Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Journal of Cell Science

• Publication date

  1999-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 10523496
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mutational analysis of the fission yeast p34cdc2 protein kinase gene

  2004cited by this paper
• Regulatory Domain of Calcium / Calmodulin-dependent Protein Kinase I 1

  2001cited by this paper
• Cell cycle control and cancer.

  2000cited by this paper
• Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast.

  1999cited by this paper
• Defects in Saccharomyces cerevisiae protein phosphatase type I activate the spindle/kinetochore checkpoint.

  1999influential reference
• The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast.

  1999influential reference
• Centrosome amplification as a possible mechanism for numerical chromosome aberrations in cerebral primitive neuroectodermal tumors with TP53 mutations

  1999cited by this paper
• In Silico Cloning of a New Protein Kinase, Aik2, Related to Drosophila Aurora Using the New Tool: EST Blast

  1999cited by this paper
• Cell Cycle-dependent Expression and Centrosome Localization of a Third Human Aurora/Ipl1-related Protein Kinase, AIK3*

  1999influential reference
• The Xenopus laevis Aurora-related Protein Kinase pEg2 Associates with and Phosphorylates the Kinesin-related Protein XlEg5*

  1999influential reference
• Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells.

  1999cited by this paper
• Cdc20 associates with the kinase aurora2/Aik.

  1999cited by this paper
• The Xenopus laevis centrosome aurora/Ipl1-related kinase.

  1999influential reference
• Cloning, Mapping, and Expression of ial, a Novel Drosophila Member of the Ipl1/aurora Mitotic Control Kinase Family

  1999cited by this paper
• Regulation of Saccharomyces cerevisiae kinetochores by the type 1 phosphatase Glc7p.

  1999influential reference
• High incidence of loss of heterozygosity at chromosome 17p13 in breast tumours from BRCA2 mutation carriers

  1998cited by this paper
• The Drosophila POLO kinase localises to multiple compartments of the mitotic apparatus and is required for the phosphorylation of MPM2 reactive epitopes.

  1998cited by this paper
• cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2.

  1998influential reference
• Identification and characterization of STK12/Aik2: a human gene related to aurora of Drosophila and yeast IPL1

  1998cited by this paper
• Protein Kinase Profile of Sperm and Eggs: Cloning and Characterization of Two Novel Testis-Specific Protein Kinases (AIE1, AIE2) Related to Yeast and Fly Chromosome Segregation Regulators

  1998influential reference
• Cloning of STK13, a third human protein kinase related to Drosophila aurora and budding yeast Ipl1 that maps on chromosome 19q13.3-ter.

  1998influential reference
• Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

  1998influential reference
• AIR-2: An Aurora/Ipl1-related Protein Kinase Associated with Chromosomes and Midbody Microtubules Is Required for Polar Body Extrusion and Cytokinesis in Caenorhabditis elegans Embryos

  1998influential reference
• The Xenopus protein kinase pEg2 associates with the centrosome in a cell cycle-dependent manner, binds to the spindle microtubules and is involved in bipolar mitotic spindle assembly.

  1998influential reference
• Polo-like kinases: a team that plays throughout mitosis.

  1998cited by this paper
• BRCA1 is associated with the centrosome during mitosis.

  1998cited by this paper
• Cytogenetic and fluorescence in situ hybridization analyses of chromosome 19 aberrations in pancreatic carcinomas: Frequent loss of 19p13.3 and gain of 19q13.1‐13.2

  1998cited by this paper
• A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

  1998influential reference
• A highly conserved centrosomal kinase, AIR-1, is required for accurate cell cycle progression and segregation of developmental factors in Caenorhabditis elegans embryos.

  1998cited by this paper
• Xe-p9, a Xenopus Suc1/Cks protein, is essential for the Cdc2-dependent phosphorylation of the anaphase- promoting complex at mitosis.

  1998cited by this paper
• Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells.

