Anti-oxidant and anti-inflammatory activities of macelignan in murine hippocampal cell line and primary culture of rat microglial cells.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Biochemical and Biophysical Research Communications - BBRC

• Publication date

  2005-06-17

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1016/J.BBRC.2005.04.036PMID 15883012
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Dibenzocyclooctadiene lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamate‐induced toxicity

  2004cited by this paper
• Oxidative neuronal death caused by glutamate uptake inhibition in cultured hippocampal neurons

  2003cited by this paper
• Separation of Leucas aspera, a medicinal plant of Bangladesh, guided by prostaglandin inhibitory and antioxidant activities.

  2003cited by this paper
• Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases.

  2002cited by this paper
• Abnormalities in oxidative processes in non-neuronal tissues from patients with Alzheimer's disease

  2001cited by this paper
• Neuroprotective Dibenzylbutyrolactone Lignans of Torreya nucifera

  2001cited by this paper
• Minocycline Provides Neuroprotection Against N-Methyl-d-aspartate Neurotoxicity by Inhibiting Microglia1

  2001cited by this paper
• Interaction of various intracellular signaling mechanisms involved in mononuclear phagocyte toxicity toward neuronal cells

  2000cited by this paper
• Regional Difference in Susceptibility to Lipopolysaccharide-Induced Neurotoxicity in the Rat Brain: Role of Microglia

  2000cited by this paper
• Oxidants, oxidative stress and the biology of ageing

  2000cited by this paper
• Gangliosides Activate Cultured Rat Brain Microglia*

  1999cited by this paper
• The Regulation of Reactive Oxygen Species Production during Programmed Cell Death

  1998cited by this paper
• Long-Term Dietary Strawberry, Spinach, or Vitamin E Supplementation Retards the Onset of Age-Related Neuronal Signal-Transduction and Cognitive Behavioral Deficits

  1998cited by this paper
• An Assessment of Oxidative Damage to Proteins, Lipids, and DNA in Brain from Patients with Alzheimer's Disease

  1997cited by this paper
• Regulation of glutamate in cultures of human monocytic THP-1 and astrocytoma U-373 MG cells.

  1997cited by this paper
• The blood-brain barrier in neuroinflammatory diseases.

  1997cited by this paper
• Microglia: a sensor for pathological events in the CNS.

  1996cited by this paper
• Immunologic NO Synthase: Elevation in Severe AIDS Dementia and Induction by HIV-1 gp41

  1996cited by this paper
• Specific Domains of β-Amyloid from Alzheimer Plaque Elicit Neuron Killing in Human Microglia

  1996cited by this paper
• Distinct distribution of apolipoprotein E and β-amyloid immunoreactivity in the hippocampus of Parkinson dementia complex of Guam

  1996cited by this paper
• Microglia, the first line of defence in brain pathologies.

  1995cited by this paper
• Activation of microglial cells by β-amyloid protein and interferon-γ

  1995cited by this paper
• 17-beta estradiol protects neurons from oxidative stress-induced cell death in vitro.

  1995cited by this paper
• Activation of microglial cells by beta-amyloid protein and interferon-gamma.

  1995cited by this paper
• Mediation of inflammation by encephalitogenic cells: interferon gamma induction of nitric oxide synthase and cyclooxygenase 2.

  1995cited by this paper
• Expression of inducible nitric oxide synthase causes delayed neurotoxicity in primary mixed neuronal-glial cortical cultures.

  1994cited by this paper
• Modulation of Intracellular Formation of Reactive Oxygen Intermediates in Peritoneal Macrophages and Microglia/Brain Macrophages by Propentofylline

  1994cited by this paper
• Microglial and astroglial reactions to inflammatory lesions of experimental autoimmune encephalomyelitis in the rat central nervous system.

  1992cited by this paper
• Role of dietary antioxidants in protection against oxidative damage.

  1990cited by this paper
• Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease.

  1989cited by this paper
• Studies on scavengers of active oxygen species. 1. Synthesis and biological activity of 2-O-alkylascorbic acids.

  1988cited by this paper
• The structure of macelignan from Myristica fragrans

  1987cited by this paper
• Insight Review Articles

  year unknowncited by this paper

• Genome survey of nutmeg (Myristica fragrans) from Indonesia: genomic resource for Myristicaceae.

