Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Blood

• Publication date

  2009-05-28

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1182/blood-2008-10-185686PMID 19336759PMCID PMC2689054
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• VEGF receptors on chronic lymphocytic leukemia (CLL) B cells interact with STAT 1 and 3: implication for apoptosis resistance

  2010cited by this paper
• Chronic lymphocytic leukemia.

  2010cited by this paper
• Signal Transducer and Activator of Transcription 3 Is Required for Hypoxia-Inducible Factor-1α RNA Expression in Both Tumor Cells and Tumor-Associated Myeloid Cells

  2008cited by this paper
• MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis

  2008cited by this paper
• Widespread changes in protein synthesis induced by microRNAs

  2008cited by this paper
• Protocol for the fast chromatin immunoprecipitation (ChIP) method

  2006cited by this paper
• The biology and treatment of chronic lymphocytic leukemia.

  2006cited by this paper
• Transcriptional regulation of the Vascular Endothelial Growth Factor gene--a concert of activating factors.

  2005cited by this paper
• HIF-1α, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas

  2005cited by this paper
• A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia.

  2005cited by this paper
• VEGF receptors on chronic lymphocytic leukemia (CLL) B cells interact with STAT 1 and 3: implication for apoptosis resistance

  2005cited by this paper
• Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element.

  2005cited by this paper
• A recombinant IL-4-Pseudomonas exotoxin inhibits protein synthesis and overcomes apoptosis resistance in human CLL B cells.

  2005cited by this paper
• Angiogenic inhibitors: a new therapeutic strategy in oncology

  2005cited by this paper
• Distinct aerobic and hypoxic mechanisms of HIF-α regulation by CSN5

  2004cited by this paper
• Distinct aerobic and hypoxic mechanisms of HIF-alpha regulation by CSN5.

  2004cited by this paper
• VEGF receptor phosphorylation status and apoptosis is modulated by a green tea component, epigallocatechin-3-gallate (EGCG), in B-cell chronic lymphocytic leukemia.

  2004cited by this paper
• HIFs and tumors--causes and consequences.

  2004cited by this paper
• Chronic lymphocytic leukemia.

  2004cited by this paper
• Vascular Endothelial Growth Factor Transcriptional Activation Is Mediated by Hypoxia-inducible Factor 1α, HDM2, and p70S6K1 in Response to Phosphatidylinositol 3-Kinase/AKT Signaling*

  2004cited by this paper
• Mutation of the von Hippel‐Lindau (VHL) gene in human colorectal carcinoma: Association with cytoplasmic accumulation of hypoxia‐inducible factor (HIF)‐1α

  2004cited by this paper
• MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias.

  2004cited by this paper
• Histone Deacetylase 7 Associates with Hypoxia-inducible Factor 1α and Increases Transcriptional Activity*

  2004cited by this paper
• Exploitation of the HIF axis for cancer therapy

  2004cited by this paper
• Antiangiogenic therapy and tumor progression.

  2004cited by this paper
• Differential activation of vascular genes by hypoxia in primary endothelial cells.

  2004cited by this paper
• Hypoxia-induced angiogenesis during carcinogenesis.

  2003cited by this paper
• Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis

  2003cited by this paper
• Hypoxia-Inducible Factor 1 Regulates Vascular Endothelial Growth Factor Expression in Human Pancreatic Cancer

  2003cited by this paper
• Regulation of angiogenesis by hypoxia: role of the HIF system

  2003cited by this paper
• Targeting HIF-1 for cancer therapy

  2003cited by this paper
• HIF prolyl‐hydroxylase 2 is the key oxygen sensor setting low steady‐state levels of HIF‐1α in normoxia

  2003cited by this paper
• Biology and treatment of chronic lymphocytic leukemia.

  2003cited by this paper
• VEGF expression in human macrophages is NF-κB-dependent: studies using adenoviruses expressing the endogenous NF-κB inhibitor IκBα and a kinase-defective form of the IκB kinase 2

  2003cited by this paper
• The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis.

  2003cited by this paper
• Constitutively activated phosphatidylinositol-3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: association with protein kinase Cdelta.

  2002cited by this paper
• Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

  2002cited by this paper
• Current and developing chemotherapy for CLL

  2002cited by this paper
• B-CLL cells are capable of synthesis and secretion of both pro- and anti-angiogenic molecules

  2002cited by this paper
• A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF

  2001cited by this paper
• Constitutive expression of hypoxia-inducible factor-1alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation.

  2001cited by this paper
• Regulation of glut1 mRNA by Hypoxia-inducible Factor-1

  2001cited by this paper
• In vitro and in vivo production of vascular endothelial growth factor by chronic lymphocytic leukemia cells.

