An emerging role of Alu RNA in geographic atrophy pathogenesis: the implication for novel therapeutic strategies.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Discover medicine

• Publication date

  2016-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 28147216
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inflammasome Complexes: Emerging Mechanisms and Effector Functions.

  2016cited by this paper
• Alu RNA accumulation in hyperglycemia augments oxidative stress and impairs eNOS and SOD2 expression in endothelial cells.

  2016cited by this paper
• Recent Advances in the Discovery of Deubiquitinating Enzyme Inhibitors

  2016cited by this paper
• NLRP3 regulates a non-canonical platform for caspase-8 activation during epithelial cell apoptosis

  2016cited by this paper
• The dynamic subcellular localization of ERK: mechanisms of translocation and role in various organelles.

  2016cited by this paper
• Antisense Oligonucleotide Therapy for Inherited Retinal Dystrophies.

  2016cited by this paper
• VDAC‐2: Mitochondrial outer membrane regulator masquerading as a channel?

  2016cited by this paper
• Oxidative stress, innate immunity, and age-related macular degeneration

  2016cited by this paper
• NLRP3 Inflammasome and Pathobiology in AMD

  2015cited by this paper
• Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector?

  2015cited by this paper
• A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

  2015cited by this paper
• Novel roles for caspase-8 in IL-1β and inflammasome regulation.

  2015cited by this paper
• How RIG-I like receptors activate MAVS.

  2015cited by this paper
• Ketone body β-hydroxybutyrate blocks the NLRP3 inflammasome-mediated inflammatory disease

  2015cited by this paper
• NLRP3 Inflammasome: Activation and Regulation in Age-Related Macular Degeneration

  2015cited by this paper
• RPE necroptosis in response to oxidative stress and in AMD.

  2015cited by this paper
• Inflammasome inhibition: putting out the fire.

  2015cited by this paper
• RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

  2015cited by this paper
• Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3

  2015cited by this paper
• Iron Toxicity in the Retina Requires Alu RNA and the NLRP3 Inflammasome.

  2015cited by this paper
• Alu RNA regulates the cellular pool of active ribosomes by targeted delivery of SRP9/14 to 40S subunits

  2015cited by this paper
• Splicing-correcting therapeutic approaches for retinal dystrophies: where endogenous gene regulation and specificity matter.

  2014cited by this paper
• DICER1/Alu RNA dysmetabolism induces Caspase-8–mediated cell death in age-related macular degeneration

  2014cited by this paper
• Age-Related Macular Degeneration in the Aspect of Chronic Low-Grade Inflammation (Pathophysiological ParaInflammation)

  2014cited by this paper
• Growth signals employ CGGBP1 to suppress transcription of Alu-SINEs

  2014cited by this paper
• IL-18 Attenuates Experimental Choroidal Neovascularization as a Potential Therapy for Wet Age-Related Macular Degeneration

  2014cited by this paper
• FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes

  2014cited by this paper
• Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non‐apoptotic caspase‐8 is required for inflammasome priming

  2014cited by this paper
• Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity

  2014cited by this paper
• HUMAN NUCLEAR DICER RESTRICTS THE DELETERIOUS ACCUMULATION OF ENDOGENOUS DOUBLE STRAND RNA

  2014cited by this paper
• DICER1 is essential for survival of postmitotic rod photoreceptor cells in mice

  2014cited by this paper
• An overview of the involvement of interleukin-18 in degenerative retinopathies.

  2014cited by this paper
• Necroptosis in health and diseases.

  2014cited by this paper
• Oligonucleotide-based therapy for neurodegenerative diseases.

  2014cited by this paper
• Control of life-or-death decisions by RIP1 kinase.

  2014cited by this paper
• Geographic atrophy: clinical features and potential therapeutic approaches.

  2014cited by this paper
• Epigenetic regulation of transcription and possible functions of mammalian short interspersed elements, SINEs.

  2013cited by this paper
• AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC

  2013cited by this paper
• Oxidative stress induced by P2X7 receptor stimulation in murine macrophages is mediated by c-Src/Pyk2 and ERK1/2.

  2013cited by this paper
• Two independent pathways of regulated necrosis mediate ischemia–reperfusion injury

  2013cited by this paper
• A2E Induces IL-1ß Production in Retinal Pigment Epithelial Cells via the NLRP3 Inflammasome

  2013cited by this paper
• Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degeneration

  2013cited by this paper
• Inflammatory mediators induced by amyloid-beta in the retina and RPE in vivo: implications for inflammasome activation in age-related macular degeneration.

  2013cited by this paper
• TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy.

  2013cited by this paper
• The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation.

  2013cited by this paper
• Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity.

  2013cited by this paper
• Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis.

  2012cited by this paper
• DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88.

  2012cited by this paper
• ERK1/2 activation is a therapeutic target in age-related macular degeneration

  2012cited by this paper
• P2X7 receptor activation induces reactive oxygen species formation in erythroid cells

  2012cited by this paper
• Age-related macular degeneration

  2012cited by this paper
• Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity

  2012cited by this paper
• Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation*

  2012cited by this paper
• Iron homeostasis regulates the activity of the microRNA pathway through poly(C)-binding protein 2.