  1998cited by this paper
• Localization of the Kinesin-like Protein Xklp2 to Spindle Poles Requires a Leucine Zipper, a Microtubule-associated Protein, and Dynein

  1998cited by this paper
• Anaphase A Chromosome Movement and Poleward Spindle Microtubule Flux Occur At Similar Rates in Xenopus Extract Spindles

  1998cited by this paper
• A model for the proposed roles of different microtubule-based motor proteins in establishing spindle bipolarity.

  1998cited by this paper
• Rigor-type mutation in the kinesin-related protein HsEg5 changes its subcellular localization and induces microtubule bundling.

  1998cited by this paper
• The kinase Eg2 is a component of the Xenopus oocyte progesterone‐activated signaling pathway

  1998influential reference
• Human AIM-1: cDNA cloning and reduced expression during endomitosis in megakaryocyte-lineage cells.

  1998cited by this paper
• AIM‐1: a mammalian midbody‐associated protein required for cytokinesis

  1998influential reference
• XCTK2: A Kinesin-related Protein That Promotes Mitotic Spindle Assembly in Xenopus laevis Egg Extracts

  1997cited by this paper
• Motoring to the Finish: Kinesin and Dynein Work Together to Orient the Yeast Mitotic Spindle

  1997cited by this paper
• Genomic instability and apoptosis are frequent in p53 deficient young mice

  1997cited by this paper
• Cell Cycle-dependent Expression and Spindle Pole Localization of a Novel Human Protein Kinase, Aik, Related to Aurora of Drosophila and Yeast Ipl1*

  1997influential reference
• The protein kinases of budding yeast: six score and more.

  1997cited by this paper
• A Novel Mammalian, Mitotic Spindle–associated Kinase Is Related to Yeast and Fly Chromosome Segregation Regulators

  1997influential reference
• Cell-cycle control: POLO-like kinases join the outer circle.

  1997cited by this paper
• Phosphorylation by p34cdc2 Protein Kinase Regulates Binding of the Kinesin-related Motor HsEg5 to the Dynactin Subunit p150Glued *

  1997cited by this paper
• The bimC family of kinesins: essential bipolar mitotic motors driving centrosome separation.

  1997cited by this paper
• Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.

  1997cited by this paper
• A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines

  1997influential reference
• Mitosis in vertebrate somatic cells with two spindles: implications for the metaphase/anaphase transition checkpoint and cleavage.

  1997cited by this paper
• Loss of heterozygosity in human ovarian cancer on chromosome 19q.

  1997cited by this paper
• ayk1, a novel mammalian gene related to Drosophila aurora centrosome separation kinase, is specifically expressed during meiosis

  1997influential reference
• When Checkpoints Fail Review

  1997cited by this paper
• Assignment of STK6 to human chromosome 20q13.2-->q13.3 and a pseudogene STK6P to 1q41-->q42.

  1997influential reference
• Saccharomyces cerevisiae genes required in the absence of the CIN8-encoded spindle motor act in functionally diverse mitotic pathways.

  1997cited by this paper
• The checkpoint control for anaphase onset does not monitor excess numbers of spindle poles or bipolar spindle symmetry.

  1997cited by this paper
• Genome stability: Keeping the centrosome cycle on track

  1996cited by this paper
• Purification and Molecular Cloning of Plx1, a Cdc25-Regulatory Kinase from Xenopus Egg Extracts

  1996cited by this paper
• Opposing motor activities are required for the organization of the mammalian mitotic spindle pole

  1996cited by this paper
• Keeping the centrosome cycle on track. Genome stability.

  1996cited by this paper
• Microtubule dynamics at the G2/M transition: abrupt breakdown of cytoplasmic microtubules at nuclear envelope breakdown and implications for spindle morphogenesis

  1996cited by this paper
• Life with 6000 Genes

  1996cited by this paper
• Xklp2, a novel Xenopus centrosomal kinesin-like protein required for centrosome separation during mitosis.

  1996cited by this paper
• Chemical induction of mitotic checkpoint override in mammalian cells results in aneuploidy following a transient tetraploid state.

  1996cited by this paper
• Abnormal Centrosome Amplification in the Absence of p53

  1996cited by this paper
• A Role for Endothelial NO Synthase in LTP Revealed by Adenovirus-Mediated Inhibition and Rescue

  1996cited by this paper
• Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage.

