The human TREX-2 complex is stably associated with the nuclear pore basket

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Journal of Cell Science

• Publication date

  2013-06-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/jcs.118000PMID 23591820
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export

  2012influential reference
• Structural basis for the assembly and nucleic acid binding of the TREX-2 transcription-export complex

  2012influential reference
• The Tightly Controlled Deubiquitination Activity of the Human SAGA Complex Differentially Modifies Distinct Gene Regulatory Elements

  2011cited by this paper
• ATAC and Mediator coactivators form a stable complex and regulate a set of non‐coding RNA genes

  2010cited by this paper
• mRNA Export from Mammalian Cell Nuclei Is Dependent on GANP

  2010influential reference
• Patch-Based Nonlocal Functional for Denoising Fluorescence Microscopy Image Sequences

  2010cited by this paper
• The nuclear pore complex: bridging nuclear transport and gene regulation

  2010cited by this paper
• Structural basis for assembly and activation of the heterotetrameric SAGA histone H2B deubiquitinase module.

  2010cited by this paper
• Structural Insights into the Assembly and Function of the SAGA Deubiquitinating Module

  2010cited by this paper
• Sem1 is a functional component of the nuclear pore complex–associated messenger RNA export machinery

  2009cited by this paper
• Sus1, Cdc31, and the Sac3 CID Region Form a Conserved Interaction Platform that Promotes Nuclear Pore Association and mRNA Export

  2009influential reference
• Arabidopsis homolog of the yeast TREX-2 mRNA export complex: components and anchoring nucleoporin.

  2009cited by this paper
• Structural Basis for the Interaction between Yeast Spt-Ada-Gcn5 Acetyltransferase (SAGA) Complex Components Sgf11 and Sus1*

  2009cited by this paper
• Pre-mRNA processing reaches back to transcription and ahead to translation.

  2009cited by this paper
• A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing.

  2008cited by this paper
• A versatile interaction platform on the Mex67–Mtr2 receptor creates an overlap between mRNA and ribosome export

  2008cited by this paper
• Yeast Ataxin-7 links histone deubiquitination with gene gating and mRNA export

  2008influential reference
• The Human SPT20-Containing SAGA Complex Plays a Direct Role in the Regulation of Endoplasmic Reticulum Stress-Induced Genes

  2008influential reference
• Nuclear pore complex assembly through the cell cycle: Regulation and membrane organization

  2008cited by this paper
• A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing.

  2008influential reference
• Systematic kinetic analysis of mitotic dis- and reassembly of the nuclear pore in living cells

  2008cited by this paper
• Centrin 2 Localizes to the Vertebrate Nuclear Pore and Plays a Role in mRNA and Protein Export

  2008cited by this paper
• Centrins in retinal photoreceptor cells: regulators in the connecting cilium.

  2008cited by this paper
• SAGA and a novel Drosophila export complex anchor efficient transcription and mRNA export to NPC

  2007cited by this paper
• Nuclear export of ribosomal 60S subunits by the general mRNA export receptor Mex67-Mtr2.

  2007cited by this paper
• Comprehensive analysis of diverse ribonucleoprotein complexes

  2007cited by this paper
• Quantitative proteomic analysis of distinct mammalian Mediator complexes using normalized spectral abundance factors

  2006cited by this paper
• The mRNA export factor Sus1 is involved in Spt/Ada/Gcn5 acetyltransferase-mediated H2B deubiquitinylation through its interaction with Ubp8 and Sgf11.

  2006cited by this paper
• SAGA interacting factors confine sub-diffusion of transcribed genes to the nuclear envelope

  2006influential reference
• Nuclear transcription is essential for specification of mammalian replication origins

  2006cited by this paper
• Recruitment of the human TREX complex to mRNA during splicing.

  2005influential reference
• Yeast centrin Cdc31 is linked to the nuclear mRNA export machinery

  2004cited by this paper
• Differential Expression and Interaction with the Visual G-protein Transducin of Centrin Isoforms in Mammalian Photoreceptor Cells*

  2004cited by this paper
• Sus1, a functional component of the SAGA histone acetylase complex and the nuclear pore-associated mRNA export machinery.

  2004cited by this paper
• Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes.

  2004influential reference
• Biochemical analysis of TREX complex recruitment to intronless and intron‐containing yeast genes

  2004cited by this paper
• Mapping the dynamic organization of the nuclear pore complex inside single living cells

  2004influential reference
• Cotranscriptionally formed DNA:RNA hybrids mediate transcription elongation impairment and transcription-associated recombination.

  2003cited by this paper
• The C-terminal domain of myosin-like protein 1 (Mlp1p) is a docking site for heterogeneous nuclear ribonucleoproteins that are required for mRNA export

  2003cited by this paper
• Immunoaffinity purification of mammalian protein complexes.

