Attenuated Inflammatory Responses in Hemochromatosis Reveal a Role for Iron in the Regulation of Macrophage Cytokine Translation1

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Journal of Immunology

• Publication date

  2008-08-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.181.4.2723PMID 18684963PMCID PMC2561261
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Vibrio vulnificus septicemia in a patient with the hemochromatosis HFE C282Y mutation.

  2009cited by this paper
• Post-transcriptional control of cytokine production

  2008cited by this paper
• Iron‐depletion limits intracellular bacterial growth in macrophages

  2008cited by this paper
• The co‐ordinated regulation of iron homeostasis in murine macrophages limits the availability of iron for intracellular Salmonella typhimurium

  2007cited by this paper
• Pyruvate kinase deficiency confers susceptibility to Salmonella typhimurium infection in mice

  2007cited by this paper
• Host-pathogen interactions: the role of iron.

  2007cited by this paper
• A role for natural killer cells in intestinal inflammation caused by infection with Salmonella enterica serovar Typhimurium.

  2007cited by this paper
• Iron homeostasis.

  2007cited by this paper
• A Plasminogen-Activating Protease Specifically Controls the Development of Primary Pneumonic Plague

  2007cited by this paper
• An essential function of the SRC-3 coactivator in suppression of cytokine mRNA translation and inflammatory response.

  2007cited by this paper
• Iron-regulatory proteins limit hypoxia-inducible factor-2α expression in iron deficiency

  2007cited by this paper
• Hereditary hemochromatosis results in decreased iron acquisition and growth by Mycobacterium tuberculosis within human macrophages

  2007cited by this paper
• Monocyte Recruitment, Activation, and Function in the Gut-Associated Lymphoid Tissue during Oral Salmonella Infection1

  2007cited by this paper
• High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin

  2007cited by this paper
• Regulation of iron metabolism by hepcidin.

  2006cited by this paper
• Hereditary hemochromatosis.

  2006cited by this paper
• The role of iron regulatory proteins in mammalian iron homeostasis and disease

  2006cited by this paper
• Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised, placebo-controlled trial.

  2006cited by this paper
• Hereditary Hemochromatosis Protein, HFE, Interaction with Transferrin Receptor 2 Suggests a Molecular Mechanism for Mammalian Iron Sensing*

  2006cited by this paper
• The Iron Efflux Protein Ferroportin Regulates the Intracellular Growth of Salmonella enterica

  2006cited by this paper
• Developmentally Regulated Intestinal Expression of IFN-γ and Its Target Genes and the Age-Specific Response to Enteric Salmonella Infection1

  2005cited by this paper
• Resistance to hepcidin is conferred by hemochromatosis-associated mutations of ferroportin.

  2005cited by this paper
• Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin.

  2005cited by this paper
• SIH--a novel lipophilic iron chelator--protects H9c2 cardiomyoblasts from oxidative stress-induced mitochondrial injury and cell death.

  2005influential reference
• Directing Transition from Innate to Acquired Immunity: Defining a Role for IL-61

  2005cited by this paper
• Genome Watch: Enemies within

  2005cited by this paper
• Hemochromatosis and the enigma of misplaced iron: Implications for infectious disease and survival

  2004cited by this paper
• Iron deficiency and malaria among children living on the coast of Kenya.

  2004cited by this paper
• Identification of small molecule inhibitors that distinguish between non-transferrin bound iron uptake and transferrin-mediated iron transport.

  2004cited by this paper
• Living in the danger zone: innate immunity to Salmonella.

  2004cited by this paper
• Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization

  2004cited by this paper
• Toll-Like Receptors Are Temporally Involved in Host Defense

  2004cited by this paper
• Role of Toll-Like Receptor 4 in Macrophage Activation and Tolerance during Salmonella enterica Serovar Typhimurium Infection

  2003cited by this paper
• Genetic regulation of cell function in response to iron overload or chelation.

  2003cited by this paper
• Pretreatment of Mice with Streptomycin Provides a Salmonella enterica Serovar Typhimurium Colitis Model That Allows Analysis of Both Pathogen and Host

  2003cited by this paper
• Stimulation of Toll-Like Receptor 4 by Lipopolysaccharide During Cellular Invasion by Live Salmonella typhimurium Is a Critical But Not Exclusive Event Leading to Macrophage Responses1

  2003cited by this paper
• Decreased liver hepcidin expression in the Hfe knockout mouse.

  2002cited by this paper
• Iron Chelation Via Deferoxamine Exacerbates Experimental Salmonellosis Via Inhibition of the Nicotinamide Adenine Dinucleotide Phosphate Oxidase-Dependent Respiratory Burst

  2002cited by this paper
• The labile iron pool: characterization, measurement, and participation in cellular processes(1).

