AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Cancer Cell

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S1535-6108(02)00235-0PMID 12559175
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Minor Alteration of Microtubule Dynamics Causes Loss of Tension across Kinetochore Pairs and Activates the Spindle Checkpoint*

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• The kinase activity of aurora B is required for kinetochore-microtubule interactions during mitosis.

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• Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules

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• The mitotic spindle is required for loading of the DASH complex onto the kinetochore.

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• Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections.

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• Inhibition of aurora B kinase blocks chromosome segregation, overrides the spindle checkpoint, and perturbs microtubule dynamics in mitosis.

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• Aurora‐A overexpression reveals tetraploidization as a major route to centrosome amplification in p53−/− cells

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• Essential Roles of Drosophila Inner Centromere Protein (Incenp) and Aurora B in Histone H3 Phosphorylation, Metaphase Chromosome Alignment, Kinetochore Disjunction, and Chromosome Segregation

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• Drosophila Aurora B Kinase Is Required for Histone H3 Phosphorylation and Condensin Recruitment during Chromosome Condensation and to Organize the Central Spindle during Cytokinesis

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• Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans

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• Molecular analysis of the mitotic checkpoint genes BUB1, BUBR1 and BUB3 in human lung cancers.

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• The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint.

  2001cited by this paper
• pEg2 Aurora-A Kinase, Histone H3 Phosphorylation, and Chromosome Assembly in Xenopus Egg Extract*

  2001cited by this paper
• Molecular analysis of kinetochore-microtubule attachment in budding yeast.

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• Tumour-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation

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• Microtubule-dependent changes in assembly of microtubule motor proteins and mitotic spindle checkpoint proteins at PtK1 kinetochores.

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• Association of centrosomal kinase STK15/BTAK mRNA expression with chromosomal instability in human breast cancers

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• Cell division: Mitotic kinases as regulators of cell division and its checkpoints

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• Frequent amplification of chromosomal region 20q12-q13 in ovarian cancer.

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• Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes.

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• INCENP binds the Aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow.

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• Centrosomal Kinases, HsAIRK1 and HsAIRK3, are Overexpressed in Primary Colorectal Cancers

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• Mutation and expression analysis of human BUB1 and BUB1B in aneuploid breast cancer cell lines.

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• Incenp and an aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis.

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• Paclitaxel‐induced cell death

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• Mutation analysis of hBUB1 in aneuploid HNSCC and lung cancer cell lines.

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• Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases.

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• Sli15 Associates with the Ipl1 Protein Kinase to Promote Proper Chromosome Segregation in Saccharomyces cerevisiae

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• Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2.

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• Characterization of MAD2B and other mitotic spindle checkpoint genes.

  1999cited by this paper
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• The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis.

  1999cited by this paper
• Mutations of mitotic checkpoint genes in human cancers

  1998cited by this paper
• Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

  1998cited by this paper
• AIM‐1: a mammalian midbody‐associated protein required for cytokinesis

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• A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

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• AIR-2: An Aurora/Ipl1-related Protein Kinase Associated with Chromosomes and Midbody Microtubules Is Required for Polar Body Extrusion and Cytokinesis in Caenorhabditis elegans Embryos

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• Involvement of Brca2 in DNA repair.

  1998cited by this paper
• A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines

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• Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage.

  1997cited by this paper
• A Novel Mammalian, Mitotic Spindle–associated Kinase Is Related to Yeast and Fly Chromosome Segregation Regulators

  1997cited by this paper
• Cell Cycle-dependent Expression and Spindle Pole Localization of a Novel Human Protein Kinase, Aik, Related to Aurora of Drosophila and Yeast Ipl1*

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• Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.

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  1994cited by this paper
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  1993cited by this paper
• A cell line that can induce thymocyte positive selection

  1992cited by this paper
• The clinical pharmacology and use of antimicrotubule agents in cancer chemotherapeutics.

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• Contribution of AurkA/TPX2 Overexpression to Chromosomal Imbalances and Cancer

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• Synergy of EGFR and AURKA Inhibitors in KRAS-mutated Non–small Cell Lung Cancers

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• Predictive and prognostic value of aurora kinase A combined with tumor-infiltrating lymphocytes in medullary thyroid carcinoma

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• Elevated expression of Aurora-A/AURKA in breast cancer associates with younger age and aggressive features

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• Selective Aurora A-TPX2 Interaction Inhibitors Have In Vivo Efficacy as Targeted Antimitotic Agents

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