  2003influential reference
• The mRNA export machinery requires the novel Sac3p–Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores

  2002cited by this paper
• Proteomic analysis of the mammalian nuclear pore complex

  2002cited by this paper
• Remodelling the walls of the nucleus

  2002cited by this paper
• The yeast THO complex and mRNA export factors link RNA metabolism with transcription and genome instability

  2002influential reference
• Stable mRNP Formation and Export Require Cotranscriptional Recruitment of the mRNA Export Factors Yra1p and Sub2p by Hpr1p

  2002cited by this paper
• Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export

  2002cited by this paper
• UV‐damaged DNA‐binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation

  2001influential reference
• The Yeast Nuclear Pore Complex: Composition, Architecture, and Transport Mechanism

  2000cited by this paper
• Yra1p, a conserved nuclear RNA‐binding protein, interacts directly with Mex67p and is required for mRNA export

  2000influential reference
• The Yeast Nuclear Pore Complex

  2000cited by this paper
• REF, an evolutionary conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export.

  2000cited by this paper
• Sequential recruitment of NPC proteins to the nuclear periphery at the end of mitosis.

  1999cited by this paper
• TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus.

  1998cited by this paper
• A novel yeast gene, THO2, is involved in RNA pol II transcription and provides new evidence for transcriptional elongation‐associated recombination

  1998cited by this paper
• Identification of a new mammalian centrin gene, more closely related to Saccharomyces cerevisiae CDC31 gene.

  1997cited by this paper
• Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores

  1997cited by this paper
• Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID.

  1995influential reference
• A nuclear pore complex protein that contains zinc finger motifs, binds DNA, and faces the nucleoplasm.

  1993cited by this paper

• How the TREX-2 complex associates with the nuclear pore

  2026cites this paper
• The THO complex in Schizosaccharomyces pombe-dissecting the composition and functional hierarchy.

  2026cites this paper
• An ATP-gated molecular switch orchestrates human mRNA export

  2025cites this paper
• Peculiarities of the e(y)2 Gene Evolution in Deuterostomes and Drosophilinae

  2025cites this paper
• Mixed Messages: Dynamic and Compositional Heterogeneity of Nuclear Messenger Ribonucleoprotein (mRNP) Complexes

  2025cites this paper
• Interdomain Interactions of the PCID2 Protein, One of the Subunits of the TREX-2 mRNA Export Complex in Drosophila melanogaster

  2025cites this paper
• Key neuropeptide and neuroendocrine pathways of the optic lobe are affected by high temperatures in the female Octopus maya.

  2025cites this paper
• CETN3 deficiency induces microcephaly by disrupting neural stem/progenitor cell fate through impaired centrosome assembly and RNA splicing

  2025cites this paper
• Nup153 and TPR/Megator Interact with TREX-2 Subunits and Are Essential for TREX-2-Dependent Nuclear Export of hsp70 mRNA in Drosophila

  2025influential citation
• LENG8 mediates RNA nuclear retention and degradation in eukaryotes

  2025cites this paper
• Structural mechanism of DDX39B regulation by human TREX-2 and a related complex in mRNP remodeling

  2025cites this paper
• The role of phase separation for RNA and protein transport through the nuclear pore complex

  2025cites this paper
• Role of the nucleotide excision repair function of CETN2 in the inhibition of the sensitivity of hepatocellular carcinoma cells to oxaliplatin.

  2025cites this paper
• Detailed characterisation of the trypanosome nuclear pore architecture reveals conserved asymmetrical functional hubs that drive mRNA export

  2025cites this paper
• Pushing the envelope - How the genome interacts with the nuclear envelope in health and disease.

  2025cites this paper
• Structures and mRNP remodeling mechanism of the TREX-2 complex.

  2025cites this paper
• TPR is required for circRNA, lncRNA and mRNA nuclear export

  2025cites this paper
• Nuclear RNA homeostasis promotes systems-level coordination of cell fate and senescence.

  2024cites this paper
• Tumorigenesis Caused by Aberrant Expression of GANP, a Central Component in the Mammalian TREX-2 Complex—Lessons from Transcription-Coupled DNA Damages

  2024cites this paper
• A combination of expansion microscopy and proximity labelling reveals conserved and unique asymmetric functional hubs at the trypanosome nuclear pore

  2024cites this paper
• Nucleoporin Nup153 docks the splicing machinery to the nuclear pore for efficient mRNA processing

  2024cites this paper
• Nuclear mRNA export

  2024cites this paper
• O-GlcNAc transferase congenital disorder of glycosylation (OGT-CDG): Potential mechanistic targets revealed by evaluating the OGT interactome

  2024cites this paper
• Oncogenes and tumor suppressor genes: functions and roles in cancers

  2024cites this paper
• Carcinogenesis caused by transcription‐coupled DNA damage through GANP and other components of the TREX‐2 complex

  2024cites this paper
• An integrative analysis of enhancer of yellow 2 homolog (ENY2) as a molecular biomarker in pan-cancer

  2023cites this paper
• Co-translational assembly pathways of nuclear multiprotein complexes involved in the regulation of gene transcription.