  2002cited by this paper
• Polymorphonuclear leukocyte migration across model intestinal epithelia enhances Salmonella typhimurium killing via the epithelial derived cytokine, IL-6.

  2002cited by this paper
• Association of pulmonary tuberculosis with increased dietary iron.

  2001cited by this paper
• Defective localization of the NADPH phagocyte oxidase to Salmonella-containing phagosomes in tumor necrosis factor p55 receptor-deficient macrophages

  2001cited by this paper
• Infections in E-β thalassemia.

  2000cited by this paper
• Infections in E-beta thalassemia.

  2000cited by this paper
• Experimental hemochromatosis due to MHC class I HFE deficiency: immune status and iron metabolism.

  1999cited by this paper
• The C282Y mutation causing hereditary hemochromatosis does not produce a null allele.

  1999cited by this paper
• Recurrent infections in homozygous sickle cell disease

  1999cited by this paper
• HFE gene knockout produces mouse model of hereditary hemochromatosis.

  1998cited by this paper
• Tuberculosis and iron overload in Africa: a review.

  1997cited by this paper
• A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis

  1996cited by this paper
• Associations of iron overload in Africa with hepatocellular carcinoma and tuberculosis: Strachan's 1929 thesis revisited.

  1996cited by this paper
• Hereditary hemochromatosis.

  1993influential reference
• Tumor necrosis factor-alpha mediates the early pathology in Salmonella infection of the gastrointestinal tract.

  1993cited by this paper
• Decreased concentrations of tumor necrosis factor-alpha in supernatants of monocytes from homozygotes for hereditary hemochromatosis.

  1992cited by this paper
• Hemochromatosis, iron and septicemia caused by Vibrio vulnificus.

  1991cited by this paper
• Role of transferrin, transferrin receptors, and iron in macrophage listericidal activity

  1991cited by this paper
• The adverse effect of iron repletion on the course of certain infections.

  1978cited by this paper
• Increased resistance of iron-deficient mice to salmonella infection

  1977cited by this paper

• Iron metabolism in rheumatic diseases

  2025cites this paper
• Linking genetics to MRI-DTI: HFE polymorphism delays Alzheimer's disease white matter degeneration in APOE4 carriers

  2025cites this paper
• HFE-Related Hemochromatosis May Be a Primary Kupffer Cell Disease

  2025cites this paper
• Iron and vitamin D intake on a diet are able to modify the in vitro immune response to Mycobacterium leprae

  2024cites this paper
• Extent of iron induced organ damage in patients with hematological disorders.

  2024cites this paper
• Trace Minerals in Laying Hen Diets and Their Effects on Egg Quality

  2024cites this paper
• Understanding How Minerals Contribute to Optimal Immune Function

  2023cites this paper
• Bacteria and macrophages in the tumor microenvironment

  2023cites this paper
• Hepcidin Alleviates LPS-Induced ARDS by Regulating the Ferritin-Mediated Suppression of Ferroptosis

  2022cites this paper
• Iron Deficiency and Overload Modulate the Inflammatory Responses and Metabolism of Alveolar Macrophages

  2022cites this paper
• Deleting Gata4 in hepatocytes promoted the progression of NAFLD via increasing steatosis and apoptosis, and desensitizing insulin signaling.

  2022cites this paper
• Relationship between Iron deposition and T lymphocytes in children with β-thalassemia with haematopoietic stem cell transplantation

  2022cites this paper
• TOR functions as a molecular switch connecting an iron cue with host innate defense against bacterial infection

  2021cites this paper
• Iron Metabolism: From Inflammation to Cancer

  2021cites this paper
• RNF217 regulates iron homeostasis through its E3 ubiquitin ligase activity by modulating ferroportin degradation

  2021cites this paper
• Iron accumulation is associated with periodontal destruction in a mouse model of HFE-related haemochromatosis.

  2021cites this paper
• Insulin resistance and adipose tissue inflammation induced by a high-fat diet are attenuated in the absence of hepcidin

  2021cites this paper
• TAM-ing the CIA—Tumor-Associated Macrophages and Their Potential Role in Unintended Side Effects of Therapeutics for Cancer-Induced Anemia

  2021cites this paper
• Ferroptotic Cell Death: New Regulatory Mechanisms for Metabolic Diseases.

  2020cites this paper
• Iron in infection and immunity.

  2020cites this paper
• Hepcidin, an Overview of Biochemical and Clinical Properties.

  2020cites this paper
• Distinct iron homeostasis in C57BL/6 and Balb/c mouse strains

  2020cites this paper
• Exploring the tumor promoting role of anti-tumor macrophage: a developmental perspective

  2020cites this paper
• Macrophage-HFE controls iron metabolism and immune responses in aged mice

  2020cites this paper
• The Role of Hepcidin and Iron Homeostasis in Atherosclerosis.

