Hepcidin, an emerging and important player in brain iron homeostasis

Hepcidin is emerging as a new important factor in brain iron homeostasis. Studies suggest that there are two sources of hepcidin in the brain; one is local and the other comes from the circulation. Little is known about the molecular mediators of local hepcidin expression, but inflammation and iron-load have been shown to induce hepcidin expression in the brain. The most important source of hepcidin in the brain are glial cells. Role of hepcidin in brain functions has been observed during neuronal iron-load and brain hemorrhage, where secretion of abundant hepcidin is related with the severity of brain damage. This damage can be reversed by blocking systemic and local hepcidin secretion. Studies have yet to unveil its role in other brain conditions, but the rationale exists, since these conditions are characterized by overexpression of the factors that stimulate brain hepcidin expression, such as inflammation, hypoxia and iron-overload.

• Publication year

  2018

• Venue

  Journal of Translational Medicine

• Publication date

  2018-02-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1186/s12967-018-1399-5PMID 29415739PMCID 5803919
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cerebral abnormalities in Friedreich ataxia: A review

  2018cited by this paper
• Serum Hepcidin Levels, Iron Dyshomeostasis and Cognitive Loss in Alzheimer’s Disease

  2017cited by this paper
• Iron homeostasis: An anthropocentric perspective

  2017influential reference
• Hepcidin Protects Neuron from Hemin-Mediated Injury by Reducing Iron

  2017cited by this paper
• Hepcidin attenuates amyloid beta‐induced inflammatory and pro‐oxidant responses in astrocytes and microglia

  2017cited by this paper
• A first-in-human phase 1 study of a hepcidin monoclonal antibody, LY2787106, in cancer-associated anemia

  2017cited by this paper
• Targeting iron metabolism in drug discovery and delivery

  2017cited by this paper
• Expression of Iron Transporters and Pathological Hallmarks of Parkinson’s and Alzheimer’s Diseases in the Brain of Young, Adult, and Aged Rats

  2017cited by this paper
• Endothelial cells produce bone morphogenetic protein 6 required for iron homeostasis in mice.

  2017cited by this paper
• Regionally progressive accumulation of iron in Parkinson's disease as measured by quantitative susceptibility mapping

  2017cited by this paper
• Astrocyte hepcidin is a key factor in LPS-induced neuronal apoptosis

  2017influential reference
• Transferrin Receptor 2 Dependent Alterations of Brain Iron Metabolism Affect Anxiety Circuits in the Mouse

  2016cited by this paper
• An essential cell-autonomous role for hepcidin in cardiac iron homeostasis

  2016cited by this paper
• Pre-treatment of rats with ad-hepcidin prevents iron-induced oxidative stress in the brain.

  2016cited by this paper
• Quantitative Susceptibility Mapping Suggests Altered Brain Iron in Premanifest Huntington Disease

  2016cited by this paper
• Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease.

  2016influential reference
• Toll-Like Receptor 4/MyD88–Mediated Signaling of Hepcidin Expression Causing Brain Iron Accumulation, Oxidative Injury, and Cognitive Impairment After Intracerebral Hemorrhage

  2016cited by this paper
• Circulating Hepcidin-25 Is Reduced by Endogenous Estrogen in Humans

  2016cited by this paper
• Ischemic stroke, inflammation, iron overload – Connection to a hepcidin

  2016cited by this paper
• Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics

  2016cited by this paper
• Mice Overexpressing Both Non-Mutated Human SOD1 and Mutated SOD1G93A Genes: A Competent Experimental Model for Studying Iron Metabolism in Amyotrophic Lateral Sclerosis

  2016cited by this paper
• Defining a role for hemoglobin in Parkinson’s disease

  2016cited by this paper
• Hepcidin as a Major Component of Renal Antibacterial Defenses against Uropathogenic Escherichia coli.

  2016cited by this paper
• Nucleic acid oxidative damage in Alzheimer's disease-explained by the hepcidin-ferroportin neuronal iron overload hypothesis?

