Development of therapeutics for high grade gliomas using orthotopic rodent models.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Current Medicinal Chemistry

• Publication date

  2013-08-31

• Fields of study

  Medicine

• Identifiers
  DOI 10.2174/0929867311320260011PMID 23521683
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Characterization of Glioma Stem Cells Through Multiple Stem Cell Markers and Their Specific Sensitization to Double‐Strand Break‐Inducing Agents by Pharmacological Inhibition of Ataxia Telangiectasia Mutated Protein

  2012cited by this paper
• Evaluation of radiation necrosis and malignant glioma in rat models using diffusion tensor MR imaging

  2012cited by this paper
• A novel multi-targeted tyrosine kinase inhibitor, linifanib (ABT-869), produces functional and structural changes in tumor vasculature in an orthotopic rat glioma model

  2012cited by this paper
• Dynamic inhibition of ATM kinase provides a strategy for glioblastoma multiforme radiosensitization and growth control

  2012cited by this paper
• [From bench to bedside: experience of the glioblastoma model for the optimization of radiosensitization].

  2012cited by this paper
• An in vivo patient-derived model of endogenous IDH1-mutant glioma.

  2012cited by this paper
• Cellular Host Responses to Gliomas

  2012cited by this paper
• Local delivery of slow-releasing temozolomide microspheres inhibits intracranial xenograft glioma growth

  2012cited by this paper
• CT322, a VEGFR-2 antagonist, demonstrates anti-glioma efficacy in orthotopic brain tumor model as a single agent or in combination with temozolomide and radiation therapy

  2012cited by this paper
• Inhibition and eradication of human glioma with tumor-targeting Salmonella typhimurium in an orthotopic nude-mouse model

  2012cited by this paper
• Rhenium-186 liposomes as convection-enhanced nanoparticle brachytherapy for treatment of glioblastoma.

  2012cited by this paper
• Maintenance of primary tumor phenotype and genotype in glioblastoma stem cells.

  2012cited by this paper
• MicroRNA-30e* promotes human glioma cell invasiveness in an orthotopic xenotransplantation model by disrupting the NF-κB/IκBα negative feedback loop.

  2012cited by this paper
• The brain microenvironment preferentially enhances the radioresistance of CD133(+) glioblastoma stem-like cells.

  2012cited by this paper
• Preclinical Pharmacokinetic and Pharmacodynamic Evaluation of Novel Anticancer Agents, ON01910.Na (Rigosertib, Estybon™) and ON013105, for Brain Tumor Chemotherapy

  2012cited by this paper
• Inhibition of cancer stem cell-like properties and reduced chemoradioresistance of glioblastoma using microRNA145 with cationic polyurethane-short branch PEI.

  2012cited by this paper
• Molecular profiling indicates orthotopic xenograft of glioma cell lines simulate a subclass of human glioblastoma

  2012cited by this paper
• Wnt activation is implicated in glioblastoma radioresistance

  2012cited by this paper
• Imaging of human mesenchymal stromal cells: homing to human brain tumors

  2012cited by this paper
• Costimulatory Protein 4IgB7H3 Drives the Malignant Phenotype of Glioblastoma by Mediating Immune Escape and Invasiveness

  2011cited by this paper
• Effect of brain- and tumor-derived connective tissue growth factor on glioma invasion.

  2011cited by this paper
• MicroRNA-146a Inhibits Glioma Development by Targeting Notch1

  2011cited by this paper
• Decreased CCAAT/enhancer binding protein β expression inhibits the growth of glioblastoma cells.

  2011cited by this paper
• Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme.

  2011cited by this paper
• Effects of photoacoustic imaging and photothermal ablation therapy mediated by targeted hollow gold nanospheres in an orthotopic mouse xenograft model of glioma.

  2011cited by this paper
• Alginate encapsulated human mesenchymal stem cells suppress syngeneic glioma growth in the immunocompetent rat

  2011cited by this paper
• Imaging, Autoradiography, and Biodistribution of 188Re-Labeled PEGylated Nanoliposome in Orthotopic Glioma Bearing Rat Model

  2011cited by this paper
• Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy

  2011cited by this paper
• Influence of glioma tumour microenvironment on the transport of ANG1005 via low-density lipoprotein receptor-related protein 1

  2011cited by this paper
• Nonredundant functions for Akt isoforms in astrocyte growth and gliomagenesis in an orthotopic transplantation model.

