The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Genes & Development

• Publication date

  2002-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1101/GAD.1017802PMID 12414734PMCID PMC187468
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer

  2002cited by this paper
• Conditional inactivation of Sox9: A mouse model for campomelic dysplasia

  2002cited by this paper
• Patterning mechanisms controlling vertebrate limb development.

  2001cited by this paper
• Interaction of growth factors regulating chondrocyte differentiation in the developing embryo.

  2001cited by this paper
• The transcription factors L-Sox5 and Sox6 are essential for cartilage formation.

  2001cited by this paper
• The Transcription Factor SOX9 Regulates Cell Cycle and Differentiation Genes in Chondrocytic CFK2 Cells*

  2001cited by this paper
• Wnt-14 plays a pivotal role in inducing synovial joint formation in the developing appendicular skeleton.

  2001cited by this paper
• Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization

  2001influential reference
• Reciprocal control of osteoblast/chondroblast and osteoblast/adipocyte differentiation of multipotential clonal human marrow stromal F/STRO‐1+ cells

  2001cited by this paper
• SOX9 Enhances Aggrecan Gene Promoter/Enhancer Activity and Is Up-regulated by Retinoic Acid in a Cartilage-derived Cell Line, TC6*

  2000cited by this paper
• Dual roles of Wnt signaling during chondrogenesis in the chicken limb.

  2000cited by this paper
• Col2a1‐directed expression of Cre recombinase in differentiating chondrocytes in transgenic mice

  2000cited by this paper
• Identification of a prx1 limb enhancer

  2000cited by this paper
• All for one and one for all: condensations and the initiation of skeletal development.

  2000cited by this paper
• Sox9 is required for cartilage formation

  1999cited by this paper
• Bone Morphogenetic Proteins Regulate Interdigital Cell Death in the Avian Embryo

  1999cited by this paper
• Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation.

  1999influential reference
• The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb.

  1999cited by this paper
• Trans‐activation of the Mouse Cartilage‐Derived Retinoic Acid‐Sensitive Protein Gene by Sox9

  1999cited by this paper
• Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton.

  1998cited by this paper
• Chondrocyte-specific Enhancer Elements in the Col11a2Gene Resemble the Col2a1 Tissue-specific Enhancer*

  1998cited by this paper
• A new long form of Sox5 (L‐Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene

  1998cited by this paper
• SOX9 directly regulates the type-ll collagen gene

  1997cited by this paper
• Parallel expression of Sox9 and Col2a1 in cells undergoing chondrogenesis

  1997cited by this paper
• SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse.

  1997cited by this paper
• Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development.

  1997cited by this paper
• SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene

  1997cited by this paper
• Limbs: a model for pattern formation within the vertebrate body plan.

  1996cited by this paper
• Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family.

  1996cited by this paper
• 1 alpha,25-dihydroxyvitamin D3 inhibits cell growth and chondrogenesis of a clonal mouse EC cell line, ATDC5.

  1996cited by this paper
• Role of TGF beta s and BMPs as signals controlling the position of the digits and the areas of interdigital cell death in the developing chick limb autopod.

  1996cited by this paper
• Requirement for BMP Signaling in Interdigital Apoptosis and Scale Formation

  1996cited by this paper
• Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein

  1996cited by this paper
• PTH/PTHrP Receptor in Early Development and Indian Hedgehog--Regulated Bone Growth

  1996cited by this paper
• 1α,25‐dihydroxyvitamin D3 inhibits cell growth and chondrogenesis of a clonal mouse EC cell line, ATDC5

  1996cited by this paper
• A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells.

  1995cited by this paper
• twist is required in head mesenchyme for cranial neural tube morphogenesis.

  1995cited by this paper
• Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting.

  1994cited by this paper
• Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene.

  1994cited by this paper
• Expression and functional involvement of N-cadherin in embryonic limb chondrogenesis.

  1994cited by this paper
• Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9.

  1994cited by this paper
• Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene

  1994cited by this paper
• Adhesion molecules in skeletogenesis: II. Neural cell adhesion molecules mediate precartilaginous mesenchymal condensations and enhance chondrogenesis

  1993cited by this paper
• Developmental expression of bone sialoprotein mRNA in rat mineralized connective tissues

  1992cited by this paper
• Exogenous retinoic acid rapidly induces anterior ectopic expression of murine Hox-2 genes in vivo.

  1992cited by this paper
• Differentiation of muscle, fat, cartilage, and bone from progenitor cells present in a bone-derived clonal cell population: effect of dexamethasone

  1988cited by this paper

• Hydrogel microwell with pneumatic soft actuator for compression formation of three-dimensional cellular tissue.