  2016cited by this paper
• Neogenin Facilitates the Induction of Hepcidin Expression by Hemojuvelin in the Liver*

  2016cited by this paper
• Meta-analysis of brain iron levels of Parkinson’s disease patients determined by postmortem and MRI measurements

  2016cited by this paper
• Serum Hepcidin Levels in Childhood-Onset Ischemic Stroke

  2016cited by this paper
• Low oxygen tension reverses antineoplastic effect of iron chelator deferasirox in human glioblastoma cells

  2016cited by this paper
• Glioblastoma Stem-Like Cells: Characteristics, Microenvironment, and Therapy

  2016cited by this paper
• Role of hepcidin and its downstream proteins in early brain injury after experimental subarachnoid hemorrhage in rats

  2016cited by this paper
• Aspirin down Regulates Hepcidin by Inhibiting NF-κB and IL6/JAK2/STAT3 Pathways in BV-2 Microglial Cells Treated with Lipopolysaccharide

  2016cited by this paper
• Mice with hepcidin‐resistant ferroportin accumulate iron in the retina

  2016cited by this paper
• Brain iron overload following intracranial haemorrhage

  2016cited by this paper
• The role of hepcidin in chronic mild stress-induced depression.

  2015cited by this paper
• Hepcidin regulation in prostate and its disruption in prostate cancer.

  2015cited by this paper
• Expression of iron homeostasis proteins in the spinal cord in experimental autoimmune encephalomyelitis and their implications for iron accumulation.

  2015cited by this paper
• Iron entry in neurons and astrocytes: a link with synaptic activity

  2015cited by this paper
• Cell-Penetrating Peptides Selectively Cross the Blood-Brain Barrier In Vivo

  2015influential reference
• A Novel Model for Brain Iron Uptake: Introducing the Concept of Regulation

  2015influential reference
• Expression and cellular localization of hepcidin mRNA and protein in normal rat brain

  2015cited by this paper
• Divalent metal transporter 1 (DMT1) in the brain: implications for a role in iron transport at the blood-brain barrier, and neuronal and glial pathology

  2015cited by this paper
• The Corticospinal Tract in Huntington's Disease.

  2015cited by this paper
• Mechanisms and regulation of iron trafficking across the capillary endothelial cells of the blood-brain barrier

  2015influential reference
• Hepcidin Levels Are Increased in Patients with Acute Ischemic Stroke: Preliminary Report.

  2015cited by this paper
• Molecular mechanisms of non‐transferrin‐bound and transferring‐bound iron uptake in primary hippocampal neurons

  2015cited by this paper
• The Pathogenesis of Cardiomyopathy in Friedreich Ataxia

  2015cited by this paper
• Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells.

  2015cited by this paper
• Unusual retinopathy associated with hemochromatosis.

  2015cited by this paper
• Immune attack: the role of inflammation in Alzheimer disease

  2015influential reference
• Hepcidin Suppresses Brain Iron Accumulation by Downregulating Iron Transport Proteins in Iron-Overloaded Rats

  2015influential reference
• Serum hepcidin concentrations correlate with serum iron level and outcome in patients with intracerebral hemorrhage

  2015cited by this paper
• The relationship between iron dyshomeostasis and amyloidogenesis in Alzheimer's disease: Two sides of the same coin.

  2015cited by this paper
• Hypoxia induced downregulation of hepcidin is mediated by platelet derived growth factor BB

  2014cited by this paper
• Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants

  2014cited by this paper
• Iron transport across the blood–brain barrier: development, neurovascular regulation and cerebral amyloid angiopathy

  2014influential reference
• Iron dysregulation in Huntington's disease

  2014influential reference
• Increased Ndfip1 in the Substantia Nigra of Parkinsonian Brains Is Associated with Elevated Iron Levels

  2014influential reference
• Iron and multiple sclerosis.

  2014cited by this paper
• Fixing frataxin: ‘ironing out’ the metabolic defect in Friedreich's ataxia

  2014cited by this paper
• β-Amyloid Precursor Protein Does Not Possess Ferroxidase Activity but Does Stabilize the Cell Surface Ferrous Iron Exporter Ferroportin

  2014cited by this paper
• Pro-inflammatory cytokine-mediated ferroportin down-regulation contributes to the nigral iron accumulation in lipopolysaccharide-induced Parkinsonian models.

  2014cited by this paper
• Genetic and biochemical markers in patients with Alzheimer's disease support a concerted systemic iron homeostasis dysregulation.

  2014cited by this paper
• Changes in skeletal muscle iron metabolism outpace amyotrophic lateral sclerosis onset in transgenic rats bearing the G93A hmSOD1 gene mutation

  2014cited by this paper
• The Potential for Transition Metal-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis

  2014influential reference
• Serum iron metabolism markers including hepcidin in multiple sclerosis patients

  2014cited by this paper
• Suppression of iron-regulatory hepcidin by vitamin D.

