Aprotinin therapy in cardiac operations: a report on use in 41 cardiac centers in the United Kingdom.

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Annals of Thoracic Surgery

• Publication date

  1993-04-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/0003-4975(93)90128-5PMID 7682055
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1992cited by this paper
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  1991cited by this paper
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  1990cited by this paper
• Perfusion for paediatric open-heart surgery.

  1990cited by this paper
• Book reviews : Wilde P et al. 1989: Doppler echocardiography, a clinical guide. London: Churchill Livingstone. 168pp; 270 ill. £29.95

  1990cited by this paper
• Aprotinin in aspirin-pretreated patients

  1990cited by this paper
• Blood transfusion in cardiac surgery

  1990cited by this paper
• Reduction of Blood Transfusion Requirement in Open Heart Surgery by Administration of High Doses of Aprotinin - Preliminary Results

  1989cited by this paper
• A trial of desmopressin (1-desamino-8-D-arginine vasopressin) to reduce blood loss in uncomplicated cardiac surgery.

  1989cited by this paper
• Reduction in blood loss and blood use after cardiopulmonary bypass with high dose aprotinin (Trasylol).

  1989cited by this paper
• The role of epsilon-aminocaproic acid in reducing bleeding after cardiac operation: a double-blind randomized study.

  1988cited by this paper
• Effect of aprotinin on need for blood transfusion in patients with septic endocarditis having open-heart surgery.

  1988cited by this paper
• Effect of aprotinin on need for blood transfusion after repeat open-heart surgery.

  1987cited by this paper
• A prospective, randomized study of the effects of prostacyclin on platelets and blood loss during coronary bypass operations.

  1986cited by this paper
• Treatment with desmopressin acetate to reduce blood loss after cardiac surgery. A double-blind randomized trial.

  1986cited by this paper
• Treatment with Desmopressin Acetate to Reduce Blood Loss after Cardiac Surgery

  1986cited by this paper
• Effects of prostacyclin infusion on platelet activation and postoperative blood loss in coronary bypass.

  1983cited by this paper
• Blood conservation techniques.

  1981cited by this paper
• Letter: Vitamin-C-induced hyperoxaluria.

  1976cited by this paper

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  2025cites this paper
• Tranexamic Acid, a Low-cost and Practical Hemostatic Agent Against Diffuse Microvascular Bleeding Due to Coagulopathy in Heart Surgery

  2019cites this paper
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  2015cites this paper
• Intraoperative strategies for transfusion‐free medicine

  2014cites this paper
• Managing bleeding in cardiac surgery

  2014cites this paper
• with high-dose regimen only Aprotinin in pediatric cardiac operations: a benefit in complex malformations and

  2013cites this paper
• cardiac surgery SMA circuits reduce platelet consumption and platelet factor release during

  2013cites this paper
• A Review of its Pharmacology and Therapeutic Efficacy in Reducing Blood Loss Associated with Cardiac Surgery

  2012cites this paper
• Low dose aprotinin increases mortality and morbidity in coronary artery bypass surgery*

  2012cites this paper
• Retraction Note: Dringliche oder notfallmäßige Koronarrevaskularisation unter Verwendung beider Arteria Thoracica interna nach vorheriger Thrombozytenaggregationshemmung mit Clopidogrel

  2012cites this paper
• Aprotinin

  2012cites this paper
• Impact of aprotinin and renal function on mortality: a retrospective single center analysis

  2011cites this paper
• The effect of sivelestat sodium hydrate on severe respiratory failure after thoracic aortic surgery with deep hypothermia.

  2011cites this paper
• TRANEKSAMİK ASİT VE APROTİNİN’İN SİSTEMİK VEYA TOPİKAL KULLANIMININ KARDİYOPULMONER BYPASS SONRASI KAN KAYBI VE KAN ÜRÜNLERİ KULLANIMI ÜZERİNE ETKİSİ

  2011cites this paper
• Question n° 4

  2009cites this paper
• Bleeding in cardiac surgery: the use of aprotinin does not affect survival.

  2008cites this paper
• Perioperative renal outcome in cardiac surgical patients with preoperative renal dysfunction: aprotinin versus epsilon aminocaproic acid.

  2008cites this paper
• Aprotinin and renal dysfunction after pediatric cardiac surgery

  2007cites this paper
• Is There Still a Role for Aprotinin in Cardiac Surgery?

  2007cites this paper
• Anaphylactic shock in a beta‐blocked child: usefulness of isoproterenol

  2007cites this paper
• Aprotinin; friend or foe? A review of recent medical literature.

  2007cites this paper
• Avoiding Transfusions in Children Undergoing Cardiac Surgery: A Meta-Analysis of Randomized Trials of Aprotinin

  2006cites this paper
• The risk of aprotinin: a conflict of evidence.

