Sex differences in opioid analgesia, hyperalgesia, tolerance and withdrawal: central mechanisms of action and roles of gonadal hormones.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Hormones and Behavior

• Publication date

  2010-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.yhbeh.2009.09.012PMID 19786031
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Neonatal and Adult Gonadal Hormone Manipulations Enhance Morphine Analgesia Elicited from the Ventrolateral Periaqueductal Gray in Female Rats

  2010cited by this paper
• Sex differences in the activation of the spinoparabrachial circuit by visceral pain.

  2009cited by this paper
• Study of morphine-induced dependence in gonadectomized male and female mice.

  2009cited by this paper
• Sexually dimorphic activation of the periaqueductal gray–rostral ventromedial medullary circuit during the development of tolerance to morphine in the rat

  2008cited by this paper
• Sex Differences in μ-Opioid Receptor Expression in the Rat Midbrain Periaqueductal Gray Are Essential for Eliciting Sex Differences in Morphine Analgesia

  2008cited by this paper
• Relationship of Spinal Dynorphin Neurons to δ-Opioid Receptors and Estrogen Receptor α: Anatomical Basis for Ovarian Sex Steroid Opioid Antinociception

  2008cited by this paper
• Response to Morphine in Male and Female Patients: Analgesia and Adverse Events

  2008cited by this paper
• Androgen and estrogen (alpha) receptor localization on periaqueductal gray neurons projecting to the rostral ventromedial medulla in the male and female rat.

  2008cited by this paper
• Sex differences in hyperalgesia during morphine infusion: effect of gonadectomy and estrogen treatment.

  2008cited by this paper
• Morphine preferentially activates the periaqueductal gray-rostral ventromedial medullary pathway in the male rat: a potential mechanism for sex differences in antinociception.

  2007cited by this paper
• Sexually Dimorphic Recruitment of Spinal Opioid Analgesic Pathways by the Spinal Application of Morphine

  2007cited by this paper
• Sex differences in the potency of κ opioids and mixed-action opioids administered systemically and at the site of inflammation against capsaicin-induced hyperalgesia in rats

  2007cited by this paper
• Sex differences in opioid-mediated pain inhibitory mechanisms during the interphase in the formalin test.

  2007cited by this paper
• Sex differences and role of gonadal hormones on glutamate level in the nucleus accumbens in morphine tolerant rats: a microdialysis study.

  2007cited by this paper
• ESTRUS PHASE DIFFERENCES IN FEMALE RATS IN MORPHINE ANTINOCICEPTION ELICITED FROM THE VENTROLATERAL PERIAQUEDUCTAL GRAY

  2007cited by this paper
• Kappa opioid receptors in the rostral ventromedial medulla of male and female rats

  2007cited by this paper
• Studying sex and gender differences in pain and analgesia: a consensus report.

  2007cited by this paper
• Estrogen modulation of morphine analgesia of visceral pain in female rats is supraspinally and peripherally mediated.

  2007cited by this paper
• PAG mu opioid receptor activation underlies sex differences in morphine antinociception.

  2007cited by this paper
• Dissociation between sex differences in the immunological, behavioral, and physiological effects of κ- and δ-opioids in Fischer rats

  2006cited by this paper
• Dissociation between sex differences in the immunological, behavioral, and physiological effects of kappa- and delta-opioids in Fischer rats.

  2006cited by this paper
• Sex differences in morphine-induced analgesia of visceral pain are supraspinally and peripherally mediated.

  2006cited by this paper
• Sex differences in the anatomical and functional organization of the periaqueductal gray‐rostral ventromedial medullary pathway in the rat: A potential circuit mediating the sexually dimorphic actions of morphine

  2006cited by this paper
• NMDA receptor antagonism disrupts the development of morphine analgesic tolerance in male, but not female C57BL/6J mice.

  2006cited by this paper
• Influence of low doses of naltrexone on morphine antinociception and morphine tolerance in male and female rats of four strains

  2006cited by this paper
• Persistent pain model reveals sex difference in morphine potency.

  2006cited by this paper
• Sex and gender differences in pain and inflammation: a rapidly maturing field.

  2006cited by this paper
• Organizational and activational effects of testosterone on carrageenan-induced inflammatory pain and morphine analgesia.