  2014cited by this paper
• Lipopolysaccharides Upregulate Hepcidin in Neuron via Microglia and the IL-6/STAT3 Signaling Pathway

  2014influential reference
• Non-HFE hemochromatosis: pathophysiological and diagnostic aspects.

  2014cited by this paper
• Hepcidin Plays a Key Role in 6-OHDA Induced Iron Overload and Apoptotic Cell Death in a Cell Culture Model of Parkinson's Disease

  2014cited by this paper
• IDENTIFICATION OF ERYTHROFERRONE AS AN ERYTHROID REGULATOR OF IRON METABOLISM

  2014cited by this paper
• Glial Cell Ceruloplasmin and Hepcidin Differentially Regulate Iron Efflux from Brain Microvascular Endothelial Cells

  2014cited by this paper
• Iron Metabolism Disturbance in a French Cohort of ALS Patients

  2014influential reference
• Correction: Iron Accumulates in Huntington’s Disease Neurons: Protection by Deferoxamine

  2013cited by this paper
• Low brain iron content in idiopathic restless legs syndrome patients detected by phase imaging

  2013cited by this paper
• Iron uptake in quiescent and inflammation-activated astrocytes: A potentially neuroprotective control of iron burden

  2013cited by this paper
• Iron Accumulates in Huntington’s Disease Neurons: Protection by Deferoxamine

  2013cited by this paper
• Biomarker-based predictive models for prognosis in amyotrophic lateral sclerosis.

  2013influential reference
• Increased Iron Levels and Decreased Tissue Integrity in Hippocampus of Alzheimer's Disease Detected in vivo with Magnetic Resonance Imaging

  2013cited by this paper
• Circulatory hepcidin is associated with the anti-inflammatory response but not with iron or anemic status in childhood malaria.

  2013cited by this paper
• Iron and neurodegeneration in the multiple sclerosis brain

  2013cited by this paper
• The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer’s disease

  2013influential reference
• 6-Hydroxydopamine promotes iron traffic in primary cultured astrocytes

  2013cited by this paper
• Decreased Serum Hepcidin Concentration Correlates with Brain Iron Deposition in Patients with HBV-Related Cirrhosis

  2013cited by this paper
• Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells

  2013influential reference
• Neonatal E. Coli Infection Causes Neuro-Behavioral Deficits Associated with Hypomyelination and Neuronal Sequestration of Iron

  2013cited by this paper
• High hepcidin level accounts for the nigral iron accumulation in acute peripheral iron intoxication rats.

  2012cited by this paper
• Iron Accumulation in Deep Cortical Layers Accounts for MRI Signal Abnormalities in ALS: Correlating 7 Tesla MRI and Pathology

  2012cited by this paper
• Impairment of Interrelated Iron- and Copper Homeostatic Mechanisms in Brain Contributes to the Pathogenesis of Neurodegenerative Disorders

  2012cited by this paper
• Iron homeostasis in astrocytes and microglia is differentially regulated by TNF‐α and TGF‐β1

  2012cited by this paper
• Iron-mediated retinal degeneration in haemojuvelin-knockout mice.

  2012influential reference
• EGCG Protects against 6-OHDA-Induced Neurotoxicity in a Cell Culture Model

  2012cited by this paper
• Friedreich's Ataxia Causes Redistribution of Iron, Copper, and Zinc in the Dentate Nucleus

  2012cited by this paper
• Restless legs syndrome--theoretical roles of inflammatory and immune mechanisms.

  2012cited by this paper
• Iron overload, measured as serum ferritin, increases brain damage induced by focal ischemia and early reperfusion.

  2012cited by this paper
• The conundrum of iron in multiple sclerosis – time for an individualised approach

  2012cited by this paper
• 1B/(−)IRE DMT1 Expression during Brain Ischemia Contributes to Cell Death Mediated by NF-κB/RelA Acetylation at Lys310

  2012cited by this paper
• Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage

  2012cited by this paper
• Heparin: a potent inhibitor of hepcidin expression in vitro and in vivo.

  2011cited by this paper
• Neurobiology Bmp 6 Regulates Retinal Iron Homeostasis and Has Altered Expression in Age-Related Macular Degeneration

  2011cited by this paper
• Profile of altered brain iron acquisition in restless legs syndrome.

