Rapid and reversible secretion changes during uncoupling of rat insulin-producing cells.

No abstract is available for this paper.

• Publication year

  1990

• Venue

  Journal of Clinical Investigation

• Publication date

  1990-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1172/JCI114772PMID 1697604PMCID PMC296790
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effect of several uncouplers of cell-to-cell communication on gap junction morphology in mammalian heart

  2006cited by this paper
• Effects of n‐alcohols on junctional coupling and amylase secretion of pancreatic acinar cells

  1989cited by this paper
• Homologous but not heterologous contact increases the insulin secretion of individual pancreatic B-cells.

  1989cited by this paper
• The gap junction: a channel for multiple functions?

  1988cited by this paper
• A diffusion-adsorption model for the computation of the amount of hormone around a secreting cell, detected by the reverse hemolytic plaque assay.

  1988cited by this paper
• Guanine nucleotides induce Ca2+-independent insulin secretion from permeabilized RINm5F cells.

  1987cited by this paper
• Rapid in vitro formation of smooth endoplasmic reticulum aggregates within peptide‐producing islet cells

  1987cited by this paper
• Ca2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion.

  1987cited by this paper
• Gap junctional coupling modulates secretion of exocrine pancreas.

  1987cited by this paper
• Second messenger function of inositol 1,4,5-trisphosphate. Early changes in inositol phosphates, cytosolic Ca2+, and insulin release in carbamylcholine-stimulated RINm5F cells.

  1986cited by this paper
• Blockage of cell-to-cell communication within pancreatic acini is associated with increased basal release of amylase

  1986cited by this paper
• Direct Identification of Electrophysiologically Monitored Cells Within Intact Mouse Islets of Langerhans

  1986cited by this paper
• Heterogeneity and contact-dependent regulation of hormone secretion by individual B cells.

  1986cited by this paper
• Signal transduction in insulin secretion: comparison between fuel stimuli and receptor agonists.

  1986cited by this paper
• Physiology and pharmacology of gap junctions.

  1985cited by this paper
• Reversible effects of heptanol on gap junction structure and cell-to-cell electrical coupling.

  1984cited by this paper
• In Vivo Modulation of Gap Junctions and Dye Coupling Between B-Cells of the Intact Pancreatic Islet

  1983cited by this paper
• Stimulus-secretion coupling in beta-cells: modulation by pH.

  1983cited by this paper
• The possible importance of contact between pancreatic islet cells for the control of insulin release.

  1982cited by this paper
• Responses of Neonatal Rat Islets to Streptozotocin: Limited B-Cell Regeneration and Hyperglycemia

  1981cited by this paper
• Junctional intercellular communication: the cell-to-cell membrane channel.

  1981cited by this paper
• Interaction of anaesthetics with electrical synapses

  1980cited by this paper
• Continuous, clonal, insulin- and somatostatin-secreting cell lines established from a transplantable rat islet cell tumor.

  1980cited by this paper
• Increase of gap junctions between pancreatic B-cells during stimulation of insulin secretion

  1979cited by this paper
• Plaque Forming Cells: Methodology and Theory

  1974cited by this paper
• Structural coupling between pancreatic islet cells

  1973cited by this paper
• Decreased Sensitivity of the Pancreatic Beta Cells to Glucose in Prediabetic and Diabetic Subjects: A Glucose Dose-Response Study

  1972cited by this paper

• Crosstalk Communications Between Islets Cells and Insulin Target Tissue: The Hidden Face of Iceberg

  2022cites this paper
• Intercellular Communication in the Islet of Langerhans in Health and Disease.

  2021cites this paper
• Fabrication of functional rat pseudo‐islets after cryopreservation of pancreatic islets or dispersed islet cells

  2021cites this paper
• The Pancreatic β-Cell: The Perfect Redox System

  2021cites this paper
• Physiology of pancreatic β-cells: Ion channels and molecular mechanisms implicated in stimulus-secretion coupling.

  2021cites this paper
• Metabolic and functional heterogeneity in pancreatic β cells.

  2020cites this paper
• Diffusion of metabolites across gap junctions mediates metabolic coordination of β-islet cells

  2020cites this paper
• Title: Engineering Functional Pseudo-Islets of Defined Sizes from Primary Murine Cells Using PEG Microwell Devices Authors/Affiliations

  2020cites this paper
• Engineering Functional Pseudo-Islets of Defined Sizes from Primary Murine Cells Using PEG Microwell Devices

  2020cites this paper
• Comparative studies on the roles of calcium ions and gap Junctions in the regulation of secretory and contractile processes: Biochemical and pharmacologic approaches

  2019cites this paper
• β-cell dedifferentiation is associated with epithelial-mesenchymal transition triggered by miR-7-mediated repression of mSwi/Snf complex

  2019cites this paper
• Human Pluripotent Stem Cells and CRISPR-Cas9 Genome Editing to Model Diabetes

  2018cites this paper
• Gap junction proteins are key drivers of endocrine function.

