopus embryos.

  1994cited by this paper
• Xenopus embryos regulate the nuclear localization of XMyoD.

  1994cited by this paper
• The zebrafish midblastula transition.

  1993cited by this paper
• Allele specific amplification by tetra-primer PCR.

  1992cited by this paper
• Cell-autonomous action of zebrafish spt-1 mutation in specific mesodermal precursors

  1990cited by this paper
• Site-directed mutagenesis by overlap extension using the polymerase chain reaction.

  1989cited by this paper
• Stability of RNA in developing Xenopus embryos and identification of a destabilizing sequence in TFIIIA messenger RNA.

  1988cited by this paper
• Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAs.

  1984cited by this paper

• BMP4 initiates and patterns ventral-caudal structures in zebrafish and human pluripotent stem cell aggregates

  2025cites this paper
• BMP–Smad1/9 signaling is required for PGC proliferation in zebrafish

  2025cites this paper
• Zebrafish Gastrulation.

  2025cites this paper
• Haploinsufficient variants in SMAD5 are associated with isolated congenital heart disease

  2025cites this paper
• Temporal regulation of endoderm convergence and extension by the BMP activity gradient through mesoderm-dependent and independent mechanisms.

  2025cites this paper
• Maternal provisioning and zygotic activation: transcriptomic dynamics of early atlantic halibut (Hippoglossus hippoglossus) embryogenesis

  2025cites this paper
• Transforming growth factor beta signaling and craniofacial development: modeling human diseases in zebrafish

  2024cites this paper
• Temporal dynamics of BMP/Nodal ratio drive tissue-specific gastrulation morphogenesis.

  2024cites this paper
• EpicTope: narrating protein sequence features to identify non-disruptive epitope tagging sites

  2024cites this paper
• Robust axis elongation by Nodal-dependent restriction of BMP signaling

  2023cites this paper
• Functional comparison of human ACVR1 and zebrafish Acvr1l FOP‐associated variants in embryonic zebrafish

  2023cites this paper
• A83-01 and DMH1 effects in the zebrafish spermatogonial niche: unraveling the roles of TGF-β and BMP signaling in the Fsh-mediated spermatogonial fate.

  2023cites this paper
• TGF-β and BMP subfamily pathways in zebrafish spermatogonial niche: A83-01 and DMH1 inhibitor effects in spermatogonial self-renewal and differentiation

  2022cites this paper
• Comprehensive maturity of nuclear pore complexes regulates zygotic genome activation.

  2022cites this paper
• Transmembrane anterior posterior transformation 1 regulates BMP signaling and modulates the protein stability of SMAD1/5

  2022cites this paper
• Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways

  2021cites this paper
• BMP Signaling: Lighting up the Way for Embryonic Dorsoventral Patterning

  2021cites this paper
• Germ layer patterning via morphogen crosstalk

  2020cites this paper
• Setting up for gastrulation in zebrafish.

  2020cites this paper
• ZMAT2, a newly-identified potential disease-causing gene in congenital radioulnar synostosis, modulates BMP signaling.

  2020cites this paper
• Proteolytic Restriction of Chordin Range Underlies BMP Gradient Formation

  2020cites this paper
• Temporal dynamics in the formation and interpretation of Nodal and BMP morphogen gradients.

  2020cites this paper
• The lateral plate mesoderm

  2020cites this paper
• bif1, a new BMP signaling inhibitor, regulates embryonic hematopoiesis in the zebrafish

  2019cites this paper
• A conserved regulatory program initiates lateral plate mesoderm emergence across chordates

  2019cites this paper
• ECM alterations in Fndc3a (Fibronectin Domain Containing Protein 3A) deficient zebrafish cause temporal fin development and regeneration defects

  2019cites this paper
• The evolution of molluscs

  2018cites this paper
• TGF-β Family Signaling in Early Vertebrate Development.

  2018cites this paper
• A conserved regulatory program drives emergence of the lateral plate mesoderm

  2018cites this paper
• Variant BMP receptor mutations causing fibrodysplasia ossificans progressiva (FOP) in humans show BMP ligand-independent receptor activation in zebrafish.