  2012cited by this paper
• Argonaute proteins couple chromatin silencing to alternative splicing

  2012cited by this paper
• The physiological impact of microRNA gene regulation in the retina

  2012cited by this paper
• A role for mitochondria in NLRP3 inflammasome activation

  2011cited by this paper
• Non-canonical inflammasome activation targets caspase-11

  2011cited by this paper
• DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration

  2011cited by this paper
• A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases

  2011cited by this paper
• Caspase-8 and bid: caught in the act between death receptors and mitochondria.

  2011cited by this paper
• Caspase-Dependent Conversion of Dicer Ribonuclease into a Death-Promoting Deoxyribonuclease

  2010cited by this paper
• Anti-inflammatory Compounds Parthenolide and Bay 11-7082 Are Direct Inhibitors of the Inflammasome*

  2010cited by this paper
• Molecular mechanisms of necroptosis: an ordered cellular explosion

  2010cited by this paper
• Experimental Characterization and Mathematical Modeling of P2X7 Receptor Channel Gating

  2010cited by this paper
• Thioredoxin-interacting protein links oxidative stress to inflammasome activation

  2010cited by this paper
• Nucleoside reverse transcriptase inhibitor toxicity and mitochondrial DNA

  2010cited by this paper
• miRNeye: a microRNA expression atlas of the mouse eye

  2010cited by this paper
• Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

  2009cited by this paper
• Dicer is regulated by cellular stresses and interferons.

  2009cited by this paper
• MicroRNAs couple cell fate and developmental timing in retina

  2009cited by this paper
• Human Alu RNA is a modular transacting repressor of mRNA transcription during heat shock.

  2008cited by this paper
• Requirement of Reactive Oxygen Species-dependent Activation of ASK1-p38 MAPK Pathway for Extracellular ATP-induced Apoptosis in Macrophage*

  2008cited by this paper
• The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

  2007cited by this paper
• ATP Activates a Reactive Oxygen Species-dependent Oxidative Stress Response and Secretion of Proinflammatory Cytokines in Macrophages*

  2007cited by this paper
• Nucleotide receptor signaling in murine macrophages is linked to reactive oxygen species generation.

  2007cited by this paper
• Useful ‘junk’: Alu RNAs in the human transcriptome

  2007cited by this paper
• Pannexin1 is part of the pore forming unit of the P2X7 receptor death complex

  2007cited by this paper
• Sustained versus transient ERK1/2 signaling underlies the anti- and proapoptotic effects of oxidative stress in human RPE cells.

  2006cited by this paper
• Cryopyrin activates the inflammasome in response to toxins and ATP

  2006cited by this paper
• Apoptosis, Pyroptosis, and Necrosis: Mechanistic Description of Dead and Dying Eukaryotic Cells

  2005cited by this paper
• Fas ligation on macrophages enhances IL-1R1–Toll-like receptor 4 signaling and promotes chronic inflammation

  2004cited by this paper
• LINE-mediated retrotransposition of marked Alu sequences

  2003cited by this paper
• The role of Alu repeat clusters as mediators of recurrent chromosomal aberrations in tumors

  2002cited by this paper
• The ERK Signaling Cascade Inhibits Gonadotropin-Stimulated Steroidogenesis

  2001cited by this paper
• Nuclear factor kappaB-dependent mechanisms coordinate the synergistic effect of PMA and cytokines on the induction of superoxide dismutase 2.

  2001cited by this paper
• Mitochondria and calcium: from cell signalling to cell death

  2000cited by this paper
• Caspase-1-independent, Fas/Fas ligand-mediated IL-18 secretion from macrophages causes acute liver injury in mice.

  1999cited by this paper
• Extracellular ATP Activates Transcription Factor NF-κB through the P2Z Purinoreceptor by Selectively Targeting NF-κB p65 (RelA)

  1997cited by this paper

• Retrotransposon SINEs in Age-Related Diseases: Mechanisms and Therapeutic Implications.

  2024cites this paper
• Selective microRNA expression of exosomes from retinal pigment epithelial cells by oxidative stress.

  2024cites this paper
• Alu antisense RNA ameliorates methylglyoxal-induced human lens epithelial cell apoptosis by enhancing antioxidant defense.

  2023cites this paper
• Anti-aging Effects of Alu Antisense RNA on Human Fibroblast Senescence Through the MEK-ERK Pathway Mediated by KIF15

  2023cites this paper
• Nutraceuticals/Drugs Promoting Mitophagy and Mitochondrial Biogenesis May Combat the Mitochondrial Dysfunction Driving Progression of Dry Age-Related Macular Degeneration

  2022cites this paper
• IL-18 deficiency ameliorates the progression from AKI to CKD

  2022cites this paper
• Retinal Pigment Epithelium in Age-Related Macular Degeneration

  2020cites this paper
• Analytical Value of Cell-Free DNA Based on Alu in Psychiatric Disorders

  2020cites this paper
• Protective effects of microRNA‐22‐3p against retinal pigment epithelial inflammatory damage by targeting NLRP3 inflammasome

  2019cites this paper
• Ferulic acid may target MyD88-mediated pro-inflammatory signaling - Implications for the health protection afforded by whole grains, anthocyanins, and coffee.

  2018cites this paper
• New Treatment Modalities for Geographic Atrophy

  2017cites this paper