EGF receptor and Notch signaling act upstream of Eyeless/Pax6 to control eye specification.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Cell

• Publication date

  2001-03-09

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0092-8674(01)00265-3PMID 11257223
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Embryonic origin of the imaginal discs of the head of Drosophila melanogaster

  2004cited by this paper
• The Drosophila homeobox gene optix is capable of inducing ectopic eyes by an eyeless-independent mechanism.

  2000cited by this paper
• Sloppy paired acts as the downstream target of wingless in the Drosophila CNS and interaction between sloppy paired and gooseberry inhibits sloppy paired during neurogenesis.

  2000cited by this paper
• Notch signaling and the determination of appendage identity.

  2000cited by this paper
• Establishing neuronal identity in vertebrate neurogenic placodes.

  2000cited by this paper
• Coexpression of the homeobox genes Distal-less and homothorax determines Drosophila antennal identity.

  2000cited by this paper
• DER signaling restricts the boundaries of the wing field during Drosophila development.

  2000cited by this paper
• Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics.

  2000cited by this paper
• Notch signaling in the nervous system. Pieces still missing from the puzzle.

  2000cited by this paper
• Cell fate specification in the Drosophila retina.

  2000cited by this paper
• Early retinal development in Drosophila.

  2000cited by this paper
• pannier acts upstream of wingless to direct dorsal eye disc development in Drosophila.

  2000cited by this paper
• Overexpression of the m4 and mα genes of the E(spl)-Complex antagonizes Notch mediated lateral inhibition

  1999cited by this paper
• Engineered truncations in the Drosophila mastermind protein disrupt Notch pathway function.

  1999cited by this paper
• Several levels of EGF receptor signaling during photoreceptor specification in wild-type, Ellipse, and null mutant Drosophila.

  1999cited by this paper
• Antagonism of EGFR and notch signalling in the reiterative recruitment of Drosophila adult chordotonal sense organ precursors.

  1999cited by this paper
• Notch signaling: cell fate control and signal integration in development.

  1999cited by this paper
• EGF receptor signaling in Drosophila oogenesis.

  1999cited by this paper
• twin of eyeless, a second Pax-6 gene of Drosophila, acts upstream of eyeless in the control of eye development.

  1999cited by this paper
• Pax 6: mastering eye morphogenesis and eye evolution.

  1999cited by this paper
• Eye development: Notch lends a handedness.

  1999cited by this paper
• A conserved blueprint for the eye?

  1999cited by this paper
• Ci: a complex transducer of the hedgehog signal.

  1999cited by this paper
• Sprouty: a common antagonist of FGF and EGF signaling pathways in Drosophila.

  1999cited by this paper
• Prospero distinguishes sibling cell fate without asymmetric localization in the Drosophila adult external sense organ lineage.

  1999cited by this paper
• Eye development in Drosophila: formation of the eye field and control of differentiation.

  1998cited by this paper
• Ectopic expression of activated Ras1 induces hyperplastic growth and increased cell death in Drosophila imaginal tissues.

  1998cited by this paper
• Photoreceptor development: breaking down the barriers.

  1998cited by this paper
• The Drosophila Pax gene eye gone is required for embryonic salivary duct development.

  1998cited by this paper
• Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation.

  1998cited by this paper
• The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling.

  1998cited by this paper
• decapentaplegic and wingless are regulated by eyes absent and eyegone and interact to direct the pattern of retinal differentiation in the eye disc.

  1998cited by this paper
• Ras promotes cell survival in Drosophila by downregulating hid expression.

  1998cited by this paper
• Heartbroken is a specific downstream mediator of FGF receptor signalling in Drosophila.

  1998cited by this paper
• Specification of primary pigment cell and outer photoreceptor fates by BarH1 homeobox gene in the developing Drosophila eye.

  1998cited by this paper
• Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling.

  1998cited by this paper
• Multiple roles of the eyes absent gene in Drosophila.

  1998cited by this paper
• Regulatory control of signal transduction during morphogenesis in Drosophila.

  1998cited by this paper
• Complexity of EGF receptor signalling revealed in Drosophila.

  1998cited by this paper
• Master Control Genes in Development and Evolution

  1998cited by this paper
• Master control genes in development and evolution : the homeobox story

  1998cited by this paper
• The Drosophila 14-3-3 protein Leonardo enhances Torso signaling through D-Raf in a Ras 1-dependent manner.

