The role of vitamin E in atherogenesis: linking the chemical, biological and clinical aspects of the disease.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Atherosclerosis

• Publication date

  2001-08-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0021-9150(00)00741-3PMID 11472726
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Continuous Monitoring of in Vztro Oxidation of Human Low Density Lipoprotein

  2009cited by this paper
• The effect of pharmacological doses of different antioxidants on oxidation parameters and atherogenesis in hyperlipidaemic rabbits.

  2001cited by this paper
• Induction of cancer cell apoptosis by α‐tocopheryl succinate: molecular pathways and structural requirements

  2001cited by this paper
• Selective cancer cell killing by α-tocopheryl succinate

  2001cited by this paper
• Vitamin E reduces the uptake of oxidized LDL by inhibiting CD36 scavenger receptor expression in cultured aortic smooth muscle cells.

  2000cited by this paper
• The antioxidant paradox.

  2000cited by this paper
• Molecular Basis of Vitamin E Action

  2000cited by this paper
• Modulation by α- and γ-tocopherol and oxidized low-density lipoprotein of apoptotic signaling in human coronary smooth muscle cells

  2000cited by this paper
• Alpha- and beta-carotenes in low density lipoprotein are the preferred target for nitric oxide-induced oxidation.

  2000cited by this paper
• α- and β-Carotenes in low density lipoprotein are the preferred target for nitric oxide-induced oxidation

  2000cited by this paper
• Overexpression of 15-Lipoxygenase in Vascular Endothelium Accelerates Early Atherosclerosis in LDL Receptor–Deficient Mice

  2000cited by this paper
• Increased lipoprotein oxidation in Alzheimer's disease.

  2000cited by this paper
• Regulation of cdk2 activity in endothelial cells that are inhibited from growth by cell contact.

  2000cited by this paper
• Time-course of oxidation of lipids in human cerebrospinal fluid in vitro

  2000cited by this paper
• Caspase-Dependent Cdk Activity Is a Requisite Effector of Apoptotic Death Events

  2000cited by this paper
• Heart Outcomes Prevention Evaluation Study Investigators. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. N Engl J Med 2000;342:145-53.

  2000cited by this paper
• Vitamin E and heart disease: basic science to clinical intervention trials.

  2000cited by this paper
• Vitamin E supplementation and cardiovascular events in high-risk patients.

  2000cited by this paper
• Modulation by alpha- and gamma-tocopherol and oxidized low-density lipoprotein of apoptotic signaling in human coronary smooth muscle cells.

  2000cited by this paper
• Tocopherol‐mediated peroxidation of lipoproteins: implications for vitamin E as a potential antiatherogenic supplement

  1999influential reference
• Lipophilic antioxidants in blood plasma as markers of atherosclerosis: the role of alpha-carotene and gamma-tocopherol.

  1999cited by this paper
• Coexistence of oxidized lipids and alpha-tocopherol in all lipoprotein density fractions isolated from advanced human atherosclerotic plaques.

  1999cited by this paper
• Lipophilic antioxidants in blood plasma as markers of atherosclerosis: the role of α-carotene and γ-tocopherol

  1999cited by this paper
• Interleukin-4-dependent production of PPAR-γ ligands in macrophages by 12/15-lipoxygenase

  1999cited by this paper
• Plasma ubiquinol‐10 as a marker for disease: Is the assay worthwhile?

  1999cited by this paper
• Vitamin E ingestion does not improve arterial endothelial dysfunction in older adults.

  1999cited by this paper
• Is NF-kappaB the sensor of oxidative stress?

  1999cited by this paper
• The agonising negative trend in monitoring of clinical trials.

  1999cited by this paper
• Apoptosis. Basic concepts and implications in coronary artery disease.

  1999cited by this paper
• Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase.

  1999cited by this paper
• Efflux of hepatic ascorbate: a potential contributor to the maintenance of plasma vitamin C.

  1999cited by this paper
• Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico.

  1999cited by this paper
• Nuclear factor-kappa B regulates induction of apoptosis and inhibitor of apoptosis protein-1 expression in vascular smooth muscle cells.

  1999cited by this paper
• The ambivalence of vitamin E in atherogenesis.

  1999cited by this paper
• At last, direct evidence that lipoxygenases play a role in atherogenesis.