  2023cites this paper
• Tpr Misregulation in Hippocampal Neural Stem Cells in Mouse Models of Alzheimer’s Disease

  2023cites this paper
• Super-enhancer trapping by the nuclear pore via intrinsically disordered regions of proteins in squamous cell carcinoma cells.

  2023cites this paper
• PCID2 dysregulates transcription and viral RNA processing to promote HIV-1 latency

  2023cites this paper
• A genome-wide screen reveals new regulators of the 2-cell-like cell state

  2023cites this paper
• PCID2 Subunit of the Drosophila TREX-2 Complex Has Two RNA-Binding Regions

  2023influential citation
• Auxin-inducible degron system: an efficient protein degradation tool to study protein function.

  2023cites this paper
• An evolutionarily conserved bimodular domain anchors ZC3HC1 and its yeast homologue Pml39p to the nuclear basket

  2023cites this paper
• Export of discarded splicing intermediates requires mRNA export factors and the nuclear basket

  2023influential citation
• Cotranslational Mechanisms of Protein Biogenesis and Complex Assembly in Eukaryotes.

  2022cites this paper
• ZC3HC1 is a structural element of the nuclear basket effecting interlinkage of TPR polypeptides

  2022cites this paper
• Nuclear basket protein ZC3HC1 and its yeast homolog Pml39p feature an evolutionary conserved bimodular construction essential for initial binding to NPC-anchored homologs of scaffold protein TPR

  2022cites this paper
• Sending the message: specialized RNA export mechanisms in trypanosomes.

  2022cites this paper
• Mechanisms of RNA export and nuclear retention

  2022cites this paper
• Structural assembly of the nucleic-acid-binding Thp3–Csn12–Sem1 complex functioning in mRNA splicing

  2022cites this paper
• Spelling out the roles of individual nucleoporins in nuclear export of mRNA

  2022cites this paper
• Evolution and diversification of the nuclear pore complex

  2021cites this paper
• SUPT3H-less SAGA coactivator can assemble and function without significantly perturbing RNA polymerase II transcription in mammalian cells

  2021cites this paper
• Crosstalk between nucleocytoplasmic trafficking and the innate immune response to viral infection

  2021influential citation
• Peripheral neuropathy linked mRNA export factor GANP reshapes gene regulation in human motor neurons

  2021cites this paper
• Nuclear mRNA maturation and mRNA export control: from trypanosomes to opisthokonts

  2021cites this paper
• PCID2, a subunit of the Drosophila TREX-2 nuclear export complex, is essential for both mRNA nuclear export and its subsequent cytoplasmic trafficking

  2021cites this paper
• Choosing the right exit: How functional plasticity of the nuclear pore drives selective and efficient mRNA export

  2021influential citation
• The Great Escape: mRNA Export through the Nuclear Pore Complex

  2021cites this paper
• C. elegans THSC/TREX-2 deficiency causes replication stress and genome instability.

  2021influential citation
• Distinct roles of nuclear basket proteins in directing the passage of mRNA through the nuclear pore

  2021cites this paper
• Pathogenic variants in nucleoporin TPR (translocated promoter region, nuclear basket protein) cause severe intellectual disability in humans.

  2021cites this paper
• Nuclear pore complex acetylation regulates mRNA export and cell cycle commitment in budding yeast

  2021cites this paper
• ZC3HC1 Is a Novel Inherent Component of the Nuclear Basket, Resident in a State of Reciprocal Dependence with TPR

  2021cites this paper
• Into the basket and beyond: the journey of mRNA through the nuclear pore complex.

  2020cites this paper
• Distinct effects on mRNA export factor GANP underlie neurological disease phenotypes and alter gene expression depending on intron content

  2020cites this paper
• Alternative splicing (AS) mechanism plays important roles in response to different salinity environments in spotted sea bass.

  2020cites this paper
• Extrachromosomal Circular DNA: Current Knowledge and Implications for CNS Aging and Neurodegeneration

  2020influential citation
• iTRAQ-based quantitative proteomic analysis of Colletotrichum lini reveals ethanol induced mechanism for enhancing dihydroxylation efficiency of DHEA.