  1997cited by this paper
• Control of midline glia development in the embryonic Drosophila CNS.

  1997cited by this paper
• Dominant enhancers of Egfr in Drosophila melanogaster: genetic links between the Notch and Egfr signaling pathways.

  1997cited by this paper
• A functional analysis of Notch mutations in Drosophila.

  1997cited by this paper
• A thousand and one roles for the Drosophila EGF receptor.

  1997cited by this paper
• Serrate-mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginal disc.

  1997cited by this paper
• Ras1-mediated modulation of Drosophila homeotic function in cell and segment identity.

  1997cited by this paper
• Establishing primordia in the Drosophila eye-antennal imaginal disc: the roles of decapentaplegic, wingless and hedgehog.

  1997cited by this paper
• The Drosophila eyes absent gene directs ectopic eye formation in a pathway conserved between flies and vertebrates.

  1997cited by this paper
• Ectopic activation of torpedo/Egfr, a Drosophila receptor tyrosine kinase, dorsalizes both the eggshell and the embryo.

  1997cited by this paper
• The Drosophila mushroom body is a quadruple structure of clonal units each of which contains a virtually identical set of neurones and glial cells.

  1997cited by this paper
• The Drosophila TGF alpha homolog Spitz acts in photoreceptor recruitment in the developing retina.

  1997cited by this paper
• A network of interacting transcriptional regulators involved in Drosophila neural fate specification revealed by the yeast two-hybrid system.

  1997cited by this paper
• Expression and function of clift in the development of somatic gonadal precursors within the Drosophila mesoderm.

  1997cited by this paper
• Control of cell fates and segmentation in the Drosophila mesoderm.

  1997cited by this paper
• Photoreceptor cell differentiation requires regulated proteolysis of the transcriptional repressor Tramtrack.

  1997cited by this paper
• Control of midline glia development in the embryonic Drosophila CNS.

  1997cited by this paper
• Feedback regulation is central to Delta-Notch signalling required for Drosophila wing vein morphogenesis.

  1997cited by this paper
• Functional dissection of the Drosophila enhancer of split protein, a suppressor of neurogenesis.

  1997cited by this paper
• Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye.

  1996cited by this paper
• Heartless, a Drosophila FGF receptor homolog, is essential for cell migration and establishment of several mesodermal lineages.

  1996cited by this paper
• The roles of engrailed.

  1996cited by this paper
• heartless encodes a fibroblast growth factor receptor (DFR1/DFGF-R2) involved in the directional migration of early mesodermal cells in the Drosophila embryo.

  1996cited by this paper
• Cell-cell interactions during neural development: multiple types of lateral inhibitions involved in Drosophila eye development.

  1996cited by this paper
• Vein is a novel component in the Drosophila epidermal growth factor receptor pathway with similarity to the neuregulins.

  1996cited by this paper
• Regulated Breathless receptor tyrosine kinase activity required to pattern cell migration and branching in the Drosophila tracheal system.

  1996cited by this paper
• hedgehog, wingless and orthodenticle specify adult head development in Drosophila.

  1996cited by this paper
• Inhibition of cell fate in Drosophila by Enhancer of split genes.

  1995cited by this paper
• Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway.

  1995cited by this paper
• Segmental patterning of heart precursors in Drosophila.

  1995cited by this paper
• Notch signaling.

  1995cited by this paper
• dachshund encodes a nuclear protein required for normal eye and leg development in Drosophila.

  1994cited by this paper
• The Ets transcription factors encoded by the Drosophila gene pointed direct glial cell differentiation in the embryonic CNS.

  1994cited by this paper
• Specificity of bone morphogenetic protein-related factors: cell fate and gene expression changes in Drosophila embryos induced by decapentaplegic but not 60A.

  1994cited by this paper
• Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs.

  1994cited by this paper
• The Drosophila sine oculis locus encodes a homeodomain-containing protein required for the development of the entire visual system.

  1994cited by this paper
• Homology of the eyeless gene of Drosophila to the Small eye gene in mice and Aniridia in humans.

  1994cited by this paper
• spalt encodes an evolutionarily conserved zinc finger protein of novel structure which provides homeotic gene function in the head and tail region of the Drosophila embryo.

  1994cited by this paper
• Elucidation of the role of breathless, a Drosophila FGF receptor homolog, in tracheal cell migration.