  2006cited by this paper
• Activation of Opioid Receptor Like-1 Receptor in the Spinal Cord Produces Sex-Specific Antinociception in the Rat: Estrogen Attenuates Antinociception in the Female, whereas Testosterone Is Required for the Expression of Antinociception in the Male

  2006cited by this paper
• Low efficacy opioids: implications for sex differences in opioid antinociception.

  2006cited by this paper
• Gender- and morphine dose-linked expression of spontaneous somatic opiate withdrawal in mice.

  2006cited by this paper
• Characterization of the antinociceptive effect of oxycodone in male and female rats.

  2006cited by this paper
• Potentiation of morphine antinociception by pentobarbital in female vs. male rats

  2006cited by this paper
• Effects of memantine on estrogen-dependent acute tolerance to the morphine analgesia in female rats.

  2006cited by this paper
• Morphine responses and experimental pain: sex differences in side effects and cardiovascular responses but not analgesia.

  2005cited by this paper
• Alfentanil and Placebo Analgesia: No Sex Differences Detected in Models of Experimental Pain

  2005cited by this paper
• Characterization of morphine‐induced hyperalgesia in male and female rats

  2005cited by this paper
• Differential modulation of TMJ neurons in superficial laminae of trigeminal subnucleus caudalis/upper cervical cord junction region of male and cycling female rats by morphine

  2005cited by this paper
• Melanocortin-1 receptor gene variants affect pain and μ-opioid analgesia in mice and humans

  2005cited by this paper
• Pharmacokinetics and effects of 17beta-estradiol and progesterone implants in ovariectomized rats.

  2005cited by this paper
• Morphine withdrawal syndrome: involvement of the dopaminergic system in prepubertal male and female mice.

  2005cited by this paper
• Nociceptive Sensitivity and Opioid Antinociception and Antihyperalgesia in Freund's Adjuvant-Induced Arthritic Male and Female Rats

  2005cited by this paper
• The influence of dextromethorphan on morphine analgesia in Swiss Webster mice is sex-specific.

  2005cited by this paper
• NMDA antagonist modulation of morphine antinociception in female vs. male rats.

  2005cited by this paper
• Experimental Pain Thresholds Influenced by Sex of Experimenter

  2005cited by this paper
• Organizational manipulation of gonadal hormones and systemic morphine analgesia in female rats: effects of adult ovariectomy and estradiol replacement.

  2005cited by this paper
• Influence of estrous cycle and gonadal hormone depletion on nociception and opioid antinociception in female rats of four strains.

  2005cited by this paper
• Comparison of the antinociceptive effect of acute morphine in female and male Sprague-Dawley rats using the long-lasting mu-antagonist methocinnamox.

  2005cited by this paper
• Gonadal hormone modulation of mu, kappa, and delta opioid antinociception in male and female rats.

  2005cited by this paper
• The case for the inclusion of female subjects in basic science studies of pain.

  2005cited by this paper
• Behavioral assessment of temporal summation in the rat: sensitivity to sex, opioids and modulation by NMDA receptor antagonists

  2005cited by this paper
• Baclofen reestablishes μ‐opioid receptor levels modified by morphine withdrawal syndrome in either sex

  2004cited by this paper
• Sex differences in pain and analgesia: the role of gonadal hormones

  2004cited by this paper
• Kappa opioid receptors in rat spinal cord: sex-linked distribution differences.

  2004cited by this paper
• Sexual dimorphism in the antinociception mediated by kappa opioid receptors in the rat temporomandibular joint.

  2004cited by this paper
• Antinociceptive and nociceptive actions of opioids.

  2004cited by this paper
• Interactions of "ultra-low" doses of naltrexone and morphine in mature and young male and female rats.

  2004cited by this paper
• Estrous cycle stage-dependent expression of acute tolerance to morphine analgesia in rats.

  2004cited by this paper
• Modulation of morphine analgesia by site‐specific N‐methyl‐d‐aspartate receptor antagonists: dependence on sex, site of antagonism, morphine dose, and time

  2004cited by this paper
• Sex differences in systemic morphine analgesic tolerance following intrathecal morphine injections.

  2004cited by this paper
• Pharmacokinetic-Pharmacodynamic Modeling of Morphine-6-glucuronide-induced Analgesia in Healthy Volunteers: Absence of Sex Differences

  2004cited by this paper
• Morphine tolerance in male and female rats.

  2004cited by this paper
• The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans

  2003cited by this paper
• Epidemiology of substance use disorders in women.

