Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Life Science

• Publication date

  2018-02-01

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.lfs.2017.12.005PMID 29225112
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Kaempferol – A dietary anticancer molecule with multiple mechanisms of action: Recent trends and advancements

  2017cited by this paper
• Fisetin inhibits cellular proliferation and induces mitochondria‐dependent apoptosis in human gastric cancer cells

  2017cited by this paper
• Fisetin regulates astrocyte migration and proliferation in vitro

  2017cited by this paper
• Fisetin inhibits IL‐1&bgr;‐induced inflammatory response in human osteoarthritis chondrocytes through activating SIRT1 and attenuates the progression of osteoarthritis in mice

  2017cited by this paper
• Design and development of dry powder sulfobutylether‐&bgr;‐cyclodextrin complex for pulmonary delivery of fisetin

  2017cited by this paper
• Mechanistic insight into carnosol‐mediated pharmacological effects: Recent trends and advancements

  2017cited by this paper
• Enhanced oral bioavailability and anticancer efficacy of fisetin by encapsulating as inclusion complex with HPβCD in polymeric nanoparticles

  2017cited by this paper
• Exploring the molecular targets of dietary flavonoid fisetin in cancer.

  2016cited by this paper
• Hepatitis C Virus NS5A Protein Triggers Oxidative Stress by Inducing NADPH Oxidases 1 and 4 and Cytochrome P450 2E1

  2016cited by this paper
• Dietary flavonoid fisetin increases abundance of high-molecular-mass hyaluronan conferring resistance to prostate oncogenesis.

  2016cited by this paper
• Synergistic effect of fisetin combined with sorafenib in human cervical cancer HeLa cells through activation of death receptor-5 mediated caspase-8/caspase-3 and the mitochondria-dependent apoptotic pathway

  2016cited by this paper
• Fisetin and hesperetin induced apoptosis and cell cycle arrest in chronic myeloid leukemia cells accompanied by modulation of cellular signaling

  2016cited by this paper
• Fisetin induces apoptosis and endoplasmic reticulum stress in human non-small cell lung cancer through inhibition of the MAPK signaling pathway

  2016cited by this paper
• The Dietary Flavonoid Fisetin Causes Cell Cycle Arrest, Caspase‐Dependent Apoptosis, and Enhanced Cytotoxicity of Chemotherapeutic Drugs in Triple‐Negative Breast Cancer Cells

  2016cited by this paper
• Targeting metastasis

  2016cited by this paper
• Potentiation of luteolin cytotoxicity by flavonols fisetin and quercetin in human chronic lymphocytic leukemia cell lines.

  2016cited by this paper
• Ursolic acid (UA): A metabolite with promising therapeutic potential.

  2016cited by this paper
• Dietary flavonoid fisetin for cancer prevention and treatment.

  2016cited by this paper
• Fisetin Reduces Cell Viability Through Up-Regulation of Phosphorylation of ERK1/2 in Cholangiocarcinoma Cells.

  2016cited by this paper
• Nanoencapsulation of dietary flavonoid fisetin: Formulation and in vitro antioxidant and α-glucosidase inhibition activities.

  2016cited by this paper
• Molecular mechanisms of action of quercetin in cancer: recent advances

  2016cited by this paper
• Fisetin Modulates Antioxidant Enzymes and Inflammatory Factors to Inhibit Aflatoxin-B1 Induced Hepatocellular Carcinoma in Rats

  2015cited by this paper
• The pleiotropic effects of fisetin and hesperetin on human acute promyelocytic leukemia cells are mediated through apoptosis, cell cycle arrest, and alterations in signaling networks

  2015cited by this paper
• Fisetin Inhibits UVB‐induced Cutaneous Inflammation and Activation of PI3K/AKT/NFκB Signaling Pathways in SKH‐1 Hairless Mice

  2015cited by this paper
• Dietary flavonoid fisetin binds to β-tubulin and disrupts microtubule dynamics in prostate cancer cells.

  2015cited by this paper
• Fisetin, a phytochemical, potentiates sorafenib-induced apoptosis and abrogates tumor growth in athymic nude mice implanted with BRAF-mutated melanoma cells

  2015cited by this paper
• Fisetin, a dietary flavonoid, augments the anti-invasive and anti-metastatic potential of sorafenib in melanoma

  2015cited by this paper
• Fisetin regulates TPA-induced breast cell invasion by suppressing matrix metalloproteinase-9 activation via the PKC/ROS/MAPK pathways.