  2011influential reference

• The liver as a metabolic and immune hub in Alzheimer’s disease: From mechanisms to therapeutic opportunities

  2026cites this paper
• Targeting ferroptosis for neuroprotection: potential therapeutic avenues in neurodegenerative and neuropsychiatric diseases

  2025cites this paper
• Imaging of Cerebral Iron as an Emerging Marker for Brain Aging, Neurodegeneration, and Cerebrovascular Diseases

  2025cites this paper
• Hepcidin: A multifaceted hormone in iron homeostasis and tumor biology.

  2025cites this paper
• Altered iron homeostasis in neonatal hypoxic-ischemic encephalopathy

  2025cites this paper
• Comparative study of liver injury protection by Akkermansia muciniphila and Faecalibacterium prausnitzii interventions in live and cell-free supernatant forms via targeting the hepcidin – ferroportin axis in mice with CCl₄-induced liver fibrosis

  2025cites this paper
• Nature's answer to Ferroptosis: how bioactive compounds rewire oxidative stress circuits in cerebral ischemia.

  2025cites this paper
• Astrocyte–microglia crosstalk in subarachnoid hemorrhage: mechanisms and treatments

  2025cites this paper
• The Role of Hepcidin Level in Pediatric Mortality-related Sepsis

  2025cites this paper
• The prognostic value of serum hepcidin-25 in predicting cardiovascular events among maintenance hemodialysis patients: insights from the INFINITY cohort

  2025cites this paper
• Iron, the Essential Micronutrient: A Comprehensive Review of Regulatory Pathways of Iron Metabolism

  2025cites this paper
• A critical appraisal of drug transport across the blood-brain barrier: Evaluation using new-age microfluidic technique.

  2025cites this paper
• Hepcidin as an emerging predictor biomarker of leptomeningeal metastases in patients with metastatic breast cancer

  2025cites this paper
• Tumor-associated Macrophages protect Glioblastoma cells from ferroptosis by inducing the release of Ferritin-bound iron via exosomes

  2025cites this paper
• A review of studies on vascular dementia and iron metabolism

  2025influential citation
• Single-cell transcriptomic and functional studies identify glial state changes and a role for inflammatory RIPK1 signaling in ALS pathogenesis.

  2025cites this paper
• Melatonin ameliorates tauopathy and ferroptosis in P301S Tau transgenic mice

  2025cites this paper
• Implications for soluble iron accumulation, oxidative stress, and glial glutamate release in motor neuron death associated with sporadic amyotrophic lateral sclerosis

  2025cites this paper
• Deciphering the role of hepcidin in iron metabolism and anemia management.

  2025cites this paper
• Neuronal Injury after Ischemic Stroke: Mechanisms of Crosstalk Involving Necroptosis

  2025cites this paper
• Involvement of Astrocytes in the Formation, Maintenance, and Function of the Blood–Brain Barrier

  2024cites this paper
• A Review of the Association Between Dietary Intake and Brain Iron Levels in Older Adults: Preliminary Findings and Future Directions

  2024cites this paper
• Hepcidin: A potent antimicrobial peptide involved in iron homeostasis

  2024cites this paper
• The role of iron transporters and regulators in Alzheimer's disease and Parkinson's disease: Pathophysiological insights and therapeutic prospects.

  2024cites this paper
• Insights into Iron Metabolism Parameters in Ischemic Stroke: A Single-Center Prospective Cohort Study

  2024cites this paper
• Hepcidin depending on astrocytic NEO1 ameliorates blood-brain barrier dysfunction after subarachnoid hemorrhage

  2024cites this paper
• Iron Deficiency and Sleep/Wake Behaviors: A Scoping Review of Clinical Practice Guidelines—How to Overcome the Current Conundrum?

  2024cites this paper
• Genetic Correlation of HBB, HFE and HAMP Genes to Endocrinal Complications in Egyptian Beta Thalassemia Major Patients

  2024cites this paper
• Brain Iron Dyshomeostasis and Ferroptosis in Alzheimer’s Disease Pathophysiology: Two Faces of the Same Coin

  2024cites this paper
• Transporters, Ion Channels, and Junctional Proteins in Choroid Plexus Epithelial Cells

  2024cites this paper
• The Iron Metabolism with a Specific Focus on the Functioning of the Nervous System

  2024influential citation
• Transcript Profiles of Microglia/Macrophage Cells at the Borders of Chronic Active and Subpial Gray Matter Lesions in Multiple Sclerosis

  2024cites this paper
• Effect of electroacupuncture on global cerebral ischemia‑reperfusion injury in rats: A urine proteome analysis

  2024cites this paper
• Iron in multiple sclerosis - Neuropathology, immunology, and real-world considerations.