  2026cites this paper
• Protective effects of macelignan against mesenteric ischemia–reperfusion injury: experimental study

  2025cites this paper
• Mechanisms and Therapeutic Roles of Medicinal Plants in Skin Photoaging

  2025cites this paper
• Síndrome do ovário policístico: revisão sistemática de recentes pesquisas referentes à investigação de metabólitos secundários para o tratamento

  2025cites this paper
• Neuroprotective Effects of Noncanonical PAR1 Agonists on Cultured Neurons in Excitotoxicity

  2024cites this paper
• Attenuating Oxidative Damage with Macelignan in Glutamate-Induced HT22 Hippocampal Cells

  2024cites this paper
• Development, basic information, classifications, pharmacological activities, and underlying mechanisms of medicine food homology: A review

  2024cites this paper
• Phytoconstituents and Ergosterol Biosynthesis-Targeting Antimicrobial Activity of Nutmeg (Myristica fragans Houtt.) against Phytopathogens

  2024cites this paper
• Macelignan prevents colorectal cancer metastasis by inhibiting M2 macrophage polarization.

  2023cites this paper
• Treatment of polycystic ovary syndrome and its associated psychiatric symptoms with the Mongolian medicine Nuangong Qiwei Pill and macelignan.

  2023cites this paper
• Inhibitory Effects of Macelignan on Tau Phosphorylation and Aβ Aggregation in the Cell Model of Alzheimer's Disease

  2022cites this paper
• Inhibition of LPS-Induced Microglial Activation by the Ethyl Acetate Extract of Pueraria mirifica

  2022cites this paper
• Bioactive Based Nanocarriers for the Treatment of Viral Infections and SARS-CoV-2

  2022cites this paper
• High-throughput analysis of fungal communities in Myristicae Semen

  2020cites this paper
• Phytochemical and pharmacological properties of Myristica fragrans Houtt.: an updated review

  2020cites this paper
• Macelignan protects against renal ischemia-reperfusion injury via inhibition of inflammation and apoptosis of renal epithelial cells.

  2020cites this paper
• Role of Spices Beyond a Flavouring Agent

  2020cites this paper
• Neuroprotective effects of myristargenol A against glutamate-induced apoptotic HT22 cell death

  2019cites this paper
• Pharmacokinetics and Tissue Distribution of Anwuligan in Rats after Intravenous and Intragastric Administration by Liquid Chromatography-Mass Spectrometry

  2019cites this paper
• Increased Oxidative Damage Contributes to Mitochondrial Dysfunction in Muscle of Depressed Rats Induced by Chronic Mild Stress Probably Mediated by SIRT3 Pathway

  2019cites this paper
• A Mini Review on the Protective Effect of Lignans for the Treatment of Neurodegenerative Disorders

  2019cites this paper
• Therapeutic Effect of Ershen Pill (二神丸) Extract on Pi (Spleen)-Shen (Kidney) Yang Deficiency-Induced Diarrhea in Rat Model

  2019cites this paper
• Myristica fragrans Houtt.: Botanical, Pharmacological, and Toxicological Aspects

  2019cites this paper
• Potent inhibition of acetylcholinesterase by sargachromanol I from Sargassum siliquastrum and by selected natural compounds.

  2019cites this paper
• 3-21-2018 3 D Tissue Engineering , an Emerging Technique for Pharmaceutical Research

  2019cites this paper
• Macelignan inhibits the inflammatory response of microglia and regulates neuronal survival.

  2019cites this paper
• Total Synthesis of Leoligin from Edelweiss Roots

  2018cites this paper
• 3D tissue engineering, an emerging technique for pharmaceutical research

  2018cites this paper
• Anti-inflammatory activity of medicinal plants: A review

  2018cites this paper
• Delavatine A, an unusual isoquinoline alkaloid exerts anti-inflammation on LPS-induced proinflammatory cytokines production by suppressing NF-κB activation in BV-2 microglia.

  2018cites this paper
• New neolignans from the seeds of Myristica fragrans and their cytotoxic activities

  2018cites this paper
• In vitro cytotoxicity of lignans isolated from Ficus citrifolia P . Miller ( Moraceae ) on C 6 glioma cell line

  2018cites this paper
• Biosynthesis of silver nanoparticles using Myristica fragrans seed (nutmeg) extract and its antibacterial activity against multidrug-resistant (MDR) Salmonella enterica serovar Typhi isolates

  2017cites this paper
• Alismol, a Sesquiterpenoid Isolated from Vladimiria souliei, Suppresses Proinflammatory Mediators in Lipopolysaccharide-Stimulated Microglia

  2017cites this paper
• Mucuna pruriens Protects against MPTP Intoxicated Neuroinflammation in Parkinson’s Disease through NF-κB/pAKT Signaling Pathways

  2017cites this paper
• Neuroprotective compounds from Reynoutria sachalinensis

  2017cites this paper
• Neuroprotective compounds from Reynoutria sachalinensis

  2017cites this paper
• Plant-Derived Antiinflammatory Steroid Analogs for Neuroprotection: A Recent Update

  2017cites this paper
• Myristica fragrans : A Review

  2017cites this paper
• Delivery of a protein transduction domain-mediated Prdx6 protein ameliorates oxidative stress-induced injury in human and mouse neuronal cells.

