The role of the zinc transporter SLC30A2/ZnT2 in transient neonatal zinc deficiency.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Metallomics

• Publication date

  2017-10-18

• Fields of study

  Medicine

• Identifiers
  DOI 10.1039/c7mt00162bPMID 28665435
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The interactome of the copper transporter ATP7A belongs to a network of neurodevelopmental and neurodegeneration factors

  2017cited by this paper
• Structural insights of ZIP4 extracellular domain critical for optimal zinc transport

  2016cited by this paper
• Direct Comparison of Manganese Detoxification/Efflux Proteins and Molecular Characterization of ZnT10 Protein as a Manganese Transporter*

  2016cited by this paper
• Molecular regulation of lactation: The complex and requisite roles for zinc.

  2016cited by this paper
• Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect.

  2016cited by this paper
• Differential Targeting of SLC30A10/ZnT10 Heterodimers to Endolysosomal Compartments Modulates EGF‐Induced MEK/ERK1/2 Activity

  2016cited by this paper
• Molecular Basis of Transient Neonatal Zinc Deficiency

  2016cited by this paper
• ZnT2-Mediated Zinc Import Into Paneth Cell Granules Is Necessary for Coordinated Secretion and Paneth Cell Function in Mice

  2016cited by this paper
• Su1902 Genetic Variation in the Zinc Transporter Znt2 (Slc30a2) Is Associated With Altered Establishment of Intestinal Microbiota in Preterm Infants

  2016cited by this paper
• Subtype-specific accumulation of intracellular zinc pools is associated with the malignant phenotype in breast cancer

  2016cited by this paper
• The PP-motif in luminal loop 2 of ZnT transporters plays a pivotal role in TNAP activation.

  2016cited by this paper
• Novel mutations in SLC30A2 involved in the pathogenesis of transient neonatal zinc deficiency

  2016cited by this paper
• Rac1 Controls Both the Secretory Function of the Mammary Gland and Its Remodeling for Successive Gestations

  2016cited by this paper
• Infants and elderlies are susceptible to zinc deficiency

  2016cited by this paper
• Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism–dystonia

  2016cited by this paper
• Essential Role for Zinc Transporter 2 (ZnT2)-mediated Zinc Transport in Mammary Gland Development and Function during Lactation*

  2015cited by this paper
• Autosomal-Recessive Intellectual Disability with Cerebellar Atrophy Syndrome Caused by Mutation of the Manganese and Zinc Transporter Gene SLC39A8.

  2015cited by this paper
• Exome Sequencing of SLC30A2 Identifies Novel Loss- and Gain-of-Function Variants Associated with Breast Cell Dysfunction

  2015cited by this paper
• Overview of Inherited Zinc Deficiency in Infants and Children.

  2015cited by this paper
• TNFα Post‐Translationally Targets ZnT2 to Accumulate Zinc in Lysosomes

  2015cited by this paper
• SLC39A14 Is Required for the Development of Hepatocellular Iron Overload in Murine Models of Hereditary Hemochromatosis.

  2015cited by this paper
• The Physiological, Biochemical, and Molecular Roles of Zinc Transporters in Zinc Homeostasis and Metabolism.

  2015cited by this paper
• SLC39A8 Deficiency: A Disorder of Manganese Transport and Glycosylation.

  2015cited by this paper
• Computation and Functional Studies Provide a Model for the Structure of the Zinc Transporter hZIP4*

  2015cited by this paper
• A high molecular mass zinc transporter MTP12 forms a functional heteromeric complex with MTP5 in the Golgi in Arabidopsis thaliana

  2015cited by this paper
• Heterodimerization, Altered Subcellular Localization, and Function of Multiple Zinc Transporters in Viable Cells Using Bimolecular Fluorescence Complementation

  2015cited by this paper
• Genetic causes and gene–nutrient interactions in mammalian zinc deficiencies: acrodermatitis enteropathica and transient neonatal zinc deficiency as examples.

  2015cited by this paper
• ZnT2 is a critical mediator of lysosomal-mediated cell death during early mammary gland involution

  2015cited by this paper
• Altered expression of two zinc transporters, SLC30A5 and SLC30A6, underlies a mammary gland disorder of reduced zinc secretion into milk

  2015cited by this paper
• A novel approach to probiotic delivery for neonatal necrotizing enterocolitis

  2015cited by this paper
• ZnT-1 extrudes zinc from mammalian cells functioning as a Zn(2+)/H(+) exchanger.