  2003cited by this paper
• Sex differences in (−)-pentazocine antinociception: Comparison to morphine and spiradoline in four rat strains using a thermal nociceptive assay

  2003cited by this paper
• Women Experience More Pain and Require More Morphine Than Men to Achieve a Similar Degree of Analgesia

  2003cited by this paper
• Sex differences in opioid-induced enhancement of contact hypersensitivity.

  2003cited by this paper
• Sex-related differences in the enhancement of morphine antinociception by NMDA receptor antagonists in rats.

  2003cited by this paper
• Gonadal steroid hormone modulation of nociception, morphine antinociception and reproductive indices in male and female rats

  2003cited by this paper
• Pharmacogenetic analysis of sex differences in opioid antinociception in rats

  2003cited by this paper
• Sex Differences in Opioid Analgesia: “From Mouse to Man”

  2003cited by this paper
• From mouse to man

  2003cited by this paper
• Potentiation of the excitatory action of NMDA in ventrolateral periaqueductal gray by the mu-opioid receptor agonist, DAMGO.

  2002cited by this paper
• Gender and pain upon movement are associated with the requirements for postoperative patient-controllediv analgesia: a prospective survey of 2,298 Chinese patients

  2002cited by this paper
• Influence of gonadectomy on the antinociceptive effects of opioids in male and female rats

  2002cited by this paper
• Gender-linked differences in the expression of physical dependence in the rat.

  2002cited by this paper
• Sex and rat strain determine sensitivity to kappa opioid-induced antinociception.

  2002cited by this paper
• Role of steroids in sex differences in morphine-induced analgesia: activational and organizational effects.

  2002cited by this paper
• Sex-related differences in mechanical nociception and antinociception produced by mu- and kappa-opioid receptor agonists in rats.

  2002cited by this paper
• Sex-related differences in mechanical nociception and antinociception produced by μ- and κ-opioid receptor agonists in rats

  2002cited by this paper
• Central Neural States Relating Sex and Pain

  2002cited by this paper
• Sex and rat strain determine sensitivity to κ opioid-induced antinociception

  2002cited by this paper
• Reversal of sex differences in morphine analgesia elicited from the ventrolateral periaqueductal gray in rats by neonatal hormone manipulations.

  2002cited by this paper
• Contribution of GIRK2-mediated postsynaptic signaling to opiate and α2-adrenergic analgesia and analgesic sex differences

  2002cited by this paper
• Lack of sex-related differences in the prevention by baclofen of the morphine withdrawal syndrome in mice

  2001cited by this paper
• Sex-related differences in antinociception and tolerance development following chronic intravenous infusion of morphine in the rat: modulatory role of testosterone via morphine clearance.

  2001cited by this paper
• Early neonatal experience of Long-Evans rats results in long-lasting changes in morphine tolerance and dependence

  2001cited by this paper
• Importance of sex and relative efficacy at the µ opioid receptor in the development of tolerance and cross-tolerance to the antinociceptive effects of opioids

  2001cited by this paper
• Morphine tolerance after chronic intracerebroventricular injection in male and female mice.

  2001cited by this paper
• Sex differences in opioid antinociception: κ and ‘mixed action’ agonists

  2001cited by this paper
• Assessment of acute and chronic morphine dependence in male and female mice.

  2001cited by this paper
• Sex differences in opioid antinociception: kappa and 'mixed action' agonists.

  2001cited by this paper
• Sex differences in thermal nociception and morphine antinociception in rodents depend on genotype.

  2000cited by this paper
• Analysis of sex and gonadectomy differences in beta-endorphin antinociception elicited from the ventrolateral periaqueductal gray in rats.

  2000cited by this paper
• Presynaptic and postsynaptic relations of μ‐opioid receptors to γ‐aminobutyric acid‐immunoreactive and medullary‐projecting periaqueductal gray neurons

  2000cited by this paper
• Sex-related differences in the antinociceptive effects of opioids: importance of rat genotype, nociceptive stimulus intensity, and efficacy at the µ opioid receptor

  2000cited by this paper
• Sex Differences in Morphine Analgesia: An Experimental Study in Healthy Volunteers

  2000cited by this paper
• A comparison of morphine analgesic tolerance in male and female mice.

  2000cited by this paper
• Sex differences in supraspinal morphine analgesia are dependent on genotype.

  1999cited by this paper
• Opioid antinociception in ovariectomized monkeys: comparison with antinociception in males and effects of estradiol replacement.

