Mechanisms of prion protein assembly into amyloid

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2008-02-19

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1073/pnas.0712036105PMID 18268326PMCID PMC2268150
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular model of an alpha-helical prion protein dimer and its monomeric subunits as derived from chemical cross-linking and molecular modeling calculations.

  2008cited by this paper
• Counting of single prion particles bound to a capture-antibody surface (surface-FIDA).

  2007cited by this paper
• Formation of native prions from minimal components in vitro

  2007cited by this paper
• Prion detection by an amyloid seeding assay

  2007cited by this paper
• Ultrasensitive detection of scrapie prion protein using seeded conversion of recombinant prion protein

  2007cited by this paper
• Detection of prion particles in samples of BSE and scrapie by fluorescence correlation spectroscopy without proteinase K digestion

  2006cited by this paper
• Prion clearance in bigenic mice.

  2005cited by this paper
• Search for a Prion-Specific Nucleic Acid

  2005cited by this paper
• In vitro generation of infectious scrapie prions.

  2005cited by this paper
• Assembly of natural and recombinant prion protein into fibrils

  2005cited by this paper
• Synthetic prions generated in vitro are similar to a newly identified subpopulation of PrPSc from sporadic Creutzfeldt‐Jakob Disease

  2005cited by this paper
• Strain-specified characteristics of mouse synthetic prions.

  2005cited by this paper
• Prion kinetics. Authors' reply

  2004cited by this paper
• Evidence for assembly of prions with left-handed β-helices into trimers

  2004cited by this paper
• Synthetic Mammalian Prions

  2004cited by this paper
• Prion kinetics.

  2004influential reference
• Evidence for assembly of prions with left-handed beta-helices into trimers.

  2004cited by this paper
• The structural transition of the prion protein into its pathogenic conformation is induced by unmasking hydrophobic sites.

  2004cited by this paper
• Prion Kinetics (multiple letters)

  2004cited by this paper
• Atypical Effect of Salts on the Thermodynamic Stability of Human Prion Protein*

  2003cited by this paper
• Widespread PrPSc accumulation in muscles of hamsters orally infected with scrapie

  2003cited by this paper
• Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding

  2001influential reference
• BSE und das Prionen Problem.

  2001influential reference
• Structural Intermediates in the Putative Pathway from the Cellular Prion Protein to the Pathogenic Form

  2001cited by this paper
• Solution structure of Syrian hamster prion protein rPrP(90-231).

  1999cited by this paper
• Mapping the Prion Protein Using Recombinant Antibodies

  1998cited by this paper
• Eight prion strains have PrPSc molecules with different conformations

  1998cited by this paper
• Rapid Acquisition of β-Sheet Structure in the Prion Protein Prior to Multimer Formation

  1998cited by this paper
• Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins.

  1997cited by this paper
• High-level expression and characterization of a purified 142-residue polypeptide of the prion protein.

  1996cited by this paper
• Prionics or the kinetic basis of prion diseases.

  1996cited by this paper
• Structural clues to prion replication.

  1994cited by this paper
• Thermal stability and conformational transitions of scrapie amyloid (prion) protein correlate with infectivity

  1993cited by this paper
• Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.

  1993cited by this paper
• Further analysis of nucleic acids in purified scrapie prion preparations by improved return refocusing gel electrophoresis.

  1992cited by this paper
• N-terminal truncation of the scrapie-associated form of PrP by lysosomal protease(s): implications regarding the site of conversion of PrP to the protease-resistant state

  1991cited by this paper
• Scrapie prion rod formation in vitro requires both detergent extraction and limited proteolysis

  1991cited by this paper
• Scrapie prions aggregate to form amyloid-like birefringent rods.

  1983cited by this paper
• A protease-resistant protein is a structural component of the scrapie prion.

  1983cited by this paper
• THERMODYNAMIC ANALYSIS OF MULTICOMPONENT SOLUTIONS.