  2016cites this paper
• Plant based indian traditional medicine for neurodegenerative diseases - a novel Approach to treat alzheimer

  2016cites this paper
• Anti-Inflammatory and Cytoprotective Effects of TMC-256C1 from Marine-Derived Fungus Aspergillus sp. SF-6354 via up-Regulation of Heme Oxygenase-1 in Murine Hippocampal and Microglial Cell Lines

  2016cites this paper
• Macelignan inhibits bee pathogenic fungi Ascophaera apis growth through HOG1 pathway

  2016cites this paper
• Biological effects induced by estrogenic activity of lignans

  2016cites this paper
• The Blood-Brain Barrier Permeability of Lignans and Malabaricones from the Seeds of Myristica fragrans in the MDCK-pHaMDR Cell Monolayer Model

  2016cites this paper
• Neuroprotective effect of nerolidol against neuroinflammation and oxidative stress induced by rotenone

  2016cites this paper
• Inhibition of TYRO3/Akt signaling participates in hypoxic injury in hippocampal neurons

  2016cites this paper
• Intranasal PRGF-Endoret enhances neuronal survival and attenuates NF-κB-dependent inflammation process in a mouse model of Parkinson's disease.

  2015cites this paper
• A natural compound macelignan protects midbrain dopaminergic neurons from inflammatory degeneration via microglial arginase-1 expression.

  2015cites this paper
• Tyrosinase Inhibitory Activities of Meso-dihydroguaiaretic Acid from Machilus thunbergii

  2015cites this paper
• Call for Papers : Cell Signaling : Proteins , Pathways and Mechanisms Delivery of a protein transduction domain-mediated Prdx 6 protein ameliorates oxidative stress-induced injury in human and mouse neuronal cells

  2015cites this paper
• Glucuronidation of macelignan by human liver microsomes and expressed UGT enzymes: identification of UGT1A1 and 2B7 as the main contributing enzymes

  2014cites this paper
• Neuroprotective Activity of Phytosterols Isolated from Artemisia apiacea

  2014cites this paper
• Lignans from the stems of Clematis armandii ("Chuan-Mu-Tong") and their anti-neuroinflammatory activities.

  2014influential citation
• Multiple biological properties of macelignan and its pharmacological implications

  2013cites this paper
• Curcumin abates hypoxia-induced oxidative stress based-ER stress-mediated cell death in mouse hippocampal cells (HT22) by controlling Prdx6 and NF-κB regulation.

  2013cites this paper
• 1-Phenil-6,7-dihydroxy-isochroman inhibits inflammatory activation of microglia.

  2013cites this paper
• Cognitive-enhancing effects of Rhus verniciflua bark extract and its active flavonoids with neuroprotective and anti-inflammatory activities.

  2013cites this paper
• Multiple biological properties of macelignan and its pharmacological implications

  2013cites this paper
• Carvedilol, a third-generation β-blocker prevents oxidative stress-induced neuronal death and activates Nrf2/ARE pathway in HT22 cells.

  2013cites this paper
• Neuroprotective benzyl benzoate glycosides from Disporum viridescens roots in HT22 hippocampal neuronal cells.

  2013cites this paper
• New inhibitors of nitric oxide production from the seeds of Myristica fragrans.

  2013cites this paper
• Catalpol inhibits LPS plus IFN-γ-induced inflammatory response in astrocytes primary cultures.

  2013cites this paper
• Macelignan attenuated allergic lung inflammation and airway hyper-responsiveness in murine experimental asthma.

  2013cites this paper
• hippocampal cells (HT22) by controlling Prdx6 and NF-κB regulation 2

  2013cites this paper
• Chapter 3 – Phenolics

  2013cites this paper
• Anti‐platelet Activity of Erythro‐(7S,8R)‐7‐acetoxy‐3,4,3′,5′‐tetramethoxy‐8‐O‐4′‐neolignan from Myristica fragrans

  2013influential citation
• Protection of MPTP-induced neuroinflammation and neurodegeneration by Pycnogenol.

  2013cites this paper
• Antioxidant and anti-inflammatory activities of Thai medicinal plants in Sahasthara remedy for muscle pain treatment.

  2012cites this paper
• Health benefits of bioactive molecules from spices and aromatic plants.