  2018cites this paper
• Genetic and molecular studies in hyperinsulinemic hypoglycemia and congenital polycystic kidney disease (HIPKD)

  2018cites this paper
• Gap-junction coupling and ATP-sensitive potassium channels in human β-cell clusters: Effects on emergent dynamics.

  2017cites this paper
• Electrical Synapses and Neuroendocrine Cell Function

  2017cites this paper
• Local and regional control of calcium dynamics in the pancreatic islet

  2017cites this paper
• Relations intercellulaires dans les îlots de Langerhans et leur rôle dans la sécrétion du glucagon

  2017cites this paper
• Ionic imbalance, in addition to molecular crowding, abates cytoskeletal dynamics and vesicle motility during hypertonic stress

  2015cites this paper
• Pseudoislet formation enhances gene expression, insulin secretion and cytoprotective mechanisms of clonal human insulin-secreting 1.1B4 cells

  2015cites this paper
• Generation and function of glucose-responsive insulin producing cells derived from human induced pluripotent stem cells

  2015cites this paper
• The Edges of Pancreatic Islet β Cells Constitute Adhesive and Signaling Microdomains.

  2015cites this paper
• Role of topology in complex functional networks of beta cells.

  2015cites this paper
• Slow potentials encode intercellular coupling and insulin demand in pancreatic beta cells

  2015cites this paper
• Everolimus Improves Microcirculatory Derangements in Experimental Postischemic Pancreatitis Modulating the Expression of Vascular Endothelial Growth Factor, Interleukin 6, and Toll-Like Receptor 4

  2015cites this paper
• Role of Connexins and Pannexins in the Pancreas.

  2015cites this paper
• Involvement of RhoA/ROCK in insulin secretion of pancreatic β-cells in 3D culture

  2014cites this paper
• Signaux électriques des îlots pancréatiques enregistrés sur matrices de microélectrodes : caractérisation et application au phénotypage d'animaux transgéniques

  2014cites this paper
• Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells

  2014cites this paper
• Phase transitions in pancreatic islet cellular networks and implications for type-1 diabetes.

  2014cites this paper
• Membranes to achieve immunoprotection of transplanted islets.

  2014cites this paper
• Caracterización funcional de hemicanales y su implicación en el mecamismo de secreción de insulina

  2013cites this paper
• Entering the era of nanoscience: time to be so small.

  2013cites this paper
• Protein-Mediated Interactions of Pancreatic Islet Cells

  2013cites this paper
• A stochastic mathematical model to study the autoimmune progression towards type 1 diabetes

  2013cites this paper
• Functional Connectivity in Islets of Langerhans from Mouse Pancreas Tissue Slices

  2013cites this paper
• Connexins and b-cell functions

  2013cites this paper
• Connexins and β-cell functions.

  2013cites this paper
• Insulin Trafficking in a Glucose Responsive Engineered Human Liver Cell Line is Regulated by the Interaction of ATP-Sensitive Potassium Channels and Voltage-Gated Calcium Channels

  2013cites this paper
• Size-controlled insulin-secreting cell clusters.

  2012cites this paper
• Connexin-dependent signaling in neuro-hormonal systems.

  2012cites this paper
• The anti-ulcer agent, irsogladine, increases insulin secretion by MIN6 cells.

  2012cites this paper
• Enhanced the Insulin Secretion of HIT-T15 Cells by Hyaluronic Acid-Coating Involves Cytosolic Free [Ca2+]i Response

  2011cites this paper
• Connexin Implication in the Control of the Murine Beta-Cell Mass

  2011cites this paper
• Connexins: key mediators of endocrine function.

  2011influential citation
• Differentiation of human embryonic stem cells into pancreatic endoderm in patterned size-controlled clusters.

  2011cites this paper
• Patterning of mono- and multilayered pancreatic beta-cell clusters.

  2010cites this paper
• Beta cell coupling and connexin expression change during the functional maturation of rat pancreatic islets

  2010cites this paper
• Cx36 makes channels coupling human pancreatic b-cells, and correlates with insulin expression

  2009cites this paper
• Connexin36 : a novel therapeutic target to correct beta-cell dysfunctions ?

  2009influential citation
• Connexins, diabetes and the metabolic syndrome.

  2009cites this paper
• Cx36 makes channels coupling human pancreatic beta-cells, and correlates with insulin expression.

  2009cites this paper
• Insulin secretion from human beta cells is heterogeneous and dependent on cell-to-cell contacts

  2008cites this paper
• Gap Junctions and Insulin Secretion

  2008cites this paper
• Islet‐cell‐to‐cell communication as basis for normal insulin secretion

  2007cites this paper
• Cx36-Mediated Coupling Reduces β-Cell Heterogeneity, Confines the Stimulating Glucose Concentration Range, and Affects Insulin Release Kinetics

  2007cites this paper
• Novel Function of the Ciliogenic Transcription Factor RFX3 in Development of the Endocrine Pancreas

  2007cites this paper
• Beta cells preferentially exchange cationic molecules via connexin 36 gap junction channels

  2007cites this paper
• Implication des connexions dans les effets de l'ischémie cardiaque

  2007cites this paper
• Dexamethasone-induced insulin resistance is associated with increased connexin 36 mRNA and protein expression in pancreatic rat islets.