  1999cited by this paper

• Practical management of the patient with a centrally mediated disorder of gastrointestinal pain

  2025cites this paper
• Determination of the effective dose of oliceridine combined with propofol using the modified Dixon’s up-and-down method in painless gastroscopy

  2025cites this paper
• A 40-year analysis of central neuroanatomical and neurochemical circuits mediating homeostatic intake and hedonic intake and preferences in rodents.

  2025cites this paper
• Acute aerobic exercise intensity does not modulate pain potentially due to differences in fitness levels and sex effects: results from a pharmacological fMRI study

  2025cites this paper
• Disrupted circadian rhythms and opioid‐mediated adverse effects: Bidirectional relationship and putative mechanisms

  2025cites this paper
• Oxycodone self-administration and drug-primed responding in male and female squirrel monkeys: Effects of alternative reinforcer availability.

  2025cites this paper
• Comparison of total morphine milligram equivalents at hospital discharge between opioid-naive and opioid-experienced surgical patients: a single-centre retrospective cohort study

  2025cites this paper
• Projections from infralimbic medial prefrontal cortex glutamatergic outputs to amygdala mediates opioid induced hyperalgesia in male rats

  2024cites this paper
• Morphine-induced side effects can be differentially modulated by cannabidiol in male and female rats

  2024cites this paper
• The cell-permeant antioxidant D-thiol ester D-cysteine ethyl ester overcomes physical dependence to morphine in male Sprague Dawley rats

  2024cites this paper
• Sex differences in opioid response: a role for the gut microbiome?

  2024cites this paper
• The epigenetic signatures of opioid addiction and physical dependence are prevented by D-cysteine ethyl ester and betaine

  2024cites this paper
• Chronic Morphine Treatment Induces Sex- and Synapse-Specific Cellular Tolerance on Thalamo-Cortical Mu Opioid Receptor Signaling.

  2024cites this paper
• Lipophilic analogues of D-cysteine prevent and reverse physical dependence to fentanyl in male rats

  2024cites this paper
• Orally Administered N-Oleoyl Alanine Blocks Acute Opioid Withdrawal Induced-Conditioned Place Preference and Attenuates Somatic Withdrawal following Chronic Opioid Exposure in Rats

  2024cites this paper
• Chronic Morphine Induces Adaptations in Opioid Receptor Signaling in a Thalamostriatal Circuit That Are Location Dependent, Sex Specific, and Regulated by μ-Opioid Receptor Phosphorylation

  2023cites this paper
• L-cysteine ethyl ester prevents and reverses acquired physical dependence on morphine in male Sprague Dawley rats

  2023influential citation
• Gender Differences in Pain Threshold, Unpleasantness, and Descending Pain Modulatory Activation Across the Adult Life Span: A Cross Sectional Study.

  2023cites this paper
• The use of ketamine infusion to dramatically reduce opioid requirements in a patient whose high‐dose intrathecal opioid pump was inadvertently cut during surgery

  2023cites this paper
• Spinal microRNA-134-5p targets glutamate receptor ionotropic kainate 3 to modulate opioid induced hyperalgesia in mice

  2023cites this paper
• Chronic morphine induces adaptations in opioid receptor signaling in a thalamo-cortico-striatal circuit that are projection-dependent, sex-specific and regulated by mu opioid receptor phosphorylation

  2023cites this paper
• Integrating mechanistic-based and classification-based concepts into perioperative pain management: an educational guide for acute pain physicians

  2023cites this paper
• Oxycodone self-administration and reinstatement in male and female squirrel monkeys: Effects of alternative reinforcer availability

  2023cites this paper
• Opioid use for a first-incident upper extremity fracture in 220,440 patients without recent prior use in Ontario, Canada: a retrospective cohort study

  2022cites this paper
• Modeling spontaneous opioid withdrawal in male and female outbred mice using traditional endpoints and hyperalgesia

  2022cites this paper
• Opioid analgesia alters corticospinal coupling along the descending pain system in healthy participants

  2022cites this paper
• Sex‐specific role of the circadian transcription factor NPAS2 in opioid tolerance, withdrawal and analgesia

  2022cites this paper
• Gender differences in the effective dose of alfentanil in painless bronchoscopy

  2022cites this paper
• An Immunconjugate Vaccine Alters Distribution and Reduces the Antinociceptive, Behavioral and Physiological Effects of Fentanyl in Male and Female Rats

  2022cites this paper
• Amygdala Metabotropic Glutamate Receptor 1 Influences Synaptic Transmission to Participate in Fentanyl-Induced Hyperalgesia in Rats

  2022cites this paper
• Sex Differences in Opioid Receptor Mediated Effects: Role of Androgens.