  1964cited by this paper

• Intracellular Transport of Monomeric Peptides, (Poly)Peptide-Based Coacervates and Fibrils: Mechanisms and Prospects for Drug Delivery

  2025cites this paper
• High-Level Expression, Purification and Biophysical Characterization of GPI-anchored native-like human Prion Protein using Leishmania tarentolae

  2025cites this paper
• Coalescence-Driven Local Crowding Promotes Liquid-to-Solid-Like Phase Transition in a Homogeneous and Heterogeneous Droplet Assembly: Regulatory Role of Ligands.

  2025cites this paper
• Kinetics of Amyloid Oligomer Formation.

  2025cites this paper
• Coalescence-Driven Local Crowding Promotes Liquid-to-Solid-Like Phase Transition in a Homogeneous and Heterogeneous Droplet Assembly

  2024cites this paper
• Slow misfolding of a molten globule form of a mutant prion protein variant into a β-rich dimer.

  2024cites this paper
• The expression of pro-prion, a transmembrane isoform of the prion protein, leads to the constitutive activation of the canonical Wnt/β-catenin pathway to sustain the stem-like phenotype of human glioblastoma cells

  2024cites this paper
• Syntaxin-6 delays prion protein fibril formation and prolongs the presence of toxic aggregation intermediates

  2023cites this paper
• Amyloidosis-history and development, emphasis on insulin and prion amyloids

  2023cites this paper
• Realization of Amyloid-like Aggregation as a Common Cause for Pathogenesis in Diseases

  2023cites this paper
• Fibrinogen Mitigates Prion-Mediated Platelet Activation and Neuronal Cell Toxicity

  2022cites this paper
• Evidence of Orientation-Dependent Early States of Prion Protein Misfolded Structures from Single Molecule Force Spectroscopy

  2022cites this paper
• The G127V variant of the prion protein interferes with dimer formation in vitro but not in cellulo

  2021cites this paper
• Scaling analysis reveals molecular mechanism of prion self-replication in vivo .

  2021cites this paper
• Scaling analysis reveals the mechanism and rates of prion replication in vivo

  2021cites this paper
• Mutation-Dependent Refolding of Prion Protein Unveils Amyloidogenic-Related Structural Ramifications: Insights from Molecular Dynamics Simulations.

  2021cites this paper
• The prion-like nature of amyotrophic lateral sclerosis.

  2020cites this paper
• The Role of Vesicle Trafficking Defects in the Pathogenesis of Prion and Prion-Like Disorders

  2020cites this paper
• Prion protein post-translational modifications modulate heparan sulfate binding and limit aggregate size in prion disease.

  2020cites this paper
• Formation of distinct prion protein amyloid fibrils under identical experimental conditions

  2020cites this paper
• Prion protein transcription is auto-regulated through dynamic interactions with G-quadruplex motifs in its own promoter.

  2020cites this paper
• The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation.

  2020cites this paper
• Carbon Nanoparticles Inhibit the Aggregation of Prion Protein as Revealed by Experiments and Atomistic Simulations

  2019cites this paper
• Prion dimer is heterogenous and is modulated by multiple negative and positive motifs.

  2019cites this paper
• Mechanistic Insights into the Early Events in the Aggregation of Immunoglobulin Light Chains.

  2019cites this paper
• Direct interaction of DNMT inhibitors to PrPC suppresses pathogenic process of prion

  2019cites this paper
• Dynamics and Control of Peptide Self-Assembly and Aggregation.

  2019cites this paper
• Biological and Bio-inspired Nanomaterials: Properties and Assembly Mechanisms

  2019cites this paper
• The role of liquid–liquid phase separation in aggregation of the TDP-43 low-complexity domain

  2019cites this paper
• The prion-like properties of assembled human alpha-synuclein

  2018cites this paper
• Inability of DNAzymes to cleave RNA in vivo is due to limited Mg$$^{2+}$$2+ concentration in cells

  2018cites this paper
• Evidence for a central role of PrP helix 2 in the nucleation of amyloid fibrils

  2018cites this paper
• Molecular and Clinical Aspects of Protein Aggregation Assays in Neurodegenerative Diseases

  2018cites this paper
• Structural Determinants of the Prion Protein N-Terminus and Its Adducts with Copper Ions

  2018cites this paper
• Structural mechanisms of oligomer and amyloid fibril formation by the prion protein.

