The role of beta 2-microglobulin in peptide binding by class I molecules.

No abstract is available for this paper.

• Publication year

  1990

• Venue

  Science

• Publication date

  1990-12-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1126/SCIENCE.2124002PMID 2124002
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pillars Article: The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

  2005cited by this paper
• Interspecies exchange of β2-microglobulin and associated MHC and differentiation antigens

  2004cited by this paper
• Class I MHC molecules rather than other mouse genes dictate influenza epitope recognition by cytotoxic T cells

  2004cited by this paper
• Antigen presentation requires transport of MHC class I molecules from the endoplasmic reticulum.

  1990cited by this paper
• Defective presentation of endogenous antigen by a cell line expressing class I molecules.

  1990cited by this paper
• Presentation of viral antigen controlled by a gene in the major histocompatibility complex

  1990cited by this paper
• Direct binding of influenza peptides to class I HLA molecules

  1989cited by this paper
• Consequences of self-presentation of peptide antigen by cytolytic T lymphocytes.

  1989cited by this paper
• Role of beta 2-microglobulin in the intracellular transport and surface expression of murine class I histocompatibility molecules.

  1989cited by this paper
• Peptide-dependent recognition of H–2Kb by alloreactive cytotoxic T lymphocytes

  1989cited by this paper
• Association of class I major histocompatibility heavy and light chains induced by viral peptides

  1989cited by this paper
• Brefeldin A implicates egress from endoplasmic reticulum in class I restricted antigen presentation

  1989cited by this paper
• Cytolytic T-lymphocyte response to isolated class I H–2 proteins and influenza peptides

  1989cited by this paper
• Brefeldin A specifically inhibits presentation of protein antigens to cytotoxic T lymphocytes.

  1989cited by this paper
• The conformation of Ld induced by beta 2-microglobulin is fixed during de novo synthesis and irreversible by exchange or dissociation.

  1989cited by this paper
• Class I-restricted presentation occurs without internalization or processing of exogenous antigenic peptides.

  1989cited by this paper
• Induction of ovalbumin-specific cytotoxic T cells by in vivo peptide immunization

  1989cited by this paper
• T-cell antigen receptor genes and T-cell recognition

  1988cited by this paper
• Introduction of soluble protein into the class I pathway of antigen processing and presentation.

  1988cited by this paper
• Enhanced recognition of a modified peptide antigen by cytotoxic T cells specific for influenza nucleoprotein.

  1988cited by this paper
• On the role of the transmembrane anchor sequence of influenza hemagglutinin in target cell recognition by class I MHC-restricted, hemagglutinin-specific cytolytic T lymphocytes

  1987cited by this paper
• Structure of the human class I histocompatibility antigen, HLA-A2

  1987cited by this paper
• Spontaneous deletion at the B2m locus: evidence for site-specific genetic rearrangement.

  1987cited by this paper
• Cytotoxic T lymphocytes recognize a fragment of influenza virus matrix protein in association with HLA-A2

  1987cited by this paper
• Beta 2-microglobulin is not required for cell surface expression of the murine class I histocompatibility antigen H-2Db or of a truncated H-2Db.

  1986cited by this paper
• H—2-restricted cytolytic T cells specific for HLA can recognize a synthetic HLA peptide

  1986cited by this paper
• The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides.

  1986cited by this paper
• Cytotoxic T cells recognize fragments of the influenza nucleoprotein.

  1985cited by this paper
• Association of serum beta 2-microglobulin with H-2 class I heavy chains on the surface of mouse cells in culture.

  1984cited by this paper
• Beta 2-microglobulin from serum associates with MHC class I antigens on the surface of cultured cells.

  1984cited by this paper
• Serum β2-microglobulin binds to a T-cell differentiation antigen and increases its expression

  1984cited by this paper
• Large-scale purification of murine I-Ak and I-Ek antigens and characterization of the purified proteins.

  1983cited by this paper
• Exchange of cell-associated beta 2-microglobulin in mouse chimeras.

  1983cited by this paper
• Dissociation and exchange of the beta 2-microglobulin subunit of HLA-A and HLA-B antigens.

  1979cited by this paper
• The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin.

  1978cited by this paper

• A subclass of small RNAs is encoded by exons of protein-coding genes

  2025cites this paper
• Surface emergence and persistence of MHC class I free heavy chains

  2025cites this paper
• Alternate MHC I antigen presentation pathways allow CD8+ T-cell recognition and killing of cancer cells in the absence of ß2M or TAP.