  1999cited by this paper
• Protein Kinase Cα Regulates Human Monocyte O·̄2Production and Low Density Lipoprotein Lipid Oxidation*

  1999cited by this paper
• Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice.

  1999cited by this paper
• Apoptosis overrides survival signals through a caspase-mediated dominant-negative NF-κB loop

  1999cited by this paper
• γ-Tocopherol Decreases Ox-LDL-Mediated Activation of Nuclear Factor-κB and Apoptosis in Human Coronary Artery Endothelial Cells

  1999cited by this paper
• Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico.

  1999cited by this paper
• Nuclear factor-κB regulates induction of apoptosis and inhibitor of apoptosis protein-1 expression in vascular smooth muscle cells

  1999cited by this paper
• Is NF‐κB the sensor of oxidative stress?

  1999cited by this paper
• Apoptosis overrides survival signals through a caspase-mediated dominant-negative NF-kappa B loop.

  1999cited by this paper
• gamma-tocopherol decreases ox-LDL-mediated activation of nuclear factor-kappaB and apoptosis in human coronary artery endothelial cells.

  1999cited by this paper
• The macrophage scavenger receptor type A directs modified proteins to antigen presentation

  1999cited by this paper
• α‐Tocopheryl succinate‐induced apoptosis in Jurkat T cells involves caspase‐3 activation, and both lysosomal and mitochondrial destabilisation

  1999cited by this paper
• Vitamin E and vascular homeostasis: implications for atherosclerosis

  1999cited by this paper
• Interleukin-4 and -13 induce upregulation of the murine macrophage 12/15-lipoxygenase activity: evidence for the involvement of transcription factor STAT6.

  1998cited by this paper
• Monocyte superoxide production is inversely related to normal content of alpha-tocopherol in low-density lipoprotein.

  1998cited by this paper
• Interaction of very late antigen-4 with VCAM-1 supports transendothelial chemotaxis of monocytes by facilitating lateral migration.

  1998cited by this paper
• Effect of dietary catechin and vitamin E on aortic fatty streak accumulation in hypercholesterolemic hamsters.

  1998cited by this paper
• α-Tocopherol in Atherogenesis: Do we Know its Real Role?

  1998cited by this paper
• alpha-Tocopherol specifically inactivates cellular protein kinase C alpha by changing its phosphorylation state.

  1998cited by this paper
• Immunoglobulin treatment reduces atherosclerosis in apo E knockout mice.

  1998cited by this paper
• Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils

  1998cited by this paper
• Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ

  1998cited by this paper
• Vitamins E plus C and interacting conutrients required for optimal health. A critical and constructive review of epidemiology and supplementation data regarding cardiovascular disease and cancer.

  1998cited by this paper
• Vitamin E administration improves impairment of endothelium-dependent vasodilation in patients with coronary spastic angina.

  1998cited by this paper
• alpha-tocopherol inhibits the respiratory burst in human monocytes. Attenuation of p47(phox) membrane translocation and phosphorylation.

  1998cited by this paper
• The Rabbit 15-Lipoxygenase Preferentially Oxygenates LDL Cholesterol Esters, and This Reaction Does Not Require Vitamin E*

  1998cited by this paper
• PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL.

  1998cited by this paper
• Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice

  1998influential reference
• Overexpression of human superoxide dismutase inhibits oxidation of low-density lipoprotein by endothelial cells.

  1998cited by this paper
• Radical-induced lipoprotein and plasma lipid oxidation in normal and apolipoprotein E gene knockout (apoE-/-) mice: apoE-/- mouse as a model for testing the role of tocopherol-mediated peroxidation in atherogenesis.

  1998cited by this paper
• Impact of LDL carotenoid and alpha-tocopherol content on LDL oxidation by endothelial cells in culture.

  1998cited by this paper
• Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma.

  1998cited by this paper
• Alpha-tocopherol supplementation of macrophages does not influence their ability to oxidize LDL.

  1998cited by this paper
• PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL

  1998cited by this paper
• Secretory phospholipase A2 and lipoprotein lipase enhance 15-lipoxygenase-induced enzymic and nonenzymic lipid peroxidation in low-density lipoproteins.

  1998cited by this paper
• Membrane translocation of 15-lipoxygenase in hematopoietic cells is calcium-dependent and activates the oxygenase activity of the enzyme.