  2018cites this paper
• Vegetally localised Vrtn functions as a novel repressor to modulate bmp2b transcription during dorsoventral patterning in zebrafish

  2017cites this paper
• Vrtn functions as a novel repressor to modulate bmp 2 b transcription during dorsoventral patterning in zebrafish

  2017cites this paper
• Embryonic transplantation experiments: Past, present, and future.

  2017cites this paper
• Evolutionary developmental transition from median to paired morphology of vertebrate fins: Perspectives from twin-tail goldfish.

  2017cites this paper
• Vegetally localized Vrtn functions as a novel repressor to modulate bmp2b transcription during dorsoventral patterning in zebrafish

  2017cites this paper
• Vertebrate Axial Patterning: From Egg to Asymmetry.

  2017cites this paper
• Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway.

  2017cites this paper
• Brorin is required for neurogenesis, gliogenesis, and commissural axon guidance in the zebrafish forebrain

  2017cites this paper
• Goldfish morphology as a model for evolutionary developmental biology

  2016cites this paper
• Zebrafish kidney development.

  2016cites this paper
• Investigating the functional role of SMOC-1 in zebrafish

  2016cites this paper
• Antisense Oligonucleotide-Mediated Transcript Knockdown in Zebrafish

  2015cites this paper
• TGFβ1a regulates zebrafish posterior lateral line formation via Smad5 mediated pathway.

  2015cites this paper
• Taking the Middle Road: Vertebrate Mesoderm Formation and the Blastula-Gastrula Transition

  2015cites this paper
• Formation of the vertebrate embryo: Moving beyond the Spemann organizer.

  2015cites this paper
• Temporally coordinated signals progressively pattern the anteroposterior and dorsoventral body axes.

  2015cites this paper
• Etude fonctionnelle de l'induction neurale chez le céphalochordé Branchiostoma lanceolatum

  2014cites this paper
• Blood Induction and Embryonic Formation

  2014cites this paper
• The strength of SMAD1/5 activity determines the mode of stem cell division in the developing spinal cord

  2014cites this paper
• Extraembryonic signals under the control of MGA, Max, and Smad4 are required for dorsoventral patterning.

  2014cites this paper
• Bmp Suppression in Mangrove Killifish Embryos Causes a Split in the Body Axis

  2014cites this paper
• Novel bone morphogenetic protein signaling through Smad2 and Smad3 to regulate cancer progression and development

  2014cites this paper
• Transcriptional Factors Smad1 and Smad9 Act Redundantly to Mediate Zebrafish Ventral Specification Downstream of Smad5*

  2014cites this paper
• 3-OST-7 Regulates BMP-Dependent Cardiac Contraction

  2013cites this paper
• BMP-Smad 1/5/8 signalling in the development of the nervous system.

  2013cites this paper
• The role of BMP signalling in HSC ontogeny

  2013cites this paper
• Anteroposterior and dorsoventral patterning are coordinated by an identical patterning clock

  2013cites this paper
• Kidney organogenesis in the zebrafish: insights into vertebrate nephrogenesis and regeneration

  2013cites this paper
• Long-chain Acyl-CoA synthetase 4A regulates Smad activity and dorsoventral patterning in the zebrafish embryo.

  2013cites this paper
• The Integrator Complex Subunit 6 (Ints6) Confines the Dorsal Organizer in Vertebrate Embryogenesis

  2013cites this paper
• Araf kinase antagonizes Nodal-Smad2 activity in mesendoderm development by directly phosphorylating the Smad2 linker region

  2013cites this paper
• Characterisation of the role of canonical BMP-Smad 1/5/8 signalling in the development of ventral midbrain dopaminergic neurons

  2013influential citation
• Kzp controls canonical wnt8 signaling to modulate dorsoventral patterning during zebrafish gastrulation.

  2012cites this paper
• The dynamic role of bone morphogenetic proteins in neural stem cell fate and maturation

  2012cites this paper
• Protein phosphatase 4 cooperates with Smads to promote BMP signaling in dorsoventral patterning of zebrafish embryos.

