Differential regulation of centrosome integrity by DNA damage response proteins

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Cell Cycle

• Publication date

  2008-07-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4161/cc.7.14.6303PMID 18635967PMCID PMC2557875
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• MCPH1 Functions in an H2AX-dependent but MDC1-independent Pathway in Response to DNA Damage*

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• Structure meets function--centrosomes, genome maintenance and the DNA damage response.

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• The BRCA1 E3 Ubiquitin Ligase Controls Centrosome Dynamics

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• The centrosome cycle.

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• Microcephalin Encodes a Centrosomal Protein

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• Induction of centrosome amplification in p53 siRNA‐treated human fibroblast cells by radiation exposure

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• BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer.

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• A centrosomal mechanism involving CDK5RAP2 and CENPJ controls brain size

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• BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly.

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• Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

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• MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

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• MDC1 is required for the intra-S-phase DNA damage checkpoint

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• NFBD1/KIAA0170 Is a Chromatin-associated Protein Involved in DNA Damage Signaling Pathways*

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• 53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage.

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• Centrosome abnormalities and chromosome instability occur together in pre-invasive carcinomas.

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• Polo-like Kinase 1 and Chk2 Interact and Co-localize to Centrosomes and the Midbody*

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• Amplified Centrosomes in Breast Cancer: A Potential Indicator of Tumor Aggressiveness

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• "It takes two to tango": understanding how centrosome duplication is regulated throughout the cell cycle.

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