  2023cites this paper
• Brain metabolism in Alzheimer’s disease: biological mechanisms of exercise

  2023cites this paper
• Apo- and holo- transferrin differentially interact with ferroportin and hephaestin to regulate iron release at the blood-brain barrier

  2023cites this paper
• JAK/STAT signaling and cellular iron metabolism in hepatocellular carcinoma: therapeutic implications

  2023cites this paper
• Brain iron acquisition: An overview of homeostatic regulation and disease dysregulation

  2023cites this paper
• Effects of liraglutide on astrocyte polarization and neuroinflammation in db/db mice: focus on iron overload and oxidative stress

  2023cites this paper
• Apo- and holo-transferrin differentially interact with hephaestin and ferroportin in a novel mechanism of cellular iron release regulation

  2023cites this paper
• Apo- and holo- transferrin differentially interact with ferroportin and hephaestin to regulate iron release at the blood-brain barrier

  2023cites this paper
• Microglial-specific knockdown of iron import gene, Slc11a2, blunts LPS-induced neuroinflammatory responses in a sex-specific manner.

  2023cites this paper
• The Role of Iron Metabolism in Sepsis-associated Encephalopathy: a Potential Target

  2023influential citation
• Astrocyte-derived hepcidin aggravates neuronal iron accumulation after subarachnoid hemorrhage by decreasing neuronal ferroportin1.

  2023cites this paper
• Glycosylation: A new signaling paradigm for the neurovascular diseases.

  2023cites this paper
• Enriched environment attenuates ferroptosis after cerebral ischemia/reperfusion injury by regulating iron metabolism.

  2023cites this paper
• Banxia-Houpu decoction inhibits iron overload and chronic intermittent hypoxia-induced neuroinflammation in mice.

  2023cites this paper
• Intracellular Iron Accumulation Induces Inflammatory and Oxidative Status of the Host After Japanese Encephalitis Viral Infection

  2023cites this paper
• Autolysis Affects the Iron Cargo of Ferritins in Neurons and Glial Cells at Different Rates in the Human Brain

  2023cites this paper
• Expression of antimicrobial host defence peptides in the central nervous system during health and disease

  2022cites this paper
• Molecular characterization of HEPCIDIN-1 (HAMP1) gene in red-bellied pacu (Piaractus brachypomus).

  2022cites this paper
• Dithiolethiones Protect Against Iron Overload-Induced Cytotoxicity and Serve as Ferroptosis Inhibitors in U-87 MG Cells

  2022cites this paper
• Aberrant Cerebral Iron Trafficking Co-morbid With Chronic Inflammation: Molecular Mechanisms and Pharmacologic Intervention

  2022cites this paper
• Iron Dyshomeostasis and Ferroptosis: A New Alzheimer’s Disease Hypothesis?

  2022cites this paper
• Hepcidin (rs10421768), Transferrin (rs3811647, rs1049296) and Transferrin Receptor 2 (rs7385804) Gene Polymorphism Might Be Associated with the Origin of Multiple Sclerosis

  2022cites this paper
• Activation of the Hepcidin-Ferroportin1 pathway in the brain and astrocytic–neuronal crosstalk to counteract iron dyshomeostasis during aging

  2022cites this paper
• HUBUNGAN LINGKAR LENGAN ATAS (LILA) DAN KADAR HEMOGLOBIN DENGAN KEJADIAN ANEMIA PADA IBU HAMIL TRIMESTER III

  2022cites this paper
• Inflaming the Brain with Iron

  2021cites this paper
• Dysregulation of iron homeostasis and methamphetamine reward behaviors in Clk1-deficient mice

  2021cites this paper
• Dose- and sex-dependent effects of phlebotomy-induced anemia on the neonatal mouse hippocampal transcriptome

  2021cites this paper
• Mitochondrial iron metabolism and neurodegenerative diseases.

  2021cites this paper
• The effect of underlying inflammation on iron metabolism, cardiovascular risk and renal function in patients with type 2 diabetes

  2021cites this paper
• Regular Physical Exercise Modulates Iron Homeostasis in the 5xFAD Mouse Model of Alzheimer’s Disease

  2021influential citation
• Involvement of Hepcidin in Cognitive Damage Induced by Chronic Intermittent Hypoxia in Mice

  2021cites this paper
• BBB damage in aging causes brain iron deposits via astrocyte-neuron crosstalk and Hepc/Fpn1 pathway

  2021cites this paper
• Hepcidin: An emerging hormone in iron homeostasis: A review

  2021cites this paper
• Restless legs syndrome among subjects having chronic liver disease: A systematic review and meta-analysis.

