The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Nature reviews. Immunology

• Publication date

  2007-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nri2079PMID 17457343
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Absence of Innate MyD88 Signaling Promotes Inducible Allograft Acceptance1

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• Trif-related adapter molecule is phosphorylated by PKC during Toll-like receptor 4 signaling

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• Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling.

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• Evidence for licensing of IFN-γ-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program

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• SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production.

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• Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

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• Title: Impaired Toll-like receptor 8-mediated IL-6 and TNF-α production in antigen presenting cells from patients with X-linked agammaglobulinaemia Running title: Defective TLR-8 signaling in XLA

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• MyD88 Adapter-like (Mal) Is Phosphorylated by Bruton's Tyrosine Kinase during TLR2 and TLR4 Signal Transduction*

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• The Genome of the Sea Urchin Strongylocentrotus purpuratus

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• TNF receptor‐associated factor‐1 (TRAF1) negatively regulates Toll/IL‐1 receptor domain‐containing adaptor inducing IFN‐β (TRIF)‐mediated signaling

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• A polymorphism in Toll-interleukin 1 receptor domain containing adaptor protein is associated with susceptibility to meningeal tuberculosis.

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• Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis.

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• Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling.

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• The dsRNA binding site of human Toll‐like receptor 3

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• Pathogen recognition and innate immunity.

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• Nonredundant roles of TIRAP and MyD88 in airway response to endotoxin, independent of TRIF, IL-1 and IL-18 pathways

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• The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction.

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• Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation

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• Toll/IL-1R Domain-Containing Adaptor Protein (TIRAP) Is a Critical Mediator of Antibacterial Defense in the Lung against Klebsiella pneumoniae but Not Pseudomonas aeruginosa1

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• MyD88-mediated stabilization of interferon-γ-induced cytokine and chemokine mRNA

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• Structural and Functional Evidence for the Role of the TLR2 DD Loop in TLR1/TLR2 Heterodimerization and Signaling*

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• The Functional Effects of Physical Interactions among Toll-like Receptors 7, 8, and 9*

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• Targeting signal transduction as a strategy to treat inflammatory diseases

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• MyD88-mediated stabilization of interferon-gamma-induced cytokine and chemokine mRNA.

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• The human adaptor SARM negatively regulates adaptor protein TRIF–dependent Toll-like receptor signaling

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• Cutting Edge: NF-κB-Activating Kinase-Associated Protein 1 Participates in TLR3/Toll-IL-1 Homology Domain-Containing Adapter Molecule-1-Mediated IFN Regulatory Factor 3 Activation1

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• Achieving Stability of Lipopolysaccharide-Induced NF-κB Activation

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• Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF.

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• Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-beta.

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• TLR4 and Toll-IL-1 Receptor Domain-Containing Adapter-Inducing IFN-β, but Not MyD88, Regulate Escherichia coli-Induced Dendritic Cell Maturation and Apoptosis In Vivo1

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• MyD88-dependent induction of allergic Th2 responses to intranasal antigen.

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• Bruton's Tyrosine Kinase Is Involved in p65-mediated Transactivation and Phosphorylation of p65 on Serine 536 during NFκB Activation by Lipopolysaccharide*

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• Transforming growth factor-beta differentially inhibits MyD88-dependent, but not TRAM- and TRIF-dependent, lipopolysaccharide-induced TLR4 signaling.

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• Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors

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• Inhibition of phosphoinositide 3‐kinase enhances TRIF‐dependent NF‐κB activation and IFN‐β synthesis downstream of Toll‐like receptor 3 and 4

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• Apoptosis Induced by the Toll-Like Receptor Adaptor TRIF Is Dependent on Its Receptor Interacting Protein Homotypic Interaction Motif1

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• Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NFkappaB activation by lipopolysaccharide.

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• A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses

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• TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway

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• Structural Complementarity of Toll/Interleukin-1 Receptor Domains in Toll-like Receptors and the Adaptors Mal and MyD88*

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• Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

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• Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4.

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• Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

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