  2011cited by this paper
• Bevacizumab Has Differential and Dose-Dependent Effects on Glioma Blood Vessels and Tumor Cells

  2011cited by this paper
• Identification of a peptide that interacts with Nestin protein expressed in brain cancer stem cells.

  2011cited by this paper
• Targeted signal-amplifying enzymes enhance MRI of EGFR expression in an orthotopic model of human glioma.

  2011cited by this paper
• Comparison of Corticotropin-Releasing Factor, Dexamethasone, and Temozolomide: Treatment Efficacy and Toxicity in U87 and C6 Intracranial Gliomas

  2011cited by this paper
• Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

  2011cited by this paper
• NUMB does not impair growth and differentiation status of experimental gliomas.

  2011cited by this paper
• Trans sodium crocetinate: functional neuroimaging studies in a hypoxic brain tumor.

  2011cited by this paper
• SOX2-RNAi attenuates S-phase entry and induces RhoA-dependent switch to protease-independent amoeboid migration in human glioma cells

  2011cited by this paper
• Novel cryo-imaging of the glioma tumor microenvironment reveals migration and dispersal pathways in vivid three-dimensional detail.

  2011cited by this paper
• Complementary information from magnetic resonance imaging and (18)F-fluoromisonidazole positron emission tomography in the assessment of the response to an antiangiogenic treatment in a rat brain tumor model.

  2011cited by this paper
• Using the heat-shock response to discover anticancer compounds that target protein homeostasis.

  2011cited by this paper
• Temozolomide modifies caveolin-1 expression in experimental malignant gliomas in vitro and in vivo.

  2011cited by this paper
• Tumor eradication in rat glioma and bypass of immunosuppressive barriers using internal radiation with (188)Re-lipid nanocapsules.

  2011cited by this paper
• Sensitivity of MRI Tumor Biomarkers to VEGFR Inhibitor Therapy in an Orthotopic Mouse Glioma Model

  2011cited by this paper
• Restoring Soluble Guanylyl Cyclase Expression and Function Blocks the Aggressive Course of Glioma

  2011cited by this paper
• Serine/threonine protein phosphatase 6 modulates the radiation sensitivity of glioblastoma

  2011cited by this paper
• EGFR Gene Overexpression Retained in an Invasive Xenograft Model by Solid Orthotopic Transplantation of Human Glioblastoma Multiforme Into Nude Mice

  2011cited by this paper
• A critical role for regulatory T cells in driving cytokine profiles of Th17 cells and their modulation of glioma microenvironment

  2011cited by this paper
• The miR 302-367 cluster drastically affects self-renewal and infiltration properties of glioma-initiating cells through CXCR4 repression and consequent disruption of the SHH-GLI-NANOG network

  2011cited by this paper
• Near-infrared Optical Imaging of Exposed Phosphatidylserine in a Mouse Glioma Model.

  2011cited by this paper
• Magnetic resonance imaging-guided microdialysis cannula implantation in a spontaneous high-grade glioma murine model.

  2011cited by this paper
• Antiglioma effects of a new, low molecular mass, inhibitor of fibroblast growth factor.

  2011cited by this paper
• Effects of targeting the VEGF and PDGF pathways in diffuse orthotopic glioma models

  2011cited by this paper
• Systemic combinatorial peptide selection yields a non-canonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastoma.

  2011cited by this paper
• A comparative study of neural and mesenchymal stem cell-based carriers for oncolytic adenovirus in a model of malignant glioma.

  2011cited by this paper
• Comparative evaluation of preclinical in vivo models for the assessment of replicating retroviral vectors for the treatment of glioblastoma

  2011cited by this paper
• PDGF-B Can sustain self-renewal and tumorigenicity of experimental glioma-derived cancer-initiating cells by preventing oligodendrocyte differentiation.