  1994cited by this paper
• Pulling springs to tune transduction: adaptation by hair cells.

  1994cited by this paper
• The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway.

  1994cited by this paper
• Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway.

  1994cited by this paper
• Misexpression of the Drosophila argos gene, a secreted regulator of cell determination.

  1994cited by this paper
• Control of imaginal cell development by the escargot gene of Drosophila.

  1993cited by this paper
• An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye

  1993cited by this paper
• Vertebrate eye development.

  1992cited by this paper
• breathless, a Drosophila FGF receptor homolog, is essential for migration of tracheal and specific midline glial cells.

  1992cited by this paper
• The Drosophila sloppy paired locus encodes two proteins involved in segmentation that show homology to mammalian transcription factors.

  1992cited by this paper
• An extensive 3' cis-regulatory region directs the imaginal disk expression of decapentaplegic, a member of the TGF-beta family in Drosophila.

  1991cited by this paper
• Spatial and temporal control elements of the Drosophila engrailed gene.

  1990cited by this paper
• Coordinately and differentially mutable activities of torpedo, the Drosophila melanogaster homolog of the vertebrate EGF receptor gene.

  1989cited by this paper
• Notch is required for successive cell decisions in the developing Drosophila retina.

  1989cited by this paper
• Neuronal differentiation in Drosophila ommatidium.

  1987cited by this paper
• A clonal analysis of development in Drosophila melanogaster: morphogenesis, determination, and growth in the wild-type antenna.

  1971cited by this paper

• Modulating the levels and activity of the retinal determination network Is sufficient to induce the specification of distinct tissue fates in Drosophila.

  2025cites this paper
• Pax6 expressing neuroectodermal and ocular stem cells: Its role from a developmental biology perspective

  2024cites this paper
• Two distinct functions of Lim1 in the Drosophila antenna

  2024cites this paper
• Expression Activity of the ras85D Gene in Phylogenetically Distant Drosophila Species

  2024cites this paper
• Control of fate specification within the dorsal head of Drosophila melanogaster.

  2024cites this paper
• Polycomb safeguards imaginal disc specification through control of the Vestigial-Scalloped complex.

  2023cites this paper
• Bispecific antibodies targeting EGFR/Notch enhance the response to talazoparib by decreasing tumour-initiating cell frequency

  2023cites this paper
• The emerging regulatory roles of non-coding RNAs associated with Glucose metabolism in Breast Cancer.

  2023cites this paper
• The timing of cell fate decisions is crucial for initiating pattern formation in the Drosophila eye.

  2022cites this paper
• The early history of the eye-antennal disc of Drosophila melanogaster.

  2022cites this paper
• A multi-gene knockdown approach reveals a new role for Pax6 in controlling organ number in Drosophila.

  2021cites this paper
• Hippo pathway and Bonus control developmental cell fate decisions in the Drosophila eye

  2021influential citation
• Remodelling of oxygen-transporting tracheoles drives intestinal regeneration and tumorigenesis in Drosophila

  2021cites this paper
• Shaping an optical dome: The size and shape of the insect compound eye.

  2021cites this paper
• Early Eye Development: Specification and Determination

  2020cites this paper
• Negative Regulation for Neural Patterning in the Drosophila Eye

  2020cites this paper
• Catching the Next Wave: Patterning of the Drosophila Eye by the Morphogenetic Furrow

  2020cites this paper
• Intimate functional interactions between TGS1 and the Smn complex revealed by an analysis of the Drosophila eye development

  2020cites this paper
• Generation of Third Dimension: Axial Patterning in the Developing Drosophila Eye

  2020cites this paper
• Molecular Genetics of Axial Patterning, Growth and Disease in the Drosophila Eye

  2020influential citation
• Molecular aspects of eye development and regeneration in the Australian redclaw crayfish, Cherax quadricarinatus

  2019cites this paper
• Salt inducible kinases as novel Notch interactors in the developing Drosophila retina

  2019influential citation
• Characterization of sine oculis, eyes absent and dachshund Mutant Phenotypes and the Search for Novel Regulators

  2019cites this paper
• Selective elimination of cancer cells by the adenovirus E4orf4 protein in a Drosophila cancer model: a new paradigm for cancer therapy

  2019cites this paper
• EGFR/Notch Antagonists Enhance the Response to Inhibitors of the PI3K-Akt Pathway by Decreasing Tumor-Initiating Cell Frequency