  2007cites this paper
• Inhibition of Insulin Secretion by Betagranin, an N-terminal Chromogranin A Fragment*

  2007cites this paper
• Interleukin-1 receptor antagonist is upregulated during diet-induced obesity and regulates insulin sensitivity in rodents

  2006cites this paper
• Connexin36 and pancreatic beta-cell functions.

  2006cites this paper
• MIN6 beta-cell-beta-cell interactions influence insulin secretory responses to nutrients and non-nutrients.

  2006cites this paper
• Connexin36 and pancreatic β-cell functions

  2006cites this paper
• The effect of hyaluronic acid on insulin secretion in HIT-T15 cells through the enhancement of gap-junctional intercellular communications.

  2006cites this paper
• MIN6 β-cell-β-cell interactions influence insulin secretory responses to nutrients and non-nutrients

  2006cites this paper
• Role of insulin in glucose-stimulated insulin secretion in beta cells.

  2005cites this paper
• Connexin Modulators of Endocrine Function

  2005cites this paper
• Co-expression and regulation of connexins 36 and 43 in cultured neonatal rat pancreatic islets.

  2005cites this paper
• Involvement of gap junctional communication in secretion.

  2005cites this paper
• Differentiating the effects of Cx36 and E-cadherin for proper insulin secretion of MIN6 cells.

  2004cites this paper
• Electrophysiological characterization of insulin secreting beta-cells in pancreatic tissue slices

  2004cites this paper
• Pax2 mutant mice display increased number and size of islets of Langerhans but no change in insulin and glucagon content.

  2004cites this paper
• Upregulation of the expression of tight and adherens junction-associated proteins during maturation of neonatal pancreatic islets in vitro

  2004cites this paper
• Estimating and eliminating junctional current in coupled cell populations by leak subtraction. A computational study

  2004cites this paper
• Cell-specific Ca(2+) responses in glucose-stimulated single and aggregated beta-cells.

  2003cites this paper
• ATP-Dependent Mechanism for Coordination of Intercellular Ca2+ Signaling and Renin Secretion in Rat Juxtaglomerular Cells

  2003cites this paper
• On-line analysis of gap junctions reveals more efficient electrical than dye coupling between islet cells.

  2003cites this paper
• Connexin 36 controls synchronization of Ca2+ oscillations and insulin secretion in MIN6 cells.

  2003cites this paper
• Lentivirus-mediated transduction of connexin cDNAs shows level- and isoform-specific alterations in insulin secretion of primary pancreaticβ -cells

  2003cites this paper
• Connexin-36 Contributes to Control Function of Insulin-producing Cells*

  2003cites this paper
• Cell-specific Ca2+ responses in glucose-stimulated single and aggregated ß-cells

  2003cites this paper
• Co-ordinated Ca(2+)-signalling within pancreatic islets: does beta-cell entrainment require a secreted messenger.

  2002cites this paper
• Molecular Basis for Pacemaker Cells in Epithelia*

  2002cites this paper
• Connexins and secretion

  2002cites this paper
• Overexpression of dominant-negative mutant hepatocyte nuclear fctor-1 alpha in pancreatic beta-cells causes abnormal islet architecture with decreased expression of E-cadherin, reduced beta-cell proliferation, and diabetes.

  2002cites this paper
• Overexpression of Dominant-Negative Mutant Hepatocyte Nuclear Factor-1α in Pancreatic β-Cells Causes Abnormal Islet Architecture With Decreased Expression of E-Cadherin, Reduced β-cell Proliferation, and Diabetes

  2002cites this paper
• Differential expression of major gap junction proteins, connexins 26 and 32, in rat mammary glands during pregnancy and lactation

  2001cites this paper
• Assaying the molecular permeability of connexin channels.

  2001cites this paper
• Modulation of Gap and Adherens Junctional Proteins in Cultured Neonatal Pancreatic Islets

  2001cites this paper
• Communication of Islet Cells: Molecules and Functions

  2001cites this paper
• to the control of insulin secretion and glucose tolerance

  2000cites this paper
• Synchronization of Ca(2+)-signals within insulin-secreting pseudoislets: effects of gap-junctional uncouplers.

  2000cites this paper
• Expression of connexin 30 in Xenopus embryos and its involvement in hatching gland function

  2000cites this paper
• Gap junction function

  2000cites this paper
• Junctional communication of pancreatic beta cells contributes to the control of insulin secretion and glucose tolerance.

  2000influential citation
• Probing the function of connexin channels in primary tissues.

  2000cites this paper
• Expressio no fConnexi n3 0i nXenopu sEmbryo san dIts Involvemen ti nHatchin gGlan dFunction

  2000cites this paper
• Multiple connexin expression in peripheral nerve, Schwann cells, and Schwannoma cells

  1999cites this paper