  2026cites this paper
• miR-145-5p combined with miR-140-5p regulates the differentiation of bone marrow mesenchymal stem cells into nucleus pulposus cells and its mechanism in the treatment of intervertebral disc degeneration.

  2026cites this paper
• The Runx2 switch: unlocking osteoblast-related disorders through signaling pathways and non-coding RNAs.

  2026cites this paper
• Spatiotemporal Regulation and Lineage Specification in Embryonic Endochondral Ossification

  2026cites this paper
• Identification of Genes and microRNAs Associated with Midfacial Hypoplasia in Mice

  2026cites this paper
• The intersection of disorders of sex development and cardiovascular diseases.

  2026cites this paper
• SRY-box transcription factor 9 and insulin-like growth factor 1 as potential regulators in the pathogenesis of unilateral condylar hyperplasia: a pilot study.

  2026cites this paper
• Precisely regulated physically-crosslinked carriers enable synergetic release of bioactive factors for MSC-mediated cartilage regeneration

  2026cites this paper
• Protocol to investigate the effects of localized gene expression disruption on mouse limb development via direct siRNA injection and explant culture.

  2026cites this paper
• Combining engineered post-implantation embryoid and xenotransplantation for improved modeling of early human organogenesis

  2026cites this paper
• TGF-β/BMP signaling in skeletal biology: molecular mechanisms, regulatory networks, and therapeutic implications in development, regeneration, and disease

  2026cites this paper
• Knockdown of ARID1A Protects H9c2 Cells Against Hypoxia/Reoxygenation (H/R)-Induced Injury by Targeting SOX9

  2026cites this paper
• The Self-Assembling Peptide P11-4 Induces the Expression of Mineralization-Related Genes in Odontoblasts Independently of Metabolic Alterations

  2026cites this paper
• Differences of benzo[a]anthracene- and pyrene-induced disruption of craniofacial chondrogenesis in Japanese medaka.

  2025cites this paper
• Therapeutic potential of SOX family transcription factors in osteoarthritis

  2025cites this paper
• Rapid and quantitative functional interrogation of human enhancer variant activity in live mice

  2025cites this paper
• CXXC Finger Protein 1 drives BMP signaling and progenitor cell differentiation during limb development.

  2025cites this paper
• Sox9 prevents retinal degeneration and is required for limbal stem cell differentiation in the adult mouse eye

  2025cites this paper
• Innovative injectable, self-healing, exosome cross-linked biomimetic hydrogel for cartilage regeneration.

  2025cites this paper
• The Expression Level of SOX Family Transcription Factors’ mRNA as a Diagnostic Marker for Osteoarthritis

  2025influential citation
• Pattern of SOX9 expression in pleomorphic adenoma, carcinoma ex pleomorphic adenoma, and matrix-producing metaplastic carcinoma of the breast lends support to common biology

  2025cites this paper
• Mechanism of Intervertebral Disc Degeneration via the β‐Catenin/CCL2 Pathway in Sox9 Conditional Knockout Mice

  2025cites this paper
• HIF-1α regulates the proliferation and differentiation of mouse cranial base sphenoid-occipital synchondrosis chondrocytes via PI3K/Akt signaling

  2025cites this paper
• Skeletal progenitor LRP1 deficiency causes severe and persistent skeletal defects with Wnt pathway dysregulation

  2025cites this paper
• Elevated MMP9 Expression—A Potential In Vitro Biomarker for COMPopathies

  2025cites this paper
• In silico functional, structural, and pathogenicity assessment of single nucleotide polymorphisms in the human SOX9 gene

  2025cites this paper
• AAV-mediated silencing of Sox4 leads to long-term amelioration of liver phenotypes in mouse models of Alagille syndrome.

  2025cites this paper
• The Role of SUMO1 Modification of SOX9 in Cartilage Development Stimulated by Zinc Ions in Mice

  2025cites this paper
• Monitoring the kinetic evolution of mesenchymal stem cell differentiation using Raman microspectroscopy.

  2025cites this paper
• A RUNX2 GFP reporter is expressed prior to osteochondral differentiation and models Metaphyseal Dysplasia with Maxillary Hypoplasia and Brachydactyly (MDMHB)

  2025cites this paper
• Pig meniscus single-cell sequencing reveals highly active red zone chondrocyte populations involved in stemness maintenance and vascularization development

  2025cites this paper
• Novel Insights Into Egyptian Tortoise (Testudo kleinmanni) Tongue Morphology Using Immunofluorescence Analysis.