  2019cites this paper
• Protein Phosphatases—A Touchy Enemy in the Battle Against Glioblastomas: A Review

  2019cites this paper
• The fly eye: Through the looking glass

  2018cites this paper
• Notch1 promotes mouse spinal neural stem and progenitor cells proliferation via p‐p38‐pax6 induced cyclin D1 activation

  2018cites this paper
• Signalling crosstalk during early tumorigenesis in the absence of Polycomb silencing

  2018cites this paper
• Polycomb group (PcG) proteins and Pax6 cooperate to inhibit in vivo reprogramming of the developing Drosophila eye

  2018cites this paper
• Specification and Patterning of Drosophila Appendages

  2018cites this paper
• Allocation of distinct organ fates from a precursor field requires a shift in expression and function of gene regulatory networks

  2018cites this paper
• Dynamic genome wide expression profiling of Drosophila head development reveals a novel role of Hunchback in retinal glia cell development and blood-brain barrier integrity

  2017cites this paper
• Drosophila Pax6 promotes development of the entire eye-antennal disc, thereby ensuring proper adult head formation

  2017cites this paper
• Eya2 overexpression promotes the invasion of human astrocytoma through the regulation of ERK/MMP9 signaling

  2017cites this paper
• Mechanisms controlling diversification of olfactory sensory neuron classes

  2017cites this paper
• Expression profiling reveals novel role of Hunchback in retinal glia cell development and blood-brain barrier integrity

  2017cites this paper
• Insect-Like Organization of the Stomatopod Central Complex: Functional and Phylogenetic Implications

  2017cites this paper
• Artificial selection for odor-guided behavior in Drosophila reveals changes in food consumption

  2017cites this paper
• Master regulators in development: Views from the Drosophila retinal determination and mammalian pluripotency gene networks.

  2017cites this paper
• Antagonism of EGFR and Notch limits resistance to EGFR inhibitors and radiation by decreasing tumor-initiating cell frequency

  2017cites this paper
• Regulatory mechanisms of EGFR signalling during Drosophila eye development

  2016cites this paper
• MicroRNA-101 inhibits cell proliferation and induces apoptosis by targeting EYA1 in breast cancer.

  2016cites this paper
• Arthropod eyes: The early Cambrian fossil record and divergent evolution of visual systems.

  2016cites this paper
• Distal‐less homeobox genes of insects and spiders: genomic organization, function, regulation and evolution

  2016cites this paper
• Notching on Cancer’s Door: Notch Signaling in Brain Tumors

  2015cites this paper
• Identification and analysis of novel insect head patterning genes

  2015cites this paper
• Cell proliferation control by Notch signalling during imaginal discs development in Drosophila

  2015cites this paper
• VEGF and Notch Signaling in Angiogenesis

  2015cites this paper
• Further Evidence for Pre-metamorphosis Larval Eye Reduction in the Holometabola (Insecta: Mecoptera: Panorpa vulgaris Imhoff & Labram, 1836).

  2015cites this paper
• Drosophila E3 ubiquitin ligase Hyperplastic Discs interacts with Shaggy and regulates morphogen signalling in the developing eye

  2015cites this paper
• Are there ergodic limits to evolution? Ergodic exploration of genome space and convergence

  2015cites this paper
• Mutation of potential MAPK phosphorylation sites in the Notch antagonist Hairless.

  2014cites this paper
• A vertex specific dorsal selector Dve represses the ventral appendage identity in Drosophila head.

  2014cites this paper
• miR-30a suppresses breast cancer cell proliferation and migration by targeting Eya2.

  2014cites this paper
• An Intronic microRNA Links Rb/E2F and EGFR Signaling

  2014cites this paper
• Notch-EGFR/HER2 Bidirectional Crosstalk in Breast Cancer

  2014cites this paper
• Dissection and immunostaining of imaginal discs from Drosophila melanogaster.

  2014cites this paper
• Expression of mutant CHMP2B, an ESCRT‐III component involved in frontotemporal dementia, causes eye deformities due to Notch misregulation in Drosophila

  2014cites this paper
• The atypical cadherin fat directly regulates mitochondrial function and metabolic state.

  2014cites this paper
• Linking pathways in the developing and aging brain with neurodegeneration.

