The role of metabolism in the pathogenesis of osteoarthritis

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Nature Reviews Rheumatology

• Publication date

  2017-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nrrheum.2017.50PMID 28381830
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Research perspective

  2018cited by this paper
• The joint synovium: A critical determinant of articular cartilage fate in inflammatory joint diseases.

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• Mitochondria as Molecular Platforms Integrating Multiple Innate Immune Signalings.

  2017cited by this paper
• Inflammatory mediators in osteoarthritis: A critical review of the state-of-the-art, current prospects, and future challenges.

  2016cited by this paper
• Overexpression of microRNA-634 suppresses survival and matrix synthesis of human osteoarthritis chondrocytes by targeting PIK3R1

  2016cited by this paper
• Immunometabolism: Is it under the eye of the clock?

  2016cited by this paper
• A guide to immunometabolism for immunologists

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  2016cited by this paper
• Inflammation (or synovitis)-driven osteoarthritis: an opportunity for personalizing prognosis and treatment?

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• Ageing and the pathogenesis of osteoarthritis

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• Critical Role of Glucose Metabolism in Rheumatoid Arthritis Fibroblast‐like Synoviocytes

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• PFKFB3 modulates glycolytic metabolism and alleviates endoplasmic reticulum stress in human osteoarthritis cartilage

  2016cited by this paper
• Wnts talking with the TGF-β superfamily: WISPers about modulation of osteoarthritis.

  2016cited by this paper
• Targeting oxidative stress to reduce osteoarthritis

  2016cited by this paper
• Age-Related Alterations in Signaling Pathways in Articular Chondrocytes: Implications for the Pathogenesis and Progression of Osteoarthritis - A Mini-Review

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• CT imaging for evaluation of calcium crystal deposition in the knee: initial experience from the Multicenter Osteoarthritis (MOST) study.

  2015cited by this paper
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  2015cited by this paper
• Age-related degeneration of articular cartilage in the pathogenesis of osteoarthritis: molecular markers of senescent chondrocytes.

  2015cited by this paper
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  2015cited by this paper
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  2015cited by this paper
• Metabolic triggered inflammation in osteoarthritis.

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• Is osteoarthritis a metabolic disorder?

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• Osteoarthritis

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• Reactive oxygen species induce Cox-2 expression via TAK1 activation in synovial fibroblast cells

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• State of the evidence

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• Chondrosenescence: definition, hallmarks and potential role in the pathogenesis of osteoarthritis.

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• Mitochondrial Biogenesis Is Impaired in Osteoarthritis Chondrocytes but Reversible via Peroxisome Proliferator–Activated Receptor γ Coactivator 1α

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• Immunometabolism: Cellular Metabolism Turns Immune Regulator*

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• Berberine attenuates CCN2-induced IL-1β expression and prevents cartilage degradation in a rat model of osteoarthritis.

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• PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage

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• Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis

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• Rescue of proinflammatory cytokine-inhibited chondrogenesis by the antiarthritic effect of melatonin in synovium mesenchymal stem cells via suppression of reactive oxygen species and matrix metalloproteinases.

  2014cited by this paper
• Adipokines as drug targets in joint and bone disease.

  2014cited by this paper
• Classification of osteoarthritis phenotypes by metabolomics analysis

  2014cited by this paper
• Local intra-articular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis

  2014cited by this paper
• The Future of Osteoarthritis Therapeutics: Emerging Biological Therapy

  2013cited by this paper
• Tackling obesity in knee osteoarthritis

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• To Wnt or not to Wnt: the bone and joint health dilemma

  2013cited by this paper
• Metabolism of inflammation limited by AMPK and pseudo-starvation

  2013cited by this paper
• Macrophages, fat, and the emergence of immunometabolism.

  2013cited by this paper
• C/EBP homologous protein drives pro-catabolic responses in chondrocytes

  2013cited by this paper
• SIRT1, a class III histone deacetylase, regulates TNF-α-induced inflammation in human chondrocytes.

  2013cited by this paper
• Mitochondrial dysfunction in osteoarthritis is associated with down-regulation of superoxide dismutase 2.

  2013cited by this paper
• Mitochondrial respiratory chain dysfunction modulates metalloproteases -1, -3 and -13 in human normal chondrocytes in culture

  2013cited by this paper
• Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!).

  2013cited by this paper
• The overexpression of SIRT1 inhibited osteoarthritic gene expression changes induced by interleukin‐1β in human chondrocytes

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• Oxidative stress and status of antioxidant enzymes in children with Kashin-Beck disease.

  2013cited by this paper
• High glucose induces vascular endothelial growth factor production in human synovial fibroblasts through reactive oxygen species generation.

  2013cited by this paper
• Value of biomarkers in osteoarthritis: current status and perspectives

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• Is osteoarthritis a metabolic disease?

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• Differential expression of adipokines in infrapatellar fat pad (IPFP) and synovium of osteoarthritis patients and healthy individuals

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• Synovium and the Innate Inflammatory Network in Osteoarthritis Progression

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• Osteoarthritis: Metabolomic characterization of metabolic phenotypes in OA

  2012cited by this paper
• Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review.

  2012cited by this paper
• Effects of aging on articular cartilage homeostasis.

  2012cited by this paper
• Anterior cruciate ligament changes in the human knee joint in aging and osteoarthritis.

  2012cited by this paper
• Mitochondrial electron transport and glycolysis are coupled in articular cartilage.

  2012cited by this paper
• Diagnosis of osteoarthritis: imaging.

  2012cited by this paper
• Why subchondral bone in osteoarthritis? The importance of the cartilage bone interface in osteoarthritis

  2012cited by this paper
• Metabolic stress-induced inflammation plays a major role in the development of osteoarthritis in mice.

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  2011cited by this paper
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  2011cited by this paper
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  2010cited by this paper

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