  2020cites this paper
• Nutritional and stress effects on immunologic function

  2020cites this paper
• Cytokines and metabolic regulation: A framework of bidirectional influences affecting Leishmania infection.

  2020cites this paper
• Cargo-laden erythrocyte ghosts target liver mediated by macrophages.

  2020cites this paper
• Higher iron stores and the HFE 187C>G variant delay onset of peripheral neuropathy during combination antiretroviral therapy

  2020cites this paper
• Relationship between blood Lead status and anemia in Ugandan children with malaria infection

  2020cites this paper
• Prevention of infection in primary THA and TKA

  2020cites this paper
• Cytokine and Gene Expression Profiling in Patients with HFE-Associated Hereditary Hemochromatosis according to Genetic Profile

  2020cites this paper
• Phenylbutyrate facilitates homeostasis of non-resolving inflammatory macrophages

  2019cites this paper
• The commensal bacterium Bacteroides fragilis down‐regulates ferroportin expression and alters iron homeostasis in macrophages

  2019cites this paper
• Hepcidin, iron, and bacterial infection.

  2019cites this paper
• Genome-Wide Association Study in Mexican Holstein Cattle Reveals Novel Quantitative Trait Loci Regions and Confirms Mapped Loci for Resistance to Bovine Tuberculosis

  2019cites this paper
• Supercritical Fluid Extract of Angelica sinensis and Zingiber officinale Roscoe Ameliorates TNBS-Induced Colitis in Rats

  2019cites this paper
• Dietary iron variably modulates assembly of the intestinal microbiota in colitis-resistant and colitis-susceptible mice

  2019cites this paper
• The YrbE phospholipid transporter of Salmonella enterica serovar Typhi regulates the expression of flagellin and influences motility, adhesion and induction of epithelial inflammatory responses

  2019cites this paper
• Enhanced insulin signaling and its downstream effects in iron-overloaded primary hepatocytes from hepcidin knock-out mice.

  2019cites this paper
• New insights into the role of iron in inflammation and atherosclerosis

  2019cites this paper
• Classical and intermediate monocytes scavenge non-transferrin-bound iron and damaged erythrocytes

  2019cites this paper
• Centrifugation‐free washing: A novel approach for removing immunoglobulin A from stored red blood cells

  2018cites this paper
• Oxidative stress in sickle cell disease; more than a DAMP squib

  2018cites this paper
• HFE Genotype Restricts the Response to Paraquat in a Mouse Model of Neurotoxicity

  2018cites this paper
• Hepcidin mediated iron homoeostasis as immune regulator in visceral leishmaniasis patients

  2018cites this paper
• Iron and innate antimicrobial immunity-Depriving the pathogen, defending the host.

  2018cites this paper
• Cystathionine β‐synthase is required for body iron homeostasis

  2018cites this paper
• The role of HFE genotype in macrophage phenotype

  2018cites this paper
• Increased transferrin saturation is associated with subgingival microbiota dysbiosis and severe periodontitis in genetic haemochromatosis

  2018cites this paper
• Emerging Regulatory Role of Nrf2 in Iron, Heme, and Hemoglobin Metabolism in Physiology and Disease

  2018cites this paper
• Macrophage ferroportin is essential for stromal cell proliferation in wound healing

  2018cites this paper
• Impact of Childhood Malnutrition on Host Defense and Infection

  2017cites this paper
• Fer et prédisposition aux infections

  2017cites this paper
• 23 Are Hemochromatosis Mutations Protective Against Iron-Mediated Atherogenesis ?

  2017influential citation
• Pathophysiological consequences and benefits of HFE mutations: 20 years of research

  2017cites this paper
• Liver inflammation and fibrosis.

  2017cites this paper
• [Iron and susceptibility to infections].

  2017cites this paper
• Hemojuvelin regulates the innate immune response to peritoneal bacterial infection in mice

  2017cites this paper
• Guanosine 5′-monophosphate-chelated calcium and iron feed additives maintains egg production and prevents Salmonella Gallinarum in experimentally infected layers

  2017cites this paper
• Open-array analysis of genetic variants in Egyptian patients with type 2 diabetes and obesity

  2017cites this paper
• Hereditary Hemochromatosis Predisposes Mice to Yersinia pseudotuberculosis Infection Even in the Absence of the Type III Secretion System

  2016influential citation
• Molecular pathogenesis and clinical consequences of iron overload in liver cirrhosis.

  2016cites this paper
• Iron acquisition in Leishmania and its crucial role in infection

  2016cites this paper
• Targeting Iron Deficiency Anemia in Heart Failure.