  2014cites this paper
• Eye-specification genes in the bacterial light organ of the bobtail squid Euprymna scolopes, and their expression in response to symbiont cues.

  2014influential citation
• Mef2 Interacts with the Notch Pathway during Adult Muscle Development in Drosophila melanogaster

  2014cites this paper
• Advances in Retinal Stem Cell Biology

  2013cites this paper
• Catching the Next Wave: Patterning of the Drosophila Eye by the Morphogenetic Furrow

  2013cites this paper
• Ectopic Antenna Induction by Overexpression of CG17836/Xrp1 Encoding an AT-Hook DNA Binding Motif Protein in Drosophila

  2013cites this paper
• Notch signaling in the brain: in good and bad times.

  2013cites this paper
• Molecular Genetic Mechanisms of Axial Patterning: Mechanistic Insights into Generation of Axes in the Developing Eye

  2013cites this paper
• A Hh-driven gene network controls specification, pattern and size of the Drosophila simple eyes

  2013cites this paper
• Competition among gene regulatory networks imposes order within the eye-antennal disc of Drosophila

  2013influential citation
• MK3 controls Polycomb target gene expression via negative feedback on ERK

  2012cites this paper
• Segregation of eye and antenna fates maintained by mutual antagonism in Drosophila

  2012cites this paper
• A glimpse into dorso‐ventral patterning of the Drosophila eye

  2012influential citation
• Regulation and function of Pax-6 during head and eye development in Drosophila melanogaster

  2012cites this paper
• Genetic and developmental mechanisms underlying the formation of the Drosophila compound eye

  2012cites this paper
• The MAP kinase ERK and its scaffold protein MP1 interact with the chromatin regulator Corto during Drosophila wing tissue development

  2011influential citation
• Activation of JNK Signaling Mediates Amyloid-ß-Dependent Cell Death

  2011cites this paper
• Growth Factor Receptor Pathways Communication of Notch and Epidermal MUC5AC Expression through Bidirectional

  2011cites this paper
• Specificity of Drosophila Cytonemes for Distinct Signaling Pathways

  2011cites this paper
• PAX6 (paired box 6)

  2011cites this paper
• Regulation of cell identity and growth during early eye development: studies in drosophila and zebrafish.

  2011cites this paper
• The protein kinase Nemo integrates specification, proliferation and morphogenesis to shape the Drosophila eye

  2011cites this paper
• Interkinetic Nuclear Movement in the Ventricular Zone of the Cortex

  2011cites this paper
• Opposing interactions between homothorax and Lobe define the ventral eye margin of Drosophila eye.

  2011cites this paper
• MUC5AC Expression through Bidirectional Communication of Notch and Epidermal Growth Factor Receptor Pathways

  2011cites this paper
• The Retinal Determination Gene eyes absent Is Regulated by the EGF Receptor Pathway Throughout Development in Drosophila

  2010cites this paper
• Development and evolution: the case of eye development

  2010cites this paper
• Origin of Pax and Six gene families in sponges: Single PaxB and Six1/2 orthologs in Chalinula loosanoffi.

  2010cites this paper
• The transcriptional co-factor Chip acts with LIM-homeodomain proteins to set the boundary of the eye field in Drosophila

  2010cites this paper
• Retinal determination the beginning of eye development.

  2010cites this paper
• Size matters: the contribution of cell proliferation to the progression of the specification Drosophila eye gene regulatory network.

  2010cites this paper
• Rabex-5 ubiquitin ligase activity restricts Ras signaling to establish pathway homeostasis in Drosophila.

  2010cites this paper
• Identification of Retinal Transformation Hot Spots in Developing Drosophila Epithelia

  2010cites this paper
• Probing the Drosophila retinal determination gene network in Tribolium (I): The early retinal genes dachshund, eyes absent and sine oculis.

  2009cites this paper
• Hipk is an essential protein that promotes Notch signal transduction in the Drosophila eye by inhibition of the global co-repressor Groucho.

  2009cites this paper
• Position dependent responses to discontinuities in the retinal determination network.

  2009cites this paper
• eye dysplasia of Xenopus laevis

  2009cites this paper
• Wingless and Hedgehog signaling pathways regulate orthodenticle and eyes absent during ocelli development in Drosophila.

  2009cites this paper
• Principles of Drosophila eye differentiation.

  2009influential citation
• The molecular circuitry governing retinal determination.

  2009cites this paper