  2012cites this paper
• Canonical BMP7 activity is required for the generation of discrete neuronal populations in the dorsal spinal cord

  2012cites this paper
• IGF binding protein 3 exerts its ligand-independent action by antagonizing BMP in zebrafish embryos

  2011cites this paper
• Zili Antagonizes Bmp Signaling to Regulate Dorsal-Ventral Patterning during Zebrafish Early Embryogenesis

  2011cites this paper
• The role of Smad signaling in hematopoiesis and translational hematology

  2011cites this paper
• Dynamic analysis of BMP‐responsive smad activity in live zebrafish embryos

  2011cites this paper
• Zebrafish eve1 regulates the lateral and ventral fates of mesodermal progenitor cells at the onset of gastrulation.

  2011cites this paper
• Maternal and zygotic control of zebrafish dorsoventral axial patterning.

  2011cites this paper
• FGF Signalling in Vertebrate Development

  2010cites this paper
• Maternal Control of Development in Vertebrates

  2010influential citation
• Kzp Controls Canonical wnt8 Signaling to Modulate Dorsoventral Patterning during Zebrafish Gastrulation*

  2010cites this paper
• Zebrafish kidney development.

  2010cites this paper
• The gene regulatory network basis of the "community effect," and analysis of a sea urchin embryo example.

  2010cites this paper
• Neurogenesis.

  2010cites this paper
• bmp2b and bmp4 are dispensable for zebrafish tooth development

  2010cites this paper
• Development of repressible sterility to prevent the establishment of feral populations of exotic and genetically modified animals.

  2009cites this paper
• Analysis of the arachidonyl-CoA synthetase ACSL4a as a potential regulator of BMP expression and of the role of BMPs in timing of cell commitment along the dorsoventral axis of the gastrulating zebrafish embryo

  2009influential citation
• Differential requirement for BMP signaling in atrial and ventricular lineages establishes cardiac chamber proportionality.

  2009cites this paper
• Developmental gene regulatory networks in the zebrafish embryo.

  2009cites this paper
• Disruption of embryonic development in common carp, Cyprinus carpio, and channel catfish, Ictalurus punctatus, via knock down of BMP2 gene for repressible transgenic sterilization

  2009cites this paper
• BMP inhibition initiates neural induction via FGF signaling and Zic genes

  2009cites this paper
• The Integrator subunits function in hematopoiesis by modulating Smad/BMP signaling

  2009cites this paper
• A Late Role for bmp2b in the Morphogenesis of Semicircular Canal Ducts in the Zebrafish Inner Ear

  2009cites this paper
• Identification of a BMP7 homolog in zebrafish expressed in developing organ systems.

  2008cites this paper
• Regulation of hematopoiesis by the BMP signaling pathway in adult zebrafish.

  2008cites this paper
• odd skipped related1 reveals a novel role for endoderm in regulating kidney versus vascular cell fate

  2008cites this paper
• Characterization of an associated protein kinase of the BMP type II receptor

  2008cites this paper
• The Role of Bone Morphogenetic Protein Mediated Signalling in the Neurogenic Niche of Adult Mouse brain

  2008cites this paper
• The BMP signaling gradient patterns dorsoventral tissues in a temporally progressive manner along the anteroposterior axis.

  2008cites this paper
• Mechanisms of brain ventricle development

  2008cites this paper
• Models of biological pattern formation: from elementary steps to the organization of embryonic axes.

  2008cites this paper
• The CCN family member Wisp3, mutant in progressive pseudorheumatoid dysplasia, modulates BMP and Wnt signaling.

  2007cites this paper
• Inactivation of serine protease Matriptase1a by its inhibitor Hai1 is required for epithelial integrity of the zebrafish epidermis

  2007influential citation
• Analysis of neural development using ligand-trap transgenic lines

  2007cites this paper
• The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesion.

  2007cites this paper
• Bone morphogenetic proteins in the early development of zebrafish

  2007cites this paper