  2024cites this paper
• Antigen presentation in vertebrates: Structural and functional aspects.

  2023cites this paper
• Four Faces of Cell-Surface HLA Class-I: Their Antigenic and Immunogenic Divergence Generating Novel Targets for Vaccines

  2022cites this paper
• NLRC5 regulates expression of MHC-I and provides a target for anti-tumor immunity in transmissible cancers

  2020cites this paper
• Computational characterization of residue couplings and micropolymorphism-induced changes in the dynamics of two differentially disease-associated human MHC class-I alleles

  2018cites this paper
• The Obligate Intracellular Bacterium Orientia tsutsugamushi Targets NLRC5 To Modulate the Major Histocompatibility Complex Class I Pathway

  2018cites this paper
• Effect of feeding Lipopolysaccharide as an immunostimulant on immune response and immune gene expression of Labeo bata.

  2017cites this paper
• Investigating the mechanism by which the atypical antipsychotic clozapine reduces disease in experimental autoimmune encephalomyelitis

  2017cites this paper
• The Implication and Significance of Beta 2 Microglobulin: A Conservative Multifunctional Regulator

  2016cites this paper
• Evolution and comparative analysis of the bat MHC-I region

  2016cites this paper
• Genomic characterization and sequence diversity of the β2-microglobulin gene in the miiuy croaker, Miichthys miiuy.

  2015cites this paper
• Using Autoimmunity To Inform Tumor Immunity

  2015cites this paper
• Identification and Molecular Characterization of Z/ZE Lineage MHC Class I Heavy Chain Homologue and β2-microglobulin from Rock Bream Oplegnathus fasciatus

  2014cites this paper
• Classification of Human Leukocyte Antigen (HLA) Supertypes

  2014cites this paper
• Population Differentiation of Ontario Lake trout (Salvelinus namaycush) using the Major Histocompatibility Complex class II β gene

  2014cites this paper
• Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin

  2013cites this paper
• Molecular cloning and characterization of sea bass (Dicentrarchus labrax, L.) MHC class I heavy chain and β2-microglobulin.

  2013cites this paper
• Purification and Characterization of a Naturally Processed Hepatitis B Virus Peptide Recognized by CD 8 1 Cytotoxic T Lymphocytes

  2013cites this paper
• Etude du repliement des protéines par RMN temps réel et autres méthodes biophysiques : l'exemple de la Beta-2-microglobuline

  2012cites this paper
• Pillars article: T cell receptor antagonist peptides induce positive selection. Cell. 1994. 76: 17-27.

  2012cites this paper
• Effects of chronic exposure to the aqueous fraction of produced water on growth, detoxification and immune factors of Atlantic cod.

  2012cites this paper
• Ranaviruses: Detection, differentiation and host immune response

  2012cites this paper
• Expression of immune-related genes in rohu Labeo rohita (Hamilton) by experimental freshwater lice Argulus siamensis (Wilson) infection.

  2011cites this paper
• Structural diversity of class I MHC-like molecules and its implications in binding specificities.

  2011cites this paper
• β2-microglobulin distribution in trout body fluids and release from intestinal epithelial cells in response to plant meal components

  2011influential citation
• Identification and Validation of Novel Cerebrospinal Fluid Biomarkers for Staging Early Alzheimer's Disease

  2011cites this paper
• Clinical and immunologic responses of HLA-A3+ breast cancer patients vaccinated with the HER2/neu-derived peptide vaccine, E75, in a phase I/II clinical trial.

  2010cites this paper
• Beta2-microglobulin is involved in the immune response of large yellow croaker to Aeromonas hydrophila: a proteomic based study.

  2010cites this paper
• the Endoplasmic Reticulum Binding to MHC Class I Molecules in Anti-Peptide Antibody Blocks Peptide

  2010cites this paper
• Modified Human Beta 2‐Microglobulin (desLys58) Displays Decreased Affinity for the Heavy Chain of MHC Class I and Induces Nitric Oxide Production and Apoptosis

  2009cites this paper
• Molecular characterization and expression analysis of β2-microglobulin in large yellow croaker Pseudosciaena crocea

  2009cites this paper
• Class I HLA Folding and Antigen Presentation in β2-Microglobulin-Defective Daudi Cells1

  2009influential citation
• Dynamic influence of the two membrane-proximal immunoglobulin-like domains upon the peptide-binding platform domain in class I and class II major histocompatibility complexes: normal mode analysis.