  2022cites this paper
• Amygdala Metabotropic Glutamate Receptor 1 In�uences Synaptic Transmission To Participate In Fentanyl-Induced Hyperalgesia In Rats

  2022cites this paper
• HPA Axis Dysfunction during Morphine Withdrawal in Offspring of Female Rats Exposed to Opioids Preconception.

  2022cites this paper
• Opioids alter paw placement during walking, confounding assessment of analgesic efficacy in a postsurgical pain model in mice

  2022cites this paper
• Interactions between the κ opioid system, corticotropin-releasing hormone and oxytocin in partner loss

  2022cites this paper
• Influences of Gender on Intravenous Nalbuphine Actions After Major Abdominal Surgery: A Multicenter Study

  2021cites this paper
• Paw placement during walking is altered by analgesic doses of opioids and post-surgical injury in mice

  2021cites this paper
• The influence of methadone on cerebral gray matter and functional connectivity.

  2021cites this paper
• Cortico-spinal coupling along descending pain system differentiates between opioid and saline treatment in healthy participants

  2021cites this paper
• Sex and Estrous Cycle Differences in Analgesia and Brain Oxycodone Levels

  2021cites this paper
• The role of network interactions in opioid analgesia

  2021influential citation
• Sex differences in neuroimmune and glial mechanisms of pain.

  2021cites this paper
• Central amygdala inflammation drives pain hypersensitivity and attenuates morphine analgesia in experimental autoimmune encephalomyelitis.

  2021cites this paper
• Sexually Dimorphic Neuroimmune Response to Chronic Opioid Treatment and Withdrawal.

  2021cites this paper
• Rapid tolerance to morphine in the myenteric neurons of the small intestine is independent of β-arrestin-2 and mediated by PKC

  2020cites this paper
• Addiction among women and sexual minority groups.

  2020cites this paper
• Predictors of Long‐Term Opioid Effectiveness in Patients With Chronic Non‐Cancer Pain Attending Multidisciplinary Pain Treatment Clinics: A Quebec Pain Registry Study

  2020cites this paper
• Fundamental sex differences in morphine withdrawal-induced neuronal plasticity.

  2020cites this paper
• Sex Differences and the Role of Estradiol in Mesolimbic Reward Circuits and Vulnerability to Cocaine and Opiate Addiction

  2020cites this paper
• Review of addiction risk potential associated with adolescent opioid use.

  2020cites this paper
• Role of β-arrestin-2 in short- and long-term opioid tolerance in the dorsal root ganglia

  2020cites this paper
• Ranking the Harm of Psychoactive Drugs Including Prescription Analgesics to Users and Others–A Perspective of German Addiction Medicine Experts

  2020cites this paper
• Predictors of long-term opioid effectiveness in chronic non-cancer pain patients attending

  2020cites this paper
• Careful Breakthrough Cancer Pain Treatment through Rapid-Onset Transmucosal Fentanyl Improves the Quality of Life in Cancer Patients: Results from the BEST Multicenter Study

  2020cites this paper
• Examining Relationships between Gender, Opioid Dependence, and Distress Tolerance among Patients in Substance Use Disorder Treatment

  2020cites this paper
• Implications of Chronic Opioid Therapy on Perioperative Complications and Long-Term Surgical Recovery

  2019cites this paper
• Individuals with Chronic Pain Who Misuse Prescription Opioids Report Sex-Based Differences in Pain and Opioid Withdrawal.

  2019cites this paper
• Female-male differences in prescription pain reliever dependence levels: Evidence on newly incident adolescent and young adult users in the United States, 2002-2014.

  2019cites this paper
• The association between frequency of opioid misuse and opioid use disorder among youth and adults in the United States.

  2019cites this paper
• The Burden of Opioid Adverse Events and the Influence on Cancer Patients' Symptomatology.

  2019cites this paper
• A review of factors affecting analgesic selection in large animals undergoing translational research.