  2006cites this paper
• Safety aspects of aprotinin therapy in cardiac surgery patients

  2006cites this paper
• Pro: Aprotinin Has a Good Efficacy and Safety Profile Relative to Other Alternatives for Prevention of Bleeding in Cardiac Surgery

  2006cites this paper
• The systemic inflammatory response syndrome and cardiopulmonary bypass.

  2005cites this paper
• Disminución del sangrado en la nefrolitotomía anatrófica en pacientes manejados con aprotinina en el Hospital Juárez de México

  2005cites this paper
• Kidney‐specific proteins in patients receiving aprotinin at high‐ and low‐dose regimens during coronary artery bypass graft with cardiopulmonary bypass

  2005cites this paper
• Forty years of clinical aprotinin use: a review of 124 hypersensitivity reactions.

  2005cites this paper
• Modulation of Systemic Inflammatory Response after Cardiac Surgery

  2005cites this paper
• [Urgent or emergent coronary revascularization using bilateral internal thoracic artery after previous clopidogrel antiplatelet therapy].

  2004cites this paper
• Perioperative Renal Dysfunct ion and Cardiovascular Anesthesia : Concerns and Controversies

  2004cites this paper
• ZURÜCKGEZOGEN: Dringliche oder notfallmäßige Koronarrevaskularisation unter Verwendung beider Arteria Thoracica interna nach vorheriger Thrombozytenaggregationshemmung mit Clopidogrel

  2004cites this paper
• Pharmacotherapeutic considerations in anesthesia.

  2003cites this paper
• Safety of low-flow sevoflurane anesthesia in patients with chronically impaired renal function is not proven.

  2003cites this paper
• Age and Left Ventricular Impairment Predict Reopening for Bleeding

  2003cites this paper
• Fatal intraoperative anaphylaxis related to aprotinin after local application of fibrin glue.

  2003cites this paper
• Pharmacologic Manipulation of Systemic Inflammatory Response after Cardiac Surgery

  2003cites this paper
• Use of aprotinin in patients undergoing deep hypothermic circulatory arrest: a review.

  2003cites this paper
• Blood Conservation Strategies in Cardiac Surgery

  2003cites this paper
• [Are there risk factors of allergic reactions related to patient factors, to drugs, techniques of use? Predictive indications].

  2002cites this paper
• Allergie à l’aprotinine

  2002cites this paper
• Soluble Adhesion Molecules in Coronary Surgery and Cardiopulmonary Bypass with Pump Prime Aprotinin

  2002cites this paper
• Y a-t-il des facteurs favorisant la réaction allergique, inhérents au terrain, aux médicaments, à la technique d'utilisation ? Indication du bilan prédictif

  2002cites this paper
• Safety and efficacy of methods for reducing perioperative allogeneic transfusion: a critical review of the literature.

  2002cites this paper
• A model of the direct and indirect effects of aprotinin administration on the overall costs of coronary revascularization surgery in a university teaching hospital cardiothoracic unit.

  2002cites this paper
• Y a-t-il des facteurs favorisant la réaction allergique, inhérents au terrain, aux médicaments, à la technique dˈutilisation ?Indication du bilan prédictif

  2002cites this paper
• Aprotinin: Antithrombotic and Vasoactive Mechanisms of Action

  2002cites this paper
• The Systemic Inflammatory Response to Cardiac Surgery: Implications for the Anesthesiologist

  2002cites this paper
• Pump prime aprotinin fails to limit proinflammatory cytokine release after coronary artery bypass surgery.

  2001cites this paper
• Cytokine responses and anti-inflammatory strategies in Coronary Artery Bypass Grafting

  2001cites this paper
• New antiinflammatory and platelet-preserving effects of aprotinin.

  2001cites this paper
• Transfusion Medicine

  2001cites this paper
• Epsilon-aminocaproic acid promotes the release of alpha2-antiplasmin during and after cardiopulmonary bypass.

  2001cites this paper
• Pump Prime Aprotinin Fails to Limit Proinflammatory Cytokine Release After Coronary Artery Bypass Surgery

  2001cites this paper
• Low-dose aprotinin in heart valve reoperations.

  2001cites this paper
• The antithrombotic and antiinflammatory mechanisms of action of aprotinin.

  2001cites this paper
• Structure, Pharmacology, and Clinical Use of Antifibrinolytic Agents

  2001cites this paper
• Pharmacological Interventions to Prevent the Need for Blood and Blood Component Therapies:.: Protease Inhibitor or Lysine Analogue?

  2001cites this paper
• Tranexamic acid in aortic valve replacement.