  1998cited by this paper
• Oxidation and antioxidation of human low-density lipoprotein and plasma exposed to 3-morpholinosydnonimine and reagent peroxynitrite.

  1998cited by this paper
• Dietary antioxidants do not reduce fatty streak formation in the C57BL/6 mouse atherosclerosis model.

  1998influential reference
• The effects of alpha-tocopherol on critical cells in atherogenesis.

  1998cited by this paper
• Hypercholesterolemia is associated with a T helper (Th) 1/Th2 switch of the autoimmune response in atherosclerotic apo E-knockout mice.

  1998cited by this paper
• Oxidants and antioxidants in the pathogenesis of atherosclerosis: implications for the oxidized low density lipoprotein hypothesis.

  1998cited by this paper
• Atherosclerosis is an Inflammatory Disease

  1998influential reference
• Identification of the prooxidant site of human ceruloplasmin: a model for oxidative damage by copper bound to protein surfaces.

  1997cited by this paper
• γ-Tocopherol traps mutagenic electrophiles such as NOx and complements α-tocopherol: Physiological implications

  1997cited by this paper
• Potential involvement of type II phospholipase A2 in atherosclerosis.

  1997cited by this paper
• Increased oxidation of LDL in patients with coronary artery disease is independent from dietary vitamins E and C.

  1997cited by this paper
• Plasma ubiquinol-10 is decreased in patients with hyperlipidaemia.

  1997cited by this paper
• Combined effects of lipid peroxidation and antioxidant status on carotid atherosclerosis in a population aged 59-71 y: The EVA Study. Etude sur le Vieillisement Artériel.

  1997cited by this paper
• Plasma and LDL levels of major lipophilic antioxidants are similar in patients with advanced atherosclerosis and age-matched controls.

  1997cited by this paper
• α‐Tocopherol does not inhibit hypochlorite‐induced oxidation of apolipoprotein B‐100 of low‐density lipoprotein

  1997cited by this paper
• Alpha-tocopheryl hydroquinone is an efficient multifunctional inhibitor of radical-initiated oxidation of low density lipoprotein lipids.

  1997influential reference
• Antioxidants and atherosclerotic heart disease.

  1997influential reference
• Vascular superoxide dismutase deficiency impairs endothelial vasodilator function through direct inactivation of nitric oxide and increased lipid peroxidation.

  1997cited by this paper
• Requirement for, promotion, or inhibition by alpha-tocopherol of radical-induced initiation of plasma lipoprotein lipid peroxidation.

  1997cited by this paper
• beta-Carotene and alpha-tocopherol inhibit the development of atherosclerotic lesions in hypercholesterolemic rabbits.

  1997cited by this paper
• Role of alpha-tocopheroxyl radical in the initiation of lipid peroxidation in human low-density lipoprotein exposed to horse radish peroxidase.

  1997cited by this paper
• Direct Copper Reduction by Macrophages

  1997cited by this paper
• Oxidation of Free Fatty Acids in Low Density Lipoprotein by 15-Lipoxygenase Stimulates Nonenzymic, α-Tocopherol-mediated Peroxidation of Cholesteryl Esters*

  1997cited by this paper
• Fibroblasts that overexpress 15-lipoxygenase generate bioactive and minimally modified LDL.

  1997cited by this paper
• Extent of antioxidant protection of plasma LDL is not a predictor of the antiatherogenic effect of antioxidants.

  1997cited by this paper
• Low Density Lipoprotein Oxidation and Its Pathobiological Significance*

  1997cited by this paper
• gamma-tocopherol traps mutagenic electrophiles such as NO(X) and complements alpha-tocopherol: physiological implications.

  1997cited by this paper
• Attenuation of diet‐induced atherosclerosis in rabbits with a highly selective 15‐lipoxygenase inhibitor lacking significant antioxidant properties

  1997influential reference
• alpha-Tocopheryl succinate inhibits monocytic cell adhesion to endothelial cells by suppressing NF-kappa B mobilization.

  1997cited by this paper
• Alpha-tocopherol does not inhibit hypochlorite-induced oxidation of apolipoprotein B-100 of low-density lipoprotein.

  1997cited by this paper
• Role of alpha L beta 2 integrin avidity in transendothelial chemotaxis of mononuclear cells.

  1997cited by this paper

• Reactivity of Vitamin E as an Antioxidant in Red Meat and the Stomach Medium.