  2025cites this paper
• Molecular basis of individual locomotor function: Integrated understanding of gene expression regulation in the development and homeostasis of the musculoskeletal system

  2025cites this paper
• A single-cell atlas of the murine limb skeleton integrating the developmental and adult stages

  2025cites this paper
• Sox9 inhibits Activin A to promote biliary maturation and branching morphogenesis

  2025cites this paper
• SOX9 haploinsufficiency reveals SOX9-Noggin interaction in BMP-SMAD signaling pathway in chondrogenesis

  2025cites this paper
• Recapitulation of endochondral ossification by hPSC-derived SOX9+ sclerotomal progenitors

  2025cites this paper
• Integration of Mechanics and Immunology: Perspective for Understanding Fibrotic Disease Mechanisms and Innovating Therapeutic Strategies.

  2025cites this paper
• SOX9 Is a Key Factor for the Postnatal Maturation of the Intrahepatic Bile Duct Network

  2025cites this paper
• Perichondral telocytes and their role in cartilage development and regeneration: Insights from histochemistry, immunohistochemistry, and TEM.

  2025cites this paper
• A Vascularized Microphysiological System Reproducing Endochondral Ossification in Vitro to Study Ewing Sarcoma Proliferation and Migration

  2025cites this paper
• How vascularization is reciprocally coupled to chondrogenesis and osteogenesis in bone healing: lessons from the growth plate.

  2025cites this paper
• Porcupine inhibition enhances hypertrophic cartilage differentiation

  2025cites this paper
• Dynamic interactions between cartilaginous and tendinous/ligamentous primordia during musculoskeletal integration.

  2025cites this paper
• Identifying pathological myopia associated genes with GenePlexus in protein-protein interaction network

  2025cites this paper
• Sox9 and Nfi transcription factors regulate the timing of neurogenesis and ependymal maturation in dopamine progenitors.

  2025cites this paper
• Nutritional strategies for managing joint health in companion animals

  2025cites this paper
• Chondrocyte maturation bridges two cross-inhibitory subnetworks of the skeletal cell gene regulatory network.

  2025cites this paper
• A RUNX2 GFP reporter is expressed prior to osteochondral differentiation and models Metaphyseal Dysplasia with Maxillary Hypoplasia and Brachydactyly (MDMHB).

  2025cites this paper
• Differentiation of Human Induced Pluripotent Stem Cells Toward Implantable Chondroprogenitor Cells.

  2025cites this paper
• Neanderthal-derived variants increase SOX9 enhancer activity in craniofacial progenitors that shape jaw development

  2025cites this paper
• Mechanical reinforcement and growth factor delivery strategies for in situ cartilage repair

  2025cites this paper
• Specialized signaling centers direct cell fate and spatial organization in a mesodermal organoid model

  2025cites this paper
• TGF-β signaling in heterotopic ossification: the pathogenesis and the target for its treatment

  2025cites this paper
• Articular Cartilage: Structure, Biomechanics, and the Potential of Conventional and Advanced Diagnostics

  2025cites this paper
• Variants in the SOX9 transactivation middle domain induce axial skeleton dysplasia and scoliosis

  2025cites this paper
• Spatio-temporal reconstruction of gene expression patterns in developing mice

  2024cites this paper
• The role of NF-κB-SOX9 signalling pathway in osteoarthritis

  2024cites this paper
• Characterization of CDS Region of Exons 1 and 2 of SOX9 Gene as Potential Gene in Construction of Syrinx Structure in Junglefowl (Gallus sp.)

  2024cites this paper
• Regulation mechanism of endochondral ossification in Rana zhenhaiensis during metamorphosis based on histomorphology and transcriptome analyses.

  2024cites this paper
• Growth deficiency in a mouse model of Kabuki syndrome 2 bears mechanistic similarities to Kabuki syndrome 1

  2024cites this paper
• Evaluation of Potential Roles of Zinc Finger Homeobox 3 (Zfhx3) Expressed in Chondrocytes and Osteoblasts on Skeletal Growth in Mice

  2024cites this paper
• Chromatin profiling identifies chondrocyte-specific Sox9 enhancers important for skeletal development

  2024cites this paper
• Bioceramic-mediated chondrocyte hypertrophy promotes calcified cartilage formation for rabbit osteochondral defect repair

  2024cites this paper
• MiR-6839-5p inhibits cell proliferation, migration and invasion; a possible correlation with the suppressing VEGFA expression in human chondrosarcoma cells

  2024cites this paper
• Dissecting SOX2 expression and function reveals an association with multiple signaling pathways during embryonic development and in cancer progression.