  2000cited by this paper
• Hyperinducibility of hypoxia-responsive genes without p53/p21-dependent checkpoint in aggressive prostate cancer.

  2000cited by this paper
• Increased bone marrow angiogenesis in B cell chronic lymphocytic leukemia

  2000cited by this paper
• Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300.

  1999cited by this paper
• Increased serum levels of vascular endothelial growth factor predict risk of progression in early B‐cell chronic lymphocytic leukaemia

  1999cited by this paper
• Recruitment of CBP/p300 by the IFNβ Enhanceosome Is Required for Synergistic Activation of Transcription

  1998cited by this paper
• B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues.

  1997cited by this paper
• Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

  1996cited by this paper
• An essential role for p300/CBP in the cellular response to hypoxia.

  1996cited by this paper
• p300, and p300-associated proteins, are components of TATA-binding protein (TBP) complexes.

  1993cited by this paper

• Exploring the role of microRNA-155 as a biomarker and regulatory modulator of target genes in metabolic syndrome.

  2026cites this paper
• Regulatory networks of HIFs in tumor-infiltrating immune cells: From molecular mechanisms to therapeutic implications (Review)

  2026cites this paper
• Hypoxia-adenosinergic regulation of B cell responses

  2024cites this paper
• Diagnostic, prognostic, and therapeutic potential of exosomal microRNAs in renal cancer

  2024cites this paper
• MiR-155 deficiency and hypoxia results in metabolism switch in the leukemic B-cells

  2024cites this paper
• Metabolic reprogramming in the CLL TME; potential for new therapeutic targets.

  2024cites this paper
• Inflammation mediated angiogenesis in chronic lymphocytic leukemia

  2024cites this paper
• Tamoxifen exerts anti-peritoneal fibrosis effects by inhibiting H19-activated VEGFA transcription

  2023cites this paper
• miRNAs as cornerstones in chronic lymphocytic leukemia pathogenesis and therapeutic resistance- An emphasis on the interaction of signaling pathways.

  2023cites this paper
• LDHA: The Obstacle to T cell responses against tumor

  2022cites this paper
• iASPP is essential for HIF-1α stabilization to promote angiogenesis and glycolysis via attenuating VHL-mediated protein degradation

  2022cites this paper
• Splenic Marginal Zone B Lymphocytes Regulate Cardiac Remodeling After Acute Myocardial Infarction in Mice.

  2022cites this paper
• Hypoxic stress and hypoxia-inducible factors in leukemias

  2022cites this paper
• One Omics Approach Does Not Rule Them All: The Metabolome and the Epigenome Join Forces in Haematological Malignancies

  2021influential citation
• Targeting HIF-1α Regulatory Pathways as a Strategy to Hamper Tumor-Microenvironment Interactions in CLL

  2021cites this paper
• The Complexity of the Tumor Microenvironment and Its Role in Acute Lymphoblastic Leukemia: Implications for Therapies

  2021cites this paper
• Epigenetic Regulation of miR-92a and TET2 and Their Association in Non-Hodgkin Lymphoma

  2021cites this paper
• miRNAs Involved in Esophageal Carcinogenesis and miRNA-Related Therapeutic Perspectives in Esophageal Carcinoma

  2021cites this paper
• Hypoxia-Induced LXRα Contributes to the Migration and Invasion of Gastric Cancer Cells.

  2021cites this paper
• HIF-1฀ is overexpressed in leukemic cells from TP53-disrupted patients and is a promising therapeutic target in chronic lymphocytic leukemia

  2021cites this paper
• Breakthrough Science: Hypoxia-Inducible Factors, Oxygen Sensing, and Disorders of Hematopoiesis.

  2021cites this paper
• Modulation of cytokine production by monocytes and developing‐dendritic cells under the influence of leukemia and lymphoma cell products

  2020cites this paper
• HIF-1α: a potential treatment target in chronic lymphocytic leukemia

  2020cites this paper
• Non-Coding RNAs as Cancer Hallmarks in Chronic Lymphocytic Leukemia

  2020cites this paper
• Stem cell factor Is implicated In microenvironmental interactions and cellular dynamics of chronic lymphocytic leukemia.

  2020cites this paper
• Structural and functional regulation of lactate dehydrogenase-A in cancer.

