Lysyl oxidase inhibits ras-mediated transformation by preventing activation of NF-kappa B.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Molecular and Cellular Biology

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  PMID 12640111PMCID PMC150722
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Fully processed lysyl oxidase catalyst translocates from the extracellular space into nuclei of aortic smooth‐muscle cells

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• Lysyl Oxidase Activates the Transcription Activity of Human Collagene III Promoter

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• Growth hormone prevents apoptosis through activation of nuclear factor-kappaB in interleukin-3-dependent Ba/F3 cell line.

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• Aberrant rel/nfkb genes and activity in human cancer

  1999cited by this paper
• Oncogenic Ras Enhances NF-κB Transcriptional Activity through Raf-dependent and Raf-independent Mitogen-activated Protein Kinase Signaling Pathways*

  1999cited by this paper
• Epigenetic inhibition of lysyl oxidase transcription after transformation by ras oncogene

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• The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells.

  1999cited by this paper
• Expression of a dominant-negative mutant inhibitor-kappaBalpha of nuclear factor-kappaB in human head and neck squamous cell carcinoma inhibits survival, proinflammatory cytokine expression, and tumor growth in vivo.

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• IκB Kinase (IKK)-Associated Protein 1, a Common Component of the Heterogeneous IKK Complex

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• Akt/PKB localisation and 3' phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction.

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• Comparative functional study of the lysyl oxidase promoter in fibroblasts, Ras-transformed fibroblasts, myofibroblasts and smooth muscle cells.

  1999cited by this paper
• Reduced lysyl oxidase messenger RNA levels in experimental and human prostate cancer.

  1998cited by this paper
• Lysyl oxidase: properties, regulation and multiple functions in biology.

  1998cited by this paper
• Mechanisms and consequences of activation of protein kinase B/Akt.

  1998cited by this paper
• IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex.

  1998cited by this paper
• Identification and characterization of an IkappaB kinase.

  1997cited by this paper
• Nuclear factor-kappaB/Rel blocks transforming growth factor beta1-induced apoptosis of murine hepatocyte cell lines.

  1997cited by this paper
• Rel/NF-kappa B transcription factors and the control of apoptosis.

  1997cited by this paper
• Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras.

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• Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells.

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• IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK.

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• Oncogenic Ha-Ras-induced Signaling Activates NF-κB Transcriptional Activity, Which Is Required for Cellular Transformation*

  1997cited by this paper
• Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer.

  1997cited by this paper
• IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation.

  1997cited by this paper
• Micro‐injection of recombinant lysyl oxidase blocks oncogenic p21‐Ha‐Ras and progesterone effects on Xenopus laevis oocyte maturation

  1997cited by this paper
• Rel/NF-kappaB/IkappaB proteins and cancer.

  1996cited by this paper
• The Ras-Raf pathway is activated in human immunodeficiency virus-infected monocytes and particpates in the activation of NF-kappa B

  1996cited by this paper
• Identification of the lysyl oxidase gene as target of the antioncogenic transcription factor, IRF-1, and its possible role in tumor suppression.

  1996cited by this paper
• Akt, a Pleckstrin Homology Domain Containing Kinase, Is Activated Primarily by Phosphorylation*

  1996cited by this paper
• Activation of the Raf-1/MAP kinase cascade is not sufficient for Ras transformation of RIE-1 epithelial cells.

  1996cited by this paper
• Mutant ras epitopes as targets for cancer vaccines.

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• Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation

  1996cited by this paper
• Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity.

  1996cited by this paper
• Quantitative Polymerase Chain Reaction of Lysyl Oxidase mRNA in Malignantly Transformed Human Cell Lines Demonstrates That Their Low Lysyl Oxidase Activity Is Due to Low Quantities of Its mRNA and Low Levels of Transcription of the Respective Gene (*)

  1995cited by this paper
• Increased expression of lysyl oxidase in skin with scleroderma

  1995cited by this paper
• Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

  1995cited by this paper
• Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation

  1995cited by this paper
• Phosphorylation of human I kappa B‐alpha on serines 32 and 36 controls I kappa B‐alpha proteolysis and NF‐kappa B activation in response to diverse stimuli.

  1995cited by this paper
• Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.

  1995cited by this paper
• Function and activation of NF-kappa B in the immune system.

  1994cited by this paper
• Activation of Raf as a result of recruitment to the plasma membrane.

  1994cited by this paper
• Involvement of phosphoinositide 3‐kinase in insulin‐ or IGF‐1‐induced membrane ruffling.

  1994cited by this paper
• The activation of phosphatidylinositol 3-kinase by Ras.

  1994cited by this paper
• Lysyl oxidase cDNA of myofibroblast from mouse fibrotic liver.

  1994cited by this paper
• Up-regulation of lysyl oxidase in spontaneous revertants of H-ras-transformed rat fibroblasts.

  1993cited by this paper
• Transient expression of lysyl oxidase by liver myofibroblasts in murine schistosomiasis.

  1993cited by this paper
• The 65-kDa subunit of human NF-kappa B functions as a potent transcriptional activator and a target for v-Rel-mediated repression.

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• Isolation of genes specifically expressed in flat revertant cells derived from activated ras-transformed NIH 3T3 cells by treatment with azatyrosine.

  1992cited by this paper
• Post-translational glycosylation and proteolytic processing of a lysyl oxidase precursor.

  1992cited by this paper
• NF‐kappa B contacts DNA by a heterodimer of the p50 and p65 subunit.

  1991cited by this paper
• Lysyl oxidase and rrg messenger RNA.

  1991cited by this paper
• Interaction of an NF-kappa B-like factor with a site upstream of the c-myc promoter.

  1990cited by this paper
• Immunohistochemical localization of lysyl oxidase with monoclonal antibodies.

  1990cited by this paper
• Expression of gene rrg is associated with reversion of NIH 3T3 transformed by LTR-c-H-ras.

  1990cited by this paper
• ras GTPase activating protein: signal transmitter and signal terminator.

  1989cited by this paper
• ras oncogenes in human cancer: a review.

  1989cited by this paper
• Deficient production of lysyi oxidase in cultures of malignantly transformed human cells

  1986cited by this paper
• Ultrastructural immunolocalization of lysyl oxidase in vascular connective tissue

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• The cross-linking of collagen and elastin: enzymatic conversion of lysine in peptide linkage to alpha-aminoadipic-delta-semialdehyde (allysine) by an extract from bone.

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• The Propeptide Domain of Lysyl Oxidase Induces Phenotypic Reversion of Ras-transformed Cells*

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