  2016cites this paper
• Q fever hepatitis and endocarditis in the context of haemochromatosis

  2016cites this paper
• Macrophagic control of the response to uropathogenic E. coli infection by regulation of iron retention in an IL‐6‐dependent manner

  2016cites this paper
• Commensal Bacteria-Induced Inflammasome Activation in Mouse and Human Macrophages Is Dependent on Potassium Efflux but Does Not Require Phagocytosis or Bacterial Viability

  2016cites this paper
• Lipocalin 2 alleviates iron toxicity by facilitating hypoferremia of inflammation and limiting catalytic iron generation

  2016cites this paper
• Iron and innate immunity

  2016cites this paper
• Low dietary iron intake restrains the intestinal inflammatory response and pathology of enteric infection by food‐borne bacterial pathogens

  2015cites this paper
• Hepcidin and Host Defense against Infectious Diseases

  2015influential citation
• Rôle des récepteurs Toll-like et de la protéine adaptatrice MyD88 dans la régulation de l’hepcidine et le développement des hyposidérémies associées à l’inflammation

  2015cites this paper
• Iron homeostasis in immune mononuclear cells : a potential role in a atherogenesis

  2015cites this paper
• The HFE genotype and a formulated diet controlling for iron status attenuate experimental cerebral malaria in mice.

  2015cites this paper
• Viscoelasticity and Ultrastructure in Coagulation and Inflammation: Two Diverse Techniques, One Conclusion

  2015cites this paper
• Hepatic Hepcidin Protects against Polymicrobial Sepsis in Mice by Regulating Host Iron Status

  2015cites this paper
• Nramp1 and Other Transporters Involved in Metal Withholding during Infection*

  2015cites this paper
• Eyam’s Guardian Gene; C282Y, H63D or Delta 32?

  2015cites this paper
• Iron Deficiency Anaemia is Associated with Decreased Levels of Macrophage Migration Inhibitory Factor and Monocyte Chemoattractant Protein-1

  2015cites this paper
• Iron, Inflammation, and Early Death in Adults With Sickle Cell Disease

  2015cites this paper
• Ironing out Ferroportin.

  2015cites this paper
• Régulation de l'hepcidine et le rôle de la lipocaline 2 dans l'homéostasie du fer / Novel insights into the regulation of hepcidin and the role of lipocalin 2 in iron homeostasis

  2014cites this paper
• T2(∗) MRI changes in the heart and liver of ex-thalassemic patients after hematopoietic stem cell transplantation.

  2014cites this paper
• Macrophages clear refrigerator storage–damaged red blood cells and subsequently secrete cytokines in vivo, but not in vitro, in a murine model

  2014influential citation
• Hepcidin expression in colon during trinitrobenzene sulfonic acid-induced colitis in rats.

  2014cites this paper
• Nutritional iron turned inside out: intestinal stress from a gut microbial perspective.

  2014cites this paper
• Salmonella Adhesion, Invasion and Cellular Immune Responses Are Differentially Affected by Iron Concentrations in a Combined In Vitro Gut Fermentation-Cell Model

  2014cites this paper
• Endothelial function, antioxidant status and vascular compliance in newly diagnosed HFE C282Y homozygotes.

  2014cites this paper
• Disordered vascular compliance in haemochromatosis

  2014cites this paper
• Silencing airway epithelial cell-derived hepcidin exacerbates sepsis-induced acute lung injury

  2014influential citation
• Genetic, phenotypic and clinical evaluation of haemophilia A in Pakistan

  2014cites this paper
• Review on Iron, Immunity and Intensive Care

  2014cites this paper
• Understanding the role of hfe polymorphism in cancer

  2014cites this paper
• Responses of the gut microbiota to supplementary iron: a survey at the host-microbial interface

  2014cites this paper
• Inverse agonist of estrogen-related receptor γ controls Salmonella typhimurium infection by modulating host iron homeostasis

  2014cites this paper
• A Novel Nrf2-Mediated Antioxidative and Antiinflammatory Mechanism through Ferroportin 1 Induction : A Potential Cytoprotective Mechanism against Ischemia-Reperfusion Injuries [Innovation in Transplant and Regenerative Medicine. The 13th Meeting of Hirosaki International Forum of Medical Science. Co

  2013cites this paper
• Iron transport and liver injury in mouse models of hereditary haemochromatosis

  2013cites this paper
• Does non-transferrin bound iron contribute to transfusion related immune-modulation in preterms?

  2013cites this paper
• Clostridium difficile colitis in the United States: a decade of trends, outcomes, risk factors for colectomy, and mortality after colectomy.

  2013cites this paper