  1996cited by this paper
• Genotoxicity of dental materials.

  1996cited by this paper
• Cell-cycle-dependent expression of the STK-1 gene encoding a novel murine putative protein kinase.

  1996influential reference
• Dynamic changes in nuclear architecture during mitosis: on the role of protein phosphorylation in spindle assembly and chromosome segregation.

  1996cited by this paper
• Genetic aberrations detected by comparative genomic hybridization predict outcome in node-negative breast cancer.

  1995cited by this paper
• Comparative genomic in situ hybridization of colon carcinomas with replication error.

  1995cited by this paper
• Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles.

  1995influential reference
• The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores

  1995cited by this paper
• Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo.

  1995influential reference
• The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells.

  1995cited by this paper
• Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function

  1995cited by this paper
• Activity of the MAP kinase ERK2 is controlled by a flexible surface loop.

  1995cited by this paper
• Type 1 protein phosphatase acts in opposition to IpL1 protein kinase in regulating yeast chromosome segregation

  1994influential reference
• Cell cycle control and cancer.

  1994cited by this paper
• Mitotic regulation of microtubule cross-linking activity of CENP-E kinetochore protein.

  1994cited by this paper
• Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization.

  1994cited by this paper
• Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle

  1994cited by this paper
• Isolation and characterization of chromosome-gain and increase-in-ploidy mutants in yeast.

  1993cited by this paper
• The kinesin-like protein KLP61F is essential for mitosis in Drosophila

  1993cited by this paper
• The cdc2‐related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2.

  1993influential reference
• The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin‐dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues.

  1993influential reference
• At least two kinases phosphorylate the MPM-2 epitope during Xenopus oocyte maturation

  1993cited by this paper
• Phosphorylation and activation of human cdc25‐C by cdc2‐‐cyclin B and its involvement in the self‐amplification of MPF at mitosis.

  1993cited by this paper
• Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells.

  1992cited by this paper
• Protein phosphatase type 1 in mammalian cell mitosis: chromosomal localization and involvement in mitotic exit

  1992cited by this paper
• Mitotic spindle organization by a plus-end-directed microtubule motor

  1992cited by this paper
• Cyclin is degraded by the ubiquitin pathway

  1991cited by this paper
• Microtubule destabilization by cdc2/H1 histone kinase: phosphorylation of a "pro-rich region" in the microtubule-binding domain of MAP-4.

  1991cited by this paper
• Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members.

  1991influential reference
• In vitro disassembly of the nuclear lamina and M phase-specific phosphorylation of lamins by cdc2 kinase.

  1990cited by this paper
• Inhibition of mutant troponin C activity by an intra-domain disulphide bond

  1990cited by this paper
• Poly(A) metabolism and polysomal recruitment of maternal mRNAs during early Xenopus development.

  1990cited by this paper
• Regulation of microtubule dynamics by cdc2 protein kinase in cell-free extracts of Xenopus eggs

  1990cited by this paper
• Nucleation of microtubules from mitotic centrosomes is modulated by a phosphorylated epitope.

  1990cited by this paper

• Transcriptomic landscape of Gallbladder cancer reveals altered pathways related to cell cycle and Aurora kinase

  2025cites this paper
• Association of AURKA Polymorphisms with the Development and Progression of Hepatocellular Carcinoma in Egyptian Patients

  2025cites this paper
• Identifying the Function of Kinesin Superfamily Proteins in Gastric Cancer: Implications for Signal Transduction, Clinical Significance, and Potential Therapeutic Approaches.

  2025cites this paper
• Advances in the design, discovery, and optimization of aurora kinase inhibitors as anticancer agents

  2025cites this paper
• Caspase-mediated AURKA cleavage at Asp132 is essential for paclitaxel to elicit cell apoptosis

  2024cites this paper
• A comprehensive review on role of Aurora kinase inhibitors (AKIs) in cancer therapeutics.