  2009cites this paper
• Analysis and clinical relevance of human leukocyte antigen class I, heavy chain, and beta2-microglobulin downregulation in breast cancer.

  2009cites this paper
• Dynamic interaction among the platform domain and two membrane-proximal immunoglobulin-like domains of class I major histocompatibility complex: normal mode analysis.

  2008cites this paper
• Cellular Expression or Binding of desLys58‐β2 Microglobulin is not Dependent on the Presence of the Tri‐molecular MHC Class I Complex

  2008cites this paper
• A study on anti-tumor immunity induced by gene-modified melanoma B16 cells.

  2008cites this paper
• Cloning and characterization of ovine beta2-microglobulin cDNAs.

  2008influential citation
• Correlates for disease progression and prognosis during concurrent HIV/TB infection.

  2007cites this paper
• A Functional Study of Major Histocompatibility Expression and Immune Function in Rainbow Trout, (Oncorhynchus mykiss)

  2006cites this paper
• Beta-2-microglobulin gene expression is maintained in rainbow trout and Atlantic salmon kept at low temperatures.

  2006cites this paper
• Cloning and sequence analysis of the beta2-microglobulin transcript from flounder, Paralichthys olivaceous.

  2006cites this paper
• Membrane-anchored beta 2-microglobulin stabilizes a highly receptive state of MHC class I molecules.

  2005cites this paper
• Membrane-Anchored β2-Microglobulin Stabilizes a Highly Receptive State of MHC Class I Molecules1

  2005cites this paper
• Beta2-microglobulin required for cell surface expression of blastocyst MHC.

  2005cites this paper
• Gene expression and differentiation

  2005cites this paper
• Association of β2-microglobulin with the α3 domain of H-2Db heavy chain

  2004cites this paper
• Real-time measurement of in vitro peptide binding to soluble HLA-A*0201 by fluorescence polarization.

  2004cites this paper
• The β2-Microglobulin Locus of Rainbow Trout (Oncorhynchus mykiss) Contains Three Polymorphic Genes1

  2004cites this paper
• Association of beta2-microglobulin with the alpha3 domain of H-2Db heavy chain.

  2004cites this paper
• Hydrolysis of the tumor-associated antigen epitope gp100(280-288) by membrane-associated and soluble enzymes expressed by immature and mature dendritic cells.

  2004cites this paper
• Polymorphic specificity of Q1/28, a monoclonal antibody that preferentially reacts with free class I heavy chains

  2004cites this paper
• A Dominant Negative Mutant β2-Microglobulin Blocks the Extracellular Folding of a Major Histocompatibility Complex Class I Heavy Chain*

  2003cites this paper
• Tests for Positive Selection on Immune and Reproductive Genes in Closely Related Species of the Murine Genus Mus

  2003cites this paper
• Disparate peptide‐dependent thymic selection outcomes in β2M‐deficient mice versus TAP‐1‐deficient mice: implications for repertoire formation

  2003cites this paper
• Macrophages Are Deficient in Vacuolar Alternate Class I MHC (MHC-I) Processing due to Decreased MHC-I Stability at Phagolysosomal pH

  2003cites this paper
• Heat-Aggregated Noninfectious Influenza Virus Induces a More Balanced CD8+-T-Lymphocyte Immunodominance Hierarchy Than Infectious Virus

  2003cites this paper
• Degradation of the immunogenic peptide gp100(280-288) by the monocyte-like U937 cell line.

  2003cites this paper
• Tapasin−/− and TAP1−/− Macrophages Are Deficient in Vacuolar Alternate Class I MHC (MHC-I) Processing due to Decreased MHC-I Stability at Phagolysosomal pH1

  2003cites this paper
• Ganglioside expression in tissues of mice lacking β2‐microglobulin

  2002cites this paper
• Phylogenetic relationships in the genus mus, based on paternally, maternally, and biparentally inherited characters.

  2002cites this paper
• In vivo CTL immunity can be elicited by OVA-linker-beta2m fusion protein.

  2002cites this paper
• Alternative processing of endogenous or exogenous antigens extends the immunogenic, H-2 class I-restricted peptide repertoire.