  2014cited by this paper
• Cation Diffusion Facilitators Transport Initiation and Regulation Is Mediated by Cation Induced Conformational Changes of the Cytoplasmic Domain

  2014cited by this paper
• Quantitative mapping of zinc fluxes in the mammalian egg reveals the origin of fertilization-induced zinc sparks

  2014cited by this paper
• Visualizing the kinetic power stroke that drives proton-coupled Zn(II) transport

  2014cited by this paper
• Zinc signals and immune function

  2014cited by this paper
• Prolactin (PRL)-stimulated Ubiquitination of ZnT2 Mediates a Transient Increase in Zinc Secretion Followed by ZnT2 Degradation in Mammary Epithelial Cells*

  2014cited by this paper
• Role of zinc trafficking in male fertility: from germ to sperm.

  2014cited by this paper
• Current understanding of ZIP and ZnT zinc transporters in human health and diseases

  2014cited by this paper
• Transient Neonatal Zinc Deficiency Due to a New Autosomal Dominant Mutation in Gene SLC30A2 (ZnT‐2)

  2014cited by this paper
• In Situ Dimerization of Multiple Wild Type and Mutant Zinc Transporters in Live Cells Using Bimolecular Fluorescence Complementation

  2014cited by this paper
• Prolactin receptor attenuation induces zinc pool redistribution through ZnT2 and decreases invasion in MDA-MB-453 breast cancer cells.

  2014cited by this paper
• Transient Neonatal Zinc Deficiency Caused by a Heterozygous G87R Mutation in the Zinc Transporter ZnT-2 (SLC30A2) Gene in the Mother Highlighting the Importance of Zn2+ for Normal Growth and Development

  2013cited by this paper
• The SLC30 family of zinc transporters - a review of current understanding of their biological and pathophysiological roles.

  2013cited by this paper
• Compound Heterozygous Mutations in SLC30A2/ZnT2 Results in Low Milk Zinc Concentrations: A Novel Mechanism for Zinc Deficiency in a Breast-Fed Infant

  2013cited by this paper
• Cooperative Functions of ZnT1, Metallothionein and ZnT4 in the Cytoplasm Are Required for Full Activation of TNAP in the Early Secretory Pathway

  2013cited by this paper
• The SLC39 family of zinc transporters.

  2013cited by this paper
• Zinc-binding and structural properties of the histidine-rich loop of Arabidopsis thaliana vacuolar membrane zinc transporter MTP1☆

  2013cited by this paper
• Update on Zinc Deficiency and Excess in Clinical Pediatric Practice

  2013cited by this paper
• Molecular architecture and function of ZnT transporters.

  2012cited by this paper
• Physiologic implications of metal-ion transport by ZIP14 and ZIP8

  2012cited by this paper
• Cellular Mechanisms of Zinc Dysregulation: A Perspective on Zinc Homeostasis as an Etiological Factor in the Development and Progression of Breast Cancer

  2012cited by this paper
• A Dominant Negative Heterozygous G87R Mutation in the Zinc Transporter, ZnT-2 (SLC30A2), Results in Transient Neonatal Zinc Deficiency

  2012cited by this paper
• Inward-facing conformation of the zinc transporter YiiP revealed by cryoelectron microscopy

  2012cited by this paper
• Hepcidin and iron homeostasis.

  2012cited by this paper
• Zinc networks: the cell-specific compartmentalization of zinc for specialized functions

  2012cited by this paper
• Histidine pairing at the metal transport site of mammalian ZnT transporters controls Zn2+ over Cd2+ selectivity

  2012cited by this paper
• Transient zinc deficiency syndrome in a breast-fed infant due to decreased zinc in breast milk (type II hypozincemia of infancy): A case report and review of the literature

  2012cited by this paper
• Zinc in specialized secretory tissues: roles in the pancreas, prostate, and mammary gland.

  2011cited by this paper
• Biochemical Characterization of Human ZIP13 Protein

  2011cited by this paper
• Longitudinal analysis of macronutrients and minerals in human milk produced by mothers of preterm infants.

  2011cited by this paper
• A histidine‐rich motif mediates mitochondrial localization of ZnT2 to modulate mitochondrial function

  2011cited by this paper
• Measuring steady-state and dynamic endoplasmic reticulum and Golgi Zn2+ with genetically encoded sensors

  2011cited by this paper
• Molecular and genetic features of zinc transporters in physiology and pathogenesis.