  2024cites this paper
• Chromosomal Instability in Gastric Cancer: Role in Tumor Development, Progression, and Therapy

  2023cites this paper
• Design, Synthesis, and In Silico Insights into Dual-Inhibition of CDK-6/Aurora A Kinase by 2-Phenylbenzimidazole-Based Small Molecules

  2023cites this paper
• Binding selectivity analysis of AURKs inhibitors through molecular dynamics simulation studies

  2023cites this paper
• Searching for Natural Aurora a Kinase Inhibitors from Peppers Using Molecular Docking and Molecular Dynamics

  2023cites this paper
• Exploring Plant Meiosis: Insights from the Kinetochore Perspective

  2023cites this paper
• The Functions and Effects of CUL3-E3 Ligases Mediated Non-degradative Ubiquitination.

  2022cites this paper
• Integrated bioinformatics analysis for the screening of hub genes and therapeutic drugs in Hepatocellular carcinoma.

  2022cites this paper
• Exploration of the structural requirements of Aurora Kinase B inhibitors by a combined QSAR, modelling and molecular simulation approach

  2021cites this paper
• Discovery of potential Aurora-A kinase inhibitors by 3D QSAR pharmacophore modeling, virtual screening, docking, and MD simulation studies

  2021cites this paper
• Defining the Transcriptional and Epigenetic Basis of Organotypic Endothelial Diversity in the Developing and Adult Mouse

  2021cites this paper
• Investigational Drug Treatments for Triple-Negative Breast Cancer

  2021cites this paper
• Increased expression levels of AURKA and KIFC1 are promising predictors of progression and poor survival associated with gastric cancer.

  2021cites this paper
• Aurora kinase inhibitors as potential anticancer agents: Recent advances.

  2021cites this paper
• OTUD6A Is an Aurora Kinase A-Specific Deubiquitinase

  2021cites this paper
• Antrodia cinnamomea exerts an anti-hepatoma effect by targeting PI3K/AKT-mediated cell cycle progression in vitro and in vivo

  2021cites this paper
• A high-content screen for anti-mitosis and polyploidy-induction identifies an unknown activity of two benzophenanthridine alkaloids from Corydalis longicalcarata

  2021cites this paper
• Co-relation with novel phosphorylation sites of IκBα and necroptosis in breast cancer cells

  2020cites this paper
• Identification of abnormally expressed genes and their roles in invasion and migration of hepatocellular carcinoma.

  2020cites this paper
• Targeting the protein-protein interface pocket of Aurora-A-TPX2 complex: rational drug design and validation

  2020cites this paper
• Mitotic kinase anchoring proteins: the navigators of cell division

  2020influential citation
• Promising Therapy in Lung Cancer: Spotlight on Aurora Kinases

  2020cites this paper
• Purification, identification, and characterization of two benzophenanthridine alkaloids from Corydalis longicalcarata rhizomes with anti-mitotic and polyploidy-inducing activities

  2019cites this paper
• Aurora kinase Ipl1 facilitates bilobed distribution of clustered kinetochores to ensure error-free chromosome segregation in Candida albicans

  2019cites this paper
• A novel indirubin derivative that increases somatic cell plasticity and inhibits tumorigenicity.

  2019cites this paper
• A Novel AURKA Mutant-Induced Early-Onset Severe Hepatocarcinogenesis Greater than Wild-Type via Activating Different Pathways in Zebrafish

  2019cites this paper
• Determining the regulation and requirements of the three Aurora kinases in mammalian female meiosis

  2018cites this paper
• P190RhoGAP prevents mitotic spindle fragmentation and is required to activate Aurora A kinase at acentriolar poles

  2018cites this paper
• 1 LOCALIZATION OF AURORA A AND AURORA B KINASES DURING INTERPHASE : ROLE OF THE N-TERMINAL DOMAIN

  2018cites this paper
• Aurora Kinase Inhibitors in Head and Neck Cancer.

  2018cites this paper
• The functional diversity of Aurora kinases: a comprehensive review

  2018cites this paper
• Aurora kinase and FGFR3 inhibition results in significant apoptosis in molecular subgroups of multiple myeloma

  2018cites this paper
• Phase I study combining the aurora kinase a inhibitor alisertib with mFOLFOX in gastrointestinal cancer

  2018cites this paper
• Pharmacology and pharmacodynamics of selected antimalarials against P. falciparum gametocytes

  2017cites this paper
• Effect of small molecules on cell reprogramming.