  2001cites this paper
• Meta-Analysis of Placebo-Controlled Trials of Aprotinin Assessing the Relative Risk of Reoperations in Patients Undergoing Coronary Artery Bypass Graft Surgery

  2000cites this paper
• Aprotinin and tranexamic acid for high transfusion risk cardiac surgery.

  2000cites this paper
• ANTIFIBRINOLÍTICOS EN CIRUGÍA CARDIACA

  2000cites this paper
• Aprotinin does not impair renal haemodynamics and function after cardiac surgery.

  2000cites this paper
• SMA circuits reduce platelet consumption and platelet factor release during cardiac surgery.

  2000cites this paper
• [Allergic risk of aprotinin].

  2000cites this paper
• Le risque allergique de l'aprotinine

  2000cites this paper
• Maintenance of blood heparin concentration rather than activated clotting time better preserves the coagulation system in hypothermic cardiopulmonary bypass.

  2000cites this paper
• Role of aprotinin in the management of patients during and after cardiac surgery

  2000cites this paper
• Hemostatic agents and their safety.

  1999cites this paper
• Bridging to cardiac transplantation: a clinical laboratory for the development of mechanical alternatives to transplantation.

  1999cites this paper
• Topical use of aprotinin in coronary artery bypass surgery.

  1999cites this paper
• Bloodless Medicine and Surgery

  1999cites this paper
• Is ε-Aminocaproic Acid as Effective as Aprotinin in Reducing Bleeding With Cardiac Surgery? A Meta-Analysis

  1999cites this paper
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  1999cites this paper
• Antifibrinolytic Therapy with Tranexamic Acid in Cardiac Operations

  1999cites this paper
• Is epsilon-aminocaproic acid as effective as aprotinin in reducing bleeding with cardiac surgery?: a meta-analysis.

  1999cites this paper
• Case 3--1999. Intraoperative coronary thrombosis in association with low-dose aprotinin therapy.

  1999cites this paper
• Platelet function during cardiac surgery and cardiopulmonary bypass with low-dose aprotinin.

  1999cites this paper
• Economic evaluation of high-dose and low-dose aprotinin therapy during cardiopulmonary bypass.

  1999cites this paper
• Disappearance of glycoprotein Ib from the platelet surface in pericardial blood during cardiopulmonary bypass.

  1998cites this paper
• Perioperative renal dysfunction and cardiovascular anesthesia: concerns and controversies.

  1998cites this paper
• Aprotinin versus lysine analogues: the debate continues.

  1998cites this paper
• Aprotinin and antifibrinolytics in cardiopulmonary bypass bleeding

  1998cites this paper
• A Risk-Benefit Assessment of Aprotinin in Cardiac Surgical Procedures

  1998cites this paper
• The effect on costs of the use of half-dose aprotinin for first-time reoperative coronary artery bypass patients.

  1998cites this paper
• Aprotinin in pediatric cardiac operations: a benefit in complex malformations and with high-dose regimen only.

  1998cites this paper
• Aprotinin versus epsilon-aminocaproic acid for aortic surgery using deep hypothermic circulatory arrest.

  1998cites this paper
• Effekte der intraoperativen Aprotininapplikation auf perioperative Hämostase- und Fibrinolyseveränderungen und ihre Auswirkungen auf Blutverlust und Transfusionsbedarf bei lungenchirurgischen Eingriffen

  1998cites this paper
• Aprotinin versus ϵ-aminocaproic acid for aortic surgery using deep hypothermic circulatory arrest☆

  1998cites this paper
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  1998cites this paper
• Is (cid:101) -Aminocaproic Acid as Effective as Aprotinin in Reducing Bleeding With Cardiac Surgery? A Meta-Analysis

  1998cites this paper
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  1997cites this paper
• Tranexamic Acid Reduces Bleeding After Cardiopulmonary Bypass When Compared to Epsilon Aminocaproic Acid and Placebo

  1997cites this paper
• Aprotinin Reduces Blood Loss after Cardiopulmonary Bypass by Direct Inhibition of Plasmin

  1997cites this paper
• Avoidance of allogeneic blood transfusions by treatment with epoetin beta (recombinant human erythropoietin) in patients undergoing open-heart surgery.

  1997cites this paper
• The continuing evolution of mechanical ventricular assistance.

  1997cites this paper
• Kinetics of reticulocyte maturity fractions and indices and iron status during therapy with epoetin beta (recombinant human erythropoietin) in cardiac surgery patients

  1997cites this paper
• Relationship between leukocyte count and patient risk for excessive blood loss after cardiac surgery.

  1997cites this paper
• Shed mediastinal blood in 500 elective cardiac surgery patients: is there enough for retransfusion routinely?

  1997cites this paper