  2018cites this paper
• Interrogating the Dimerization Interface of the Prion Protein Via Site-Specific Mutations to p-Benzoyl-L-Phenylalanine.

  2018cites this paper
• Structure-Property Relationship of Amyloidogenic Prion Nanofibrils

  2017cites this paper
• Production of Hydrophobins from fungi

  2017cites this paper
• Prion-like proteins and their computational identification in proteomes

  2017cites this paper
• Modulation of prion polymerization and toxicity by rationally designed peptidomimetics.

  2017cites this paper
• Title Ultrasensitive human prion detection in cerebrospinal fluid by real-timequaking-induced conversion

  2017cites this paper
• Fabrication of Magnetic Conjugation Clusters via Intermolecular Assembling for Ultrasensitive Surface Plasmon Resonance (SPR) Detection in a Wide Range of Concentrations.

  2017cites this paper
• Role of polysaccharide and lipid in lipopolysaccharide induced prion protein conversion

  2016cites this paper
• Investigation on salt bridge interactions of mammalian prion proteins by molecular dynamics simulation / Memeli prion proteinlerinin moleküler dinamik simulasyon ile tuz köprüleri etkileşimlerinin araştırılması

  2016cites this paper
• Replica Exchange Molecular Dynamics Study of Dimerization in Prion Protein: Multiple Modes of Interaction and Stabilization.

  2016cites this paper
• Comparing the energy landscapes for native folding and aggregation of PrP

  2016cites this paper
• Confined Water in Amyloid-Competent Oligomers of the Prion Protein.

  2016cites this paper
• The physics of the phase transition in crystallogenesis and amyloid fibrillogenesis

  2016cites this paper
• Creutzfeldt–Jakob Disease

  2015cites this paper
• Conformational Switching and Nanoscale Assembly of Human Prion Protein into Polymorphic Amyloids via Structurally Labile Oligomers.

  2015cites this paper
• Molecular-level insights of early-stage prion protein aggregation on mica and gold surface determined by AFM imaging and molecular simulation.

  2015cites this paper
• Common Mechanisms in Neurodegenerative Diseases

  2015cites this paper
• 181 – Prions and Prion Diseases of the Central Nervous System (Transmissible Neurodegenerative Diseases)

  2015cites this paper
• Modelling human prion replication in cell-free systems

  2014cites this paper
• How Does Domain Replacement Affect Fibril Formation of the Rabbit/Human Prion Proteins

  2014cites this paper
• Shaking Alone Induces De Novo Conversion of Recombinant Prion Proteins to β-Sheet Rich Oligomers and Fibrils

  2014cites this paper
• Regulation of PrPC signaling and processing by dimerization

  2014cites this paper
• Comparative Analysis of Cellular Prion Detection by Mass‐Sensitive Immunosensors

  2014cites this paper
• The case for involvement of spiroplasma in the pathogenesis of transmissible spongiform encephalopathies.

  2014cites this paper
• Lipopolysaccharide induced conversion of recombinant prion protein

  2014cites this paper
• Solubility and supersaturation-dependent protein misfolding revealed by ultrasonication.

  2014cites this paper
• Evaluating prion models based on comprehensive mutation data of mouse PrP.

  2014cites this paper
• Amyloid Oligomers and Protofibrils, but Not Filaments, Self-Replicate from Native Lysozyme

  2014cites this paper
• Distinct synthetic Aβ prion strains producing different amyloid deposits in bigenic mice

  2014cites this paper
• Single-molecule studies of prion protein folding and misfolding

  2013cites this paper
• Recent progress in prion and prion-like protein aggregation.