  2020cites this paper
• Role of Non-Coding RNAs in the Development of Targeted Therapy and Immunotherapy Approaches for Chronic Lymphocytic Leukemia

  2020influential citation
• Ionizing Radiation-inducible microRNA-21 Induces Angiogenesis by Directly Targeting PTEN

  2019cites this paper
• Association of GRP78, HIF-1α and BAG3 Expression with the Severity of Chronic Lymphocytic Leukemia.

  2019cites this paper
• Micromanaging aerobic respiration and glycolysis in cancer cells

  2019cites this paper
• Extracellular Vesicles as Transmitters of Hypoxia Tolerance in Solid Cancers

  2019cites this paper
• HIF-1α is over-expressed in leukemic cells from TP53-disrupted patients and is a promising therapeutic target in chronic lymphocytic leukemia

  2019cites this paper
• Hypoxia-inducible factors promote breast cancer stem cell specification and maintenance in response to hypoxia or cytotoxic chemotherapy.

  2019cites this paper
• HIF-1a is overexpressed in leukemic cells from TP53-disrupted patients and is a promising therapeutic target in chronic lymphocytic leukemia

  2019cites this paper
• HIF-α factors as potential therapeutic targets in leukemia

  2018cites this paper
• The Ins and Outs of Autophagy and Metabolism in Hematopoietic and Leukemic Stem Cells: Food for Thought

  2018influential citation
• Chronic Lymphocytic Leukemia

  2018cites this paper
• Expression of VHL tumor suppressor mRNA and miR-92a in papillary thyroid carcinoma and their correlation with clinical and pathological parameters

  2018cites this paper
• microRNA as a systemic intervention in the specific breast cancer subtypes with C‐MYC impacts; introducing subtype‐based appraisal tool

  2018cites this paper
• State of the art in microRNA as diagnostic and therapeutic biomarkers in chronic lymphocytic leukemia

  2018cites this paper
• Hypoxia and B cells.

  2017cites this paper
• mRNA overexpression of the hypoxia inducible factor 1 alpha subunit gene (HIF1A): An independent predictor of poor overall survival in chronic lymphocytic leukemia.

  2017cites this paper
• Integration of hypoxic HIF-α signaling in blood cancers

  2017cites this paper
• Exosome-derived microRNAs in cancer metabolism: possible implications in cancer diagnostics and therapy

  2017cites this paper
• Differences in genetic and epigenetic alterations between von Hippel–Lindau disease–related and sporadic hemangioblastomas of the central nervous system

  2017cites this paper
• MIR-92 stimulates VEGF by inhibiting von Hippel-Lindau gene product in epithelial ovarian cancer.

  2017cites this paper
• A randomized phase II trial comparing chemoimmunotherapy with or without bevacizumab in previously untreated patients with chronic lymphocytic leukemia

  2016cites this paper
• MIRNA-BASED METABOLIC MODULATION IN GLIOBLASTOMA CELLS: A STRATEGY TO SURPASS TUMOR CHEMORESISTANCE

  2016cites this paper
• LYMPHOID NEOPLASIA HIF-1 a regulates the interaction of chronic lymphocytic leukemia cells with the tumor microenvironment

  2016cites this paper
• SOXC and MiR17‐92 gene expression profiling defines two subgroups with different clinical outcome in mantle cell lymphoma

  2016cites this paper
• MicroRNA in Metabolic Re-Programming and Their Role in Tumorigenesis

  2016cites this paper
• MicroRNA-92 promotes invasion and chemoresistance by targeting GSK3β and activating Wnt signaling in bladder cancer cells

  2016cites this paper
• Adenosine signaling mediates hypoxic responses in the chronic lymphocytic leukemia microenvironment.

  2016cites this paper
• Dynamic regulation of stem cell specification and maintenance by hypoxia-inducible factors.

  2016cites this paper
• HIF-1α regulates the interaction of chronic lymphocytic leukemia cells with the tumor microenvironment.

  2016cites this paper
• Tris (dibenzylideneacetone) dipalladium: a small-molecule palladium complex is effective in inducing apoptosis in chronic lymphocytic leukemia B-cells

  2016cites this paper
• Signaling and molecular basis of bone marrow niche angiogenesis in leukemia

  2016influential citation
• Effect of hypoxia-inducible factors in normal and leukemic stem cell regulation and their potential therapeutic impact

  2016influential citation
• Metabolic plasticity in CLL: adaptation to the hypoxic niche

  2015cites this paper
• Coordinate regulation of residual bone marrow function by paracrine trafficking of AML exosomes

  2015cites this paper
• Searching for diabetic retinopathy genetic markers by whole exome sequencing

  2015cites this paper
• Phase II study of pazopanib as second-line treatment after sunitinib in patients with metastatic renal cell carcinoma: a Southern China Urology Cancer Consortium Trial.