  2011cited by this paper
• Selective Electrodiffusion of Zinc Ions in a Zrt-, Irt-like Protein, ZIPB*♦

  2010cited by this paper
• STAT5-glucocorticoid receptor interaction and MTF-1 regulate the expression of ZnT2 (Slc30a2) in pancreatic acinar cells

  2010cited by this paper
• Zinc Availability Regulates Exit from Meiosis in Maturing Mammalian Oocytes

  2010cited by this paper
• Zinc transporter expression profiles in the rat prostate following alterations in dietary zinc

  2010cited by this paper
• Effects of Zinc Exposure on Zinc Transporter Expression in Human Intestinal Cells of Varying Maturity

  2010cited by this paper
• Genetically encoded FRET sensors to monitor intracellular Zn2+ homeostasis

  2009cited by this paper
• Zinc deficiency

  2009cited by this paper
• Structural Basis for Auto-regulation of the Zinc Transporter YiiP

  2009cited by this paper
• Identification of the Zn2+ Binding Site and Mode of Operation of a Mammalian Zn2+ Transporter*

  2009cited by this paper
• Mammalian zinc transporters: nutritional and physiologic regulation.

  2009cited by this paper
• Prolactin regulates ZNT2 expression through the JAK2/STAT5 signaling pathway in mammary cells.

  2009cited by this paper
• Demonstration and Characterization of the Heterodimerization of ZnT5 and ZnT6 in the Early Secretory Pathway*

  2009cited by this paper
• SLC30A3 (ZnT3) Oligomerization by Dityrosine Bonds Regulates Its Subcellular Localization and Metal Transport Capacity

  2009cited by this paper
• Insights into Zn2+ homeostasis in neurons from experimental and modeling studies.

  2008cited by this paper
• Deletion of a Histidine-rich Loop of AtMTP1, a Vacuolar Zn2+/H+ Antiporter of Arabidopsis thaliana, Stimulates the Transport Activity*

  2008cited by this paper
• Cation diffusion facilitator Cis4 is implicated in Golgi membrane trafficking via regulating zinc homeostasis in fission yeast.

  2008cited by this paper
• The genetics of essential metal homeostasis during development

  2008cited by this paper
• Zinc fluxes and zinc transporter genes in chronic diseases.

  2007cited by this paper
• Why Do We Still Have a Maternally Inherited Mitochondrial DNA ? Insights from Evolutionary Medicine

  2007cited by this paper
• Structure of the Zinc Transporter YiiP

  2007cited by this paper
• Counting the zinc-proteins encoded in the human genome.

  2006cited by this paper
• Zinc and skin health: overview of physiology and pharmacology.

  2006cited by this paper
• Identification of a Mutation in SLC30A2 (ZnT-2) in Women with Low Milk Zinc Concentration That Results in Transient Neonatal Zinc Deficiency*

  2006cited by this paper
• Correlation between zinc status and immune function in the elderly

  2006cited by this paper
• Zinc-buffering capacity of a eukaryotic cell at physiological pZn

  2006cited by this paper
• Zinc requirements and the risks and benefits of zinc supplementation.

  2006cited by this paper
• Two Different Zinc Transport Complexes of Cation Diffusion Facilitator Proteins Localized in the Secretory Pathway Operate to Activate Alkaline Phosphatases in Vertebrate Cells*

  2005cited by this paper
• Heteromeric Protein Complexes Mediate Zinc Transport into the Secretory Pathway of Eukaryotic Cells*

  2005cited by this paper
• Zinc-induced copper deficiency: a report of three cases initially recognized on bone marrow examination.

  2005cited by this paper
• Responsive transporter genes within the murine intestinal-pancreatic axis form a basis of zinc homeostasis.

  2004cited by this paper
• Mutation spectrum of human SLC39A4 in a panel of patients with acrodermatitis enteropathica

  2003cited by this paper
• The LZT proteins; the LIV-1 subfamily of zinc transporters.

  2003cited by this paper
• Zinc transporters 1, 2 and 4 are differentially expressed and localized in rats during pregnancy and lactation.

  2003cited by this paper
• Zinc Deficiency in Nursing Infants

  2002cited by this paper
• Zinc transporters in the rat mammary gland respond to marginal zinc and vitamin A intakes during lactation.

  2002cited by this paper
• A novel member of a zinc transporter family is defective in acrodermatitis enteropathica.