  2022cites this paper
• Comparison of the Effects of Hypercholesterolemic Diets on Biochemical Outcomes of Myocardial Infarction in Rats

  2018cites this paper
• Vitamin complex (ascorbic acid, alpha-tocopherol and beta-carotene) induces micronucleus formation in PBMNC unrelated to ROS production

  2013cites this paper
• VITAMIN E | Physiology and Health Effects

  2013cites this paper
• Effects of hemodialysis and vitamin E supplementation on low-density lipoprotein oxidizability in end-stage renal failure.

  2013cites this paper
• Tomatoes as functional food

  2012cites this paper
• The anti-inflammatory effect of lycopene complements the antioxidant action of ascorbic acid and α-tocopherol

  2012cites this paper
• Caracterización química y propiedades bioactivas de hongos silvestres portugeses comestibles

  2011cites this paper
• Vitamins | Vitamin E

  2011cites this paper
• Tomato Lycopene and Inflammatory Cascade: Basic Interactions and Clinical Implications

  2010cites this paper
• Relationship between alcohol intake, health and social status and cardiovascular risk factors in the urban Paris-Ile-De-France Cohort: is the cardioprotective action of alcohol a myth?

  2010cites this paper
• Fat-Soluble Vitamins and Vitamin C in Milk and Milk Products

  2009cites this paper
• Plasma F 2-Isoprostane : A Biomarker of Lipid Peroxidation : Correlation with Cerebral Haemodynamics in Children with Chronic Renal Failure

  2009cites this paper
• Protective effects of glutamine dipeptide and alpha-tocopherol against ischemia-reperfusion injury in the isolated rat liver.

  2009cites this paper
• The response of gamma vitamin E to varying dosages of alpha vitamin E plus vitamin C.

  2009cites this paper
• Vitamin E in Human Health and Disease

  2008cites this paper
• An update on using vitamin E in Alzheimer's disease

  2008cites this paper
• Primary biliary cirrhosis and coronary atherosclerosis: Protective antioxidant effect of bilirubin

  2008cites this paper
• Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy.

  2008cites this paper
• New developments and novel therapeutic perspectives for vitamin C.

  2007cites this paper
• Protecting antioxidative effects of vitamins E and C in experimental physical stress

  2007cites this paper
• Vitamin E analogs as anticancer agents

  2006cites this paper
• Chronic Antioxidant Supplementation Impairs Coronary Endothelial Function and Myocardial Perfusion in Normal Pigs

  2006cites this paper
• The “unexpected role” of vitamin E in free radical-induced hemolysis of human erythrocytes

  2006cites this paper
• Fibrinogen is a co-antioxidant that supplements the vitamin E analog trolox in a model system

  2006cites this paper
• Exercise, oxidative stress and risk of cardiovascular disease in the elderly. Protective role of antioxidant functional foods

  2006cites this paper
• Vitamin E in humans: an explanation of clinical trial failure.

  2006cites this paper
• Dose and duration effect of alpha-tocopheryl acetate supplementation on chicken meat fatty acid composition, tocopherol content, and oxidative status.

  2006cites this paper
• Antioxidants and coronary artery disease among individuals with type 1 diabetes: Findings from the Pittsburgh Epidemiology of Diabetes Complications Study.

  2006cites this paper
• Hepatic processing determines dual activity of alpha-tocopheryl succinate: a novel paradigm for a shift in biological activity due to pro-vitamin-to-vitamin conversion.

  2005cites this paper
• beta-Carotene inhibits inflammatory gene expression in lipopolysaccharide-stimulated macrophages by suppressing redox-based NF-kappaB activation.

  2005cites this paper
• β-Carotene inhibits inflammatory gene expression in lipopolysaccharide-stimulated macrophages by suppressing redox-based NF-κB activation

  2005cites this paper
• A rational approach to antioxidant therapy and vitamin E.

  2005cites this paper
• Kinetic Modeling of Lipoprotein Peroxidation Initiated by Copper and Azo Compounds

  2005cites this paper
• The effect of tocopherol on serum iron content in experimental atherosclerosis

  2005cites this paper
• Chemistry and biology of vitamin E.

  2005cites this paper
• Chronic depletion of glutathione (GSH) and minimal modification of LDL in vivo: its prevention by glutathione mono ester (GME) therapy.