  2015cited by this paper
• Fisetin Suppresses Macrophage-Mediated Inflammatory Responses by Blockade of Src and Syk

  2015cited by this paper
• Cordycepin: A Cordyceps Metabolite with Promising Therapeutic Potential

  2015cited by this paper
• Fisetin, a dietary flavonoid induces apoptosis via modulating the MAPK and PI3K/Akt signalling pathways in human osteosarcoma (U-2 OS) cells

  2015cited by this paper
• Dietary agents for prevention and treatment of lung cancer.

  2015cited by this paper
• Assembly of a novel biosynthetic pathway for production of the plant flavonoid fisetin in Escherichia coli.

  2015cited by this paper
• Fisetin, a dietary bioflavonoid, reverses acquired Cisplatin-resistance of lung adenocarcinoma cells through MAPK/Survivin/Caspase pathway.

  2015cited by this paper
• Fisetin and luteolin protect human retinal pigment epithelial cells from oxidative stress-induced cell death and regulate inflammation

  2015cited by this paper
• Fisetin targets phosphatidylinositol-3-kinase and induces apoptosis of human B lymphoma Raji cells

  2015cited by this paper
• Natural phenolic metabolites with anti-angiogenic properties – a review from the chemical point of view

  2015cited by this paper
• Apoptotic effect of cordycepin on A549 human lung cancer cell line

  2015cited by this paper
• Molecular aspects of metal oxide nanoparticle (MO-NPs) mediated pharmacological effects.

  2015cited by this paper
• Fisetin suppresses ADAM9 expression and inhibits invasion of glioma cancer cells through increased phosphorylation of ERK1/2

  2015cited by this paper
• Fisetin, a dietary flavonoid, induces apoptosis of cancer cells by inhibiting HSF1 activity through blocking its binding to the hsp70 promoter.

  2015cited by this paper
• YB-1 expression promotes epithelial-to-mesenchymal transition in prostate cancer that is inhibited by a small molecule fisetin

  2014cited by this paper
• Ameliorative Effect of Fisetin on Cisplatin-Induced Nephrotoxicity in Rats via Modulation of NF-κB Activation and Antioxidant Defence

  2014cited by this paper
• N‐acetyl‐L‐cysteine enhances fisetin‐induced cytotoxicity via induction of ROS‐independent apoptosis in human colonic cancer cells

  2014cited by this paper
• Melatonin Enhances the Anti-Tumor Effect of Fisetin by Inhibiting COX-2/iNOS and NF-κB/p300 Signaling Pathways

  2014cited by this paper
• Molecular docking studies of flavonoids for their inhibition pattern against β-catenin and pharmacophore model generation from experimentally known flavonoids to fabricate more potent inhibitors for Wnt signaling pathway

  2014cited by this paper
• Fisetin induces apoptosis in human nonsmall lung cancer cells via a mitochondria-mediated pathway

  2014cited by this paper
• Fisetin Inhibits Human Melanoma Cell Invasion through Promotion of Mesenchymal to Epithelial Transition and by Targeting MAPK and NFκB Signaling Pathways

  2014cited by this paper
• Fisetin modulates mitochondrial enzymes and apoptotic signals in benzo(a)pyrene-induced lung cancer

  2014cited by this paper
• Involvement of ER stress and activation of apoptotic pathways in fisetin induced cytotoxicity in human melanoma.

  2014cited by this paper
• World cancer report 2014.

  2014cited by this paper
• Cytotoxic and genotoxic activity of fisetin (3, 3 ', 4 ', 7-tetrahydroxyflavone) in an osteosarcoma in vitro model

  2014cited by this paper
• Improving solubility of fisetin by cocrystallization

  2014cited by this paper
• Reactive Oxygen Species, AMP-activated Protein Kinase, and the Transcription Cofactor p300 Regulate α-Tubulin Acetyltransferase-1 (αTAT-1/MEC-17)-dependent Microtubule Hyperacetylation during Cell Stress*

  2014cited by this paper
• Anti-inflammatory activity of fisetin in human gingival fibroblasts treated with lipopolysaccharide

  2014cited by this paper
• Inhibition of Akt/mTOR signaling by the dietary flavonoid fisetin.

  2013cited by this paper
• Cordycepin: a bioactive metabolite with therapeutic potential.

  2013cited by this paper
• Concurrent regulation of the transcription factors Nrf2 and ATF4 mediates the enhancement of glutathione levels by the flavonoid fisetin.