  2017cites this paper
• Preclinical evaluation of the Aurora kinase inhibitors AMG 900, AZD1152-HQPA, and MK-5108 on SW-872 and 93T449 human liposarcoma cells

  2017influential citation
• Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.

  2017cites this paper
• Live cell imaging of anaphase bridge formation and the subsequent cleavage furrow regression induced by the Aurora B kinase inhibitor AZD1152-HQPA

  2017cites this paper
• Differential Selective Pressures Experienced by the Aurora Kinase Gene Family

  2017cites this paper
• Knockdown of Aurora A suppresses cell proliferation of human gastric cancer cells by inhibiting cell autophagy

  2017cites this paper
• Chromosomal Instability in Gastric Cancer Biology

  2017cites this paper
• The Role of Human Papillomaviruses in the Aetiopathogenesis of Head and Neck Cancer in South Asia, and Approaches to Treatment

  2017cites this paper
• Aurora A Kinase Function at Kinetochores.

  2017cites this paper
• Characterization of the Indirubin Derivative LDD970 as a Small Molecule Aurora Kinase A Inhibitor in Human Colorectal Cancer Cells

  2017cites this paper
• Specialize and Divide (Twice): Functions of Three Aurora Kinase Homologs in Mammalian Oocyte Meiotic Maturation.

  2017cites this paper
• Arsenic treatment increase Aurora-A overexpression through E2F1 activation in bladder cells

  2017cites this paper
• Association between the functional polymorphism Ile31Phe in the AURKA gene and susceptibility of hepatocellular carcinoma in chronic hepatitis B virus carriers

  2017cites this paper
• Epigenesis in Colorectal Cancer: A Lethal Change in the Cell

  2016cites this paper
• AURKA induces EMT by regulating histone modification through Wnt/β-catenin and PI3K/Akt signaling pathway in gastric cancer

  2016cites this paper
• Open‐label, multicenter, phase 1 study of alisertib (MLN8237), an aurora A kinase inhibitor, with docetaxel in patients with solid tumors

  2016cites this paper
• CHAPTER 4 The Identification of New Aurora A Kinase Inhibitors by Pharmacophore Modeling , Virtual Screening and Molecular Docking

  2016cites this paper
• Tanshinone I induces human colorectal cancer cell apoptosis: The potential roles of Aurora A-p53 and survivin-mediated signaling pathways.

  2016cites this paper
• The Dawn of Aurora Kinase Research: From Fly Genetics to the Clinic

  2015cites this paper
• Korrelation von TP53 Mutation und Stk15 Polymorphismus in Bezug auf Überleben von Patienten mit Plattenepithelkarzinomen im Kopf-Hals-Bereich

  2015cites this paper
• Regulation of AURKC expression by CpG island methylation in human cancer cells

  2015cites this paper
• AURKA upregulation plays a role in fibroblast-reduced gefitinib sensitivity in the NSCLC cell line HCC827

  2015cites this paper
• Non-motor Spindle Proteins as Cancer Chemotherapy Targets

  2015cites this paper
• Aurora Kinase Inhibitors: Current Status and Outlook

  2015cites this paper
• Aurora Kinase A is critical for the Nkx6.1 mediated β‐cell proliferation pathway

  2015cites this paper
• Understanding the molecular basis of RAS-association domain family member 7 (RASSF7) function

  2015cites this paper
• Optimizing and predicting the in vivo activity of AT9283 as a monotherapy and in combination with paclitaxel

  2015cites this paper
• Aurora-A kinase-inactive mutants disrupt the interaction with Ajuba and cause defects in mitotic spindle formation and G2/M phase arrest in HeLa cells

  2014cites this paper
• Two newly identified sites in the N-terminal regulatory domain of Aurora-A are essential for auto-inhibition

  2014cites this paper
• INSILICO APPROACHES TOWARDS THE DRUG TARGET AURORKINASES USING THE ORTHO OR META SUBSTITUTED BENZENE DERIVATIVES IN PYRAZOLES

  2014cites this paper
• QSAR studies of imidazo[4,5-b]pyridine derivatives as anticancer drugs using RASMS method

  2014cites this paper
• The mitosis-regulating and protein-protein interaction activities of astrin are controlled by aurora-A-induced phosphorylation.