  2011cited by this paper
• JLK1486, a Bis 8-Hydroxyquinoline-Substituted Benzylamine, Displays Cytostatic Effects in Experimental Gliomas through MyT1 and STAT1 Activation and, to a Lesser Extent, PPARγ Activation.

  2011cited by this paper
• Monitoring of Tumor Growth and Post‐Irradiation Recurrence in a Diffuse Intrinsic Pontine Glioma Mouse Model

  2011cited by this paper
• Lonafarnib (SCH66336) improves the activity of temozolomide and radiation for orthotopic malignant gliomas

  2011cited by this paper
• Targeted Therapy for BRAFV600E Malignant Astrocytoma

  2011cited by this paper
• Toxicity and delivery methods for the linamarase/linamarin/glucose oxidase system, when used against human glioma tumors implanted in the brain of nude rats.

  2011cited by this paper
• Green tea epigallocatechin gallate enhances therapeutic efficacy of temozolomide in orthotopic mouse glioblastoma models.

  2011cited by this paper
• A dual PI3K/mTOR inhibitor, PI-103, cooperates with stem cell-delivered TRAIL in experimental glioma models.

  2011cited by this paper
• Neural stem cell-based cell carriers enhance therapeutic efficacy of an oncolytic adenovirus in an orthotopic mouse model of human glioblastoma.

  2011cited by this paper
• The expression of BST2 in human and experimental mouse brain tumors.

  2011cited by this paper
• Minocycline reduces glioma expansion and invasion by attenuating microglial MT1-MMP expression.

  2011cited by this paper
• RGD-modified PEG-PAMAM-DOX conjugates: in vitro and in vivo studies for glioma.

  2011cited by this paper
• Combined action of the dinuclear platinum compound BBR3610 with the PI3‐K inhibitor PX‐866 in glioblastoma

  2011cited by this paper
• Frontiers in targeting glioma stem cells.

  2011cited by this paper
• Preclinical and clinical studies of NK012, an SN-38-incorporating polymeric micelles, which is designed based on EPR effect.

  2011cited by this paper
• Stem cell-mediated delivery of therapies in the treatment of glioma.

  2011cited by this paper
• Immunotherapy for glioma: getting closer to the clinical arena?

  2011cited by this paper
• hMSC-mediated concurrent delivery of endostatin and carboxylesterase to mouse xenografts suppresses glioma initiation and recurrence.

  2011cited by this paper
• Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides

  2010cited by this paper
• Intra-tumoral dendritic cells increase efficacy of peripheral vaccination by modulation of glioma microenvironment.

  2010cited by this paper
• Enhanced Cancer Therapy with the Combination of EGFR and VEGFR-2 Targeting in an Orthotopic Glioblastoma Model

  2010cited by this paper
• Combination therapy with Gamma Knife radiosurgery and antisense EGFR for malignant glioma in vitro and orthotopic xenografts.

  2010cited by this paper
• Improving the radiosensitivity of radioresistant and hypoxic glioblastoma.

  2010cited by this paper
• Angiopoietin-2 Interferes with Anti-VEGFR2–Induced Vessel Normalization and Survival Benefit in Mice Bearing Gliomas

  2010cited by this paper
• Effect of hyperoxygenation on tissue pO2 and its effect on radiotherapeutic efficacy of orthotopic F98 gliomas.

  2010cited by this paper
• Irradiation Enhances the Tumor Tropism and Therapeutic Potential of Tumor Necrosis Factor‐Related Apoptosis‐Inducing Ligand‐Secreting Human Umbilical Cord Blood‐Derived Mesenchymal Stem Cells in Glioma Therapy

  2010cited by this paper
• Dietary Curcumin Attenuates Glioma Growth in a Syngeneic Mouse Model by Inhibition of the JAK1,2/STAT3 Signaling Pathway

  2010cited by this paper
• Astrocyte Elevated Gene-1: A Novel Target for Human Glioma Therapy

  2010cited by this paper
• Trans-sodium crocetinate enhancing survival and glioma response on magnetic resonance imaging to radiation and temozolomide.

  2010cited by this paper
• Tumor localization of an anti-TGF-β antibody and its effects on gliomas.

  2010cited by this paper
• Improved intratumoral oxygenation through vascular normalization increases glioma sensitivity to ionizing radiation.