  2005cites this paper
• Effects of vitamin E on the toxicity of oxidized LDL on endothelial cells in vitro in smokers vs nonsmokers on diets rich in fish

  2005cites this paper
• Effects of Antioxidants on Gene Expression in Endothelial Cells

  2005cites this paper
• Enzymatically modified low-density lipoprotein upregulates CD36 in low-differentiated monocytic cells in a peroxisome proliferator-activated receptor-gamma-dependent way.

  2004cites this paper
• Probabilistic kinetic model of slow oxidation of low-density lipoprotein: II. Experiments.

  2004cites this paper
• Long-term taurine supplementation reduces mortality rate in streptozotocin-induced diabetic rats

  2004influential citation
• Probabilistic kinetic model of slow oxidation of low-density lipoprotein: I. Theory.

  2004cites this paper
• Vitamins in human arteriosclerosis with emphasis on vitamin C and vitamin E.

  2004cites this paper
• Chronic renal failure: oxidative stress, endothelial dysfunction and wine.

  2004cites this paper
• Vitamin E in Neurodegenerative Disorders: Alzheimer's Disease

  2004cites this paper
• Effect of supplemental tryptophan, vitamin E, and a herbal product on responses by pigs to vibration.

  2004cites this paper
• Vitamin E is not deficient in human atherosclerotic plaques.

  2004cites this paper
• The role of α-tocopherol in preventing disease

  2004cites this paper
• BESTIMMUNG VON TOCOPHEROLOXIDATIONSPRODUKTEN IM HUMANSERUM

  2004cites this paper
• Differential effects of vitamin E and three hydrophilic antioxidants on the actinomycin D-induced and colcemid-accelerated apoptosis in human leukemia CMK-7 cell line

  2003cites this paper
• Effect of vitamin E supplementation on antioxidant defense systems and humoral immune responses in young, middle-aged and elderly Korean women.

  2003cites this paper
• Childhood and adult dietary vitamin E intake and cardiovascular risk factors in mid-life in the 1946 British Birth Cohort

  2003cites this paper
• Taurine Reduces Mortality in Diabetic Rats

  2003cites this paper
• Atherosclerotic Progression : The Antioxidant Supplementation in Six-Year Effect of Combined Vitamin C and E Supplementation

  2003cites this paper
• Long-Chain Polyunsaturated Fatty Acids and Vitamin E in Cardiovascular Disease Prevention: Epiphenomenon or Causal Dependency?

  2003cites this paper
• Molecular mechanisms of cholesterol or homocysteine effect in the development of atherosclerosis: Role of vitamin E.

  2003cites this paper
• Taurine reduces mortality in diabetic rats: taurine and experimental diabetes mellitus.

  2003cites this paper
• Six-Year Effect of Combined Vitamin C and E Supplementation on Atherosclerotic Progression: The Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) Study

  2003cites this paper
• The European perspective on vitamin E: current knowledge and future research.

  2002cites this paper
• Therapy and clinical trials.

  2002cites this paper
• Vitamin E analogs: A new class of multiple action agents with anti-neoplastic and anti-atherogenic activity

  2002cites this paper
• Clinical Trials Testing Cardiovascular Benefits of Antioxidant Supplementation

  2002cites this paper
• Oxidative stress and chronic renal failure: markers and management.

  2002cites this paper
• Dissociation of apoptosis induction and CD36 upregulation by enzymatically modified low-density lipoprotein in monocytic cells.

  2002cites this paper
• Alpha-tocopheryl succinate epitomizes a compound with a shift in biological activity due to pro-vitamin-to-vitamin conversion.

  2002cites this paper
• Multifunctional roles of macrophages in the development and progression of atherosclerosis in humans and experimental animals

  2002cites this paper
• Use of vitamin C and E in the treatment of Alzheimer's disease

  2002cites this paper
• Vitamin E in cell signaling.

  2002cites this paper
• Serum ex vivo lipoprotein oxidizability in patients with ischemic heart disease supplemented with vitamin E.

  2002cites this paper
• Non-antioxidant molecular functions of alpha-tocopherol (vitamin E).

  2002cites this paper
• Non‐antioxidant molecular functions of α‐tocopherol (vitamin E)

  2002cites this paper
• Characterization of the vitamin E-binding properties of human plasma afamin.

  2002cites this paper
• Editorial comment Therapy and clinical trials

  2001cites this paper