  2020cites this paper
• Gene Architecture and Sequence Composition Underpin Selective Dependency of Nuclear Export of Long RNAs on NXF1 and the TREX Complex.

  2020cites this paper
• Speculating on the Roles of Nuclear Speckles: How RNA‐Protein Nuclear Assemblies Affect Gene Expression

  2020cites this paper
• The critical role of germinal center-associated nuclear protein (GANP) in cell biology, immunohematology, and hematolymphoid oncogenesis.

  2020cites this paper
• Global transcriptional downregulation of TREX and nuclear trafficking machinery as pan-senescence phenomena: evidence from human cells and tissues

  2020cites this paper
• Nucleoporin TPR is an integral component of the TREX-2 mRNA export pathway

  2020cites this paper
• TPR is required for the efficient nuclear export of mRNAs and lncRNAs from short and intron-poor genes

  2020influential citation
• GC‐content biases in protein‐coding genes act as an “mRNA identity” feature for nuclear export

  2020cites this paper
• Buffering noise: KAT2A modular contributions to stabilization of transcription and cell identity in cancer and development.

  2020cites this paper
• Viral regulation of mRNA export with potentials for targeted therapy.

  2020cites this paper
• Recessive Charcot-Marie-Tooth and multiple sclerosis associated with a variant in MCM3AP

  2019cites this paper
• The Biology of mRNA: Structure and Function

  2019cites this paper
• Imaging within single NPCs reveals NXF1’s role in mRNA export on the cytoplasmic side of the pore

  2019cites this paper
• Distinct Basket Nucleoporins roles in Nuclear Pore Function and Gene Expression: Tpr is an integral component of the TREX-2 mRNA export pathway

  2019cites this paper
• It's Not the Destination, It's the Journey: Heterogeneity in mRNA Export Mechanisms.

  2019cites this paper
• Co-translational assembly of mammalian nuclear multisubunit complexes

  2019cites this paper
• Mechanism and Regulation of Co-transcriptional mRNP Assembly and Nuclear mRNA Export.

  2019cites this paper
• TPR is required for the nuclear export of mRNAs and lncRNAs from intronless and intron-poor genes

  2019influential citation
• Structure and Function of the TREX-2 Complex.

  2019cites this paper
• Localization of immunoreactive, dystonia-associated protein torsinA near the Golgi apparatus of cultured rodent astrocytes

  2019cites this paper
• The Structure of the Nuclear Pore Complex (An Update).

  2019cites this paper
• Localization of the signal of dystonia-associated protein torsinA near the Golgi apparatus in cultured central neurons

  2019cites this paper
• Sequence Determinants for Nuclear Retention and Cytoplasmic Export of mRNAs and lncRNAs

  2018cites this paper
• Quality control of mRNAs at the entry of the nuclear pore: Cooperation in a complex molecular system

  2018cites this paper
• The Adaptor Protein ENY2 Is a Component of the Deubiquitination Module of the Arabidopsis SAGA Transcriptional Co-activator Complex but not of the TREX-2 Complex.

  2018cites this paper
• Role of the mRNA export factor Sus1 in oxidative stress tolerance in Candida albicans.

  2018cites this paper
• Nuclear-Cytoplasmic Transport

  2018cites this paper
• Transcription and mRNA export machineries SAGA and TREX-2 maintain monoubiquitinated H2B balance required for DNA repair

  2018influential citation
• mRNA Export and Its Dysregulation in Disease

  2018cites this paper
• Co-translation drives the assembly of mammalian nuclear multisubunit complexes

  2018cites this paper
• The mRNA export factor Sac3 maintains nuclear homeostasis and regulates cytoskeleton organization in Candida albicans.

  2018cites this paper
• Piwi interacts with chromatin at nuclear pores and promiscuously binds nuclear transcripts in Drosophila ovarian somatic cells

  2017cites this paper
• RNA Nuclear Export: From Neurological Disorders to Cancer.

  2017cites this paper
• The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components

  2017cites this paper
• Sharing the SAGA.

  2017cites this paper
• Nuclear export of RNA: Different sizes, shapes and functions.

  2017cites this paper
• Nucleoporins redistribute inside the nucleus after cell cycle arrest induced by histone deacetylases inhibition

  2017cites this paper
• The function of the inner nuclear envelope protein SUN1 in mRNA export is regulated by phosphorylation

  2017cites this paper
• Coactivators and general transcription factors have two distinct dynamic populations dependent on transcription

  2017cites this paper
• Integration of mRNP formation and export

  2017cites this paper
• 5-methylcytosine promotes mRNA export — NSUN2 as the methyltransferase and ALYREF as an m5C reader

  2017cites this paper