  2002cited by this paper
• Identification of SLC39A4, a gene involved in acrodermatitis enteropathica

  2002cited by this paper

• Genomic characterization of normal and aberrant human milk production

  2025cites this paper
• Transient neonatal zinc deficiency in a 3-month-old infant: A case report

  2025cites this paper
• Improved linear growth after routine zinc supplementation in preterm very low birth weight infants

  2025cites this paper
• Heterozygous Variants of the SLC39A4 Gene and Possible Increased Risk for Developing Acrodermatitis Enteropathica with Kaposi’s Varicelliform Eruption

  2025cites this paper
• Distribution of free amino acids in human breast milk from Asian countries

  2025cites this paper
• ZnTs: Key Regulators of Zn2+ Homeostasis in Diseases

  2025cites this paper
• Dietary Zn—Recent Advances in Studies on Its Bioaccessibility and Bioavailability

  2025cites this paper
• Acrodermatitis enteropathica in the pediatric population: a literature review of real-world studies

  2025cites this paper
• Zinc deficiency as possible link between immunosenescence and age-related diseases

  2025cites this paper
• Transient neonatal zinc deficiency or acrodermatitis enteropathica?

  2024cites this paper
• Deficiência neonatal transitória de zinco ou acrodermatite enteropática?

  2024cites this paper
• Emerging Perspectives in Zinc Transporter Research in Prostate Cancer: An Updated Review

  2024cites this paper
• Zinc and its binding proteins: essential roles and therapeutic potential

  2024cites this paper
• Novel SLC30A2 mutations in the pathogenesis of transient neonatal zinc deficiency

  2023cites this paper
• Neurodevelopmental Consequences of Dietary Zinc Deficiency: A Status Report

  2023cites this paper
• Trace elements status in human breast milk of mothers from Île-de-France region.

  2023cites this paper
• Impact of Zinc Transport Mechanisms on Embryonic and Brain Development

  2022cites this paper
• Zinc deficiency associated with cutaneous toxicities induced by epidermal growth factor receptor tyrosine kinase inhibitor therapy in patients with lung adenocarcinoma

  2022cites this paper
• Case report: Acrodermatitis enteropathica result from a novel SLC39A4 gene mutation

  2022cites this paper
• Zinc and Zinc Transporters in Dermatology

  2022cites this paper
• Erythematous scaly plaques with erosions in a 4-month-old

  2022cites this paper
• Zinc Signaling in the Mammary Gland: For Better and for Worse

  2021cites this paper
• Metal transport mechanism of the cation diffusion facilitator (CDF) protein family – a structural perspective on human CDF (ZnT)-related diseases

  2021cites this paper
• Metal- and metalloid-based compounds to target and reverse cancer multidrug resistance.

  2021cites this paper
• Channels and Transporters in Zymogen Granule Membranes and their Role in Granule Function: A Critical Assessment

  2020cites this paper
• A novel homozygous mutation p.E88K in maternal SLC30A2 gene as a cause of transient neonatal zinc deficiency

  2020cites this paper
• A common genetic variant in ZnT2 (Thr288Ser) is present in women with low milk volume and alters lysosome function and cell energetics.

  2020cites this paper
• Metallothionein isoforms as double agents - Their roles in carcinogenesis, cancer progression and chemoresistance.

  2020cites this paper
• Genetic and Physiological Factors Affecting Human Milk Production and Composition

  2020cites this paper
• Role of zinc in neonatal growth and brain growth: review and scoping review

  2020cites this paper
• Zinc transporters in physiology and pathophysiology

  2020cites this paper
• Zinc Transporters Involved in Vectorial Zinc Transport in Intestinal Epithelial Cells

  2020cites this paper
• ZnT2 is an electroneutral proton-coupled vesicular antiporter displaying an apparent stoichiometry of two protons per zinc ion

  2019cites this paper
• Maintenance of Intestinal Epithelial Homeostasis by Zinc Transporters

  2019cites this paper
• Zinc Transporter Proteins: A Review and a New View from Biochemistry

  2019cites this paper
• Zinc Transporters and Zinc Signaling in Skin Formation and Diseases

  2019cites this paper
• NICU Diet, Physical Growth and Nutrient Accretion, and Preterm Infant Brain Development.

  2019cites this paper
• "Zinc homeostasis and zinc signaling in white matter development and injury".

  2019cites this paper
• Evaluation of the roles of the cytosolic N-terminus and His-rich loop of ZNT proteins using ZNT2 and ZNT3 chimeric mutants

  2018cites this paper
• How cellular Zn2+ signaling drives physiological functions.

  2018cites this paper
• High proportion of transient neonatal zinc deficiency causing alleles in the general population

  2018influential citation
• Demonstrating aspects of multiscale modeling by studying the permeation pathway of the human ZnT2 zinc transporter

  2018cites this paper
• Polymerization led selective detection and removal of Zn2+ and Cd2+ ions: isolation of Zn- and Cd-MOFs and reversibility studies.

  2018cites this paper
• Zinc

  1978cites this paper