  2018cites this paper
• Altered Signaling in the Descending Pain-modulatory System after Short-Term Infusion of the μ-Opioid Agonist Remifentanil

  2018cites this paper
• Sex-related differences in effect-site concentration of remifentanil for preventing anesthetic emergence cough in elderly patients

  2018cites this paper
• The Opioid Epidemic: Overcoming Challenges by Using a Sex and Gender Lens.

  2018cites this paper
• Women and the Experience of Pain and Opioid Use Disorder: A Literature-based Commentary.

  2018cites this paper
• Postoperative Pain and Opioid Analgesic Requirements After Orthognathic Surgery.

  2018cites this paper
• Women and opioids: something different is happening here.

  2018cites this paper
• Preliminary evidence of different and clinically meaningful opioid withdrawal phenotypes

  2018cites this paper
• The analgesic efficacy of morphine varies with rat strain and experimental pain model: implications for target validation efforts in pain drug discovery

  2018cites this paper
• Effectiveness of long-term opioid therapy among chronic non-cancer pain patients attending multidisciplinary pain treatment clinics: A Quebec Pain Registry study

  2018cites this paper
• sex-related differences in effect-site concentration of remifentanil for preventing anesthetic emergence cough in elderly patients

  2018cites this paper
• Men, Women, and Pain

  2017cites this paper
• Side effects of pain and analgesia in animal experimentation

  2017cites this paper
• Time course of copeptin during a model of experimental pain and hyperalgesia: A randomised volunteer crossover trial

  2017cites this paper
• Endogenous opioid system: a promising target for future smoking cessation medications

  2017cites this paper
• Article Commentary: Men, Women, and Pain

  2017cites this paper
• Central mechanisms of pain suppression: Central mechanisms of pain modulation

  2016cites this paper
• conception birth prenatal exposure to drugs or alcohol postnatal exposure to drugs or alcohol sex differences in placental gene

  2016cites this paper
• Methadone-induced Damage to White Matter Integrity in Methadone Maintenance Patients: A Longitudinal Self-control DTI Study

  2016cites this paper
• Naltrexone Prevents in Males and Attenuates in Females the Expression of Behavioral Sensitization to Ethanol Regardless of Maternal Separation

  2016cites this paper
• Opioid-induced hyperalgesia: Cellular and molecular mechanisms.

  2016cites this paper
• Effect of estrogen on morphine- and oxycodone-induced antinociception in a female femur bone cancer pain model.

  2016cites this paper
• Does Fentanyl Lead to Opioid-induced Hyperalgesia in Healthy Volunteers?: A Double-blind, Randomized, Crossover Trial

  2016cites this paper
• Pain and sex hormones: a review of current understanding.

  2016cites this paper
• An examination of sex differences in the effects of early-life opiate and alcohol exposure

  2016cites this paper
• Sex differences in responsiveness to the prescription opioid oxycodone in mice.

  2016cites this paper
• Kappa Opioids, Salvinorin A and Major Depressive Disorder

  2016cites this paper
• Analgesic Activity of Tramadol and Buprenorphine after Voluntary Ingestion by Rats (Rattus norvegicus).

  2016cites this paper
• Spinal and supraspinal N-methyl-D-aspartate and melanocortin-1 receptors contribute to a qualitative sex difference in morphine-induced hyperalgesia.

  2015cites this paper
• Pressure Pain Sensitivity in Patients With Suspected Opioid-Induced Hyperalgesia

  2015cites this paper
• Aspects of opioid regulation and effects on opioid users

  2015cites this paper
• Efficacy of Tramadol as a Sole Analgesic for Postoperative Pain in Male and Female Mice.

  2015cites this paper
• Sex Differences in Kappa Opioid Receptor Function and Their Potential Impact on Addiction

  2015cites this paper
• Interactions between glia, the immune system and pain processes during early development.

  2014cites this paper
• ROLE OF ENDOGENOUS OPIOIDS IN NOCICEPTION AMONG MALE AND DIFFERENT PHASES OF THE MICE ESTROUS CYCLE

  2014cites this paper
• Supraspinal And Spinal Mechanisms Of Morphine-Induced Hyperalgesia

  2014cites this paper
• Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities

  2014cites this paper
• Supraspinal And Spinal Mechanisms Of Morphine-Induced Hyperalgesia

  2014influential citation
• The Opioid System and Brain Development: Effects of Methadone on the Oligodendrocyte Lineage and the Early Stages of Myelination

  2014cites this paper
• Gender-dependent effect on nociceptive response induced by chronic variable stress.

  2014cites this paper