  2013cited by this paper
• HSP90 Inhibitors, Geldanamycin and Radicicol, Enhance Fisetin-Induced Cytotoxicity via Induction of Apoptosis in Human Colonic Cancer Cells

  2013cited by this paper
• Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs.

  2013cited by this paper
• Fisetin Inhibits Matrix Metalloproteinases and Reduces Tumor Cell Invasiveness and Endothelial Cell Tube Formation

  2013cited by this paper
• Fisetin inhibits osteoclastogenesis through prevention of RANKL-induced ROS production by Nrf2-mediated up-regulation of phase II antioxidant enzymes.

  2013cited by this paper
• Inhibition of glioma growth by minocycline is mediated through endoplasmic reticulum stress-induced apoptosis and autophagic cell death.

  2013cited by this paper
• Fisetin Inhibits Migration and Invasion of Human Cervical Cancer Cells by Down-Regulating Urokinase Plasminogen Activator Expression through Suppressing the p38 MAPK-Dependent NF-κB Signaling Pathway

  2013cited by this paper
• Fisetin inhibits growth, induces G2/M arrest and apoptosis of human epidermoid carcinoma A431 cells: role of mitochondrial membrane potential disruption and consequent caspases activation

  2013cited by this paper
• Cocrystals of fisetin, luteolin and genistein with pyridinecarboxamide coformers: crystal structures, analysis of intermolecular interactions, spectral and thermal characterization

  2013cited by this paper
• Dual inhibition of phosphatidylinositol 3‐kinase/Akt and mammalian target of rapamycin signaling in human nonsmall cell lung cancer cells by a dietary flavonoid fisetin

  2012cited by this paper
• Dietary flavonoid fisetin: a novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management.

  2012cited by this paper
• Inflammation in Atherosclerosis

  2012cited by this paper
• Fisetin inhibits various attributes of angiogenesis in vitro and in vivo--implications for angioprevention.

  2012cited by this paper
• The dietary flavonol fisetin enhances the apoptosis-inducing potential of TRAIL in prostate cancer cells.

  2011cited by this paper
• Immunosuppressive effects of fisetin in ovalbumin-induced asthma through inhibition of NF-κB activity.

  2011cited by this paper
• Fisetin induces Nrf2‐mediated HO‐1 expression through PKC‐δ and p38 in human umbilical vein endothelial cells

  2011cited by this paper
• Anticancer Activity of a Combination of Cisplatin and Fisetin in Embryonal Carcinoma Cells and Xenograft Tumors

  2011cited by this paper
• Fisetin induces apoptosis in human cervical cancer HeLa cells through ERK1/2-mediated activation of caspase-8-/caspase-3-dependent pathway

  2011cited by this paper
• Tumor angiogenesis: molecular pathways and therapeutic targets

  2011cited by this paper
• Progress in the Chemistry of Organic Natural Products

  2011cited by this paper
• Inhibition of human melanoma cell growth by the dietary flavonoid fisetin is associated with disruption of Wnt/β-catenin signaling and decreased Mitf levels.

  2011cited by this paper
• Improved antiangiogenic and antitumour activity of the combination of the natural flavonoid fisetin and cyclophosphamide in Lewis lung carcinoma-bearing mice

  2011cited by this paper
• Fisetin, a dietary flavonoid, induces cell cycle arrest and apoptosis through activation of p53 and inhibition of NF-kappa B pathways in bladder cancer cells.

  2011cited by this paper
• Securin depletion sensitizes human colon cancer cells to fisetin-induced apoptosis.

  2011cited by this paper
• Enhancement of p53-mutant human colorectal cancer cells radiosensitivity by flavonoid fisetin.

  2010cited by this paper
• Blocking the Wnt pathway, a unifying mechanism for an angiogenic inhibitor in the serine proteinase inhibitor family

  2010cited by this paper
• Fisetin induces apoptosis in Huh-7 cells via downregulation of BIRC8 and Bcl2L2.

  2010cited by this paper
• Involvement of the ERK signaling pathway in fisetin reduces invasion and migration in the human lung cancer cell line A549.

  2009cited by this paper
• Metabolism and pharmacokinetics of 3,3',4',7-tetrahydroxyflavone (fisetin), 5-hydroxyflavone, and 7-hydroxyflavone and antihemolysis effects of fisetin and its serum metabolites.