  2015cites this paper
• MicroRNAs in the Regulation of Cellular Stress Responses

  2015cites this paper
• Biology of the bone marrow microenvironment and myelodysplastic syndromes.

  2015cites this paper
• Endothelin-converting enzyme is a plausible target gene for hypoxia-inducible factor.

  2015cites this paper
• MDR1 will play a key role in pharmacokinetic changes under hypoxia at high altitude and its potential regulatory networks

  2015cites this paper
• Interactional role of microRNAs and bHLH-PAS proteins in cancer (Review).

  2015cites this paper
• Hypoxia-inducible factor-1alpha in hepatic fibrosis: A promising therapeutic target.

  2015cites this paper
• MicroRNAs in the pathogenesis of cystic kidney disease

  2015cites this paper
• The MIR-17-92 Cluster Contributes to MLL Leukemia Development Through the Repression of the Meis1 Competitor Pknox1

  2015cites this paper
• microRNA and Chronic Lymphocytic Leukemia.

  2015cites this paper
• RETRACTED CHAPTER: Molecular Testing in Adult Kidney Tumors

  2014cites this paper
• The Role of Hypoxia and Exploitation of the Hypoxic Environment in Hematologic Malignancies

  2014cites this paper
• Gambogic acid suppresses hypoxia-induced hypoxia-inducible factor-1α/vascular endothelial growth factor expression via inhibiting phosphatidylinositol 3-kinase/Akt/mammalian target protein of rapamycin pathway in multiple myeloma cells

  2014cites this paper
• MicroRNA regulation of cancer metabolism: role in tumour suppression.

  2014cites this paper
• Role of microRNAs in B cell leukemias and lymphomas.

  2014cites this paper
• Targeting Cell Metabolism in Chronic Lymphocytic Leukaemia (cll); Aviable Therapeutic Approach?

  2014cites this paper
• MicroRNAs as regulators of mitochondrial function: role in cancer suppression.

  2014cites this paper
• miR-92a family and their target genes in tumorigenesis and metastasis.

  2014cites this paper
• Physiological and Pharmacological Regulation of the STAT3 Pathway in Cancer

  2013cites this paper
• c-myc but not Hif-1α-dependent downregulation of VEGF influences the proliferation and differentiation of HL-60 cells induced by ATRA.

  2013cites this paper
• Hypoxia: a master regulator of microRNA biogenesis and activity.

  2013cites this paper
• MicroRNAs as Biomarkers in Cancer

  2013cites this paper
• HIF-1α of Bone Marrow Endothelial Cells Implies Relapse and Drug Resistance in Patients with Multiple Myeloma and May Act as a Therapeutic Target

  2013cites this paper
• Stable tumor vessel normalization with pO2 increase and endothelial PTEN activation by inositol trispyrophosphate brings novel tumor treatment

  2013cites this paper
• Friend or foe: the role of microRNA in chemotherapy resistance

  2013cites this paper
• The Warburg effect: insights from the past decade.

  2013cites this paper
• In vivo evidence suggesting reciprocal renal hypoxia‐inducible factor‐1 upregulation and signal transducer and activator of transcription 3 activation in response to hypoxic and non‐hypoxic stimuli

  2013cites this paper
• Critical signal transduction pathways in CLL.

  2013cites this paper
• Fcγ Receptor-induced Soluble Vascular Endothelial Growth Factor Receptor-1 (VEGFR-1) Production Inhibits Angiogenesis and Enhances Efficacy of Anti-tumor Antibodies*

  2013cites this paper
• Signaling of miRNAs-FOXM1 in cancer and potential targeted therapy.

  2013cites this paper
• Cited2 in hematopoietic stem cell function

  2013cites this paper
• Epigenetic regulation of hypoxia inducible factor in diseases and therapeutics

  2013cites this paper
• Hematological malignancies: role of miRNAs and their in silico aspects

  2013cites this paper
• Kidney Cancer Genomics: Paving the Road to a New Paradigm of Personalized Medicine

  2013cites this paper
• P53 responses to fludarabine in human B-lymphoid cancers

  2013cites this paper
• protein-coding genes Chronic lymphocytic leukemia: interplay between noncoding RNAs and

  2013cites this paper
• miRNAs link metabolic reprogramming to oncogenesis.

  2013cites this paper
• Overexpression of miR-92a correlates with tumor metastasis and poor prognosis in patients with colorectal cancer

  2012cites this paper
• Adapting to Hypoxia: Lessons from Vascular Endothelial Growth Factor

  2012cites this paper