  2021cites this paper
• The Role of 2-Oxoglutarate Dependent Dioxygenases in Gliomas and Glioblastomas: A Review of Epigenetic Reprogramming and Hypoxic Response

  2021cites this paper
• Body weight and its influence on hepcidin levels in patients with type 2 diabetes: A systematic review and meta-analysis of clinical studies

  2021cites this paper
• The Effect of TCM-Induced HAMP on Key Enzymes in the Hydrolysis of AD Model Cells

  2021cites this paper
• The Role of Butyrylcholinesterase and Iron in the Regulation of Cholinergic Network and Cognitive Dysfunction in Alzheimer’s Disease Pathogenesis

  2021cites this paper
• Pursuing Orally Bioavailable Hepcidin Analogues via Cyclic N-Methylated Mini-Hepcidins

  2021cites this paper
• Association between Malaria Infection and Early Childhood Development Mediated by Anemia in Rural Kenya

  2020cites this paper
• Recent advances in iron homeostasis and regulation - a focus on epigenetic regulation and stroke

  2020cites this paper
• Iron Therapeutics in Women’s Health: Past, Present, and Future

  2020cites this paper
• Hepcidin overexpression in astrocytes alters brain iron metabolism and protects against amyloid-β induced brain damage in mice

  2020cites this paper
• Astrocyte hepcidin ameliorates neuronal loss through attenuating brain iron deposition and oxidative stress in APP/PS1 mice.

  2020cites this paper
• PIEZO1 might be involved in cerebral ischemia-reperfusion injury through ferroptosis regulation: a hypothesis.

  2020cites this paper
• Oxidative Stress-Mediated Blood-Brain Barrier (BBB) Disruption in Neurological Diseases

  2020cites this paper
• Retinal Degeneration and Alzheimer’s Disease: An Evolving Link

  2020cites this paper
• Age-Related Changes and Sex-Related Differences in Brain Iron Metabolism

  2020cites this paper
• Cobalt accumulation and iron-regulatory protein profile expression in immature mouse brain after perinatal exposure to cobalt chloride.

  2020cites this paper
• Hepcidin-to-Ferritin Ratio Is Decreased in Astrocytes With Extracellular Alpha-Synuclein and Iron Exposure

  2020cites this paper
• Hepcidin and its therapeutic potential in neurodegenerative disorders

  2020influential citation
• Higher cerebrospinal fluid to plasma ratio of p-cresol sulfate and indoxyl sulfate in patients with Parkinson's disease.

  2019cites this paper
• Systemic hepcidin quantified with LC-MS/MS in dementia in association with disease pathology and severity and with structural changes in the brain.

  2019cites this paper
• Hypoxia decreases macrophage glycolysis and M1 percentage by targeting microRNA‐30c and mTOR in human gastric cancer

  2019cites this paper
• Brain iron transport

  2019cites this paper
• Fractalkine Induces Hepcidin Expression of BV-2 Microglia and Causes Iron Accumulation in SH-SY5Y Cells

  2019cites this paper
• Iron Metabolism and Brain Development in Premature Infants

  2019cites this paper
• A Novel Human Neuronal Cell Model to Study Iron Accumulation in Parkinson’s Disease

  2019cites this paper
• Deciphering the Iron Side of Stroke: Neurodegeneration at the Crossroads Between Iron Dyshomeostasis, Excitotoxicity, and Ferroptosis

  2019cites this paper
• Extrahepatic hepcidin production: The intriguing outcomes of recent years

  2019cites this paper
• Genetic Variability and Trajectories of DNA Methylation May Support a Role for HAMP in Patient Outcomes After Aneurysmal Subarachnoid Hemorrhage

  2019cites this paper
• Iron and Alzheimer’s Disease: From Pathogenesis to Therapeutic Implications

  2018cites this paper
• Systemic and local hepcidin as emerging and important peptides in renal homeostasis and pathology

  2018cites this paper
• The Functional Versatility of Transferrin Receptor 2 and Its Therapeutic Value

  2018cites this paper
• Research Advances of Germinal Matrix Hemorrhage: An Update Review

  2018cites this paper
• Marked Age-Related Changes in Brain Iron Homeostasis in Amyloid Protein Precursor Knockout Mice

  2018cites this paper
• The Association of Serum Hepcidin Levels and Insulin Resistance in PCOS Patients: A Case-Control Study

  2018cites this paper