  2013cites this paper
• Thienyl pyrimidine derivatives with PrP(Sc) oligomer-inducing activity are a promising tool to study prions.

  2013cites this paper
• Prion protein oligomer and its neurotoxicity.

  2013cites this paper
• Prion Protein Self-Peptides

  2013cites this paper
• Prion and Prion-like Diseases in Humans

  2013cites this paper
• Expression and characterisation of fully posttranslationally modified cellular prion protein in Pichia pastoris

  2013cites this paper
• Homodimerization as a molecular switch between low and high efficiency PrPC cell surface delivery and neuroprotective activity

  2013cites this paper
• Infectivity versus Seeding in Neurodegenerative Diseases Sharing a Prion-Like Mechanism

  2013cites this paper
• Characterization of intracellular protein aggregates

  2013cites this paper
• Protein Structure and Biology

  2013cites this paper
• Seeded Fibrillation as Molecular Basis of the Species Barrier in Human Prion Diseases

  2013influential citation
• Nanopore analysis reveals differences in structural stability of ovine PrPC proteins corresponding to scrapie susceptible (VRQ) and resistance (ARR) genotypes

  2013cites this paper
• Prions as Seeds and Recombinant Prion Proteins as Substrates

  2013cites this paper
• True and apparent inhibition of amyloid fibril formation

  2013cites this paper
• Dissection of conformational conversion events during prion amyloid fibril formation using hydrogen exchange and mass spectrometry.

  2013cites this paper
• Use of Proteinase K Nonspecific Digestion for Selective and Comprehensive Identification of Interpeptide Cross-links: Application to Prion Proteins*

  2012cites this paper
• Prion protein aggregation and fibrillogenesis in vitro.

  2012influential citation
• Enhanced sampling molecular dynamics identifies PrP(Sc) structures harboring a C-terminal β-core.

  2012cites this paper
• Importance of dimerization in aggregation and neurotoxicity of Prion and [alpha]-Synuclein in prion and Parkinson's diseases

  2012cites this paper
• Exploring the essential collective dynamics of interacting proteins: Application to prion protein dimers

  2012cites this paper
• Spiroplasma spp. biofilm formation is instrumental for their role in the pathogenesis of plant, insect and animal diseases.

  2012cites this paper
• A Generic Crystallization-like Model That Describes the Kinetics of Amyloid Fibril Formation*♦

  2012cites this paper
• pH modulation of fibril dissociation and copper binding properties of the prion protein

  2012cites this paper
• Stem-forming regions that are essential for the amyloidogenesis of prion proteins.

  2012cites this paper
• Computational Prediction of Strand Residues from Protein Sequences

  2012cites this paper
• Effect of divalent metals on the neuronal proteasomal system, prion protein ubiquitination and aggregation.

  2012cites this paper
• Role of elongation and secondary pathways in S6 amyloid fibril growth.

  2012cites this paper
• Relationship between Prion Propensity and the Rates of Individual Molecular Steps of Fibril Assembly

  2011cites this paper
• Globular Domain of the Prion Protein Needs to Be Unlocked by Domain Swapping to Support Prion Protein Conversion*

  2011cites this paper
• Fibril formation of the rabbit/human/bovine prion proteins.

  2011cites this paper
• Sialylated and O‐glycosidically linked glycans in prion protein deposits in a case of Gerstmann‐Sträussler‐Scheinker disease

  2011cites this paper
• Prion Disease Blood Test Using Immunoprecipitation and Improved Quaking-Induced Conversion

  2011cites this paper
• Tauons and Prions: Infamous Cousins?

  2011cites this paper
• Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion

  2011cites this paper
• Effect of Hydrophobic Mutations in the H2-H3 Subdomain of Prion Protein on Stability and Conversion In Vitro and In Vivo

  2011cites this paper