  2024cites this paper
• Biological functions and therapeutic potential of SRY related high mobility group box 5 in human cancer

  2024cites this paper
• Gene Expression Patterns and Phenotypic Associations in Chondrogenesis: Insights into Skeletal Dysplasia Nosology

  2024cites this paper
• Ionic release from bioactive SiO2-CaOCME/poly(tetrahydrofuran)/poly(caprolactone) hybrids drives human-bone marrow stromal cell osteogenic differentiation.

  2024cites this paper
• Sox9 downregulation in non-obstructive azoospermia by UTF1 and mediator role of POU5F1

  2024cites this paper
• Abaloparatide promotes bone repair of vertebral defects in ovariectomized rats by increasing bone formation.

  2024cites this paper
• Expression of Chondrogenic Potential Markers in Cultured Chondrocytes from the Human Knee Joint

  2024cites this paper
• The tongue of the red-eared slider (Trachemys scripta elegans): morphological characterization through gross, light, scanning electron, and immunofluorescence microscopic examination

  2024influential citation
• Molecular functional characterization of the setdb1 and its potential target gene sox5 illuminate the histone modification-mediated orchestration of gonadal development in Chinese tongue sole (Cynoglossus semilaevis).

  2024cites this paper
• CHD7 regulates craniofacial cartilage development via controlling HTR2B expression

  2024cites this paper
• Influence of DNA-methylation at multiple stages of limb chondrogenesis.

  2024cites this paper
• Association of SOX6 gene polymorphisms with Kashin-Beck disease risk in the Chinese Han population

  2024cites this paper
• Stem-Cell-Driven Chondrogenesis: Perspectives on Amnion-Derived Cells

  2024cites this paper
• Involvement of Yes-Associated Protein 1 Activation in the Matrix Degradation of Human-Induced-Pluripotent-Stem-Cell-Derived Chondrocytes Induced by T-2 Toxin and Deoxynivalenol Alone and in Combination

  2024cites this paper
• Skeletal progenitor LRP1 deficiency causes severe and persistent skeletal defects with WNT/planar cell polarity dysregulation

  2024cites this paper
• An integrated single-cell atlas of the limb skeleton from development through adulthood

  2024cites this paper
• Using Load to Improve Tendon/Ligament Tissue Engineering and Develop Novel Treatments for Tendinopathy.

  2024cites this paper
• NSAID-mediated cyclooxygenase inhibition disrupts ectodermal derivative formation in axolotl embryos

  2024cites this paper
• Generation of self-organized neuromusculoskeletal tri-tissue organoids from human pluripotent stem cells.

  2024cites this paper
• Metabolic reprogramming in skeletal cell differentiation

  2024cites this paper
• Neanderthal-derived variants shape craniofacial enhancer activity at a human disease locus

  2024cites this paper
• Sox9 links biliary maturation to branching morphogenesis

  2024cites this paper
• Sox9 regulates alternative splicing and pancreatic beta cell function

  2024cites this paper
• Rheb1 is required for limb growth through regulating chondrogenesis in growth plate

  2024cites this paper
• Ovine Mesenchymal Stem Cell Chondrogenesis on a Novel 3D-Printed Hybrid Scaffold In Vitro

  2024cites this paper
• BMP signaling maintains auricular chondrocyte identity and prevents microtia development by inhibiting protein kinase A

  2024cites this paper
• Skeletal growth is enhanced by a shared role for SOX8 and SOX9 in promoting reserve chondrocyte commitment to columnar proliferation

  2024cites this paper
• Neonatal persistent pulmonary hypertension related to a novel TBX4 mutation: case report and review of the literature

  2024cites this paper
• Isolation and Culturing of Primary Murine Chondroprogenitor Cells: A Mammalian Model of Chondrogenesis

  2024cites this paper
• Chimerization of human ESC-derived extraembryonic cells with the mouse blastocyst

  2024cites this paper
• Convergent evolution of noncoding elements associated with short tarsus length in birds

  2024cites this paper
• Distinct roles of SOX9 in self-renewal of progenitors and mesenchymal transition of the endothelium

  2024cites this paper
• PI15, a novel secreted WNT-signaling antagonist, regulates chondrocyte differentiation

  2024cites this paper
• A comparative analysis of stem cell differentiation on 2D and 3D substrates using Raman microspectroscopy.

  2024cites this paper
• Cathepsin D elevates the fibrocalcific activity in human aortic valve cells through the ERK1/2-Sox9 pathway

  2024cites this paper