  2014cites this paper
• Reprogram or reboot: small molecule approaches for the production of induced pluripotent stem cells and direct cell reprogramming.

  2014cites this paper
• The Role of LIM Kinase 1 and its Substrates in Cell Cycle Progression

  2014cites this paper
• A novel mechanism for activation of Aurora-A kinase by Ajuba.

  2014cites this paper
• Profiling of the kinome of cytomegalovirus-infected cells reveals the functional importance of host kinases Aurora A, ABL and AMPK.

  2013cites this paper
• Evaluation von Kinase-Inhibitoren zur Behandlung des Hepatoblastoms

  2013cites this paper
• Structural and mechanistic insights into centromere specification and kinetochore regulation

  2013cites this paper
• Skp-cullin-F box E3 ligase component FBXL2 ubiquitinates Aurora B to inhibit tumorigenesis

  2013cites this paper
• Upregulation of the TPX2 gene is associated with enhanced tumor malignance of esophageal squamous cell carcinoma.

  2013cites this paper
• Dissecting roles and regulation of the fission yeast kinetochore protein Spc7

  2013influential citation
• Development of a Fluorescence Intensity Assay for the Mitotic Serine/Threonine Protein Kinase Aurora-A

  2013influential citation
• AURORA KINASES-THE KEY MITOTIC REGULATORS

  2013cites this paper
• Tanshinones Inhibit the Growth of Breast Cancer Cells through Epigenetic Modification of Aurora A Expression and Function

  2012cites this paper
• The Transcription Factor YY1 Is a Novel Substrate for Aurora B Kinase at G2/M Transition of the Cell Cycle

  2012cites this paper
• Novel Agents In CML Therapy: Tyrosine Kinase Inhibitors and Beyond

  2012cites this paper
• Kaposi's Sarcoma Herpesvirus Upregulates Aurora A Expression to Promote p53 Phosphorylation and Ubiquitylation

  2012cites this paper
• AT9283, a novel aurora kinase inhibitor, suppresses tumor growth in aggressive B‐cell lymphomas

  2012cites this paper
• Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest

  2012cites this paper
• Identifying and Targeting Molecular Deregulations in Uterine Leiomyosarcoma: A Role for mTOR Inhibition-Based Combination Therapies

  2012cites this paper
• A novel role for TPX2 as a scaffold and co-activator protein of the Chromosomal Passenger Complex.

  2012cites this paper
• Phase I Pharmacokinetic/Pharmacodynamic Study of MLN8237, an Investigational, Oral, Selective Aurora A Kinase Inhibitor, in Patients with Advanced Solid Tumors

  2012cites this paper
• Spatio-Temporal Expression Patterns of Aurora Kinases A, B in Mouse Zygotes during the First Mitosis

  2011cites this paper
• PAR, a protein involved in the cell cycle, is functionally related to chromosomal passenger proteins.

  2011cites this paper
• New molecular targets in mantle cell lymphoma.

  2011cites this paper
• Aurora-A kinase inhibitor scaffolds and binding modes.

  2011cites this paper
• Phase I assessment of new mechanism-based pharmacodynamic biomarkers for MLN8054, a small-molecule inhibitor of Aurora A kinase.

  2011cites this paper
• Biology of Aurora A kinase: Implications in cancer manifestation and therapy

  2011cites this paper
• Phase 1 study of MLN8054, a selective inhibitor of Aurora A kinase in patients with advanced solid tumors

  2011cites this paper
• The potential role of Aurora kinase inhibitors in haematological malignancies

  2011cites this paper
• Overexpression of Active Aurora-C Kinase Results in Cell Transformation and Tumour Formation

  2011cites this paper