  2002cites this paper
• Dendritic cells pulsed with exogenous hepatitis B surface antigen particles efficiently present epitopes to MHC class I‐restricted cytotoxic T cells

  2002cites this paper
• Probing T cell membrane organization using dimeric MHC-Ig complexes.

  2002cites this paper
• A Naturally Processed Mitochondrial Self-Peptide in Complex with Thymic Mhc Molecules Functions as a Selecting Ligand for a Viral-Specific T Cell Receptor

  2001cites this paper
• Kinetics and thermodynamics of beta 2-microglobulin binding to the alpha 3 domain of major histocompatibility complex class I heavy chain.

  2001cites this paper
• Peptide loading of nascent MHC class I molecules.

  2001cites this paper
• Anti-Peptide Antibody Blocks Peptide Binding to MHC Class I Molecules in the Endoplasmic Reticulum1

  2001cites this paper
• Thymic selection is influenced by subtle structural variation involving the p4 residue of an MHC class I‐bound peptide

  2000cites this paper
• Major histocompatibility complex heavy chain accumulation in the endoplasmic reticulum of oligodendrocytes results in myelin abnormalities

  2000cites this paper
• Structural features of MHC class I molecules that might facilitate alternative pathways of presentation.

  2000cites this paper
• The isolated major histocompatibility complex class I α3 domain binds β2m and CD8αα dimers

  2000cites this paper
• The isolated major histocompatibility complex class I alpha3 domain binds beta2m and CD8alphaalpha dimers.

  2000cites this paper
• CD86 (B7-2) can function to drive MHC-restricted antigen-specific CTL responses in vivo.

  1999cites this paper
• Soluble CD8 stabilizes the HLA class I molecule by promoting beta2M exchange: analysis in real-time.

  1999cites this paper
• Novel approaches to generating cytotoxic T lymphocyte target structures

  1999cites this paper
• Beta 2-microglobulin-deficient background ameliorates lethal phenotype of the TGF-beta 1 null mouse.

  1999cites this paper
• β2-Microglobulin-Deficient Background Ameliorates Lethal Phenotype of the TGF-β1 Null Mouse

  1999cites this paper
• Alternative pathways for processing exogenous and endogenous antigens that can generate peptides for MHC class I‐restricted presentation

  1999cites this paper
• Class IMHC molecules: assembly and antigen presentation

  1999cites this paper
• Use of a high-affinity peptide that aborts MHC-restricted cytotoxic T lymphocyte activity against multiple viruses in vitro and virus-induced immunopathologic disease in vivo.

  1999cites this paper
• Covalent linkage to beta2-microglobulin enhances the MHC stability and antigenicity of suboptimal CTL epitopes.

  1999cites this paper
• Extracellular processing and presentation of a 69-mer synthetic polypetide to MHC class I-restricted T cells.

  1999cites this paper
• Peptide exchange in MHC molecules

  1999cites this paper
• Expression of MHC class I and beta2-microglobulin in rat spinal motoneurons: regulatory influences by IFN-gamma and axotomy.

  1998cites this paper
• The influence of exogenous peptide on β2–microglobulin exchange in the HLA complex: analysis in real-time

  1998cites this paper
• Effects of β2–microglobulin mutations on the alpha-1 helical region of H2-Ld

  1998cites this paper
• Creating CTL targets with epitope-linked beta 2-microglobulin constructs.

  1998cites this paper
• Creating CTL Targets with Epitope-Linked β2-Microglobulin Constructs

  1998cites this paper
• Physical and Functional Association of the Major Histocompatibility Complex Class I Heavy Chain α3 Domain with the Transporter Associated with Antigen Processing

  1998cites this paper
• β2-microglobulin of Ictalurid catfishes

  1998cites this paper
• Beta 2-microglobulin of ictalurid catfishes.

  1998cites this paper
• The Effect of Human β2-Microglobulin on Major Histocompatibility Complex I Peptide Loading and the Engineering of a High Affinity Variant

  1998cites this paper
• Antigen-dependent and -independent Ca2+ Responses Triggered in T Cells by Dendritic Cells Compared with B Cells

  1998cites this paper
• A europium fluoroimmunoassay for measuring peptide binding to MHC class I molecules.

  1998cites this paper
• Peptide ligand structure influences the exchange of beta2-microglobulin by cell surface Kb.

  1998cites this paper
• In vitro induction of naive cytotoxic T lymphocytes with complexes of peptide and recombinant MHC class I molecules coated onto beads: role of TCR/ligand density

  1998cites this paper