  2012cites this paper
• Rhinacanthus nasutus Extracts Prevent Glutamate and Amyloid-β Neurotoxicity in HT-22 Mouse Hippocampal Cells: Possible Active Compounds Include Lupeol, Stigmasterol and β-Sitosterol

  2012cites this paper
• Neuroprotective and anti-inflammatory effects of flavonoids isolated from Rhus verniciflua in neuronal HT22 and microglial BV2 cell lines.

  2012cites this paper
• Effects of macelignan isolated from Myristica fragrans (Nutmeg) on expression of matrix metalloproteinase-1 and type I procollagen in UVB-irradiated human skin fibroblasts.

  2012cites this paper
• ANTI-INFLAMMATORY AND ANTI-ULCEROGENIC ACTIVITIES OF CHANTALEELA

  2012cites this paper
• Anti-inflammatory and anti-ulcerogenic activities of Chantaleela recipe.

  2012cites this paper
• Potential anti-inflammatory bioactives from medicinal plants of Western Ghats, India

  2012cites this paper
• Ric1-Rgp1 Complex Is a Guanine Nucleotide Exchange Factor for the Late Golgi Rab6A GTPase and an Effector of the Medial Golgi Rab33B GTPase*

  2012cites this paper
• Involvement of Heme Oxygenase-1 Induction in the Cytoprotective and Immunomodulatory Activities of Viola patrinii in Murine Hippocampal and Microglia Cells

  2012cites this paper
• Ameliorative potential of Myristica fragrans extract as hypoglycemic agent on oxidative stress produced by diabetes mellitus in mice

  2012cites this paper
• Compounds from the Seeds of Myristica fragrans and Their Cytotoxic Activity

  2012cites this paper
• Involvement of heme oxygenase-1 induction in the cytoprotective and immunomodulatory activities of 6,4'-dihydroxy-7-methoxyflavanone in murine hippocampal and microglia cells.

  2012cites this paper
• Macelignan Inhibits Histamine Release and Inflammatory Mediator Production in Activated Rat Basophilic Leukemia Mast Cells

  2012cites this paper
• Myrislignan Attenuates Lipopolysaccharide‐induced Inflammation Reaction in Murine Macrophage Cells Through Inhibition of NF‐κB Signalling Pathway Activation

  2012cites this paper
• Biological evaluation of phenolic constituents from the trunk of Berberis koreana.

  2011cites this paper
• Rhinacanthus nasutus Protects Cultured Neuronal Cells against Hypoxia Induced Cell Death

  2011cites this paper
• Inhibitory effect on NO production of phenolic compounds from Myristica fragrans.

  2011cites this paper
• Neuroprotective and anti-inflammatory effects of mollugin via up-regulation of heme oxygenase-1 in mouse hippocampal and microglial cells.

  2011cites this paper
• The Intestinal Permeability of Neolignans from the Seeds of Myristica fragrans in the Caco-2 Cell Monolayer Model

  2010cites this paper
• Neuroprotective phenolics in medicinal plants

  2010cites this paper
• Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins.

  2010cites this paper
• Non-Steroidal Anti-Inflammatory Drugs and Brain Inflammation: Effects on Microglial Functions

  2010cites this paper
• Suppression of inducible nitric oxide synthase expression by furfuran lignans from flower buds of Magnolia fargesii in BV‐2 microglial cells

  2010cites this paper
• Effects of macelignan isolated from Myristica fragrans Houtt. on UVB-induced matrix metalloproteinase-9 and cyclooxygenase-2 in HaCaT cells.

  2010cites this paper
• Effect of maceligan on the systemic exposure of paclitaxel: in vitro and in vivo evaluation.

  2010cites this paper
• Antioxidant and nitric oxide inhibition activities of Thai medicinal plants.

  2010influential citation
• The Hypoglycemic Effect of Complex of Chinese Traditional Herbs (CTH) and Macelignan in Type 2 Diabetic Animal Model

  2010cites this paper
• Inhibition of Urokinase-Type Plasminogen Activator Expression by Macelignan in Porphyromonas gingivalis Supernatant-Induced Human Oral Epithelial Cells

  2010cites this paper
• Inhibition of Urokinase-Type Plasminogen Activator Expression by Macelignan in Porphyromonas gingivalis Supernatant-Induced Human Oral Epithelial Cells

  2010cites this paper
• Cytoprotective and anti-inflammatory effects of spinasterol via the induction of heme oxygenase-1 in murine hippocampal and microglial cell lines.

  2010cites this paper
• New Secoisolariciresinol Derivatives from Lindera obtusiloba Stems and Their Neuroprotective Activities

  2009cites this paper