  2009cited by this paper
• Antimetastatic potential of fisetin involves inactivation of the PI3K/Akt and JNK signaling pathways with downregulation of MMP-2/9 expressions in prostate cancer PC-3 cells

  2009cited by this paper
• Fisetin, a natural flavonoid, targets chemoresistant human pancreatic cancer AsPC‐1 cells through DR3‐mediated inhibition of NF‐κB

  2009cited by this paper
• Induction of p53 contributes to apoptosis of HCT-116 human colon cancer cells induced by the dietary compound fisetin.

  2009cited by this paper
• Lipid peroxidation and antioxidants in different stages of cervical cancer: Prognostic significance.

  2009cited by this paper
• Molecular principles of cancer invasion and metastasis (review).

  2009cited by this paper
• Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cells.

  2008cited by this paper
• Flavonoids inhibit histamine release and expression of proinflammatory cytokines in mast cells

  2008cited by this paper
• A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF-kappaB-signaling pathways.

  2008cited by this paper
• Vitamin antioxidants, lipid peroxidation, tumour stage, the systemic inflammatory response and survival in patients with colorectal cancer

  2008cited by this paper
• A novel dietary flavonoid fisetin inhibits androgen receptor signaling and tumor growth in athymic nude mice.

  2008cited by this paper
• Fisetin, an Inhibitor of Cyclin-Dependent Kinase 6, Down-Regulates Nuclear Factor-κB-Regulated Cell Proliferation, Antiapoptotic and Metastatic Gene Products through the Suppression of TAK-1 and Receptor-Interacting Protein-Regulated IκBα Kinase Activation

  2007cited by this paper
• Angiogenesis in Cancer

  2006cited by this paper
• Distinctive antioxidant and antiinflammatory effects of flavonols.

  2006cited by this paper
• Inflammation and insulin resistance.

  2006cited by this paper

• Fisetin: a multitarget flavonol bridging oxidative stress, inflammation, aging, and cancer.

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• Oncopreventive and Oncotherapeutic Potential of Plant Secondary Metabolites Against Gastric Cancer: A Review

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• Fisetin Inhibits Periodontal Pathogen-Induced EMT in Oral Squamous Cell Carcinoma via the Wnt/β-Catenin Pathway

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• Effects of polyphenols on cancer cell progression mediated by inhibition of cyclin-dependent kinases (CDKs): the emerging drug targets in cancer

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• The Role of Senolytics in Osteoporosis

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• Isorhamnetin: Reviewing Recent Developments in Anticancer Mechanisms and Nanoformulation-Driven Delivery

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• Fisetin ameliorates atherosclerosis through activating FXR-mediated hepatic cholesterol metabolism and transintestinal cholesterol excretion.

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• Recent Advances in Aging and Immunosenescence: Mechanisms and Therapeutic Strategies

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• Exploring the therapeutic promise of fisetin: molecular mechanisms and clinical aspects in lung cancer

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• Fisetin as a chemoprotective and chemotherapeutic agent: mechanistic insights and future directions in cancer therapy

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• The structural changes of Fisetin-Myofibrillar protein complexes induced by different non-covalent binding methods influence the adsorption of mucin glycoprotein: Spectroscopy, molecular docking and QCM-D

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• Fisetin disrupts mitochondrial homeostasis via superoxide dismutase 2 acetylation in pancreatic adenocarcinoma

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• An Insight into Fisetin, The Miraculous Multifaceted Flavonol: Paving the Road for Enhanced Delivery Through Promising Pharmaceutical Nano-Formulations.

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• Fisetin Promotes Functional Recovery after Spinal Cord Injury by Inhibiting Microglia/Macrophage M1 Polarization and JAK2/STAT3 Signaling Pathway.

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• Fisetin-loaded pluronic-based nanogel: Radiation synthesis for alleviating neurocognitive impairments in a rat model of alzheimer's disease via modulation of the apoptotic cascade.

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• Fisetin from Dietary Supplement to a Drug Candidate: An Assessment of Potential - A Review.

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• Use of kersetin and fisetin flavonoids in combination with pregabalin and gabapentin in the treatment of neuropathic pain.

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• Fisetin derivatives exhibit enhanced anti-inflammatory activity and modulation of endoplasmic reticulum stress.

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• Fisetin Attenuates Paracetamol-Induced Hepatotoxicity by Regulating CYP2E1 Enzyme.

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• Insight into the Biological Roles and Mechanisms of Phytochemicals in Different Types of Cancer: Targeting Cancer Therapeutics

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• Fisetin, a Natural Polyphenol, Ameliorates Endometriosis Modulating Mast Cells Derived NLRP-3 Inflammasome Pathway and Oxidative Stress

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