  2010cited by this paper
• Microenvironmental Regulation of Glioblastoma Radioresponse

  2010cited by this paper
• Long-term in vitro treatment of human glioblastoma cells with temozolomide increases resistance in vivo through up-regulation of GLUT transporter and aldo-keto reductase enzyme AKR1C expression.

  2010cited by this paper
• The Telomerase Antagonist, Imetelstat, Efficiently Targets Glioblastoma Tumor-Initiating Cells Leading to Decreased Proliferation and Tumor Growth

  2010cited by this paper
• EGFRvIII and DNA double-strand break repair: a molecular mechanism for radioresistance in glioblastoma.

  2009cited by this paper
• Different Response of Human Glioma Tumor-initiating Cells to Epidermal Growth Factor Receptor Kinase Inhibitors*

  2009cited by this paper
• A color‐coded orthotopic nude‐mouse treatment model of brain‐metastatic paralyzing spinal cord cancer that induces angiogenesis and neurogenesis

  2009cited by this paper
• Inhibition of invasion-associated thromboxane synthase sensitizes experimental gliomas to γ-radiation

  2009cited by this paper
• Tissue pO2 of orthotopic 9L and C6 gliomas and tumor-specific response to radiotherapy and hyperoxygenation.

  2009cited by this paper
• Radiation sensitization of glioblastoma by cilengitide has unanticipated schedule‐dependency

  2009cited by this paper
• Evaluation of MGMT promoter methylation status and correlation with temozolomide response in orthotopic glioblastoma xenograft model

  2009cited by this paper
• Comparative Analysis of DNA Repair in Stem and Nonstem Glioma Cell Cultures

  2009cited by this paper
• Dendritic cell vaccines for cancer stem cells.

  2009cited by this paper
• Tumour control by whole brain irradiation of anti-VEGF-treated mice bearing intracerebral glioma.

  2009cited by this paper

• Designing a web-based platform for dynamic estimation of individualized conditional survival in grade 3 gliomas

  2025cites this paper
• Circular RNAs in EMT-driven metastasis regulation: modulation of cancer cell plasticity, tumorigenesis and therapy resistance

  2024cites this paper
• Most recent update of preclinical and clinical data on radioresistance and radiosensitivity of high-grade gliomas—a radiation oncologist’s perspective

  2022cites this paper
• Improving control of high‐grade glioma by ultra‐hyper‐fractionated radiotherapy

  2022cites this paper
• Ultra‐hyper‐fractionated radiotherapy for high‐grade gliomas

  2021cites this paper
• Circ_0000215 Increases the Expression of CXCR2 and Promoted the Progression of Glioma Cells by Sponging miR-495-3p

  2020cites this paper
• The efficacy and toxicity of ATM inhibition in glioblastoma initiating cells-driven tumor models.

  2019cites this paper
• Circular RNA hsa-circ-0012129 Promotes Cell Proliferation and Invasion in 30 Cases of Human Glioma and Human Glioma Cell Lines U373, A172, and SHG44, by Targeting MicroRNA-661 (miR-661)

  2018cites this paper
• ATR kinase inhibitors NVP-BEZ235 and AZD6738 effectively penetrate the brain after systemic administration

  2018cites this paper
• Blocking epithelial-to-mesenchymal transition in glioblastoma with a sextet of repurposed drugs: the EIS regimen

  2017cites this paper
• Snail homolog 1 is involved in epithelial-mesenchymal transition-like processes in human glioblastoma cells.

  2017cites this paper
• Non-routine Tracers for PET Imaging of High-grade Glioma.

  2016cites this paper
• Nanoparticle-mediated drug delivery to high-grade gliomas.

  2016cites this paper
• In vivo MRI visualization of U87 glioblastoma development dynamics in the model of orthotopic xenotransplantation to the SCID mouse

  2016cites this paper
• Targeting the Ataxia Telangiectasia Mutated Protein in Cancer Therapy.

  2016cites this paper
• In vivo MRI visualization of growth and morphology in the orthotopic xenotrasplantation U 87 glioblastoma mouse SCID model

  2015cites this paper